Faculty Profiles - FUJIHARA Kazuya

Papers - FUJIHARA Kazuya

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Skipping breakfast, late-night eating and current smoking are associated with medication adherence in Japanese patients with diabetes. Reviewed International journal

Yuta Yaguchi, Kazuya Fujihara, Mayuko Harada Yamada, Yasuhiro Matsubayashi, Masaru Kitazawa, Taeko Osawa, Masahiko Yamamoto, Masanori Kaneko, Nauta Yamanaka, Hiroyasu Seida, Satoru Kodama, Hirohito Sone

Primary care diabetes 14 ( 6 ) 753 - 759 2020.12

Language：English Publishing type：Research paper (scientific journal)

AIMS: Little is known about the relationship between medication adherence for oral hypoglycemic agents (OHAs) and glycemic control after adjusting healthy adherer effect in large scale study. Thus, adjusting for health-related behaviors, we investigated the clinical variables associated with medication adherence and the relationship between medication adherence and glycemic control using a large claims database. METHODS: Analyzed were 8805 patients with diabetes whose medication records for OHA were available for at least 1year. Medication adherence was evaluated by the proportion of days covered (PDC). Multivariate logistic regression model was used to identify clinical variables significantly associated with non-adherence. Multiple regression analysis evaluated the relationship between PDC and HbA1c after adjusting for health-related behaviors. RESULTS: Mean PDC was 80.1% and 32.8% of patients were non-adherence. Logistic analysis indicated that older age and taking concomitant medications were significantly associated with adherence while skipping breakfast (odds ratio 0.66 [95% CI 0.57-0.76]), late-night eating (0.86 [0.75-0.98]), and current smoking (0.89 [0.80-0.99]) were significantly associated with non-adherence. CONCLUSIONS: Skipping breakfast, late-night eating and current smoking were significantly associated with medication adherence, suggesting that clinicians pay attention to those health-related behaviors to achieve good medication adherence.

DOI： 10.1016/j.pcd.2020.05.002

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眼科処置を要する糖尿病重症眼疾患発生と飲酒についての検討

山本正彦, 藤原和哉, 矢口雄大, 大澤妙子, 山田万祐子, 松林泰弘, 長谷部日, 曽根博仁

糖尿病合併症 34 ( Suppl.1 ) 269 - 269 2020.11

心血管・動脈硬化耐糖能別にみた収縮期血圧と冠動脈疾患、脳血管疾患発症との関連

山田万祐子, 藤原和哉, 大澤妙子, 矢口雄大, 北澤勝, 松林泰弘, 岩永みどり, 清田浩康, 山中菜詩, 山田貴穂, 曽根博仁

糖尿病合併症 34 ( Suppl.1 ) 219 - 219 2020.11

心血管・動脈硬化耐糖能別にみた収縮期血圧と冠動脈疾患、脳血管疾患発症との関連

山田万祐子, 藤原和哉, 大澤妙子, 矢口雄大, 北澤勝, 松林泰弘, 岩永みどり, 清田浩康, 山中菜詩, 山田貴穂, 曽根博仁

糖尿病合併症 34 ( Suppl.1 ) 219 - 219 2020.11

眼科処置を要する糖尿病重症眼疾患発生と飲酒についての検討

山本正彦, 藤原和哉, 矢口雄大, 大澤妙子, 山田万祐子, 松林泰弘, 長谷部日, 曽根博仁

糖尿病合併症 34 ( Suppl.1 ) 269 - 269 2020.11

Network Meta-Analysis of Drug Therapies for Lowering Uric Acid and Mortality Risk in Patients with Heart Failure. International journal

Satoru Kodama, Kazuya Fujihara, Chika Horikawa, Mayuko Yamada, Takaaki Sato, Yuta Yaguchi, Masahiko Yamamoto, Masaru Kitazawa, Yasuhiro Matsubayashi, Takaho Yamada, Kenichi Watanabe, Hirohito Sone

Cardiovascular drugs and therapy 35 ( 6 ) 1217 - 1225 2020.10

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: This network meta-analysis aimed to assess the current efficacy of decreasing the uric acid (UA) level with drugs to reduce mortality in patients with heart failure (HF). METHODS: Electronic literature searches using EMBASE and MEDLINE of studies published from 1 Jan 1950 to 26 Dec 2019 were conducted for randomized controlled trials or non-randomized cohort studies that included at least one group of patients who took UA-lowering drugs and with a study outcome of all-cause mortality. A random-effects network meta-analysis was performed within a frequentist framework. Hierarchy of treatments was expressed as the surface under the cumulative ranking curve (SUCRA) value, which is in proportion to mean rank (best is 100%). RESULTS: Nine studies, which included seven different types of groups, were eligible for analysis. The "untreated uricemia" group in which patients had hyperuricemia but without treatment had a significantly higher risk of mortality than the "no uricemia" group in which patients had no hyperuricemia (relative risk (RR)(95% confidence interval (CI), 1.43 (1.08-1.89)). The "start-allo" group wherein patients started to take allopurinol did not have a significantly lower risk of mortality than the "untreated uricemia" group (RR (95% CI), 0.68 (0.45-1.01)). However, in the "start-allo" group the SUCRA value was comparable to that in the "no uricemia" group (SUCRA: 65.4% for "start-allo"; 64.1% for "no uricemia"). CONCLUSIONS: Results suggested that allopurinol therapy was not associated with a significantly improved prognosis in terms of mortality but could potentially counteract the adverse effects associated with longstanding hyperuricemia in HF patients.

DOI： 10.1007/s10557-020-07097-4

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A Prospective Cohort Study of Muscular and Performance Fitness and Incident Glaucoma: The Niigata Wellness Study. International journal

Ryoko Kawakami, Yuko Gando, Kiminori Kato, Susumu S Sawada, Haruki Momma, Motohiko Miyachi, I-Min Lee, Steven N Blair, Minoru Tashiro, Chika Horikawa, Yasuhiro Matsubayashi, Takaho Yamada, Kazuya Fujihara, Hirohito Sone

Journal of physical activity & health 17 ( 11 ) 1 - 8 2020.10

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: To examine the association between muscular and performance fitness (MPF) and the incidence of glaucoma. METHODS: A total of 27,051 glaucoma-free participants aged 20-87 years underwent physical fitness tests between April 2001 and March 2002. The MPF index was calculated using an age- and sex-specific summed z-score from grip strength, vertical jump, single-leg balance, forward bending, and whole-body reaction time. The participants were divided into quartiles according to the MPF index and each physical fitness test. Participants were followed up for the development of glaucoma, which was defined based on physician-diagnosed glaucoma at an annual health examination between April 2002 and March 2008. Hazard ratios for the incidence of glaucoma were estimated using Cox proportional hazards models. RESULTS: During follow-up, 303 participants developed glaucoma. Compared with the lowest MPF index group, hazard ratio (95% confidence interval) of developing glaucoma was 0.64 (0.46-0.89) for the highest MPF index group (P for trend = .001). Vertical jump and whole-body reaction time were associated with incident glaucoma (P for trend = .01 and <.001, respectively). There were no associations between the other physical fitness tests and the incidence of glaucoma. CONCLUSION: Higher MPF is associated with lower incidence of glaucoma.

DOI： 10.1123/jpah.2019-0660

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Diabetes mellitus and risk of new-onset and recurrent heart failure: a systematic review and meta-analysis. Reviewed International journal

Satoru Kodama, Kazuya Fujihara, Chika Horikawa, Takaaki Sato, Midori Iwanaga, Takaho Yamada, Kiminori Kato, Kenichi Watanabe, Hitoshi Shimano, Tohru Izumi, Hirohito Sone

ESC heart failure 7 ( 5 ) 2146 - 2174 2020.10

Language：English Publishing type：Research paper (scientific journal)

Despite mounting evidence of the positive relationship between diabetes mellitus (DM) and heart failure (HF), the entire context of the magnitude of risk for HF in relation to DM remains insufficiently understood. The principal reason is because new-onset HF (HF occurring in participants without a history of HF) and recurrent HF (HF re-occurring in patients with a history of HF) are not discriminated. This meta-analysis aims to comprehensively and separately assess the risk of new-onset and recurrent HF depending on the presence or absence of DM. We systematically searched cohort studies that examined the relationship between DM and new-onset or recurrent HF using EMBASE and MEDLINE (from 1 Jan 1950 to 28 Jul 2019). The risk ratio (RR) for HF in individuals with DM compared with those without DM was pooled with a random-effects model. Seventy-four and 38 eligible studies presented data on RRs for new-onset and recurrent HF, respectively. For new-onset HF, the pooled RR [95% confidence interval (CI)] of 69 studies that examined HF as a whole [i.e. combining HF with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF)] was 2.14 (1.96-2.34). The large between-study heterogeneity (I2 = 99.7%, P < 0.001) was significantly explained by mean age [pooled RR (95% CI) 2.60 (2.38-2.84) for mean age < 60 years vs. pooled RR (95% CI) 1.95 (1.79-2.13) for mean age ≥ 60 years] (P < 0.001). Pooled RRs (95% CI) of seven and eight studies, respectively, that separately examined HFpEF and HFrEF risk were 2.22 (2.02-2.43) for HFpEF and 2.73 (2.71-2.75) for HFrEF. The risk magnitudes between HFpEF and HFrEF were not significantly different in studies that examined both HFpEF and HFrEF risks (P = 0.86). For recurrent HF, pooled RR (95% CI) of the 38 studies was 1.39 (1.33-1.45). The large between-study heterogeneity (I2 = 80.1%, P < 0.001) was significantly explained by the proportion of men [pooled RR (95% CI) 1.53 (1.40-1.68) for < 65% men vs. 1.32 (1.25-1.39) for ≥65% men (P = 0.01)] or the large pooled RR for studies of only participants with HFpEF [pooled RR (95% CI), 1.73 (1.32-2.26) (P = 0.002)]. Results indicate that DM is a significant risk factor for both new-onset and recurrent HF. It is suggested that the risk magnitude is large for new-onset HF especially in young populations and for recurrent HF especially in women or individuals with HFpEF. DM is associated with future HFpEF and HFrEF to the same extent.

DOI： 10.1002/ehf2.12782

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Family Support for Medical Nutritional Therapy and Dietary Intake among Japanese with Type 2 Diabetes (JDDM 56). International journal

Chika Horikawa, Mariko Hatta, Sakiko Yoshizawa Morikawa, Yasunaga Takeda, Mizuki Takeuchi, Kazuya Fujihara, Noriko Kato, Hiroki Yokoyama, Yoshio Kurihara, Koichi Iwasaki, Shiro Tanaka, Hiroshi Maegawa, Hirohito Sone

Nutrients 12 ( 9 ) 2020.8

Language：English Publishing type：Research paper (scientific journal)

The aim of this study was to investigate the association between habitual dietary intake for patients with diabetes and the content of family support for medical nutritional therapy (MNT). Analyzed were 289 Japanese with type 2 diabetes (men, 58.5%; mean age, 62.0 years; mean HbA1c, 53.4 mmol/mol) who completed the Food Frequency Questionnaire and Diabetes Family Behavior Checklist (DFBC). Relationships of mean values for food group intake to DFBC responses regarding MNT were examined using multivariate analysis of covariance. Positive response to "Praise for following diet" was associated with lower sweets intake (none: 60.1 g/day; ≥once monthly: 50.9 g/day, p = 0.038) and higher seasoning intake (none: 21.6 g/day, ≥once monthly: 24.1 g/day, p = 0.046). Energy intake was higher with positive responses to "Eat at the same time that you do" (none: 1636 kcal/day, ≥once monthly: 1818 kcal/day, p = 0.038). "Nags about not following diet" was associated with higher fish (none: 68.7 g/day, ≥once monthly: 78.7 g/day, p = 0.042) and salt intake (none: 8.3 g/day, ≥once monthly: 9.0 g/day, p = 0.014). Eating foods not part of the diabetic diet (none: 218.4 g/day, ≥once monthly: 246.9 g/day, p = 0.014) resulted in a higher vegetable intake. In females, significant differences in relationships in the overall analysis were reversed. Our results clarified relationships between types of family support of patients with type 2 diabetes and their dietary intake and the importance of sex differences for more effective MNT.

DOI： 10.3390/nu12092649

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Influence of an SGLT2 inhibitor, tofogliflozin, on the resting heart rate in relation to adipose tissue insulin resistance

T. Nojima, Y. Matsubayashi, A. Yoshida, H. Suganami, T. Abe, M. Ishizawa, K. Fujihara, S. Tanaka, K. Kaku, H. Sone

Diabetic Medicine 37 ( 8 ) 1316 - 1325 2020.8

Language：English Publishing type：Research paper (scientific journal) Publisher：Blackwell Publishing Ltd

Aims: To examine the effects of a sodium–glucose co-transporter 2 (SGLT2) inhibitor, tofogliflozin, on resting heart rate by exploring baseline factors that independently influenced changes in the resting heart rate. Methods: Data on 419 participants in tofogliflozin phase 2/3 trials were analysed. Changes in resting heart rate from baseline to week 24 were analysed using an analysis of covariance (ANCOVA) model with groups (tofogliflozin/placebo) as a fixed effect and baseline values as covariates. The antilipolytic effect was evaluated as adipose tissue insulin resistance (Adipo-IR) and was calculated as the product of fasting insulin and free fatty acid. Multivariate analysis evaluated independent factors for changes in resting heart rate from baseline to week 24. Results: Of the participants, 58% were men, and mean age, HbA1c, BMI and resting heart rate were 57.6 years, 65 mmol/mol (8.1%), 25.5 kg/m2 and 66 bpm, respectively. At week 24, adjusted mean difference vs. placebo in the change from baseline was −2.3 bpm [95% confidence interval (CI) −4.6, −0.1] with tofogliflozin. Changes in resting heart rate were positively correlated with changes in Adipo-IR, whereas reductions in HbA1c, body weight and blood pressure were similar independent of changes in resting heart among quartiles of resting heart rate change. On multivariate analysis, higher baseline resting heart rates and Adipo-IR values were significantly associated with greater reductions in resting heart rate. Conclusions: Tofogliflozin corrected resting heart rate levels in accordance with baseline levels. Correction of high resting heart rates may be attributed to improved adipose tissue insulin resistance, leading to correction of hyperinsulinaemia.

DOI： 10.1111/dme.14279

Scopus

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糖尿病の有無別にみた収縮期血圧が透析開始に及ぼす影響

大澤妙子, 藤原和哉, 山田万祐子, 山本正彦, 北澤勝, 松林泰弘, 岩永みどり, 清田浩康, 山田貴穂, 曽根博仁

糖尿病 63 ( Suppl.1 ) S - 172 2020.8

耐糖能別にみた収縮期血圧が冠動脈/脳血管疾患に及ぼす影響の検討

山田万祐子, 藤原和哉, 大澤妙子, 北澤勝, 松林泰弘, 矢口雄大, 岩永みどり, 山中菜詩, 清田浩康, 山田貴穂, 小川渉, 曽根博仁

糖尿病 63 ( Suppl.1 ) S - 206 2020.8

糖尿病と定期的な運動習慣が要介護発症へ及ぼす影響の検討

藤原和哉, 山田万祐子, 北澤勝, 松林泰弘, 矢口雄大, 八尋拓也, 筒井歩, 山田貴穂, 加藤公則, 曽根博仁

糖尿病 63 ( Suppl.1 ) S - 148 2020.8

日本人2型糖尿病患者の肥満に対するエネルギー摂取と身体活動の複合効果

治田麻理子, 藤原和哉, 森川咲子, 武田安永, 堀川千嘉, 加藤光敏, 横山宏樹, 栗原義夫, 岩崎皓一, 宮澤一裕, 山崎勝也, 田中四郎, 前川聡, 曽根博仁

糖尿病 63 ( Suppl.1 ) S - 171 2020.8

SGLT2阻害薬52週投与及び投与中止2週後の推算血漿流量変化とBNPとの関連の検討

松林泰弘, 吉田明弘, 野島俊秋, 菅波秀規, 石黒創, 岩永みどり, 山田貴穂, 藤原和哉, 加来浩平, 曽根博仁

糖尿病 63 ( Suppl.1 ) S - 223 2020.8

糖尿病の有無別にみた日本人男性におけるBMI・腹囲と冠動脈疾患発症との関連

上村和樹, 藤原和哉, 山田万祐子, 北澤勝, 矢口雄大, 清田浩康, 山中菜詩, 松林泰弘, 山田貴穂, 児玉暁, 曽根博仁

糖尿病 63 ( Suppl.1 ) S - 229 2020.8

服薬アドヒアランスと下肢切断のリスクとの関連に関する縦断的検討

金子正儀, 藤原和哉, 山田万祐子, 北澤勝, 矢口雄大, 清田浩康, 山中菜詩, 松林泰弘, 曽根博仁

糖尿病 63 ( Suppl.1 ) S - 207 2020.8

経口血糖降下薬(OHA)の服薬アドヒアランス(Ad)と血糖コントロールとの関係

矢口雄大, 藤原和哉, 山田万祐子, 北澤勝, 金子正儀, 清田浩康, 山中菜詩, 松林泰弘, 曽根博仁

糖尿病 63 ( Suppl.1 ) S - 222 2020.8

総合体力尺度から作成した体力年齢とメタボリックシンドローム(MetS)との関連

佐藤隆明, 藤原和哉, 山田万祐子, 矢口雄大, 北澤勝, 松林泰弘, 岩永みどり, 山田貴穂, 加藤公則, 曽根博仁

糖尿病 63 ( Suppl.1 ) S - 133 2020.8

スマートフォンを含むスクリーンタイムと小児の生活習慣、食品群別摂取量および肥満との関連

池田和泉, 藤原和哉, 根立梨奈, 森川咲子, 石黒創, 山田万祐子, 松林泰弘, 山田貴穂, 曽根博仁

糖尿病 63 ( Suppl.1 ) S - 275 2020.8

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Papers - FUJIHARA Kazuya