Faculty Profiles - FUJIHARA Kazuya

Papers - FUJIHARA Kazuya

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Relationship between intake of fruit separately from vegetables and triglycerides - A meta-analysis. Reviewed International journal

Satoru Kodama, Chika Horikawa, Kazuya Fujihara, Dai Ishii, Mariko Hatta, Yasunaga Takeda, Masaru Kitazawa, Yasuhiro Matsubayashi, Hitoshi Shimano, Kiminori Kato, Shiro Tanaka, Hirohito Sone

Clinical nutrition ESPEN 27 53 - 58 2018.10

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND & AIMS: High intake of fruit and vegetables is recommended for cardiovascular health. However, there have been persistent beliefs that fruits having high concentrations of fructose elevate the level of triglycerides (TG) in blood unlike vegetables. This meta-analysis aims to clarify the relationship between fruit intake and TG or hypertriglyceridemia. METHODS: Electronic literature searches were conducted for observational studies that investigated the relationship between fruit intake and hypertriglyceridemia or intervention studies that investigated the effect of increasing fruit intake on TG. Each effect size was pooled with an inverse-variance method. RESULTS: Five cross-sectional studies and only 2 intervention studies were eligible. The pooled odds ratio (OR) (95% confidence interval (CI)) of the 5 cross-sectional studies for the highest vs. the lowest fruit intake category was 0.79 (0.72-0.87). In these studies, the pooled OR for the highest vs. the lowest vegetable intake category was not significant (OR = 0.92; 95% CI, (0.82-1.03)). A linear dose-response association was observed between increases in fruit intake and ORs for hypertriglyceridemia; the OR (95% CI) for an incrementally increased intake of fruit by 1 serving/day was 0.91 (0.84-0.98). CONCLUSION: This meta-analysis suggests that high intake of fruit but not vegetables is inversely associated with hypertriglyceridemia. More trials are needed to clarify whether increasing fruit intake would reduce the level of TG and/or incident hypertriglyceridemia.

DOI： 10.1016/j.clnesp.2018.07.001

PubMed

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Network meta‐analysis of the relative efficacy of bariatric surgeries for diabetes remission Reviewed

Kodama S, Fujihara K, Horikawa C, Harada M, Ishiguro H, Kaneko M, Furukawa K, Matsubayashi Y, Matsunaga S, Shimano H, Tanaka S, Kato K, Sone H

Obesity reviews 19 ( 12 ) 1621 - 1629 2018.9

糖尿病重症視力障害発症とHbA1cの関連性についての検討 Reviewed

山本正彦, 藤原和哉, 五十嵐理沙, 石澤正博, 松林泰弘, 松永佐澄志, 伊藤知恵, 錦野理絵, 山中菜詩, 児玉暁, 曽根博仁

日本糖尿病眼学会誌 22 134 - 134 2018.9

糖尿病重症視力障害発症とHbA1cの関連性についての検討 Reviewed

山本正彦, 藤原和哉, 五十嵐理沙, 石澤正博, 松林泰弘, 松永佐澄志, 伊藤知恵, 錦野理絵, 山中菜詩, 児玉暁, 曽根博仁

日本糖尿病眼学会誌 22 134 - 134 2018.9

ステロイド糖尿病を合併し歯性感染から上顎の骨髄炎を発症した2型糖尿病の1例 Reviewed

棚橋怜生, 山本正彦, 松林泰弘, 松永佐澄志, 山田貴穂, 岩永みどり, 藤原和哉, 羽入修, 曽根博仁

糖尿病 61 ( 9 ) 644 - 644 2018.9

下肢皮膚潰瘍から骨髄炎に至った2型糖尿病の1例

張かおり, 金子正儀, 佐藤陽子, 松林泰弘, 松永佐澄志, 岩永みどり, 山田貴穂, 藤原和哉, 羽入修, 曽根博仁

糖尿病 61 ( 9 ) 646 - 646 2018.9

Malondialdehyde-modified LDL-related variables are associated with diabetic kidney disease in type 2 diabetes Reviewed

Shoko Furukawa, Hiroaki Suzuki, Kazuya Fujihara, Kazuto Kobayashi, Hitoshi Iwasaki, Yoko Sugano, Shigeru Yatoh, Motohiro Sekiya, Naoya Yahagi, Hitoshi Shimano

Diabetes Research and Clinical Practice 141 237 - 243 2018.7

Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier Ireland Ltd

Background and aims: Oxidized low-density lipoprotein (oxLDL) causes the development of atherosclerosis and kidney injury. Although circulating oxLDL levels were reportedly increased in type 2 diabetic patients with macroalbuminuria, it remains unclear whether albuminuria or the reduced glomerular filtration rate (GFR) is independently associated with the circulating oxLDL level. This study aimed to elucidate the association between the stage of diabetic nephropathy and serum malondialdehyde-modified LDL (MDA-LDL) and the ratio of MDA-LDL to LDL-cholesterol (MDA-LDL/LDL). Methods and results: This retroactive cross-sectional study used data from 402 patients with type 2 diabetes. Patients undergoing hemodialysis were excluded. Serum MDA-LDL levels were significantly increased with increases in severity of albuminuria (103 ± 44 U/L, 109 ± 54 U/L, and 135 ± 72 U/L for normoalbuminuria, microalbuminuria, and macroalbuminuria, respectively
P for trend = 0.020) but not according to the estimated GFR (eGFR). An increased MDA-LDL/LDL ratio was significantly associated with both increased albuminuria (35 ± 13, 37 ± 14, and 40 ± 15 for normoalbuminuria, microalbuminuria, and macroalbuminuria, respectively
P for trend = 0.003) and reduced eGFR (34 ± 13, 36 ± 13, 38 ± 12, and 51 ± 28 for grade 1, 2, 3 and 4, respectively
P for trend = 0.002). Multiple linear regression analysis showed that neither the albumin excretion rate nor eGFR but ln-transformed triglycerides and LDL-C levels were independent determinants of both serum MDA-LDL levels and MDA-LDL/LDL ratios. Conclusion: Serum MDA-LDL levels and MDA-LDL/LDL ratios were increased in those with dyslipidemia associated with diabetic kidney disease.

DOI： 10.1016/j.diabres.2018.05.019

Scopus

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Relationships among cardiorespiratory fitness, muscular fitness, and cardiometabolic risk factors in Japanese adolescents: Niigata screening for and preventing the development of non-communicable disease study-Agano (NICE EVIDENCE Study-Agano) 2

Morikawa, Sakiko Yoshizawa, Fujihara, Kazuya, Hatta, Mariko, Osawa, Taeko, Ishizawa, Masahiro, Yamamoto, Masahiko, Furukawa, Kazuo, Ishiguro, Hajime, Matsunaga, Satoshi, Ogawa, Yohei, Shimano, Hitoshi, Sone, Hirohito

Pediatric diabetes 2018.6

Sakiko Yoshizawa Morikawa, Kazuya Fujihara, Mariko Hatta, Taeko Osawa, Masahiro Ishizawa, Masahiko Yamamoto, Kazuo Furukawa, Hajime Ishiguro, Satoshi Matsunaga, Yohei Ogawa, Hitoshi Shimano, Hirohito Sone

Pediatric diabetes 19 ( 4 ) 593 - 602 2018.6

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: To examine the independent and combined associations of cardiorespiratory fitness (CRF) and muscular fitness (MF) with cardiometabolic risk factors in Japanese adolescents. METHODS: A cross-sectional study including 993 Japanese adolescents (aged 13-14 years) was undertaken. Height, body mass, blood pressure, lipid profile (non-fasting), and HbA1c were measured. The physical fitness (PF) test included measurements of CRF (20 m multistage shuttle run test), upper limb strength (hand grip strength), lower limb strength (standing long jump), and muscular endurance (sit-ups). The clustered cardiometabolic risk (CCMR) was estimated by summing standardized Z-scores of body mass index (BMI), mean arterial pressure (MAP), non-high-density lipoprotein cholesterol (non-HDL-C), and HbA1c. RESULTS: Linear regression analysis showed that all PF factors except for muscular endurance were inversely correlated with CCMR (P < .001). Among metabolic risk components, HbA1c was unrelated to PF, while non-HDL-C was inversely associated with CRF (B = -2.40; P < .001), upper limb strength (B = -1.77; P < .05), and lower limb strength (B = -1.53; P < .05) after adjustment for lifestyle factors. Logistic regression showed that the probability of having high CCMR (≥1SD) was synergistically higher in those with the lowest tertiles of both CRF and upper limb strength (P for interaction = .001); however, a substantially lower likelihood of having high CCMR was observed among individuals with the lowest tertile of upper limb strength but moderate CRF. CONCLUSIONS: Lower CRF and MF were significantly and synergistically associated with an unhealthier metabolic risk profile.

DOI： 10.1111/pedi.12623

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糖尿病患者における脈圧が透析導入に及ぼす影響の検討 Reviewed

大澤妙子, 藤原和哉, 山本正彦, 原田万由子, 石澤正博, 清田浩康, 山中菜詩, 松林泰弘, 松永佐澄志, 山田貴穂, 曽根博仁

糖尿病 61 ( Suppl.1 ) S - 160 2018.4

肥満境界型糖尿病患者に対する血糖自己測定と栄養指導媒体を用いた栄養教育の併用効果について Reviewed

長谷川美代, 堀川千嘉, 田代稔, 鈴木沙織, 藤原和哉, 北澤勝, 加藤公則, 曽根博仁

糖尿病 61 ( Suppl.1 ) S - 267 2018.4

2型糖尿病患者における食事エネルギー密度と肥満との関連 JDDMにおける検討 Reviewed

武田安永, 藤原和哉, 治田麻理子, 森川咲子, 堀川千嘉, 石井大, 加藤光敏, 横山宏樹, 栗原義夫, 宮澤一裕, 岩崎晧一, 川井紘一, 朝長修, 屋宜宣治, 前川聡, 曽根博仁

糖尿病 61 ( Suppl.1 ) S - 265 2018.4

眼科処置を要する重症糖尿病性眼疾患の発生リスクに対する腎症の影響についての検討 Reviewed

山本正彦, 藤原和哉, 大澤妙子, 原田万祐子, 石黒創, 石澤正博, 岩永みどり, 松永佐澄志, 松林泰弘, 清田浩康, 山中菜詩, 山田貴穂, 曽根博仁

糖尿病 61 ( Suppl.1 ) S - 161 2018.4

指先穿刺による血糖およびHbA1c迅速測定をもちいた糖尿病啓発の取り組み Reviewed

山田貴穂, 石井大, 武田安永, 橋本浩平, 三ツ間友里恵, 張かおり, 原田万祐子, 白石友信, 吉岡大志, 山本正彦, 大澤妙子, 石黒創, 金子正儀, 鈴木浩史, 松林泰弘, 松永佐澄志, 藤原和哉, 岩永みどり, 鈴木亜希子, 羽入修, 曽根博仁

糖尿病 61 ( Suppl.1 ) S - 377 2018.4

耐糖能及び肥満の有無に関わらず代謝異常は冠動脈疾患発症リスクを増大させる Reviewed

藤原和哉, 松林泰弘, 山本正彦, 松永佐澄志, 清田浩康, 山中菜詩, 児玉暁, 曽根博仁

糖尿病 61 ( Suppl.1 ) S - 260 2018.4

糖尿病治療薬別にみたHbA1cと冠動脈疾患(CAD)発症リスクとの関連 Reviewed

原田万祐子, 藤原和哉, 大澤妙子, 石澤正博, 山本正彦, 金子正儀, 松林泰弘, 松永佐澄志, 山中菜詩, 清田浩康, 山田貴穂, 曽根博仁

糖尿病 61 ( Suppl.1 ) S - 258 2018.4

診断に難渋した再発性重症低血糖の原因特定に薬物血中濃度測定が有用であった一例 Reviewed

三ツ間友里恵, 山本正彦, 橋本浩平, 金子正儀, 松林泰弘, 松永佐澄志, 山田貴穂, 岩永みどり, 藤原和哉, 曽根博仁

糖尿病 61 ( Suppl.1 ) S - 181 2018.4

当院における糖尿病合併妊娠及び妊娠糖尿病患者への分割食の栄養指導の実態と指導方法の検討

治田麻理子, 深沢尚子, 桜井健一, 津野菜津美, 佐藤かえで, 西山陽子, 藤原和哉, 曽根博仁, 鈴木克典

糖尿病 61 ( Suppl.1 ) S - 214 2018.4

DPP-4阻害薬アナグリプチン(ANA)の12週間投与時におけるインスリンクリアランスに及ぼす影響

阿部孝洋, 松林泰弘, 村岸沙也加, 吉田明弘, 菅波秀規, 古澤研一, 松永佐澄志, 岩永みどり, 山田貴穂, 藤原和哉, 加来浩平, 曽根博仁

糖尿病 61 ( Suppl.1 ) S - 246 2018.4

糖尿病患者の受診中断に関連する因子の1年間追跡調査糖尿病データマネジメント研究会(JDDM)より

谷内田潤子, 藤原和哉, 武田安永, 治田麻里子, 石井大, 和井田結佳子, 大石まり子, 川井紘一, 横山宏樹, 前川聡, 曽根博仁, 糖尿病データマネジメント研究会

糖尿病 61 ( Suppl.1 ) S - 139 2018.4

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