Faculty Profiles - TANUMA Junichi

Papers - TANUMA Junichi

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The LEXF: A new set of rat recombinant inbred strains between LE/Stm and F344 Invited Reviewed

Hayase Shisa, Lingmin Lu, Hideki Katoh, Atsuko Kawarai, Jun-Ichi Tanuma, Yoshibumi Matsushima, Hiroshi Hiai

Mammalian Genome 8 ( 5 ) 324 - 327 1997.5

Language：English Publishing type：Research paper (scientific journal)

A new set of rat RI strains consisting of 11 independent strains and 13 of their substrains was established by inbreeding F2 rats between F344/DuCrj and LE/Stm. The strain distribution pattern was examined for 66 microsatellite loci, 8 biochemical genetic markers, 2 histocompatibility loci, and 2 coat color genes. A rat salivary protein gene Spe1 was newly mapped on Chr 1.

DOI： 10.1007/s003359900432

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Tamoxifen mediated human endometrial carcinogenesis may not involve estrogenic pathways: A preliminary note Reviewed

Y Kuwashima, M Kurosumi, Y Kobayashi, J Tanuma, K Suemasu, Y Higashi, T Kasamatsu, K Shiromizu, M Matsuzawa, K Kishi

ANTICANCER RESEARCH 16 ( 5A ) 2993 - 2996 1996.9

Language：English Publishing type：Research paper (scientific journal) Publisher：INT INST ANTICANCER RESEARCH

Seven cases of endometrial adenocarcinoma patients who had experienced long-term tamoxifen treatments as adjuvant therapy of breast carcinoma, were investigated with respect to estrogen receptor (ER) status. Four cases of endometrial adenocarcinoma without tamoxifen treatment but with a previous history of breast carcinoma were investigated for comparison. One of the 7 and two of the 4 cases were positive for ER immunohistochemically. Thus, the frequency of ER positivity in secondary endometrial adenocarcinoma seemed to be at random among tamoxifen-treated and non-treated br east cancer patients. These results suggest that tamoxifen-mediated human endometrial carcinogenesis may not involve estrogenic pathway(s) but may involve other carcinogenic mechanisms such as DNA adduct formation as shown in rat liver tumorigenesis.

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Expression of bcl-2 and Apoptotic DNA Fragmentation in Human Endometrial Adenocarcinoma cells. Reviewed

Kuwashima Y, Kobayashi Y, Kawarai A, Kurozumi M, Uehara T, Tanuma J, Shiromizu K, Matsuzawa M, Kishi K

Anticancer Res 16 3221 - 3224 1996.5

Evaluation of Apoptosis in human endometrial adenocarcinoma: Comparison of Neck and Labelling Le(y) Antigen Immunostaining Method. Reviewed

Kuwashima Y, Kobayashi Y, Kawarai A, Kurozumi M, Tanuma J, Shiromizu K, Matsuzawa K, Kishi K

Anticancer Res 16 3225 - 3228 1996.5

Immunohistochemical detection of ras p21 oncoprotein in undifferentiated and well-differentiated epithelial carcinomas of the human ovary Reviewed

Y. Kuwashima, H. Shisa, T. Uehara, M. Kurosumi, Y. Kobayashi, J. Tanuma, K. Shiromizu, M. Matsuzawa, K. Kishi

Anticancer Research 15 ( 6 B ) 2847 - 2850 1995

Language：English Publishing type：Research paper (scientific journal)

Expression of ras p21 oncoproteins in human ovarian carcinomas was examined immunohistochemically by using a monoclonal antibody(clone RAS 10) with respect to the degree of their histological differentiation. To achieve this, the intensity of staining for the protein was compared between undifferentiated and well differentiated carcinomas, i.e. extreme subtypes of common epithelial carcinomas. The former was composed of 8 'solid' carcinomas and the latter
11 serous, 8 mucinous, 4 endometrioid and 4 clear cell carcinomas. All the cases examined, including both undifferentiated and well-differentiated carcinomas, showed a positive reaction to this antibody. Staining intensity and the number of positive cells somewhat varied among the cases. Additionally, 2 cases of ovarian epithelial tumors of low malignant potential (I,MP) were stained with this antibody. Both the cases were positive, but the number of positive cells seemed to be rather less than than that found in the carcinoma groups. Thus, no differences in ras p21 expression were observed between the cases examined in spite of the differences in the degree of differentiation of the epithelial ovarian carcinomas. However
the possibility remained that the number of positive cells could be an indicator of malignant potential, enabling us to distinguish LMPs from carcinomas. Thus immunodetection of ras p21 could not provide an additional means for the histological differentiation of ovarian cancer although the evaluation of basement membrane integrity and cell proliferation kinetics as reported previously was useful in differential diagnosis and in understanding the biology of ovarian undifferentiated carcinomas.

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