研究者詳細 - 池主　雅臣

MISC - 池主　雅臣

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The Efficacy of DL-Sotalol in Reentrant Ventricular Tachycardia with Special Reference to the Width of the Zone of Entrainment

AIZAWA Yoshifusa, CHINUSHI Masaomi, FURUSHIMA Hiroshi, WATANABE Hiroshi, TANABE Yasutaka, SUGIURA Hirotaka, HIRONO Takashi, FUJITA Satoshi

Acta medica et biologica 51 ( 4 ) 133 - 140 2003年12月

記述言語：英語出版者・発行元：新潟大学

Aims: In selecting effective antiarrhythmic agents for reentrant ventricular tachycardia (VT), there is no hallmark which can predict drug-efficacy. In this study, the ability of dl-sotalol to suppress the inducible VT was assessed during an electrophysiologic study with special reference to the zone of entrainment, an index of the excitable gap. Methods and Results: In 21 patients, monomorphic sustained VT was induced and entrained with rapid ventricular pacing at progressively shorter cycle lengths until VT was terminated at a critical length (=block cycle length) and the width of the zone of entrainment was calculated as the difference between the cycle length of VT and the VT-interrupting critical cycle length: the longest cycle length at which 1:1 conduction fails within the zone of slow conduction. The effective refractory period was measured by extrastimulus technique. After the administration of dlsotalol (240-320mg/day for>14 days), the drug efficacy was evaluated by an electrophysiologic study and the relation to the basal electrophysiological parameters were analyzed. After the administration of dl-sotalol, the cycle length of the sinus rate, the QT interval, and the effective refractory period were prolonged significantly. In 11 patients, VT was not induced (responders) to the end of the entire protocol of induction. In another 10 patients, dl-sotalol proved a failure and a slower VT with a similar width of zone of entrainment remained inducible. The cycle length of VT and the width of the zone of entrainment did not differ between the responders and non-responders to dl-sotalol: 300±72 vs. 275±21 msec and 57±27 vs. 50±16 msec, respectively. Conclusions: The VT induction was prevented by dl-sotalol in 52%, but the cycle length, the zone of entrainment of VT, and other variables were not different between the responders and non-responders to dl-sotalol.

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その他リンク： http://search.jamas.or.jp/link/ui/2005215530

2 アンデルセン症候群で同定されたKCNJ2-C末端における遺伝子変異の分子生物学的検討(第234回新潟循環器談話会)

保坂幸男, 塙晴雄, 鷲塚隆, 池主雅臣, 古嶋博司, 田辺靖, 山下文男, 吉田剛, 渡部裕, 小村悟, 杉浦広隆, 廣野崇, 相澤義房

新潟医学会雑誌 117 ( 7 ) 394 - 394 2003年7月

50)植込型除細動器の除細動閾値が問題となった心サルコイドーシスの二例

杉浦広隆, 古嶋博司, 鷲塚隆, 田辺靖貴, 山浦正幸, 保坂幸男, 渡部裕, 小村悟, 広野崇, 相澤義房, 池主雅臣

Circulation journal : official journal of the Japanese Circulation Society 67 768 - 768 2003年4月

器質的心疾患を伴う心機能低下例におけるICD治療の役割と問題点

池主雅臣, 鷲塚隆

循環制御 24 ( 1 ) 7 - 10 2003年3月

Evaluation of Candidates of Biventricular Pacing Therapy in Idiopathic Dilated Cardiomyopathy

Tanabe Yasutaka, Komura Satoru, Aizawa Yoshifusa, Furushima Hiroshi, Washizuka Takashi, Chinushi Masaomi, Hanawa Haruo, Kodama Makoto, Murata Minoru, Oda Hirotaka, Miyajima Seiichi, Igarashi Yutaka, Masani Fumiaki

Circulation journal : official journal of the Japanese Circulation Society 67 56 - 56 2003年3月

Difference in Ventricular Fibrillation interval between Structural Heart Disease and Brugada Syndrome : Role of Sotalol Treatmentand Defibrillation Threshold

Watanabe Hiroshi, Chinushi Masaomi, Sugiura Hirotaka, Washizuka Takashi, Hirono Takashi, Komura Satoru, Hosaka Yukio, Yamaura Masayuki, Tanabe Yasutaka, Furushima Hiroshi, Kato Kiminori, Watanabe Hiroshi, Hayashi Junichi, Aizawa Yoshifusa

Circulation journal : official journal of the Japanese Circulation Society 67 255 - 255 2003年3月

Intramural Arrhythmogenesis of ECG Phenomenon of Prolonged QT Interval, Short-Long Cardiac Cycle and T Wave Alternans in Long QT Syndrome

Chinushi Masaomi, Hosaka Yukio, Sugiura Hirotaka, Komura Satoru, Furushima Hiroshi, Washizuka Takashi, Aizawa Yoshifusa

Circulation journal : official journal of the Japanese Circulation Society 67 250 - 250 2003年3月

Long-Term Outcomes of EP-Guided Sotalol Treatment for Sustained Ventricular Tachyarrhythmias

Watanabe Hiroshi, Chinushi Masaomi, Washizuka Takashi, Sugiura Hirotaka, Hirono Takashi, Komura Satoru, Hosaka Yukio, Yamaura Masayuki, Tanabe Yasutaka, Furushima Hiroshi, Kato Kiminori, Aizawa Yoshifusa

Circulation journal : official journal of the Japanese Circulation Society 67 102 - 102 2003年3月

Severe Electrical Storm in Patients with Implantable CardioverterDefibrillators (ICD) : Does It Predict Poor Prognosis?

Washizuka Takashi, Chinushi Masaomi, Watanabe Hiroshi, Hosaka Yukio, Komura Satoru, Sugiura Hirotaka, Hirono Takashi, Yamaura Masayuki, Furushima Hiroshi, Tanabe Yasutaka, Aizawa Yoshifusa

Circulation journal : official journal of the Japanese Circulation Society 67 224 - 224 2003年3月

Arrhythmogenesis of Sympathetic Activity Related Ventricular Tachyarrhythmias in Type 3 Long QT Syndrome (LQT3)

Hosaka Yukio, Chinushi Masaomi, Sugiura Hirotaka, Komura Satoru, Furushima Hiroshi, Washizuka Takashi, Aizawa Yoshifusa

Circulation journal : official journal of the Japanese Circulation Society 67 230 - 230 2003年3月

Role of Sotalol and Nifekalant Therapy in Patients with Life-Threatening Ventricular Tachyarrhythmia

Washizuka Takashi, Chinushi Masaomi, Furushima Hiroshi, Aizawa Yoshifusa

Circulation journal : official journal of the Japanese Circulation Society 67 71 - 71 2003年3月

Short- and Long-Term Effects of Excess Thyroid Hormone on L-Type Calcium Channels of Rat Left Ventricles

Watanabe Hiroshi, Ma Meirei, Washizuka Takashi, Komura Satoru, Hosaka Yukio, Chinushi Masaomi, Watanabe Kenichi, Aizawa Yoshifusa

Circulation journal : official journal of the Japanese Circulation Society 67 416 - 416 2003年3月

12 薬剤治療抵抗性の非虚血性心不全症例に対する両心室ぺーシング療法の経験(第232回新潟循環器談話会)

池主雅臣, 鷲塚隆, 古嶋博司, 田辺靖貴, 山浦正幸, 保坂幸男, 渡部裕, 小村悟, 杉浦広隆, 相澤義房, 伊藤英一, 鈴木薫

新潟医学会雑誌 117 ( 2 ) 111 - 111 2003年2月

体表面心電図の所見と心室性不整脈発症の関係

池主雅臣, 保坂幸男, 古嶋博司, 鷲塚隆, 相澤義房

心電図 = Electrocardiology 22 ( 6 ) 700 - 700 2002年11月

3 KCNJ2のC末端の遺伝子変異が確認されたアンデルセン症候群の1例(第2回新潟ゲノム医学研究会)

保坂幸男, 塙晴雄, 鷲塚隆, 池主雅臣, 阿部晃, 古嶋博司, 山浦正幸, 田辺靖貴, 山下文男, 吉田剛, 渡部裕, 小村悟, 杉浦広隆, 廣野崇, 相澤義房

新潟医学会雑誌 116 ( 11 ) 569 - 569 2002年11月

心内膜側からの高周波通電が有効であった心外膜側左室流出路起源の特発性心室性頻拍の1例

小澤拓也, 鷲塚隆, 池主雅臣, 樋口浩太郎, 杉浦広隆, 小村悟, 保坂幸男, 渡辺裕, 田辺靖隆, 古嶋博司, 阿部晃, 相澤義房

不整脈 = Journal of arrhythmia 18 ( 4 ) 527 - 531 2002年10月

心サルコイドーシスに合併する心室性不整脈についての検討

古嶋博司, 池主雅臣, 鷲塚隆, 杉浦広隆, 阿部晃, 田辺靖貴, 保坂幸男, 渡部裕, 小村悟, 相澤義房

不整脈 = Journal of arrhythmia 18 ( 4 ) 490 - 495 2002年10月

症例初回に有効性の確認された塩酸ニフェカラントの使用で著明なQT延長を伴う多形性心室頻拍を生じた心サルコイドーシスの1例

古嶋博司, 池主雅臣, 鷲塚隆

呼吸と循環 50 ( 5 ) 535 - 540 2002年5月

Clinical characteristics of patients with inappropriate implantable cardioverter defibrillator(ICD)therapies : indication for dual-chamber ICD for sinus tachycardia

Watanabe Hiroshi, Washizuka Takashi, Sugiura Hirotaka, Komura Satoru, Hosaka Yukio, Tanabe Yasutaka, Furushima Hiroshi, Abe Akira, Aizawa Yoshifusa, Chinushi Masaomi, Watanabe Hiroshi, Hayashi Junichi

Circulation journal : official journal of the Japanese Circulation Society 66 487 - 487 2002年3月

Incidence and clinical implications of visible T-wave alternans in Brugada syndrome

Chinushi Yuko, Washizuka Takashi, Furushima Hiroshi, Abe Akira, Tanabe Yasutaka, Hosaka Yukio, Watanabe Hirosi, Toida Tatsunari, Aizawa Yoshifusa, Chinushi Masaomi

Circulation journal : official journal of the Japanese Circulation Society 66 179 - 179 2002年3月

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