研究者詳細 - 葭原　明弘

Serum albumin (SA) levels and 10-year mortality in a community-dwelling 70-year-old population 査読

Yutaka Takata, Toshihiro Ansai, Akihiro Yoshihara, Hideo Miyazaki

ARCHIVES OF GERONTOLOGY AND GERIATRICS 54 ( 1 ) 39 - 43 2012年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ELSEVIER IRELAND LTD

Although an association between SA concentrations and mortality in the patients is well known, this association is not conclusive in elderly community-dwelling populations. We therefore attempted to determine whether this association could be extended to a Japanese 70-year-old community-dwelling population. Seventy-year-old subjects residing in Niigata City, Japan participated. Baseline examinations including a determination of SA concentrations were performed in June 1998 in 600 participants, and they were followed for 10 years. During the 10-year follow up, 80 subjects died. Albumin levels were divided into four groups (highest > 45 g/l, higher 43-44 g/l, lower 41-42 g/l, lowest < 40 g/l). The survival rate using Kaplan-Meier methods was longer in the highest and higher albumin groups than in the lowest and lower groups. No differences were found between the four groups in the mortalities from cancer, cardiovascular disease (CVD) or pneumonia. Individuals with the lowest albumin levels had 2.7 or 2.9 times higher total mortality, whether adjusted with confounding factors or not, using Cox regression analysis. The mortality hazard ratio (HR) found in the lowest group was compared to the highest group. In an elderly 70-year-old Japanese community-dwelling population, lower SA concentrations were an independent predictor of total mortality, but not mortality due to cancer, CVD, or pneumonia. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.archger.2011.02.018

Serum albumin (SA) levels and 10-year mortality in a community-dwelling 70-year-old population

Yutaka Takata, Toshihiro Ansai, Akihiro Yoshihara, Hideo Miyazaki

ARCHIVES OF GERONTOLOGY AND GERIATRICS 54 ( 1 ) 39 - 43 2012年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ELSEVIER IRELAND LTD

DOI： 10.1016/j.archger.2011.02.018

乳幼児健診に併設し実施する個別指導による歯科保健行動の変容

坂入久美子, 葭原明弘, 金子昇, 林悠子, 藤山友紀, 宮崎秀夫

口腔衛生学会雑誌 62 ( 1 ) 63 - 64 2012年1月

高齢者における咀嚼能力と体力およびうつ傾向との関係について

瀧口知彌, 葭原明弘, 小川祐司, 山賀孝之, 宮崎秀夫

口腔衛生学会雑誌 62 ( 1 ) 64 - 64 2012年1月

Association Between Glucan Synthesis by Streptococcus mutans and Caries Incidence in Schoolchildren Receiving a Fluoride Mouth Rinse 査読

Umetsu, Hidehiro, Kaneko, Noboru, Yoshihara, Akihiro, Sakuma, Shihoko, Hanada, Nobuhiro, Miyazaki, Hideo

ORAL HEALTH & PREVENTIVE DENTISTRY 10 ( 2 ) 161 - 166 2012年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：QUINTESSENCE PUBLISHING CO INC

Purpose: To determine whether variation in glucan synthesis by Streptococcus mutans isolates is associated with caries development in children receiving a fluoride mouth rinse (FMR).Materials and Methods: Of 122 children (aged 9 to 10 years), 64 had received FMR (FMR(+) group) and the remaining 58 children had not (FMR() group). The number of decayed and filled teeth (DFT) and increases in the number of DFT in 1 year (dDFT) were recorded. Saliva samples were collected to isolate the clinical S. mutans strains. The isolates were incubated in heart infusion broth supplemented with 1% sucrose, then the amount of water-insoluble glucan (WIG) formed on a glass tube surface was evaluated.Results: In the FMR() group, children carrying S. mutans had a higher DFT (P = 0.039) and tended to have a higher dDFT (P = 0.080) than the others. In the FMR(+) group, although the differences between children with and without S. mutans were not significant, children carrying S. mutans that produced a high amount of WIG had higher dDFT than the other S. mutans-positive children (P = 0.034).Conclusions: This study revealed that the variation in glucan synthesis by S. mutans is associated with caries development in children receiving a FMR.

60歳代における咀嚼能力とメタボリックシンドローム判定項目との関連査読

高橋純子, 葭原明弘, 速水隆

新潟歯学会雑誌 42 ( 1 ) 21 - 26 2012年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：新潟歯学会

咀嚼能力とメタボリックシンドロームに代表される全身の健康との関連については情報が乏しい。本調査の目的は，チューインガムを用いた咀嚼能力判定結果とメタボリックシンドローム判定項目との関連を分析し，健康施策策定のための基礎情報を得ることである。新潟県胎内市内の40 ～ 74 歳の国民健康保険への加入者で，平成20年の特定健診の集団健診受診者2,295 名のうち，咀嚼能力判定試験を受けた1,104 名から受診者の多かった60 歳代798名を調査対象とした。平均年齢±標準偏差は，65.1±2.7 歳である。咀嚼能力判定には，ロッテ社製の咀嚼力判定ガムを用いた。２分間噛んでもらったあとにカラーチャートにより咀嚼能力を５段階で評価した。メタボリックシンドローム判定項目と咀嚼能力との関連を重回帰分析により評価した。従属変数として腹囲，収縮期血圧，拡張期血圧，血清中HDL コレステロールレベル，および血清中HbA1C を採用した。それぞれの従属変数に対して，咀嚼能力，喫煙歴，年齢，および性別を独立変数として採用した。喫煙経験，年齢，および性別で調整した後，咀嚼能力と有意だったのは腹囲（標準偏回帰係数（β）＝−0.09，p＝0.011），収縮期血圧（β＝0.07，p＝0.047），およびHDL コレステロール（β＝0.08，p＝0.019）であった。このことは，年齢，性別，および喫煙経験で調整した後であっても，咀嚼能力の値と腹囲の値，収縮期血圧および血清中HDL コレステロールとは統計学的に有意な関連があることを示している。咀嚼能力が低下するとにより摂取食品や栄養素に影響を与え，その結果，メタボリックシンドロームが発症し易くなると考えられた。There was a lack of information between masticatory ability and a metabolic syndrome. The purpose of this study was to evaluate the relationship between masticatory ability using a chewing gum and the several factors which are associated with a metabolic syndrome. We selected 798 subjects aged from 60 to 69 who participated in general health examination. We obtained the information about the masticatory ability according to the findings by the chewing judgment gum made by Lotte company. To evaluate the relationship between masticatory ability using a chewing gum and the several factors which are associated with a metabolic syndrome, we conduct the multiple regression analysis. We selected abdominal circumference, systolic blood pressure, diastolic pressure, serum HDL level and serum HbA1C as dependent variables. In addition, we selected the masticatory ability by a chewing gum, smoking habits, age and gender as independent variables for each dependent variable. The masticatory ability was significantly associated with abdominal circumference (β＝−0.09, p＝0.011), systolic blood pressure (β＝ 0.07, p ＝ 0.047), and serum HDL (β＝0.08, p ＝ 0.019) after controlling smoking habits, age and gender. These findings indicate the decrease of the masticatory ability influence the intake of amount of diets and nutrition, which might be associated with the occurrence of a metabolic syndrome.

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地域在住女性高齢者における咀嚼能力判定試験と開眼片足立ち保持時間の関連査読

その他リンク： http://search.jamas.or.jp/link/ui/2013092615

Association of dental status with vegetable intake in an elderly population 査読

T Hirotomi, A Yoshihara, H Ogawa, H Miyazaki

The Journal of Aging Research & Clinical Practice 1 84 - 87 2012年

岩崎正則, 葭原明弘, 宮崎秀夫

日本口腔衛生学会雑誌 62 ( 3 ) 289 - 295 2012年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：有限責任中間法人日本口腔衛生学会

本研究の目的は女性高齢者におけるガムを用いた咀嚼能力と開眼片足立ち保持時間の関連を検討することである.2009,2010年度の調査に参加し,問診,身体計測,開眼片足立ち検査,および歯・口腔に関する診査に協力の得られた65〜74歳女性138名を本研究対象とした.咀嚼能力判定試験には咀嚼力判定ガムを用いた.2分間の咀嚼による色の変化をカラーチャートと比較し,5段階(スコア1〜5)で咀嚼能力を評価した.対象者をスコアに基づき3群(咀嚼能力が高い群=スコア5,中間群=スコア4,低い群=スコア1〜3)に分けた.そして開眼片足立ち30秒保持の可否を目的変数とし,現在歯数,年齢,および運動機能を共変量とするロジスティック回帰モデルを用い咀嚼能力と開眼片足立ち保持時間の関連を評価した.咀嚼能力が低いことは開眼片足立ちが30秒間保持できないことと有意に関連していた(咀嚼能力が高い群を基準として,中間群:調整済オッズ比[95%信頼区間]=2.34[0.91-6.01],低い群=3.61[1.14-11.4]).結論として,女性高齢者において咀嚼力判定ガムにより評価された咀嚼能力と開眼片足立ち保持時間の間に有意な関連があることが本研究結果から示された.

DOI： 10.5834/jdh.62.3_289

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その他リンク： http://search.jamas.or.jp/link/ui/2012304189

Association Between Glucan Synthesis by Streptococcus mutans and Caries Incidence in Schoolchildren Receiving a Fluoride Mouth Rinse

Umetsu, Hidehiro, Kaneko, Noboru, Yoshihara, Akihiro, Sakuma, Shihoko, Hanada, Nobuhiro, Miyazaki, Hideo

ORAL HEALTH & PREVENTIVE DENTISTRY 10 ( 2 ) 161 - 166 2012年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：QUINTESSENCE PUBLISHING CO INC

地域在住女性高齢者における咀嚼能力と開眼片足立ち保持時間の関連

岩崎正則, 葭原明弘, 宮崎秀夫

口腔衛生会誌 62 ( 3 ) 289 - 295 2012年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人口腔衛生学会

本研究の目的は女性高齢者におけるガムを用いた咀嚼能力と開眼片足立ち保持時間の関連を検討することである.<br>2009,2010年度の調査に参加し,問診,身体計測,開眼片足立ち検査,および歯・口腔に関する診査に協力の得られた65〜74歳女性138名を本研究対象とした.咀嚼能力判定試験には咀嚼力判定ガムを用いた.2分間の咀嚼による色の変化をカラーチャートと比較し,5段階(スコア1〜5)で咀嚼能力を評価した.対象者をスコアに基づき3群(咀嚼能力が高い群=スコア5,中間群=スコア4,低い群=スコア1〜3)に分けた.そして開眼片足立ち30秒保持の可否を目的変数とし,現在歯数,年齢,および運動機能を共変量とするロジスティック回帰モデルを用い咀嚼能力と開眼片足立ち保持時間の関連を評価した.<br>咀嚼能力が低いことは開眼片足立ちが30秒間保持できないことと有意に関連していた(咀嚼能力が高い群を基準として,中間群:調整済オッズ比[95%信頼区間]=2.34[0.91-6.01],低い群=3.61[1.14-11.4]).<br>結論として,女性

DOI： 10.5834/jdh.62.3_289

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オーラルヂアドコキネスを用いた構音機能の評価と発生発語器官障害との関連査読

杉本智子, 葭原明弘, 伊藤加代子, 宮崎秀夫

日本口腔衛生学会雑誌 62 ( 5 ) 445 - 453 2012年

Relationship between root caries and cardiac dysrhythmia 査読

Masayuki Kaneko, Akihiro Yoshihara, Hideo Miyazaki

GERODONTOLOGY 28 ( 4 ) 289 - 295 2011年12月

Relationship between root caries and cardiac dysrhythmia

Masayuki Kaneko, Akihiro Yoshihara, Hideo Miyazaki

GERODONTOLOGY 28 ( 4 ) 289 - 295 2011年12月

Mineral content of calcium and magnesium in the serum and longitudinal periodontal progression in Japanese elderly smokers 査読

Akihiro Yoshihara, Masanori Iwasaki, Hideo Miyazaki

JOURNAL OF CLINICAL PERIODONTOLOGY 38 ( 11 ) 992 - 997 2011年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：WILEY-BLACKWELL

Objective: Evidence from physiological and clinical studies regarding the mechanism by which calcium and magnesium are associated with periodontal disease, adjusted for smoking habits, is lacking. This longitudinal study evaluated the association of serum calcium levels and the calcium/magnesium (Ca/Mg) ratio with periodontal disease progression among smokers and non-smokers.
Material and Methods: A total of 309 subjects aged 73 years were included. Followup surveys were carried out every year for 6 years. After dividing subjects into smokers and non-smokers, multiple logistic regression analysis for men was performed to evaluate the relationship between the serum Ca/Mg ratio and periodontal disease progression. We used the 25th percentile of periodontal disease events for 6 years as the dependent variable and seven other variables, including quartiles for serum Ca/Mg ratios, as independent variables.
Results: There was a clear dose-response relationship of Ca/Mg ratio quartiles for periodontal disease events among smokers. Significant differences in odds ratios in the first and second quartiles were seen compared with the fourth quartile (reference): 6.28 (p = 0.014) and 5.96 (p = 0.022), respectively. However, there was no significant dose-response relationship among non-smokers.
Conclusion: A low serum Ca/Mg ratio was significantly associated with periodontal disease progression in Japanese elderly smokers.

DOI： 10.1111/j.1600-051X.2011.01769.x

Mineral content of calcium and magnesium in the serum and longitudinal periodontal progression in Japanese elderly smokers

Akihiro Yoshihara, Masanori Iwasaki, Hideo Miyazaki

JOURNAL OF CLINICAL PERIODONTOLOGY 38 ( 11 ) 992 - 997 2011年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：WILEY-BLACKWELL

DOI： 10.1111/j.1600-051X.2011.01769.x

Physical activity and 5-year changes in physical performance tests and bone mineral density in postmenopausal women: The Yokogoshi Study 査読

Kaori Kitamura, Kazutoshi Nakamura, Ryosaku Kobayashi, Rieko Oshiki, Toshiko Saito, Mari Oyama, Shunsuke Takahashi, Tomoko Nishiwaki, Masanori Iwasaki, Akihiro Yoshihara

MATURITAS 70 ( 1 ) 80 - 84 2011年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ELSEVIER IRELAND LTD

Objective: The effect of physical activity on musculoskeletal health in older adults is not completely understood. The aim of this study was to determine the relationship between physical activity and 5-year changes in physical performance tests and bone mineral density (BMD) in postmenopausal women.
Study design: The design was a 5-year cohort study.
Main outcome measures: Subjects were 507 women (55-74 years old) living in a rural community in Japan. Physical activity assessed included housework, farm work, and moderate leisure-time physical activity within the previous week. Measurements at baseline included handgrip strength, walking time (timed "Up & Go" test) and BMD of the femoral neck and vertebrae. Five-year changes in these measures (outcome variables) were compared among groups with different levels of physical activity by analysis of covariance.
Results: Women who did not do housework performed worse in changes in handgrip strength (difference = 2.22 kg, P = 0.0201) and worse in changes in the walking time (difference = 0.54 s, P = 0.0072) than those who did housework alone. Women who spent at least 9 h per week (median = 24) doing farm work performed better in changes in handgrip strength (difference = 0.28 kg, P= 0.0334), but worse in changes in the walking time (difference = 0.66 s, P<0.0001) than those who did not do farm work. However, leisure-time activity was not associated with changes in any outcome variable, and none of the physical activities predicted BMD changes.
Conclusions: Engaging in housework and farm work are determinants of physical function in postmenopausal women, which may help them maintain independence in daily living. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.maturitas.2011.06.014

Physical activity and 5-year changes in physical performance tests and bone mineral density in postmenopausal women: The Yokogoshi Study

Kaori Kitamura, Kazutoshi Nakamura, Ryosaku Kobayashi, Rieko Oshiki, Toshiko Saito, Mari Oyama, Shunsuke Takahashi, Tomoko Nishiwaki, Masanori Iwasaki, Akihiro Yoshihara

MATURITAS 70 ( 1 ) 80 - 84 2011年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ELSEVIER IRELAND LTD

DOI： 10.1016/j.maturitas.2011.06.014

縦断調査からみた歯列欠損形態と咀嚼能力の経年変化

佐藤直子, 野村修一, 昆はるか, 櫻井直樹, 葭原明弘, 宮崎秀夫, 河野正司

老年歯科医学 26 ( 2 ) 171 - 172 2011年9月

Relationships among bone turnover, renal function and periodontal disease in elderly Japanese 査読

A. Yoshihara, Y. Hayashi, H. Miyazaki

JOURNAL OF PERIODONTAL RESEARCH 46 ( 4 ) 491 - 496 2011年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：WILEY-BLACKWELL

Background and Objective: We hypothesized that renal function is associated with the relationship between periodontal disease and bone metabolism. The present study evaluated the relationship of bone formation and resorption markers to periodontal disease, taking renal function into consideration, in elderly Japanese subjects.
Material and Methods: We selected 148 subjects aged 77 years. The periodontal examination included the assessment of clinical attachment level (CAL). We measured two bone formation markers (serum bone-specific alkaline phosphatase and serum osteocalcin) and two bone resorption markers (urinary deoxypyridinoline and urinary cross-linked N-telopeptide of type I collagen). Creatinine clearance per 24 h, as a measure of renal function, was also determined. The correlations between mean CAL or percentage of sites with >= 6 mm CAL (6+ mm CAL) and bone turnover markers, and between bone turnover markers and creatinine clearance levels, were performed by multiple linear regression analysis.
Results: There were significant negative relationships between mean CAL or 6+ mm CAL and serum osteocalcin levels adjusted for gender, smoking habits and oral care habits (beta - -0.25, p - 0.014 and beta - -0.35, p - 0.001, respectively). In addition, there was a negative relationship between serum osteocalcin and creatinine clearance levels adjusted for gender and smoking habits (beta = -0.45, p < 0.0001).
Conclusion: Results from the present study suggest that serum osteocalcin was significantly associated with renal function and periodontal disease. The low systemic bone metabolism, which might be caused by low renal function, is associated with periodontal disease.

DOI： 10.1111/j.1600-0765.2011.01365.x