研究者詳細 - 葭原　明弘

Longitudinal relationship between metabolic syndrome and periodontal disease among Japanese adults aged ≥70 years: the Niigata Study.

Iwasaki M, Sato M, Minagawa K, Manz MC, Yoshihara A, Miyazaki H

Journal of periodontology 86 ( 4 ) 491 - 498 2015年4月

地域在住高齢者における歯・口腔の健康が認知機能検査スコアに与える影響査読

岩崎正則, 葭原明弘, 小川祐司, 山賀孝之, 佐藤美寿々, 安細敏弘, 宮崎秀夫

口腔衛生学会雑誌 65 ( 2 ) 195 - 195 2015年4月

Relationship between metabolic syndrome and periodontitis in 80-year-old Japanese subjects 査読

K. Minagawa, M. Iwasaki, H. Ogawa, A. Yoshihara, H. Miyazaki

JOURNAL OF PERIODONTAL RESEARCH 50 ( 2 ) 173 - 179 2015年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：WILEY

Background and ObjectivePotentially significant associations between metabolic syndrome (MetS) and periodontitis have been reported in recent studies; however, there are limited data on their association in the very old. The aim of this cross-sectional study was to investigate the association between MetS and periodontitis among 80-year-old Japanese subjects.
Material and MethodsThe subjects were 234 Japanese aged 80years old who participated in a health and periodontal examination in June 2008 in Niigata city, Japan, and were classified into three groups: (i) severe periodontitis: having six or more interproximal sites with clinical attachment level 6mm and three or more interproximal sites with probing pocket depth (PPD) 5mm (not on the same tooth) (n=19); (ii) moderate periodontitis: having six or more interproximal sites with clinical attachment level 4mm or six or more interproximal sites with PPD 5mm (not on the same tooth) (n=162); and (iii) no or mild periodontitis: neither moderate nor severe periodontitis (n=53). MetS was defined using the modified criteria of the guidelines for the diagnosis of MetS in Japan. An ordinal logistic regression model was used to evaluate the association between MetS and periodontitis. Adjustments for gender, income, education, smoking status, dental visiting patterns, brushing frequency, exercise habits and dietary energy and food intake were considered.
ResultsOverall, 57 individuals (24.4%) were diagnosed as having MetS. MetS was associated with the presence and severity of periodontitis (crude odds ratio=2.24, 95% confidence interval=1.14-4.41). This association remained statistically significant after multivariate adjustments (adjusted odds ratio=2.10, 95% confidence interval=1.03-4.28).
ConclusionOur findings provide evidence of an association between MetS and periodontitis in elderly Japanese.

DOI： 10.1111/jre.12190

歯科医師および歯科衛生士数と医院の担える診療内容との関連

皆川久美子, 葭原明弘, 荒井節男, 清田義和, 宮崎秀夫

口腔衛生学会雑誌 65 ( 2 ) 255 - 255 2015年4月

成人女性に対する歯周病予防の取り組みへの提案

皆川久美子, 葭原明弘, 宮崎秀夫

口腔衛生学会雑誌 65 ( 1 ) 53 - 53 2015年1月

Association between dental status and food diversity among older Japanese 査読

Masanori Iwasaki, Y. Kimura, A. Yoshihara, H. Ogawa, T. Yamaga, T. Takiguchi, T. Wada, R. Sakamoto, Y. Ishimoto, E. Fukutomi, W. Chen, H. Imai, M. Fujisawa, K. Okumiya, M. C. Manz, H. Miyazaki, K. Matsubayashi

Community Dental Health 32 ( 2 ) 104 - 110 2015年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Dennis Barber Ltd

Objective: To investigate the relationship of dental status to food diversity among older Japanese. Design and Setting: A community-based cross-sectional study conducted in the town of Tosa, Kochi Prefecture, Japan. Methods: The study participants were 252 Japanese (84 men and 168 women, average age 81.2 years) and dentate participants were classified into three groups: 1-9 teeth, 10-19 teeth and 20 or more teeth. Food diversity was assessed as a validated measure of dietary quality using the 11-item Food Diversity Score Kyoto (FDSK-11), which evaluates frequency of consumption of 11 main food groups. Multivariable analysis of the differences in FDSK-11 score ranging from 0 to 11, with a higher score indicating greater food diversity, among the three dental status groups was conducted using general linear models. All the performed analyses were stratified by gender. Results: There was no association between dental status and food diversity score in models for men. In contrast, women with ≤9 teeth and with 10-19 teeth had significantly lower FDSK-11 scores than women with ≥20 teeth after adjusting for confounders (p&lt
0.001 and p=0.009, respectively). Additionally, there was a trend toward lower scores for FDSK-11 with fewer teeth (p=0.001). Conclusion: A less varied diet, as indicated by low FDSK-11 score, was observed in female participants with fewer teeth. Tooth loss was associated with poor diet quality among older Japanese women.

DOI： 10.1922/CDH_3502Iwasaki07

Scopus

Low dietary diversity among older Japanese adults with impaired dentition 査読

Iwasaki M, Kimura Y, Yoshihara A, Ogawa H, Yamaga T, Wada T, Sakamoto R, Ishimoto Y, Fukutomi E, Vhen WL, Imai H, Fujisawa M, Okumiya K, Manz MC, Ansai T, Miyazaki H, Matsubayashi K

Journal of Dentistry and Oral Hygiene 7 ( 4 ) 40 - 43 2015年

Analysis of tooth brushing cycles 査読

Yuki Tosaka, Kuniko Nakakura-Ohshima, Nozomi Murakami, Rikako Ishii, Issei Saitoh, Yoko Iwase, Akihiro Yoshihara, Akitsugu Ohuchi, Haruaki Hayasaki

CLINICAL ORAL INVESTIGATIONS 18 ( 8 ) 2045 - 2053 2014年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER HEIDELBERG

The aim of this study was to demonstrate the effectiveness of an analysis of tooth brushing cycles using a system that measures tooth brushing motion and brushing force with an accelerometer and strain tension gage attached to a toothbrush.
Mechanical plaque removal with a manual toothbrush remains the primary method of maintaining good oral hygiene for the majority of the population. Because toothbrush motion has not been fully understood, it should be clarified by analysis of tooth brushing cycles.
Twenty healthy female dental hygienists participated in this study. Their tooth brushing motions were measured and analyzed using an American Dental Association-approved manual toothbrush to which a three-dimensional (3-D) accelerometer and strain tension gage were attached. 3-D motion and brushing force on the labial surface of the mandibular right central incisor and the lingual surface of the mandibular left first molar were measured, analyzed, and compared. Multilevel linear model analysis was applied to estimate variables and compare motion and forces related to the two tooth surfaces.
The analysis of tooth brushing cycles was feasible, and significant differences were detected for durations and 3-D ranges of toothbrush motion as well as brushing force between the two tooth surfaces.
The analysis used in this study demonstrated an ability to detect characteristics of tooth brushing motion, showing tooth brushing motion to change depending on the brushed location. These results also suggest that more detailed instructions might be required according to patient's oral condition.

DOI： 10.1007/s00784-013-1172-3

Analysis of tooth brushing cycles 査読

Yuki Tosaka, Kuniko Nakakura-Ohshima, Nozomi Murakami, Rikako Ishii, Issei Saitoh, Yoko Iwase, Akihiro Yoshihara, Akitsugu Ohuchi, Haruaki Hayasaki

CLINICAL ORAL INVESTIGATIONS 18 ( 8 ) 2045 - 2053 2014年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER HEIDELBERG

DOI： 10.1007/s00784-013-1172-3

Oral health status: relationship to nutrient and food intake among 80-year-old Japanese adults 査読

Masanori Iwasaki, George W. Taylor, Michael C. Manz, Akihiro Yoshihara, Misuzu Sato, Kanako Muramatsu, Reiko Watanabe, Hideo Miyazaki

COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY 42 ( 5 ) 441 - 450 2014年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：WILEY-BLACKWELL

ObjectivesThe aim of this cross-sectional study was to investigate the relationship of oral health status defined on the basis of presence of posterior occluding pairs (POPs) and adequacy of removable denture fit as determined by self-report to nutrient and food intake among older Japanese.
MethodsThe subjects were 353 Japanese aged 80years in 2008 and were classified into four groups according to the number of POPs, defined as pairs of occluding natural, restored, or fixed prosthetic postcanine teeth (range: 0-8) and removable denture status. The groups were: (i) good dentition (n=56; 8 POPs and no removable prosthesis), (ii) well-fitting dentures (n=158; <8 POPs with self-reported good-fitting dentures), (iii) ill-fitting dentures (n=70; <8 POPs with self-reported ill-fitting dentures), and (iv) compromised dentition (n=69; <8 POPs and no removable prosthesis). Multivariable analysis of the differences in nutrient and food intake outcome variables which were collected via validated food frequency questionnaire among the four oral health status groups was conducted using general linear models.
ResultsIntake of multiple nutrients was significantly (P<0.05) lower in the group with ill-fitting dentures or compromised dentition than in the good dentition group. Vegetable, fish, and shellfish consumption was significantly lower in the ill-fitting dentures or compromised dentition groups. No significant differences were seen in dietary intake between the well-fitting dentures and good dentition groups.
ConclusionsDietary intake was poorer in those with self-perceived ill-fitting dentures or fewer POPs than among those having all POPs. Regular dental care to maintain intact dentition, as well as dental treatment to replace missing teeth and ensure adequate denture fit and function, may be important to the diet intake and subsequent nutritional status of older Japanese.

DOI： 10.1111/cdoe.12100

Oral health status: relationship to nutrient and food intake among 80-year-old Japanese adults 査読

Masanori Iwasaki, George W. Taylor, Michael C. Manz, Akihiro Yoshihara, Misuzu Sato, Kanako Muramatsu, Reiko Watanabe, Hideo Miyazaki

COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY 42 ( 5 ) 441 - 450 2014年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：WILEY-BLACKWELL

DOI： 10.1111/cdoe.12100

Comparison of periodontal conditions among three elderly populations in Japan and Germany 査読

Toshinobu Hirotomi, Thomas Kocher, Akihiro Yoshihara, Reiner Biffar, Wolfgang Micheelis, Thomas Hoffmann, Hideo Miyazaki, Birte Holtfreter

JOURNAL OF CLINICAL PERIODONTOLOGY 41 ( 7 ) 633 - 642 2014年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：WILEY-BLACKWELL

Aim: There is a growing interest in comparing periodontal conditions between countries. This study compared periodontal disease conditions in three elderly populations- one from Japan and two from Germany.
Materials and Methods: We compared periodontal data of 70-year-old subjects from the Niigata Study with 65-74-year-old subjects from the Study of Health in Pomerania (SHIP) and from West Germany (DMS III). A total of 489, 399 and 549 dentate subjects were analysed, respectively. Recording protocols were standardized. Linear or logistic models were used to compare Niigata Study with SHIP.
Results: Elderly German subjects in SHIP and DMS III had significantly more severe periodontal conditions and fewer remaining teeth compared to those in Niigata Study, though differences were less pronounced for DMS III. German subjects showed a significantly different pattern of various periodontal risk factors compared to Japanese subjects. Even after adjustment for putative periodontal risk factors, SHIP subjects still presented significantly higher adjusted values for most periodontal parameters compared to Niigata Study subjects (p < 0.05).
Conclusions: Periodontitis was more prevalent in SHIP compared with Niigata Study, even after comprehensive risk factor adjustment. Only to a very small extent, differences between studies could be explained by the risk factors explored.

DOI： 10.1111/jcpe.12267

Comparison of periodontal conditions among three elderly populations in Japan and Germany 査読

Toshinobu Hirotomi, Thomas Kocher, Akihiro Yoshihara, Reiner Biffar, Wolfgang Micheelis, Thomas Hoffmann, Hideo Miyazaki, Birte Holtfreter

JOURNAL OF CLINICAL PERIODONTOLOGY 41 ( 7 ) 633 - 642 2014年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：WILEY-BLACKWELL

DOI： 10.1111/jcpe.12267

Association between low renal function and tooth loss over 5 years. 査読

Yoshihara A, Iwasaki M, Miyazaki H, Nakamura K

Gerodontology 31 ( 2 ) 111 - 116 2014年6月

Association between low renal function and tooth loss over 5 years 査読

Akihiro Yoshihara, Masanori Iwasaki, Hideo Miyazaki, Kazutoshi Nakamura

GERODONTOLOGY 31 ( 2 ) 111 - 116 2014年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：WILEY-BLACKWELL

ObjectivesThis longitudinal study evaluated the relationship between low renal function and tooth loss in elderly subjects.
Material and methodsSubjects comprised 406 female subjects (55-74years old) who agreed to participate in a baseline examination and a follow-up examination after 5years. Serum cystatin C levels were used to assess renal function. Multiple logistic regression analysis was used to evaluate the relationship between tooth loss and change in serum cystatin C levels over 5years. Tooth loss over 5years (0: no, 1: yes) was used as the dependent variable. Seven variables were used as independent variables, including change in serum cystatin C levels over 5years.
ResultsResults of multiple logistic regression analysis showed that cystatin C change over 5years, age, number of remaining teeth at baseline, number of sites with 4mm clinical attachment level at baseline and serum 25-hydroxyvitamin D levels at baseline were significantly associated with tooth loss. The odds ratio for tooth loss with cystatin C change over 5years was 7.70 (p=0.029).
ConclusionThis study indicates a relationship between serum cystatin C levels and number of missing teeth, and thus suggests that low renal function is associated with tooth loss.

DOI： 10.1111/ger.12015

高齢者における歯周病が医療費に及ぼす影響

佐藤美寿々, 岩崎正則, 葭原明弘, 宮崎秀夫

新潟歯学会雑誌 44 ( 1 ) 56 - 56 2014年6月

The interaction between beta-3 adrenergic receptor polymorphism and obesity to periodontal disease in community-dwelling elderly Japanese 査読

Akihiro Yoshihara, Noriko Sugita, Masanori Iwasaki, Hideo Miyazaki, Kazutoshi Nakamura

JOURNAL OF CLINICAL PERIODONTOLOGY 41 ( 5 ) 460 - 466 2014年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：WILEY-BLACKWELL

Objectives
The purpose of this study was to elucidate whether the association between beta-3 adrenergic receptor polymorphism and periodontal disease is modified by body weight.
Material and Methods
We enrolled 332 postmenopausal women and determined their HbA1C levels (%) and beta-3 adrenergic receptor (rs4994) genotypes. Periodontal parameters including clinical attachment level (CAL) were measured. After selecting subjects for each body mass index (BMI) level, the prevalence rate ratio (PRR) by multiple Poisson regression analysis was calculated to evaluate the relationship between periodontal disease and beta-3 adrenergic receptor polymorphism. The number of sites with CAL >= 6mm was used as a dependent variable, and beta-3 adrenergic receptor genotype [categorized as Arg non-carriers (reference) or Arg carriers], age (y) and HbA1C (%) were adopted as independent variables. We converted the number of probing sites (n) to an offset variable.
Results
The PRR of the beta-3 adrenergic receptor genotype for the number of sites of CAL >= 6mm showed a positive association in subjects with BMI >= 25.0 and increased markedly with BMI. The PRR in subjects with BMI >= 30 was 3.10 (p<0.0001).
Conclusion
This study indicates a positive association between periodontal disease and the beta-3 adrenergic receptor genotype in obese individuals.

DOI： 10.1111/jcpe.12235