研究者詳細 - 葭原　明弘

論文 - 葭原　明弘

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Relationship between autoantibody associated with rheumatoid arthritis and tooth loss. 査読国際誌

Yuko Hayashi, George Taylor, Akihiro Yoshihara, Masanori Iwasaki, Stuart A Gansky, Hideo Miyazaki

Gerodontology 2018年5月

記述言語：英語掲載種別：研究論文（学術雑誌）

INTRODUCTION: This study evaluated the relationship between serum Rheumatoid Factor (RF) levels and tooth loss in a community-dwelling elderly Japanese women. It was hypothesised that women with high baseline RF levels would experience greater tooth loss over 10 years than age-matched women with lower baseline serum RF levels. MATERIALS AND METHODS: The study population consisted of 197 women aged 70 years with ≥12 teeth at baseline. One hundred and twenty-four participants completed a 10-year follow-up and were divided into 2 groups according to their baseline serum RF levels as follows: RF negative (<15 U/mL; n = 114) and RF positive (>15 U/mL; n = 10). Negative binomial regression was used to investigate the relationship between baseline RFs and tooth lost over the 10-year period. RF and its interaction with the baseline number of teeth were independent variables, with 9 other adjustment covariates. RESULTS: Baseline RFs were significantly associated with tooth loss (P = .035). In addition, a statistical interaction between baseline RFs and baseline number of teeth was identified (P = .023), modifying the association between RFs and tooth loss. The adjusted incidence rate ratio (IRR) for RF-positive participants with 21 baseline teeth was 1.88 (95% confidence interval (95% CI): 0.76, 4.65). IRRs obtained for participants who had 25 baseline teeth (3.02; 95% CI: 1.03, 8.83) or 30 baseline teeth (5.47; 95% CI: 1.29, 23.13) suggested that RF-positive participants with a high number of baseline teeth would exhibit greater tooth loss than RF-negative participants. CONCLUSION: High serum RF levels were associated with a greater IRR for future tooth loss in elderly Japanese women.

DOI： 10.1111/ger.12344

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Effect of lifestyle on 6-year periodontitis incidence or progression and tooth loss in older adults. 査読国際誌

Iwasaki M, Borgnakke WS, Ogawa H, Yamaga T, Sato M, Minagawa K, Ansai T, Yoshihara A, Miyazaki H

Journal of clinical periodontology 45 ( 8 ) 896 - 908 2018年5月

Chronic Intra Oral Pain and Depressive Symptoms in Japanese Community-Dwelling Elderly: A Longitudinal Study. 査読

Hanindriyo L, Yoshihara A, Takiguchi T, Miyazaki H

Community dental health 35 ( 2 ) 102 - 108 2018年5月

高次生活機能の加齢に伴う変化の軌跡と歯の本数の関連についての縦断研究

岩崎正則, 佐藤美寿々, 皆川久美子, 安細敏弘, 葭原明弘, 小川祐司, 宮崎秀夫

口腔衛生学会雑誌 68 ( 増刊 ) 112 - 112 2018年4月

納豆摂取と歯の喪失との関連地域在住閉経後女性を対象とした縦断研究

佐藤美寿々, 岩崎正則, 皆川久美子, 葭原明弘, 宮崎秀夫

口腔衛生学会雑誌 68 ( 増刊 ) 112 - 112 2018年4月

在宅超高齢者の栄養状態と栄養素摂取量との関連

濱嵜朋子, 岩崎正則, 角田聡子, 片岡正太, 濃野要, 葭原明弘, 安細敏弘, 宮崎秀夫

口腔衛生学会雑誌 68 ( 増刊 ) 113 - 113 2018年4月

Relationship between alcohol consumption and periodontal tissue condition in community-dwelling elderly Japanese. 査読国際誌

Suwama Kana, Yoshihara Akihiro, Watanabe Reiko, Stegaroiu Roxana, Shibata Satoko, Miyazaki Hideo

Gerodontology 2018年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVES: To examine the associations among alcohol consumption level, dietary intake and other lifestyle factors, and periodontal condition, in community-dwelling elderly Japanese of a specific age. BACKGROUND: The relationship between alcohol consumption level and periodontitis is a controversial issue. METHODS: Participants were 438 dentate elders aged 73 years from a larger cohort survey of elders in Niigata City, Japan. Data collected from oral examination of each participant, including number of the existing teeth, mean probing pocket depth and mean clinical attachment level (CAL) were used for the analyses. A semiquantitative food frequency questionnaire and a lifestyle habit questionnaire were used to assess food and alcohol consumption, smoking experience, frequency of tooth brushing, interdental brush use, and visits to a dental clinic during the previous year. Blood glucose control was assessed by the glycated haemoglobin (HbA1c) level. Body mass index was calculated from height and weight measurements. The relationships between each variable and the individual mean CAL were analysed by univariate and multivariate analyses. RESULTS: According to logistic regression

DOI： 10.1111/ger.12335

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Relationship between clinical periodontal parameters and changes in liver enzymes levels over an 8-year period in an elderly Japanese population

Elastria Widita, Akihiro Yoshihara, Lisdrianto Hanindriyo, Hideo Miyazaki

Journal of Clinical Periodontology 45 ( 3 ) 311 - 321 2018年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Blackwell Munksgaard

Aims: An association between periodontal disease and liver enzymes has been reported previously. This study examined the relationship between clinical periodontal parameters and changes in liver enzymes levels in 265 non-institutionalized Japanese elderly aged 72 years over 8 years. Materials and methods: The number of sites with probing pocket depth (PPD) ≥ 6 mm and clinical attachment level (CAL) ≥ 6 mm were measured. Changes in liver enzymes (alanine transaminase [ALT] and aspartate transaminase [AST]) was grouped based on any elevation of concentrations. The relationship was determined by logistic regression with adjustment for confounders. Interaction test and stratified analysis were then performed according to smoking status and alcohol drinking habits, separately. Results: Elevation in ALT, but not AST, was significantly associated with PPD (odds ratio [OR] = 1.10) and CAL (OR = 1.03). A significant interaction of periodontal parameters on ALT was observed with smoking status, but not with alcohol drinking habit. The stratified analysis suggested that ALT was found to be significantly correlated with PPD (OR = 1.20) and CAL (OR = 1.04) to those who were smoker. Conclusion: The elevation in ALT levels might be associated with clinical periodontal parameters among non-institutionalized Japanese elderly, and this association was modified by smoking status.

DOI： 10.1111/jcpe.12861

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Association between serum resistin level and periodontal condition change among elderly people 査読

Ogawa H, Damrongrungruang T, Furugen R, Hayashida H, Saito T, Yoshihara A, Miyazaki H

Stoma Edu J 5 ( 1 ) 24 - 30 2018年3月

Dentition status and frailty in community-dwelling older adults: A 5-year prospective cohort study

Masanori Iwasaki, Akihiro Yoshihara, Misuzu Sato, Kumiko Minagawa, Mieko Shimada, Mamoru Nishimuta, Toshihiro Ansai, Yutaka Yoshitake, Hideo Miyazaki

Geriatrics and Gerontology International 18 ( 2 ) 256 - 262 2018年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Blackwell Publishing

Aim: To examine the longitudinal association between dentition status and incidence of frailty in older adults. Methods: The present prospective cohort study included community-dwelling Japanese adults aged 75 years at baseline (n = 322). Dental examinations, biochemical blood examinations, physical performance and anthropometric measurements, and structured questionnaires were carried out at baseline. The presence of ≥20 teeth with nine or more occluding pairs of teeth was defined as functional dentition. Annual follow-up examinations, including physical performance, anthropometric measurements and structured questionnaires, were carried out over a 5-year period to determine the incidence of frailty, defined as three or more of the following five components derived from the Cardiovascular Health Study: weight loss, weakness, slowness, poor energy and low physical activity level. Adjusted hazard ratios of frailty incidence according to dentition status were calculated from Cox proportional hazards regression analyses. Results: At baseline, 118 participants (36.6%) were defined as having functional dentition. During the follow up, 48 participants (14.9%) developed frailty. The adjusted hazard ratio for frailty in participants with functional dentition was 0.50 (95% confidence interval 0.25–0.98) compared with participants without functional dentition, after adjusting for sex, income, education, smoking status, body mass index, serum biomarkers and comorbidities. Conclusions: Functional dentition was significantly associated with a lower risk of frailty defined by the Cardiovascular Health Study frailty index in older Japanese adults. These results suggest that maintaining healthy and functional dentition into later life is important for frailty prevention. Geriatr Gerontol Int 2018
18: 256–262.

DOI： 10.1111/ggi.13170

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Association of liver enzyme levels and alveolar bone loss: A cross-sectional clinical study in Sado Island. 査読国際誌

Ayumi Kuroki, Noriko Sugita, Shigeki Komatsu, Akio Yokoseki, Akihiro Yoshihara, Tetsuo Kobayashi, Kazutoshi Nakamura, Takeshi Momotsu, Naoto Endo, Kenji Sato, Ichiei Narita, Hiromasa Yoshie

Journal of clinical and experimental dentistry 10 ( 2 ) e100-e106 - e106 2018年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

Background: The interaction of periodontopathic bacteria with host immune system induces the production of inflammatory mediators which leads to alveolar bone loss (ABL), the essential feature of periodontitis. Concurrently, periodontal diseases cause the elevation of blood cytokine levels, the alteration of gut microbiota and the dissemination of enterobacteria to the liver. Owing to these mechanisms, periodontal disease might be a risk for liver dysfunction. Several epidemiological studies have reported associations between periodontal diseases and liver dysfunction, although the association between ABL and liver dysfunction has not been investigated. This cross-sectional study determined if elevated serum liver enzyme levels were associated with ABL in Japanese adults. Material and Methods: Japanese adults living on Sado Island who visited Sado General Hospital were invited to participate in the study. Participants over 40 years of age who underwent dental panoramic radiography and blood tests were included. Drinking and smoking habits were self-administered. After excluding patients with edentulous jaw, diagnosed liver diseases, and those on dialysis, data from 44 men and 66 women with a mean age of 73 years were analyzed. The average percentage of ABL for each participant was calculated for mesial and distal sites of all remaining teeth. The levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) were determined. Univariate analyses were performed to select covariates to be put in multivariate analyses. The association between elevated serum liver enzyme levels and the highest quartile of ABL were assessed by multiple logistic regression analysis. Results: After adjusting for covariates, no significant association was found between elevated serum AST, ALT, or GGT levels as dependent variables and the highest quartile of ABL as an explanatory variable. Conclusions: There was no significant association between the elevation of serum liver enzyme levels and ABL in Japanese adults. Key words:Liver enzymes, dental panoramic radiography, alveolar bone loss, Japanese adults.

DOI： 10.4317/jced.54555

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A 5-year longitudinal study of association of maximum bite force with development of frailty in community-dwelling older adults 査読

M. Iwasaki, A. Yoshihara, N. Sato, M. Sato, K. Minagawa, M. Shimada, M. Nishimuta, T. Ansai, Y. Yoshitake, T. Ono, H. Miyazaki

JOURNAL OF ORAL REHABILITATION 45 ( 1 ) 17 - 24 2018年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：WILEY

To determine whether maximum bite force (MBF), an objective measure of oral function, is associated with development of frailty in community-dwelling older adults. This prospective cohort study included community-dwelling Japanese adults aged 75years at baseline (n=322). Baseline MBF was measured using an electronic recording device (Occlusal Force-Meter GM10). Follow-up examinations, including physical fitness and anthropometric evaluation and structured questionnaires, were administered annually over a 5-year period to determine the incidence of frailty, which was defined by the presence of 3 or more of the following 5 components derived from the Cardiovascular Health Study: low level of mobility, low physical activity level, weakness, shrinking and poor endurance and energy. Adjusted hazard ratios (HRs) of incidence of frailty according to sex-stratified tertiles of baseline MBF were calculated using Cox proportional hazards regression models. During the follow-up, 49 participants (15.2%) developed frailty. Participants in the lower tertile of MBF exhibited a significantly greater risk of frailty than those in the upper tertile. After adjustment for sex, depression, diabetes and Eichner index, the adjusted HRs for frailty in the upper through lower tertiles of MBF were 1.00 (reference), 1.27 (95% confidence interval [CI]: 0.50-3.20) and 2.78 (95% CI: 1.15-6.72), respectively (P for trend=.01). Poor oral function, as indicated by low MBF, increases the risk of development of frailty among elderly men and women.

DOI： 10.1111/joor.12578

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視診による歯肉炎評価の有用性査読

渡辺真光, 葭原明弘, 諏訪間加奈, 角田聡子, 岩崎正則, 安細敏弘, 宮崎秀夫

口腔衛生学会雑誌 68 ( 1 ) 36 - 37 2018年1月

職域における歯科健診単独もしくは歯科健診と保健指導による行動変容

金子昇, 葭原明弘, 野々村絢子, 笹嶋真嵩, 宮本茜, 皆川久美子, 佐藤美寿々, 久保田悠, 濃野要, 山賀孝之, 宮崎秀夫

口腔衛生学会雑誌 68 ( 1 ) 37 - 37 2018年1月

地域在住高齢者における現在歯数および義歯の使用状況・主観的評価とフレイルとの関連についての横断研究査読

佐藤美寿々, 岩崎正則, 皆川久美子, 小川祐司, 山賀孝之, 葭原明弘, 宮崎秀夫

口腔衛生会誌 68 ( 2 ) 68 - 75 2018年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人口腔衛生学会

フレイルと歯・口腔の健康との関連は疫学的に十分に解明されていない．今回われわれは，地域在住高齢者における現在歯数および義歯の使用状況・主観的評価とフレイルとの関連を明らかにすることを目的とする横断研究を実施した．79歳高齢者344人を解析対象とした．フレイルは，Study of Osteoporotic Fracture Criteria for Frailty を一部改変したものを用いて定義し，目的変数とした．説明変数には現在歯数および義歯の使用状況・主観的評価を用いた．そして両者の関連を性別，体格，および精神健康状態を共変量とするロジスティック回帰分析を用いて評価した．解析対象者におけるフレイルの頻度は8.4%であった．現在歯数（1本増加ごとの調整済オッズ比［OR］=0.94，95％信頼区間［CI］= 0.90–0.99），現在歯数20本以上有すること（20本未満と比較した調整済OR=0.39，95%CI=0.15–0.97），義歯不使用（義歯使用者と比較した調整済OR=17.89，95％CI=5.00–64.32），主観的に義歯不具合の訴えがあること（訴えなしと比較した調整済OR=3.38，95％CI=1.01–11.27）はフレイルと有意に関連していた．本研究結果から，地域在住高齢者において現在歯数および義歯の使用状況・主観的評価はフレイルと有意に関連していることが示された．

DOI： 10.5834/jdh.68.2_68

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その他リンク： https://search.jamas.or.jp/link/ui/2018250455

一般地域住民における主観的な歯や歯肉の健康状態と全身健康状態との関連：8020推進財団「一般地域住民を対象とした歯・口腔の健康に関する調査研究」より

皆川久美子, 宮﨑秀夫, 葭原明弘, 佐藤美寿々, 深井穫博, 安藤雄一, 嶋﨑義浩, 古田美智子, 相田潤, 神原正樹

口腔衛生学会雑誌 68 ( 4 ) 198 - 206 2018年

記述言語：日本語出版者・発行元：一般社団法人口腔衛生学会

健康の評価方法として，歯科保健の分野においても主観的評価による健康度を評価指標にした調査が報告されている．しかし，主観的健康観についての調査対象は高齢者が多く，65歳未満の者を対象とした調査はほとんど行われていない．そのため本研究は，一般地域住民を対象に，歯や歯肉の健康状態と全身健康状態との関連を主観的健康観により明らかにすることを目的とした． 全国から20～79歳の5,000人を抽出し，質問紙による調査で回答を得た2,465人（有効回収率49.3%）の中から，分析に用いる変数に欠損値のない1,972人を分析対象者とした．対象者を年齢によって壮年（20～39歳）・中年（40～59歳）・高年（60～79歳）の３区分に分け，それぞれの群において歯や歯肉の健康状態と全身健康状態の主観的健康観の回答をそれぞれカテゴリー化した後，相互の関連を順序ロジスティック回帰分析を用いて分析した．共変量として，現在歯数，性別，仕事の有無，主観的経済状態，就学年数，治療中の疾患の有無，相談相手の有無，BMIを使用した． その結果，すべての年齢群において歯や歯肉の健康状態が良いと回答した者は全身的な健康状態がより良好であると回答していた（調整済オッズ比〔95％信頼区間〕＝壮年期12.41〔7.22–21.34〕，中年期11.77〔7.50–18.48〕，老年期10.07〔6.55–15.50〕）．一般住民において属性や関連要因を調整した分析で，いずれの年代においても主観的な歯や歯肉の健康状態と全身健康状態との間には明確な関連性が認められた．

DOI： 10.5834/jdh.68.4_198

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その他リンク： http://search.jamas.or.jp/link/ui/2019038143

在宅高齢者における簡易嚥下状態評価（EAT-10）と栄養状態との関連

秋山理加, 濱嵜朋子, 酒井理恵, 岩﨑正則, 角田聡子, 邵仁浩, 葭原明弘, 宮﨑秀夫, 安細敏弘

口腔衛生学会雑誌 68 ( 2 ) 76 - 84 2018年

記述言語：日本語出版者・発行元：一般社団法人口腔衛生学会

【目的】在宅高齢者を対象として簡易嚥下状態評価票（EAT-10）を用いて，嚥下状態と栄養状態の関連について明らかにすることを目的とした．【対象および方法】新潟市の85歳在宅高齢者129名を対象とした．口腔と全身の健康状態に関するアンケートを郵送し自記式にて調査を行った．調査内容は，EAT-10，現在歯数，簡易栄養状態評価（MNA-SF），主観的健康観，老研式活動能力指標，Oral Health Impact Profile-49（OHIP），嚙める食品数である．これらの因子について，EAT-10の合計点数が3点以上を嚥下機能低下のリスク有り群とし，3点未満の群との比較検討を行った．【結果】EAT-10によって，嚥下機能低下が疑われたものは52.7% であった．嚥下機能低下のリスク有り群ではOHIP 高値（p<0.001），嚙める食品数低値（p<0.001）と有意な関連がみられ，主観的健康観で"あまり健康ではない"者の割合が有意に高く（p<0.001），MNA-SFで"低栄養"の割合が有意に高かった（p=0.007）．さらに，MNA-SF を従属変数としたロジスティック回帰分析の結果，栄養状態と嚥下機能には有意な関連がみられ，EAT-10の点数が高くなるほどMNA-SF で"低栄養のリスク有りまたは低栄養"となるオッズ比が有意に高かった（p=0.043）．【結論】在宅高齢者の嚥下機能低下と低栄養状態との関連性が示唆された．

DOI： 10.5834/jdh.68.2_76

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その他リンク： http://search.jamas.or.jp/link/ui/2018250456

Dental caries prevalence and treatment level of neglected children at two child guidance centers 査読

Yukiko Nogami, Yoko Iwase, Akiko Kagoshima, Issei Saitoh, Tsutomu Nakajima, Hideki Takahashi, Kanehito Nakagawa, Akihiro Yoshihara, Akitsugu Ohuchi, Tomiko Asahito, Haruaki Hayasaki

Pediatric Dental Journal 27 ( 3 ) 137 - 141 2017年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Elsevier Ltd

Objective Detailed evidence of a relationship between maltreated children and dental caries is limited. The purpose of this study was to investigate the prevalence of dmft and DMFT, and the characteristics of dental treatment level of children at two child guidance centers (CGC). Subject and methods A total of 166 children (mean age: 11.6 y ± 2.8) staying at two CGCs were examine, and their results were compared with those of the Survey of Dental Disease (SDD) carried out by the Japanese Society for Oral Health. Results Mean numbers of dental caries were 5.70 at the CGCs and 2.25 in the SDD. “Completely treated” children were 21.7% of total participants in the SDD, but only 3.6% at the CGCs. In addition, 7.0% of participants were “untreated” in the SDD, but 41.0% at the CGCs. The percentage of children without dental caries was 18.7% at the CGCs and 45.7% in the SDD. These differences between the CGCs and in the SDD were statistically significant. Conclusions Our results indicate that, due to a lack of daily oral care, dental caries are significantly more prevalent in children at CGCs. CGCs may be good places to improve neglected children's dental caries and oral health care.

DOI： 10.1016/j.pdj.2017.08.003

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Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults. 査読

NCD Risk Factor Collaboration, NCD-RisC

Lancet (London, England) 390 ( 10113 ) 2627 - 2642 2017年12月

刺激唾液分泌量低下と総死亡率との関連地域在住高齢者における10年間のコホート研究

佐藤美寿々, 岩崎正則, 伊藤加代子, 濃野要, 葭原明弘, 宮崎秀夫

老年歯科医学 32 ( 2 ) 159 - 160 2017年9月

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