研究者詳細 - 葭原　明弘

The carriage of Candida species on the dorsal surface of the tongue: the correlation with the dental, periodontal and prosthetic status in elderly subjects.

Wang J, Ohshima T, Yasunari U, Namikoshi S, Yoshihara A, Miyazaki H, Maeda N

Gerodontology 23 ( 3 ) 157 - 63 2006年9月

フッ化物洗口プログラムをベースとした選択的シーラント応用の20歳成人におけるう蝕予防効果

中村文, 佐久間汐子, 葭原明弘, 八木稔, 出口知也, 宮崎秀夫

口腔衛生学会雑誌 = JOURNAL OF DENTAL HEALTH 56 ( 4 ) 520 - 520 2006年8月

Association between commensal bacteria and opportunistic pathogens in the dental plaque of elderly individuals 査読

A Tada, H Senpuku, Y Motozawa, A Yoshihara, N Hanada, H Tanzawa

CLINICAL MICROBIOLOGY AND INFECTION 12 ( 8 ) 776 - 781 2006年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BLACKWELL PUBLISHING

Opportunistic infections in the oral cavity of the elderly may increase the incidence of systemic disease. The objective of this study was to investigate the differences in the oral bacterial flora between dependent elderly (inpatients) and independent elderly (community-dwelling residents). After multiple variables were taken into account, inpatients had significantly lower detection rates than community-dwelling residents for alpha-streptococci (p < 0.001) and Neisseria (p 0.004), and higher detection rates for Pseudomonas aeruginosa (p 0.024), methicillin-resistant Staphylococcus aureus (MRSA) (p 0.011) and Actinomyces spp. (p 0.005). Among inpatients, the requirement for a high degree of care was related negatively to detection of alpha-streptococci, but was related significantly to detection of P. aeruginosa (p 0.018) or MRSA (p 0.004). Tube-fed inpatients had a significantly lower detection rate for alpha-streptococci (p 0.041) and a higher detection rate for P. aeruginosa (p 0.004) than those who did not require tube feeding. Inpatients with a history of antibiotic use had a significantly lower detection rate for alpha-streptococci (p 0.049) and a higher detection rate for MRSA (p 0.007) than those without a history of antibiotic use. The detection rates for P. aeruginosa or MRSA in inpatients without alpha-streptococci were higher than in inpatients with alpha-streptococci after controlling for age and gender (P. aeruginosa, p 0.006; MRSA, p 0.001). Overall, detection of alpha-streptococci had an inverse correlation with the detection of P. aeruginosa and MRSA in the oral cavity and is likely to be an indicator of pathogenic bacterial infection.

DOI： 10.1111/j.1469-0691.2006.01497.x

Association between serum albumin and periodontal disease in community-dwelling elderly 査読

H Ogawa, A Yoshihara, N Amarasena, T Hirotomi, H Miyazaki

JOURNAL OF CLINICAL PERIODONTOLOGY 33 ( 5 ) 312 - 316 2006年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BLACKWELL PUBLISHING

Aim: The purpose of this study was to evaluate the relationship between periodontal disease and general health status in community-dwelling elderly using serum albumin concentration as a criterion index of the severity of an underlying disease and nutrition status.
Methods: Serum albumin level was detected by the bromcresol green albumin (BCG) method and the data for serum albumin were available in 368 subjects aged 75 years. Pressure-sensitive probes were used to measure loss of attachment (LA) on six sites of all teeth present. Information relevant to gender and smoking habit was obtained by means of a personal interview, while body mass index (BMI) and biochemical serum markers were investigated.
Results: Serum albumin concentration ranged from 3.2 to 4.8 g/dl with a mean of 4.1 +/- 0.2. More than 70% of subjects had at least one site with LA 6+ mm, while 91 exhibited 10% or more sites with LA 6+ mm. Using a multiple regression analysis, we found that sites of LA 6+ mm had a significant effect on serum albumin level (correlation coefficient=-0.14; p < 0.05), which was independent of the other covariates.
Conclusions: The findings of the present study indicated that there might be an inverse relationship between periodontal disease and serum albumin concentration in these elderly subjects.

DOI： 10.1111/j.1600-051X.2005.00901.x

Association between serum albumin and periodontal disease in community-dwelling elderly

H Ogawa, A Yoshihara, N Amarasena, T Hirotomi, H Miyazaki

JOURNAL OF CLINICAL PERIODONTOLOGY 33 ( 5 ) 312 - 316 2006年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BLACKWELL PUBLISHING

DOI： 10.1111/j.1600-051X.2005.00901.x

介護認定申請者における要介護度別歯科疾患の実態および歯科的治療ニーズに関する研究査読

鈴木昭, 河野正司, 野村修一, 伊藤加代子, 豊里晃, 田巻元子, 八木稔, 葭原明弘, 大内章嗣

新潟歯学会雑誌 35 ( 2 ) 209 - 214 2006年1月

記述言語：日本語出版者・発行元：新潟歯学会

介護認定者の歯科疾患の実態と歯科的治療ニーズを把握・評価するため,要介護度を踏まえた検討を行った.対象は新潟県内の同一保険医療福祉圏内の7市町村に在住し,2002年10月から12月の間に介護認定申請をした368名(平均年齢81歳)で,調査結果を分析し,以下の結論を得た.1)平均残存歯数と要介護度には相関関係はない,2)要介護度が上がると要抜去歯が有意に増加する傾向がある,3)歯科的治療ニーズ患者割合(要歯科治療・要専門的口腔ケアは89.4%),4)要介護状態になってから歯科を受診した患者割合は35.3%.以上より,歯科治療の必要性と実際の受診状況には大きな隔たりがあることが分かった

Influence of a fluoride mouthrinse on mutans streptococci in schoolchildren

Noboru Kaneko, Akihiro Yoshihara, Hirohisa Ida, Yoshiaki Nomura, Susumu Imai, Toshiki Nisizawa, Shihoko Sakuma, Nobuhiro Hanada, Hideo Miyazaki

CARIES RESEARCH 40 ( 6 ) 501 - 507 2006年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：KARGER

This study aimed to determine whether the long-term use of a fluoride mouthrinse affects the salivary levels of mutans streptococci. Two hundred and fifteen schoolchildren (aged 9-10 years) participated. One hundred and forty-nine of these children had used a fluoride mouthrinse since 5 years of age at nursery school, and the remaining 66 children had not. DFT (decayed and filled teeth) was recorded, and the salivary levels of Streptococcus mutans and Streptococcus sobrinus were measured using mitis salivarius bacitracin agar. The group that had used a fluoride mouthrinse had a significantly lower prevalence of both S. mutans and S. sobrinus (p = 0.038) and a significantly lower DFT score (p = 0.001) than the other group. Using logistic regression analysis including caries experience at baseline as a dependent variable, the odds ratio of carrying S. mutans alone was 8.0 (p = 0.066) and that of carrying both S. mutans and S. sobrinus was 16.5 (p = 0.022) in the group that had not used the fluoride mouthrinse. Children carrying both S. mutans and S. sobrinus had a higher caries incidence in 1 year than the others, with odds ratios of 5.73 ( p = 0.067) in the group with a fluoride mouthrinse and 3.47 (p = 0.035) in the group without it. These results show that the long-term use of a fluoride mouthrinse is associated with reduced salivary levels of mutans streptococci and this bacterial reduction may partly contribute to the suppression of dental caries in children using a long-term fluoride mouthrinse. Copyright (c) 2006 S. Karger AG, Basel

DOI： 10.1159/000095649

Influence of a fluoride mouthrinse on mutans streptococci in schoolchildren 査読

Noboru Kaneko, Akihiro Yoshihara, Hirohisa Ida, Yoshiaki Nomura, Susumu Imai, Toshiki Nisizawa, Shihoko Sakuma, Nobuhiro Hanada, Hideo Miyazaki

CARIES RESEARCH 40 ( 6 ) 501 - 507 2006年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：KARGER

DOI： 10.1159/000095649

日本における集団応用でのフッ化物洗口に関する実態調査「健康日本21」における2005年中間評価に向けて査読

義歯の装着と咬合力および噛める食品との関係査読

岩舩素子, 五十嵐直子, 河野正司, 清田義和, 葭原明弘, 宮秀夫

新潟歯学会誌 34 ( 2 ) 213 - 218 2005年12月

The relationship between dietary intake and the number of teeth in elderly Japanese subjects 査読

Akihiro Yoshihara, Reiko Watanabe, Mamoru Nishimuta, Nobuhiro Hanada, Hideo Miyazaki

Gerodontology 22 211 - 218 2005年12月

木本一成, 晴佐久悟, 田浦勝彦, 志村匡代, 藤野悦男, 山本武夫, 葭原明弘, 磯崎篤則, 荒川浩久, 小林清吾, 境脩

口腔衛生会誌 55 ( 3 ) 199 - 203 2005年12月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人口腔衛生学会

NPO法人日本むし歯予防フッ素推進会議では, 2004年3月末日現在の施設における集団応用でのフッ化物洗口実施状況を調査した.この調査は1983年からほぼ2年ごとに実施しており, これらの結果から2010年における実施状況を推定した.当会議会員ならびに当会議で把握している歯科医師, 行政, 学校などのフッ化物洗口実施関係者に施設別でのフッ化物洗口実態調査を依頼して集計した.その結果, 2004年3月末日現在では, 45道府県で3,923施設, 396,702人がフッ化物洗口を実施しており, その割合は全国の当該児童数のおおむね3.1%に相当した.また, 2010年におけるフッ化物洗口実施施設数と実施人数を1996年の値を基礎として推計したところ, 2010年ではフッ化物洗口実施施設数8,782施設, 実施人数896,916人に達することが見込まれた.「健康日本21の地方計画」にフッ化物応用を組み込まず, 具体的なフッ化物洗口に関する目標値を掲げていない都道府県行政が多く存在して地域格差がみられることから, 早急に「フッ化物洗口ガイドライン」の周知が徹底されるべきである.今回の調査結果がフッ化物洗口の数値目標を検討するための基礎データとして利用され, 2005年に行われる「健康日本21」の中間評価見直しの際にフッ化物洗口が目標として採用され, かつフッ化物洗口の数値目標が設定されるように提言する.

DOI： 10.5834/jdh.55.3_199

CiNii Article

CiNii Books

その他リンク： https://search.jamas.or.jp/link/ui/2005231337

公診連携を目指した8020育成事業の評価査読

葭原明弘, 片岡照二郎, 濃野要, 峯田和彦, 高徳幸男, 河内博, 片山修, 清田義和, 石上和男, 宮秀夫

口腔衛生会誌 55 113 - 117 2005年12月

The relationship between dietary intake and the number of teeth in elderly Japanese subjects.

Yoshihara A, Watanabe R, Nishimuta M, Hanada N, Miyazaki H

Gerodontology 22 ( 4 ) 211 - 8 2005年12月

介護認定申請者における要介護度別歯科疾患の実態および歯科的治療ニーズに関する研究

鈴木昭, 河野正司, 野村修一, 伊藤加代子, 豊里晃, 田巻元子, 八木稔, 葭原明弘, 大内章嗣

新潟歯学会誌 35 ( 2 ) 25 - 30 2005年12月

Relationship between bleeding on probing and periodontal disease progression in community-dwelling older adults 査読

A. Rahardjo, A. Yoshihara, N. Amarasena, H. Ogawa, K. Nakashima, H. Miyazaki

Journal of Clinical Periodontology 32 ( 11 ) 1129 - 1133 2005年11月

記述言語：英語掲載種別：研究論文（学術雑誌）

Objective: The main objective of this study was to determine the relationship between bleeding on probing (BOP) and periodontal disease progression in community-dwelling older adults. Methods: A 3-year longitudinal study was carried out in 229 non-smoking healthy older adults aged 70 years. Using pressure-controlled periodontal probes, BOP, pocket depth and attachment level at 13,289 sites were measured annually. Periodontal disease progression was defined as an increase in attachment loss of ≥ 3 mm from the baseline to the final examination. The backward stepwise logistic regression analysis was performed to assess the relationship between the total number of sites with BOP in the four examinations and periodontal progression. Results: Logistic regression analysis showed that the odds ratios of BOP frequency for periodontal disease progression ranged from 1.4 to 6.2 after controlling for pocket depth ≥ 4 mm at baseline, number of missing teeth, jaw type and tooth site. Conclusion: Increasing frequencies of bleeding might increase the probability of periodontal disease progression in community-dwelling older adults. © Blackwell Munksgaard 2005.

DOI： 10.1111/j.1600-051X.2005.00834.x

Scopus

The relationship between bone mineral density and the number of remaining teeth in community-dwelling older adults 査読

A. Yoshihara, Y. Seida, N. Hanada, K. Nakashima, H. Miyazaki

Journal of Oral Rehabilitation 32 ( 10 ) 735 - 740 2005年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

Tooth loss and osteoporosis may share common aetiologic agents which influence the process of both diseases. The purpose of this study was to evaluate the relationship between bone mineral density (BMD) of the os calcis and the number of remaining teeth, controlling the known confounding factors. Among all 70-year-old inhabitants in Niigata City, Japan, 600 people were selected randomly in order to have approximately the same number of each gender. We analysed 460 subjects. We evaluated the BMD of the os calcis using an ultrasound bone densitometer, then we counted the number of remaining teeth excluding the third molars. Stiffness is a clinical index which is calculated by the spread speed of supersonic waves. To monitor the general health condition of the subjects, serum levels of disease markers and smoking habits were also investigated. The mean number of remaining teeth for the osteopenia group (OG) and the no-osteopenia group (NOG) was 15.97 ± 9.98 and 18.31 ± 8.06, respectively in females, and 16.32 ± 9.93 and 18.12 ± 9.33, respectively in males (OG versus NOG, P = 0.047 by two-way ANOVA). In addition, stiffness was significantly associated with the number of remaining teeth (CV = -0.157, P = 0.005) using linear multiple regression analysis adjusted by four other variables. In this study, there was a significant relationship between the number of remaining teeth and BMD of the os calcis. © 2005 Blackwell Publishing Ltd.

DOI： 10.1111/j.1365-2842.2005.01491.x

Scopus

Periodontal conditions in an elderly Japanese population influenced by smoking status and serum immunoglobulin G2 levels

K Nakashima, T Kobayashi, A Yoshihara, J Fujiwara, H Miyazaki, Y Kowashi

JOURNAL OF PERIODONTOLOGY 76 ( 4 ) 582 - 589 2005年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：AMER ACAD PERIODONTOLOGY

Background: A Japanese population residing in the same area may be suitable for evaluation of the association among IgG subclass levels, smoking status, and periodontal disease due to similar racial and environmental factors, as these factors can interact to influence serum IgG subclass levels. The present cross-sectional investigation attempted to examine the influence of serum IgG subclass levels and smoking status on periodontal condition in a population of elderly Japanese subjects.
Methods: Elderly individuals (N = 451, age, 71 years) residing in Niigata City, Japan participated in the present study. Clinical evaluations, which consisted of probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), and calculus, and serological determinations including serum IgG subclass levels and anti - Porphyromonas gingivalis fimbriae IgG subclass titers were conducted. All participants were asked to complete questionnaires regarding smoking status and were then divided into one of three groups: never smoker, former smoker, or current smoker.
Results: Distributions of the number of teeth did not differ significantly across the groups. The proportion of sites with CAL &GE; 4 mm (%CAL4) in current smokers was significantly higher in comparison with never smokers. Multiple linear regression analysis revealed that %CAL4 was influenced by number of teeth, serum IgG2 levels, gender, and smoking status (R-2 = 0.253, P &LT; 0.001). The effect of IgG2 was greater than that of smoking status. Distribution of IgG2 was not significantly different across the three groups.
Conclusion: These data indicate that serum IgG2 levels influences periodontal conditions in an elderly Japanese population independent of smoking status.

DOI： 10.1902/jop.2005.76.4.582

Periodontal conditions in an elderly Japanese population influenced by smoking status and serum immunoglobulin G2 levels 査読

Keisuke Nakashima, Takao Kobayashi, Akihiro Yoshihara, Jun Fujiwara, Hideo Miyazaki, Yusuke Kowashi

Journal of Periodontology 76 ( 4 ) 582 - 589 2005年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

Background: A Japanese population residing in the same area may be suitable for evaluation of the association among IgG subclass levels, smoking status, and periodontal disease due to similar racial and environmental factors, as these factors can interact to influence serum IgG subclass levels. The present cross-sectional investigation attempted to examine the influence of serum IgG subclass levels and smoking status on periodontal condition in a population of elderly Japanese subjects. Methods: Elderly individuals (N = 451, age, 71 years) residing in Niigata City, Japan participated in the present study. Clinical evaluations, which consisted of probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), and calculus, and serological determinations including serum IgG subclass levels and anti-Porphyromonas gingivalis fimbriae IgG subclass titers were conducted. All participants were asked to complete questionnaires regarding smoking status and were then divided into one of three groups: never smoker, former smoker, or current smoker. Results: Distributions of the number of teeth did not differ significantly across the groups. The proportion of sites with CAL ≥4 mm (%CAL4) in current smokers was significantly higher in comparison with never smokers. Multiple linear regression analysis revealed that %CAL4 was influenced by number of teeth, serum IgG2 levels, gender, and smoking status (R2 = 0.253, P &lt
0.001). The effect of IgG2 was greater than that of smoking status. Distribution of IgG2 was not significantly different across the three groups. Conclusion: These data indicate that serum IgG2 levels influences periodontal conditions in an elderly Japanese population independent of smoking status.

DOI： 10.1902/jop.2005.76.4.582

Scopus