研究者詳細 - 葭原　明弘

論文 - 葭原　明弘

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Fc gamma RIIIb genotypes and smoking in periodontal disease progression among community-dwelling older adults in Japan

A Yoshihara, N Sugita, K Yamamoto, T Kobayashi, T Hirotomi, H Ogawa, H Miyazaki, H Yoshie

JOURNAL OF PERIODONTOLOGY 76 ( 2 ) 250 - 255 2005年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：AMER ACAD PERIODONTOLOGY

Background: Fc gamma RIIIb genotypes and smoking are risk factors for periodontal disease. However, the interaction of Fc gamma RIIIb-NA1-NA2 polymorphism with smoking remains unclear. The purpose of this study was to determine if Fc gamma RIIIb-NA1-NA2 polymorphism and smoking are associated with periodontal disease progression among elderly people.
Methods: Among 70-year-old subjects, 164 with neither diabetes mellitus nor blood sugar >= 140 mg/dl, who had more than 20 teeth and who could participate in both the baseline and the follow-up examinations were included in the study. The NA1 group comprised subjects with Fc gamma RIllb-NA1NA1 genotype (N = 53), while the NA2 group included subjects with Fc gamma RIIIb-NA1NA2 or NA2NA2 genotype (N = 111). We examined the progression of periodontitis by measuring attachment loss during 3 years.
Results: The frequency of subjects who showed >= 4 mm additional attachment loss at one or more sites was 55.6% for smokers and 37.2% for non-smokers. The odds ratio (OR) was 2.13 (confidence interval [CI]: 0.92 to 4.76). We found a better association between periodontal progression and smoking in the NA2 group. The OR for smokers was 3.03 (CI: 1.12 to 8.33, P = 0.028). Additionally, the mean number of sites with >= 4 mm additional attachment loss per person between smokers and non-smokers in the NA2 group or between smokers and non-smokers in the NA1 group was 2.90 +/- 3.42 and 0.74 +/- 1.53 or 0.57 +/- 0.79 and 0.68 +/- 1.03, respectively (P < 0.001; analysis of variance [ANOVA]).
Conclusion: Our results may suggest an association between smoking and periodontal disease progression in elderly people with Fc gamma RIIIb-NA2 polymorphism.

DOI： 10.1902/jop.2005.76.2.250

Serum vitamin C-periodontal relationship in community-dwelling elderly Japanese 査読

N Amarasena, H Ogawa, A Yoshihara, N Hanada, H Miyazaki

JOURNAL OF CLINICAL PERIODONTOLOGY 32 ( 1 ) 93 - 97 2005年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BLACKWELL MUNKSGAARD

Objective: To determine the relationship between serum vitamin C and periodontitis as estimated by clinical attachment loss (CAL) in community-dwelling elderly Japanese.
Material and Methods: This analysis was confined to 413 Niigata citizens aged 70 years in whom the data for serum vitamin C and CAL were available. High-pressure liquid chromatography method was used to ascertain the serum vitamin C levels while CAL was assessed on six sites of all teeth present including third molars by means of pressure-sensitive probes. Other variables included gender, smoking, toothbrushing frequency, number of teeth present and random blood sugar levels.
Results: Serum vitamin C concentration was inversely related to CAL (r=-0.23, p<0.00005) at bivariate level. Multiple linear regression analysis showed that CAL was 4% greater in subjects with lower serum vitamin C levels than in subjects with higher serum vitamin C levels notwithstanding smoking, diabetes, oral hygiene, gender or number of teeth present.
Conclusion: The findings suggested that serum vitamin C might have relatively weak but a statistically significant relationship with periodontitis in this elderly population.

DOI： 10.1111/j.1600-051X.2004.00643.x

客観的臨床能力試験(OSCE)における概略評定の信頼性と妥当性 : 平成15年度本学歯学部OSCEの解析

興地隆史, 福島正義, 吉羽邦彦, 小林博, 葭原明弘, 星名秀行, 富沢美惠子, 高木律男, 前田健康, 山田好秋

日本歯科医学教育学会雑誌 = Journal of Japanese Association for Dental Education 20 ( 1 ) 135 - 141 2004年12月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：(一社)日本歯科医学教育学会

歯学部5年生54名に行われたOSCEでの医療面接課題および技能系課題の評価結果を対象に,評価者間の一致率,評価項目の内的整合性,概略評定と項目別評定との関連性などについて検討した.評価者2名による評点の一致率は医療面接課題で80%以上を示したが,技能系課題は70%以下であった.評価項目の内的整合性は概略評定によって負の影響を受けないことが示唆された.両課題とも概略評定と項目別評定の関連性は高かった

客観的臨床能力試験(OSCE)における概略評定の信頼性と妥当性平成15年度新潟大学歯学部OSCEの解析査読

興地隆史, 福島正義, 吉羽邦彦, 小林博, 葭原明弘, 星名秀行, 富沢美恵子, 高木律男, 前田健康, 山田好秋

日本歯科医学教育学会雑誌 Vol20(1) 135 - 141 2004年12月

咬合分類判定の再現性に関する研究査読

青砥聖二, 深町博臣, 葭原明弘, 齋藤功

Orthodontic Waves 63 ( 2 ) 95 - 99 2004年12月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：日本矯正歯科学会

本研究は,2000年に与五沢矯正研究会が発表した咬合分類法の臨床的有用性を検討することを目的とし,矯正専門開業歯科医院における初診患者100名の平行模型を用いて,矯正臨床経験年数と所属機関(本分類法の習熟度)の異なる4名の矯正医が咬合異常の判定を2か月の間隔をあけて2回行った.その判定をもとに,各咬合別に判定者内および判定者間のweighted kappa(κ_w)を求め,以下の結果を得た.1.判定者内の再現性は全判定者の平均値でみると,κ_w=0.67であった.また,判定者間の再現性は,第1回目,第2回目の判定ともに平均値でκ_w=0.62以上を示し,信頼可能な範囲にあると考えられた.2.判定者個々の一致の程度に関与する因子として,「矯正臨床経験」と「所属機関(本分類法の習熟度)」の2項目につき検討した結果,判定者内,判定者問どちらの再現性についても,矯正臨床経験年数よりも習熟度の影響が大きいと考えられた.3.咬合別にみると,上突咬合,下突咬合は再現性が高かったが,過蓋咬合,偏位咬合は再現性が低くなる傾向を示した.(Orthod Waves-Jpn Ed 63(2):95～99,2004)

その他リンク： https://projects.repo.nii.ac.jp/?action=repository_uri&item_id=171805

高齢者における歯周組織の状態と血清IgGサブクラスとの関連査読

小林孝雄, 中島啓介, 葭原明弘, 宮秀夫, 小鷲悠典

日本歯周病学会誌 46 ( 1 ) 31 - 38 2004年12月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：JAPANESE SOCIETY OF PERIODONTOLOGY

これまで, 多くの研究者により血清IgGサブクラス量と歯周炎の病態との関連が報告されてきた。本研究では, 人種, 年齢, 喫煙の影響を取り除いた状態つまり高齢日本人の非喫煙者を対象とし, 血清IgGサブクラス量と歯周組織の状態に関連があるかを明らかにすることを目的とした。1999年4月の時点で新潟市に住民票を有する71歳の高齢者451名から、無歯顎者および喫煙者を除外し340名の有歯顎の非喫煙者を被験者とした。有歯顎の非喫煙者を残存歯の少ない群 (19本以下) と多い群 (20本以上) の2群に分け, 歯周組織状態と血清データの比較を行った。その結果, 残存歯の少ない群では残存歯の多い群に比べて, アタッチメントロス量が4mm以上の部位の割合, 血清IgG1量が有意に高く, 血清IgG2-4量は有意に低かった。また, 残存歯数と血清IgGサブクラス量との相関を調べた結果, 残存歯数と血清IgG1量の間に有意な負の相関が認められた。これらの結果から, 高い血清IgG1量と残存歯の減少の間に何らかの関連がある可能性が示唆された。歯周組織破壊における血清IgG1の役割をさらに詳細に解明するためには, 縦断的研究が必要となるであろう。

DOI： 10.2329/perio.46.31

その他リンク： http://search.jamas.or.jp/link/ui/2004199192

地域在住高齢者の食欲とQOLとの関連査読

葭原明弘, 清田義和, 片岡照二郎, 花田信弘, 宮秀夫

口腔衛生会誌 54 ( 3 ) 241 - 248 2004年12月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人口腔衛生学会

日常の楽しみごととして食事をあげる高齢者は多い.本調査では,食欲とQOLの関連をほかの要因を考慮しながら評価することを目的としている.本調査の対象者は70歳の高齢者600人である.QOLを総合的にあらわす指標としてフェイススケールを用いた.生活満足状況について5つの顔の表情を示し,一番実感に近いものを選択してもらった.食欲については質問紙法により情報を得た.さらに,身体的要因,健康行動,社会的要因,口腔内症状について情報を得た.フェイススケールの結果にもとづき,食欲,口腔内症状の合計数およびほかの全身的要因との関連をロジスティック回帰分析により評価した.その際,従属変数をフェイススケールの分布にもとづき2種類のモデル(モデル1,モデル2)を作成した.いずれのモデルにおいても食欲,口腔内症状の合計数,老研式活動能力指標,睡眠時間および性別を独立変数に採用した.その結果,モデル1では,食欲(オッズ比:2.77,p<0.05) ,口腔内症状の合計数オッズ比:1.25,p<.05) ,老研式活動能力指標オッズ比:1.25,D<0.01)が統計学的に有意であった.一方,モデル2では,食欲(オッズ比:3.23,p<0.001),老研式活動能力指標(オッズ比:1.24,D<0.001) ,睡眠時間(オッズ比:1.72,n<0.0l)が統計学的に有意であった.食欲は,モデル1とモデル2において,また,口腔内症状の合計数はモデル1において有意な関連が認められた.この結果は,地域在住高齢者では,食欲とQOLが有意に関連していることを示している.さらに,口腔内症状の改善がQOLの向上には必要であると考えられた.

DOI： 10.5834/jdh.54.3_241

The long term effect of fluoride mouthrinse on changes in salivary levels of mutans streptococci in school children 査読

Akihiro Yoshihara, Shihoko Sakuma, Jing Wang, Hideo Miyazaki

Journal of Dental Health 54 233 - 240 2004年12月

歯学教育プログラムへのPBL教育の導入南カリフォルニア大学歯学部における実態調査査読

安島久雄, 小野和宏, 前田健康, 永田昌毅, 高木律男, 山田好秋, 興地隆史, 魚島勝美, 葭原明弘, 花田晃治

日本歯科医学教育学会雑誌 Vol20(1) ( 1 ) 166 - 173 2004年12月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：(一社)日本歯科医学教育学会

2001年12月に新潟大学の教員6名が南カリフォルニア大学歯学部を訪れ,米国人学生とともにPBL(問題解決型学習)教育を1週間体験した.また,PBLの概念,教科課程編成法,教材の作成法,評価方法などについて資料収集を行った.その結果,PLBでは問題への解答よりも学習者中心の問題解決過程を通じた理解の育成が重視されること,教員の役割は知識の伝授ではなくグループの作業プロセスを支援して学習目標への到達を促すものであることなどが確認された

A longitudinal study of the relationship between periodontal disease and bone mineral density in community-dwelling older adults

A Yoshihara, Y Seida, N Hanada, H Miyazaki

JOURNAL OF CLINICAL PERIODONTOLOGY 31 ( 8 ) 680 - 684 2004年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：WILEY-BLACKWELL

Objective: Bone loss is a common feature of periodontitis and osteoporosis. Both diseases may share common etiologic agents which may either affect or modulate the process of both diseases. The purpose of this study was to evaluate the relationship between systemic bone mineral density (BMD) and periodontal disease among older people.
Materials and Methods: Among all 4542 inhabitants aged 70 years according to a registry of residents in Niigata city in Japan, 600 people were selected randomly. One hundred and eighty-four subjects who did not have diabetes mellitus, whose blood sugar was <140 mg/dl, who had more than 20 teeth, who were non-smokers, and who did not take medication for osteoporosis, were included in the study. Four dentists performed clinical evaluations on probing attachment level (PAL). We also utilized the data on BMD of the heel, which we measured using an ultrasound bone densitometer. Follow-up clinical surveys were done by measuring PAL after 3 years. Finally, 179 subjects who could participate in both the baseline and the follow-up examinations were included in the analysis. After dividing the subjects into an osteopenia group (OG) and non-osteopenia group (NOG), we evaluated the relationship between BMD and the number of progressive sites which had greater than or equal to3 mm additional attachment loss during 3 years after controlling the known confounding factors.
Results: The mean number of progressive sites for the OG and the NOG, respectively, were 4.65+/-5.51 and 3.26+/-3.01 in females and 6.88+/-9.41 and 3.41+/-2.79 in males. Two-way analysis of variance was performed to discriminate among effects of gender, BMD, and gender-BMD interaction. A significant effect of BMD (OG or NOG, p=0.043) with a significant interaction (p=0.038) was observed. Furthermore, BMD was associated with the number of progressive sites which had greater than or equal to3 mm additional attachment loss during the 3 years (p=0.001) by multiple linear regression analysis.
Conclusions: This study suggested that there was a significant relationship between periodontal disease and general BMD.

DOI： 10.1111/j.1600-051X.2004.00548.x

A longitudinal study of the relationship between periodontal disease and bone mineral density in community-dwelling older adults 査読

A Yoshihara, Y Seida, N Hanada, H Miyazaki

JOURNAL OF CLINICAL PERIODONTOLOGY 31 ( 8 ) 680 - 684 2004年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：WILEY-BLACKWELL

Objective: Bone loss is a common feature of periodontitis and osteoporosis. Both diseases may share common etiologic agents which may either affect or modulate the process of both diseases. The purpose of this study was to evaluate the relationship between systemic bone mineral density (BMD) and periodontal disease among older people.
Materials and Methods: Among all 4542 inhabitants aged 70 years according to a registry of residents in Niigata city in Japan, 600 people were selected randomly. One hundred and eighty-four subjects who did not have diabetes mellitus, whose blood sugar was <140 mg/dl, who had more than 20 teeth, who were non-smokers, and who did not take medication for osteoporosis, were included in the study. Four dentists performed clinical evaluations on probing attachment level (PAL). We also utilized the data on BMD of the heel, which we measured using an ultrasound bone densitometer. Follow-up clinical surveys were done by measuring PAL after 3 years. Finally, 179 subjects who could participate in both the baseline and the follow-up examinations were included in the analysis. After dividing the subjects into an osteopenia group (OG) and non-osteopenia group (NOG), we evaluated the relationship between BMD and the number of progressive sites which had greater than or equal to3 mm additional attachment loss during 3 years after controlling the known confounding factors.
Results: The mean number of progressive sites for the OG and the NOG, respectively, were 4.65+/-5.51 and 3.26+/-3.01 in females and 6.88+/-9.41 and 3.41+/-2.79 in males. Two-way analysis of variance was performed to discriminate among effects of gender, BMD, and gender-BMD interaction. A significant effect of BMD (OG or NOG, p=0.043) with a significant interaction (p=0.038) was observed. Furthermore, BMD was associated with the number of progressive sites which had greater than or equal to3 mm additional attachment loss during the 3 years (p=0.001) by multiple linear regression analysis.
Conclusions: This study suggested that there was a significant relationship between periodontal disease and general BMD.

DOI： 10.1111/j.1600-051X.2004.00548.x

健常高齢者における咀嚼能力が栄養摂取に及ぼす影響査読

神森秀樹, 葭原明弘, 安藤雄一, 宮崎秀夫

口腔衛生会誌 53 ( 1 ) 13 - 22 2003年12月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人口腔衛生学会

本研究の目的は,高齢者における咀嚼能力が総エネルギー摂取量,栄養素摂取量および食品群別摂取量にどのような影響を与えているかを検討することである.対象者は,口腔診査,食物摂取状況調査,アンケート,血液検査に協力の得られた新潟市内在住の70歳,512人(男性265人,女性247人)である.咀嚼能力については「山本式咀嚼能率判定の変法」を,栄養摂取状況については「半定量的食物摂取頻度調査法」を使用し評価した.咀嚼能力の低い者の割合は,男女それぞれ48%および60%であった.平均総エネルギー摂取量は,男女それぞれ1,706.3kcal(SD=350.8)および1,474.9kcal(SD=252.3)であった.咀嚼能力と総エネルギー摂取量,栄養素摂取量および食品群別摂取量との関連を評価した結果,男性の対象者において咀嚼能力の低い群では,総エネルギー摂取量,緑黄色野菜群およびそのほかの野菜・果物群の摂取量が有意に少なくなっていた(p<0.01,p<0.05,p<0.05).野菜・果物群の摂取量の低下は,抗酸化物質であるビタミン類の摂取量減少につながると考えられることから,男性において咀嚼能力の低下は,心血管系疾患や食道,胃などの消化器系の疾患のリスクファクターとなる可能性が考えられる.以上の結果から,70歳の健常男性では,咀嚼能力は総エネルギー摂取量および栄養バランスに影響を及ぼすことが示唆された.

DOI： 10.5834/jdh.53.1_13

高齢者の根面う蝕の有病状況と歯冠部う蝕との関連査読

高野尚子, 葭原明弘, 安藤雄一, 小川祐司, 廣富敏伸, 山賀孝之, 花田信弘, 宮秀夫

口腔衛生会誌 53 ( 5 ) 592 - 598 2003年12月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人口腔衛生学会

本研究の目的は,高齢者の根面う蝕の有病状態に関する記述統計的分析を行い,さらに根面う蝕と歯冠う蝕の有病状態との関連について分析を行うことである.調査対象者は,新潟市内在住の70歳600名である.分析対象者は,このうちの有歯顎者544名である.有病状況は,根面う蝕の所有者率,一人平均根面う蝕歯数,部位別,歯面別の分布で評価した.関連分析では,歯冠う蝕歯数群別の根面う蝕の所有者率および一人平均歯数を求め,次に根面う蝕の有無を目的変数にしてロジスティック回帰分析を行った.分析の結果,根面う蝕(根面DF)は男性の56.9%,女性の53.5%が所有し,平均根面う蝕歯数(根面DFT)は男性1.81(SD=2.41),女性1.41(SD=1.93)だった.根面末処置う蝕(根面D)はそれぞれ21.7,19.8%が所有し,平均根面未処置う蝕歯数(根面DT)は0.46(SD=1.10),0.32(SD=0.81)たった.部位別の分布は,上顎では犬歯,下顎では小臼歯に最も多く,歯面別では,頬側に最も多かった.歯冠う蝕との関連分析では,歯冠う蝕歯数が多い者ほど根面う蝕の所有者率が高く,根面DFTの平均が高かった.ロジスティック回帰分析にて口腔内のほかの要因を調整しても,歯冠う蝕歯数は根面う蝕の有無と有意(オッズ比1.08,p<0.001)に正の関連があった.以上の結果から,高齢者の根面う蝕の所有者率は高く,また,歯冠う蝕歯数は根面う蝕の所有の有無に関連があることが示された.

DOI： 10.5834/jdh.53.5_592

Factors associated with root caries incidence in an elderly population

Naoko Takano, Yuichi Ando, Akihiro Yoshihara, Hideo Miyazaki

Community Dental Health 20 ( 4 ) 217 - 222 2003年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

Objective: To identify baseline factors associated with future root caries development in an elderly population. Basic research design Oral health and general health status examinations were carried out at baseline and after one and two years. In order to identify risk predictors of root caries with a different degree of robustness, three multiple logistic regression analyses where the dependent variables were one, two and three or more disease events were performed. Participants: Six hundred noninstitutionalised adults aged 70 in Niigata, Japan took part in the baseline examination. A total of 373 subjects were followed up for two years and identified as dentate at the two-year examination. Results: During the period of study, 35.9% of subjects developed at least one new root caries lesion. The mean number of new root caries lesions per subject was 0.9 (sd=1.7). Logistic regression analyses indicated that having one or more root D surface and mean LA ≥3.6 mm were the most robust risk predictors, having two or more prosthetic crowns, non use of interdental brushes or dental floss and LB ≥105 CFU/ml were moderately robust risk predictors, and a Body Mass Index &lt
20 was the least robust risk predictor. Conclusions: These findings suggest that oral health status is a good risk predictor, and poor general health indicated by a low Body Mass Index may also contribute to root caries occurrence in this elderly population.

新潟大学歯学部卒前教育における客観的臨床能力試験(OSCE)の導入査読

興地隆史, 福島正義, 葭原明弘, 子田晃一, 小野和宏, 小林博, 魚島勝美, 小山純市, 植田耕一郎, 高木律男, 前田健康, 花田晃治

日本歯学教育学会誌 18 ( 2 ) 300 - 307 2003年12月

パノラマX線を用いた高齢者の辺縁部および根尖部の歯周組織健康状態に関する研究査読

樋浦健二, 葭原明弘, 宮崎秀夫

口腔衛生会誌 53 ( 2 ) 130 - 136 2003年12月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人口腔衛生学会

本研究の目的は,高齢者における辺縁部および根尖部の歯周組織の状態をX線学的に評価し,骨吸収度や歯の喪失との関連要因について分析することである.対象は,1998年新潟市で実施した調査に参加した70歳600人のうち,有歯顎で,2年間の追跡調査を受けた379人から層別抽出した100人である.パノラマX線撮影をもとに骨吸収度,根尖部の状態を調査した.ベースライン時の現在歯のうち無髄歯は36.9%を占め,そのうち35.6%に根尖病巣が認められた.骨吸収度は,現在歯群別では,1〜9本群,20本以上群でそれぞれ36.4,27.5%であり20本以上群で有意に小さかった.2年間での喪失歯は50本で,ベースライン時での歯髄の状態では,有髄歯から7本,無髄歯から43本であった.ロジスティック回帰分析の結果,2年間での歯の喪失の危険性は,現在歯1〜9本群で20本以上群と比較し33.33倍,骨吸収度50%以上ありで5.11,5.80倍,無髄歯で8.01倍,根尖病巣ありで9.87倍,鉤歯で2.77,2.36倍であることが示された.本調査により,高齢者において20本以上現在歯を有する者は骨吸収が少なく,喪失リスクも小さかった.また,歯髄の保存が喪失リスクの低下につながることが示唆された.

DOI： 10.5834/jdh.53.2_130

Improvement in Gingivitis by School Based Prevention Programme at the Elementary School with the Use of Dental Floss after 18 Months 査読

Akihiro Yoshihara, Kouichi Fukai, Yuko Morozumi, Toshinobu Hirotomi, Hideo Miyazaki

Journal of Dental Health 53 91 - 97 2003年12月

Factors associated with root caries incidence in an elderly population 査読

Naoko Takano, Yuichi Ando, Akihiro Yoshihara, Hideo Miyazaki

Community Dental Health 20 ( 4 ) 217 - 222 2003年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

Objective: To identify baseline factors associated with future root caries development in an elderly population. Basic research design Oral health and general health status examinations were carried out at baseline and after one and two years. In order to identify risk predictors of root caries with a different degree of robustness, three multiple logistic regression analyses where the dependent variables were one, two and three or more disease events were performed. Participants: Six hundred noninstitutionalised adults aged 70 in Niigata, Japan took part in the baseline examination. A total of 373 subjects were followed up for two years and identified as dentate at the two-year examination. Results: During the period of study, 35.9% of subjects developed at least one new root caries lesion. The mean number of new root caries lesions per subject was 0.9 (sd=1.7). Logistic regression analyses indicated that having one or more root D surface and mean LA ≥3.6 mm were the most robust risk predictors, having two or more prosthetic crowns, non use of interdental brushes or dental floss and LB ≥105 CFU/ml were moderately robust risk predictors, and a Body Mass Index &lt
20 was the least robust risk predictor. Conclusions: These findings suggest that oral health status is a good risk predictor, and poor general health indicated by a low Body Mass Index may also contribute to root caries occurrence in this elderly population.

Association between serum albumin and root caries in community-dwelling older adults 査読

A. Yoshihara, N. Hanada, H. Miyazaki

Journal of Dental Research 82 ( 3 ) 218 - 222 2003年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Intern. and American Associations for Dental Research

Recently, associations between dental diseases and the general health condition have been reported. The purpose of this study was to evaluate, by serum albumin concentrations, the relationship between the general health condition and root caries. We randomly selected 763 individuals (600 70-year-olds and 163 80-year-olds) living in Niigata City, Japan. The variables body composition, blood measurements, daily nutrient intakes, and root caries were measured. The relationship between root caries and serum albumin concentration was evaluated. The differences in serum albumin concentrations between subjects with untreated root caries (DT = 0 and DT ≥ 3) were 75.56 mg/dL in 70-year-olds and 202.97 mg/dL in 80-year-olds (p &lt
0.05, ANOVA). The findings of the present study indicated that a relationship between root caries and serum albumin concentration in these elderly subjects is highly possible.

DOI： 10.1177/154405910308200313

Longitudinal study on periodontal conditions in healthy elderly people in Japan 査読

T Hirotomi, A Yoshihara, M Yano, Y Ando, H Miyazaki

COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY 30 ( 6 ) 409 - 417 2002年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BLACKWELL MUNKSGAARD

Objectives: A strategy for the control of periodontal disease progression is required to prevent tooth loss in older people. However, detailed epidemiological data on periodontal conditions in elderly people is limited. The purpose of the present study is to describe the natural history of periodontal disease and to evaluate the intraoral factors relating to the disease progression in systemically healthy elderly people. Methods: In the cross-sectional study, 599 and 162 subjects aged 70 and 80 years, respectively, were examined. Of those subjects aged 70 years, 436 (73%) participated in the 2-year longitudinal study. Pocket depth (PD) and attachment level (AL) were measured for all functioning teeth at six sites per tooth. In the cross-sectional study, AL of 4 mm or greater and 7 mm or greater were defined as moderate and severe disease, respectively. In the longitudinal study, a change in AL of 3 mm or greater at each site was defined as periodontal disease progression. Results: In the cross-sectional study, 97.1% of the subjects had at least one site of AL of 4 mm or greater (4 + mm). The prevalence of AL of 7 mm or greater (7 + mm) was 47.9%, with 2.8 affected teeth per person in those with AL 7 + mm. These findings reveal that periodontal disease is extremely widespread in the elderly population. However, very few had many teeth with severe periodontal conditions. In the longitudinal study, 75.1% experienced attachment loss of 3 mm or greater (3+ mm) during the 2-year study period. Of those subjects who experienced attachment loss, a mean of 4.7 teeth exhibited attachment loss. Multivariate logistic regression showed that both the highest AL in each tooth at baseline and abutment teeth for removable partial dentures were significantly related to periodontal disease progression as well as tooth loss incidence. Conclusions: These results suggest that teeth with poor periodontal conditions as well as abutment teeth for removable partial dentures were significant intraoral factors relating to periodontal disease progression as well as tooth loss.

DOI： 10.1034/j.1600-0528.2002.00005.x

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