Faculty Profiles - SONE, Hirohito

Papers - SONE, Hirohito

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Low Lung Function and Risk of Type 2 Diabetes in Japanese Men: The Toranomon Hospital Health Management Center Study 9 (TOPICS 9) Reviewed

Yoriko Heianza, Yasuji Arase, Hiroshi Tsuji, Kazumi Saito, Kazuhisa Amakawa, Shiun Dong Hsieh, Satoru Kodama, Hitoshi Shimano, Nobuhiro Yamada, Shigeko Hara, Hirohito Sone

MAYO CLINIC PROCEEDINGS 87 ( 9 ) 853 - 861 2012.9

HbA(1c) variability and the development of microalbuminuria in type 2 diabetes: Tsukuba Kawai Diabetes Registry 2 Reviewed

A. Sugawara, K. Kawai, S. Motohashi, K. Saito, S. Kodama, Y. Yachi, R. Hirasawa, H. Shimano, K. Yamazaki, H. Sone

DIABETOLOGIA 55 ( 8 ) 2128 - 2131 2012.8

[Characteristics of diabetic macroangiopathy in Japan and East Asia]. Reviewed

Sone H

Nihon rinsho. Japanese journal of clinical medicine 70 Suppl 5 305 - 312 2012.7

Present situation of exercise therapy for patients with diabetes mellitus in Japan: A nationwide survey Reviewed

Y. Sato, K. Kondo, T. Watanabe, H. Sone, M. Kobayashi, R. Kawamori, Y. Tamura, Y. Atsumi, Y. Oshida, S. Tanaka, S. Suzuki, S. Makita, I. Ohsawa, S. Imamura

Diabetology International 3 ( 2 ) 86 - 91 2012.6

[New vision of secondary and tertiary prevention in diabetic complication]. Reviewed

Fujihara K, Sone H

Nihon rinsho. Japanese journal of clinical medicine 70 Suppl 3 561 - 569 2012.5

[Japan Diabetes Complications Study (JDCS)]. Reviewed

Sone H, Katayama S, Yamashita H, Akanuma Y, Yamada N

Nihon rinsho. Japanese journal of clinical medicine 70 Suppl 3 281 - 289 2012.5

Quantification of BCR-ABL mRNA in Plasma/Serum of Patients with Chronic Myelogenous Leukemia Reviewed

Miwako Narita, Anri Saito, Aya Kojima, Minami Iwabuchi, Naoya Satoh, Takayoshi Uchiyama, Akie Yamahira, Tatsuo Furukawa, Hirohito Sone, Masuhiro Takahashi

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES 9 ( 10 ) 901 - 908 2012

Impact of psychological stress caused by the Great East Japan Earthquake on glycemic control in patients with diabetes Reviewed

K. Fujihara, A. Saito, Y. Heianza, H. Gibo, H. Suzuki, H. Shimano, K. Saito, S. Kodama, N. Yamada, H. Sone

Experimental and Clinical Endocrinology and Diabetes 120 ( 9 ) 560 - 563 2012

Diagnosis and Management of Type I and Type V Hyperlipoproteinemia Reviewed

Takanari Gotoda, Koji Shirai, Takao Ohta, Junji Kobayashi, Shinji Yokoyama, Shinichi Oikawa, Hideaki Bujo, Shun Ishibashi, Hidenori Arai, Shizuya Yamashita, Mariko Harada-Shiba, Masaaki Eto, Toshio Hayashi, Hirohito Sone, Hiroaki Suzuki, Nobuhiro Yamada

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 19 ( 1 ) 1 - 12 2012

Idiopathic Macrocytosis in Smokers

Takahashi Masuhiro, Yamahira Akie, Uchiyama Takayoshi, Iwabuchi Minami, Sato Naoya, Takizawa Jun, Sone Hirohito, Narita Miwako

Official Journal of the Japanese Society of Human Dry Dock 27 ( 4 ) 689 - 696 2012

Language：Japanese Publisher：Japan Society of Ningen Dock

Objective: Smoking has been reported to be one of the risk factors of myelodysplastic syndrome (MDS). In order to clarify the process of progression to MDS in a certain group of smokers, it is important to identify the initial hematological abnormalities associated with the early stage of MDS in smokers. Methods: Relationships of hematological parameters such as WBC count, RBC count, Hb, Ht, MCH and MCV with level of smoking were investigated by univariate and multivariate analyses in 234 male workers at a single workplace after obtaining informed consent. Results: Univariate analysis demonstrated that correlations of smoking-related factors (number of cigarettes per day, duration of smoking [years] and smoking index [defined as number of cigarettes per day x duration of smoking]) with WBC count, Ht, MCH and MCV were significantly positive. Multivariate analysis using age, smoking-related factors, alcohol intake and BMI as explanatory valuables showed that age, alcohol intake and BMI were not confounding variables for smoking-related factors and revealed a remarkable significant positive correlation between each smoking-related factor and MCV. Conclusion: Smoking-associated macrocytosis, which was demonstrated in the present study, was not due to deficiency of vitamin B12 or folic acid because of no pancytopenia observed but was considered to be a qualitative abnormality of erythrocytes. Taken together with the findings of previous studies concerning smoking-associated functional abnormalities of erythrocytes and leukocytes and the high incidence of MDS in smokers, our results indicate that idiopathic macrocytosis in smokers could be an initial sign of progression to MDS, in which macrocytosis and multi-lineage abnormalities are characteristic findings.

DOI： 10.11320/ningendock.27.689

CiNii Article

CiNii Books

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Other Link： https://jlc.jst.go.jp/DN/JALC/10013821561?from=CiNii

Low Lung Function and Risk of Type 2 Diabetes in Japanese Men: The Toranomon Hospital Health Management Center Study

Hirohito Sone

Diabetes 2012

Determining Optimal Combined Thresholds of HbA1c and Fasting Plasma Glucose as Predictors of Type 2 Diabetes: The Toranomon Hospital Health Management Center Study

Hirohito Sone

Diabetes 2012

Erratum: Accumulation of cardiovascular risks in Japanese women with abnormal glucose and mild to moderate hypercholesterolemia (International Journal of Cardiology (2011) 152,2 (254-256)) Reviewed

Tomoko Nakagami, Rimei Nishimura, Hirohito Sone, Naoko Tajima

International Journal of Cardiology 153 ( 2 ) 238 2011.12

SiRNA-mediated knockdown of aryl hydrocarbon receptor nuclear translocator 2 affects hypoxia-inducible factor-1 regulatory signaling and metabolism in human breast cancer cells

Xian-Yang Qin, Feifei Wei, Jun Yoshinaga, Junzo Yonemoto, Masaru Tanokura, Hideko Sone

FEBS Letters 585 ( 20 ) 3310 - 3315 2011.10

Xenoestrogens down-regulate aryl-hydrocarbon receptor nuclear translocator 2 mRNA expression in human breast cancer cells via an estrogen receptor alpha-dependent mechanism.

Qin XY, Zaha H, Nagano R, Yoshinaga J, Yonemoto J, Sone H

2011.10

Accumulation of cardiovascular risks in Japanese women with abnormal glucose and mild to moderate hypercholesterolemia Reviewed

Tomoko Nakagami, Rimei Nishimura, Hirohito Sone, Naoko Tajima

INTERNATIONAL JOURNAL OF CARDIOLOGY 152 ( 2 ) 254 - 256 2011.10

Ghrelin attenuates cAMP-PKA signaling to evoke insulinostatic cascade in islet β-cells. International journal

Katsuya Dezaki, Boldbaatar Damdindorj, Hideyuki Sone, Oleg Dyachok, Anders Tengholm, Erik Gylfe, Tomoyuki Kurashina, Masashi Yoshida, Masafumi Kakei, Toshihiko Yada

Diabetes 60 ( 9 ) 2315 - 24 2011.9

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: Ghrelin reportedly restricts insulin release in islet β-cells via the Gα(i2) subtype of G-proteins and thereby regulates glucose homeostasis. This study explored whether ghrelin regulates cAMP signaling and whether this regulation induces insulinostatic cascade in islet β-cells. RESEARCH DESIGN AND METHODS: Insulin release was measured in rat perfused pancreas and isolated islets and cAMP production in isolated islets. Cytosolic cAMP concentrations ([cAMP](i)) were monitored in mouse MIN6 cells using evanescent-wave fluorescence imaging. In rat single β-cells, cytosolic protein kinase-A activity ([PKA](i)) and Ca(2+) concentration ([Ca(2+)](i)) were measured by DR-II and fura-2 microfluorometry, respectively, and whole cell currents by patch-clamp technique. RESULTS: Ghrelin suppressed glucose (8.3 mmol/L)-induced insulin release in rat perfused pancreas and isolated islets, and these effects of ghrelin were blunted in the presence of cAMP analogs or adenylate cyclase inhibitor. Glucose-induced cAMP production in isolated islets was attenuated by ghrelin and enhanced by ghrelin receptor antagonist and anti-ghrelin antiserum, which counteract endogenous islet-derived ghrelin. Ghrelin inhibited the glucose-induced [cAMP](i) elevation and [PKA](i) activation in MIN6 and rat β-cells, respectively. Furthermore, ghrelin potentiated voltage-dependent K(+) (Kv) channel currents without altering Ca(2+) channel currents and attenuated glucose-induced [Ca(2+)](i) increases in rat β-cells in a PKA-dependent manner. CONCLUSIONS: Ghrelin directly interacts with islet β-cells to attenuate glucose-induced cAMP production and PKA activation, which lead to activation of Kv channels and suppression of glucose-induced [Ca(2+)](i) increase and insulin release.

DOI： 10.2337/db11-0368

PubMed

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Factors associated with inappropriate weight loss attempts by early adolescent girls in Japan Reviewed

A. Sugawara, M. Sato, K. Totsuka, K. Saito, S. Kodama, A. Fukushi, Y. Yamanashi, E. Matsushima, Y. Fujiwara, E. Suzuki, K. Kondo, S. Yamamoto, H. Sone

Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity 16 ( 3 ) e157 - e163 2011.9

AMP-activated protein kinase activates neuropeptide Y neurons in the hypothalamic arcuate nucleus to increase food intake in rats. International journal

Daisuke Kohno, Hideyuki Sone, Shigeyasu Tanaka, Hideharu Kurita, Darambazar Gantulga, Toshihiko Yada

Neuroscience letters 499 ( 3 ) 194 - 8 2011.7

Language：English Publishing type：Research paper (scientific journal)

AMP-activated protein kinase (AMPK) is an energy sensor that is activated by the increase of intracellular AMP:ATP ratio. AMPK in the hypothalamic arcuate nucleus (ARC) is activated during fasting and the activation of AMPK stimulates food intake. To clarify the pathway underlying AMPK-induced feeding, we monitored the activity of single ARC neurons by measuring cytosolic Ca(2+) concentration ([Ca(2+)](i)) with fura-2 fluorescence imaging. An AMPK activator, AICA-riboside (AICAR), at 200 μM increased [Ca(2+)](i) in 24% of ARC neurons. AMPK and acetyl CoA carboxylase were phosphorylated in the neurons with [Ca(2+)](i) responses to AICAR. AICAR-induced [Ca(2+)](i) increases were inhibited by Ca(2+)-free condition but not by thapsigargin, suggesting that AICAR increases [Ca(2+)](i) through Ca(2+) influx from extracellular space. Among AICAR-responding ARC neurons, 38% were neuropeptide Y (NPY)-immunoreactive neurons while no proopiomelanocortin (POMC)-immunoreactive neuron was observed. Intracerebroventricular administration of AICAR increased food intake, and the AICAR-induced food intake was abolished by the co-administration of NPY Y1 receptor antagonist, 1229U91. These results indicate that the activation of AMPK leads to the activation of ARC NPY neurons through Ca(2+) influx, thereby causing NPY-dependent food intake. These mechanisms could be implicated in the stimulation of food intake by physiological orexigenic substances.

DOI： 10.1016/j.neulet.2011.05.060

PubMed

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Weight History as a Screening Tool for Identifying Undiagnosed Diabetes and Pre-Diabetes in Japanese Men: The Toranomon Hospital Health Management Center Study (TOPICS) Reviewed

Sakiko Yoshizawa, Yoriko Heianza, Kazuya Fujiwara, Shigeko Hara, Kazumi Saito, Hiroshi Tsuji, Satoru Kodama, Yasuji Arase, Nobuhiro Yamada, Kinori Kosaka, Hirohito Sone

DIABETES 60 A235 - A235 2011.7

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Papers - SONE, Hirohito