Faculty Profiles - SONE, Hirohito

Papers - SONE, Hirohito

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Higher dietary protein/energy ratio is associated with a lower risk for obesity in older women with type 2 diabetes: Cross-sectional analysis of Japanese patients with type 2 diabetes mellitus

Efrem d'Ávila Ferreira, Mariko Hatta, Khin Laymon, Izumi Ikeda, Mizuki Takeuchi, Yasunaga Takeda, Sakiko Yoshizawa Morikawa, Chika Horikawa, Noriko Kato, Hiroshi Maegawa, Kazuya Fujihara, Hirohito Sone

Human Nutrition & Metabolism 200257 - 200257 2024.3

Cross-Sectional and Longitudinal Associations between Forearm Bone Mineral Density and Anthropometry in Adult Japanese Men and Women

Masahiro Ishizawa, Kazuya Fujihara, Junko Yachida, Izumi Ikeda, Takaaki Sato, Takaho Yamada, Ayako Kobayashi, Shiro Tanaka, Yoshimi Nakagawa, Takashi Matsuzaka, Hitoshi Shimano, Minoru Tashiro, Satoru Kodama, Kiminori Kato, Hirohito Sone

Journal of Bone Metabolism 31 ( 1 ) 21 - 30 2024.2

機能性甲状腺結節による甲状腺中毒症を誘因として糖尿病性ケトアシドーシスを来し甲状腺クリーゼを発症した一例

間島貴之, 鈴木浩史, 木村智佑, 佐藤隆明, 山本雅彦, 石黒創, 岩永みどり, 松林泰弘, 山田貴穂, 藤原和哉, 曽根博仁

日本内分泌学会雑誌 99 ( 4 ) 884 - 884 2024.1

機能性甲状腺結節による甲状腺中毒症を誘因として糖尿病性ケトアシドーシスを来し甲状腺クリーゼを発症した一例

間島貴之, 鈴木浩史, 木村智佑, 佐藤隆明, 山本雅彦, 石黒創, 岩永みどり, 松林泰弘, 山田貴穂, 藤原和哉, 曽根博仁

日本内分泌学会雑誌 99 ( 4 ) 884 - 884 2024.1

副交感神経障害を伴わず糖尿病性動眼神経麻痺との鑑別に難渋した下垂体卒中による動眼神経麻痺の一例

深井悠未, 村井幸四郎, 今西明, 矢口雄大, 北澤勝, 鈴木浩史, 松林泰弘, 藤原和哉, 岩永みどり, 山田貴穂, 曽根博仁, 岡田正康

日本内分泌学会雑誌 99 ( 4 ) 895 - 895 2024.1

2型糖尿病患者におけるカリウム摂取量およびナトリウム摂取量と心血管疾患発症リスクの関係 JDCP study

堀川千嘉, 高原充佳, 片上直人, 武田安永, 竹内瑞希, 藤原和哉, 鈴木浩明, 津田謹輔, 吉岡成人, 島野仁, 佐藤譲, 林野泰明, 田嶼尚子, 西村理明, 山崎義光, 曽根博仁

Journal of Epidemiology 34 ( Suppl. ) 163 - 163 2024.1

副交感神経障害を伴わず糖尿病性動眼神経麻痺との鑑別に難渋した下垂体卒中による動眼神経麻痺の一例

深井悠未, 村井幸四郎, 今西明, 矢口雄大, 北澤勝, 鈴木浩史, 松林泰弘, 藤原和哉, 岩永みどり, 山田貴穂, 曽根博仁, 岡田正康

日本内分泌学会雑誌 99 ( 4 ) 895 - 895 2024.1

ACTH産生PitNETの集学的治療戦略と成績

岡田正康, 平石哲也, 米岡有一郎, 石黒創, 北澤勝, 曽根博仁, 大石誠

日本内分泌学会雑誌 99 ( 4 ) 896 - 896 2024.1

Association between screen time, including that for smartphones, and overweight/obesity among children in Japan: NICE EVIDENCE Study 4

Izumi Ikeda, Kazuya Fujihara, Sakiko Morikawa Yoshizawa, Yasunaga Takeda, Hajime Ishiguro, Mayuko Yamada Harada, Chika Horikawa, Yasuhiro Matsubayashi, Takaho Yamada, Yohei Ogawa, Hirohito Sone

Endocrine Journal 2024

トリュフによる血糖上昇抑制効果

鈴木浩史, 渡辺賢一, カク・アンジュ, ウー・シージャ, 石黒創, 井口晃徳, 小西徹也, 曽根博仁

機能性食品と薬理栄養 17 ( 3 ) 201 - 201 2023.12

isCGMとPHRスマートフォンアプリを用いた糖尿病発症予防プログラムの有効性検証のためのランダム化比較試験

北澤勝, 武田安永, 治田麻理子, 堀川千嘉, 佐藤隆明, 大澤妙子, 石澤正博, 鈴木浩史, 松林泰弘, 藤原和哉, 山田貴穂, 曽根博仁

日本先進糖尿病治療研究会雑誌 17 ( 3 ) 152 - 152 2023.12

Impact of a history of cardiovascular disease and physical activity habits on the incidence of functional disability. International journal

Remi Kodera, Kazuya Fujihara, Tetsuya Koyama, Haruka Shiozaki, Yurie Mutsuma, Noriko Yagyuda, Mariko Hatta, Kahori Tsuruoka, Yasunada Takeda, Atsushi Araki, Hirohito Sone

Scientific reports 13 ( 1 ) 20793 - 20793 2023.11

Language：English Publishing type：Research paper (scientific journal)

We examined the impact of a history of coronary artery disease (CAD) or cerebrovascular disease (CVD) and physical activity habits on functional disability among community-dwelling Japanese adults. This population-based retrospective cohort study included 10,661 people aged 39-98 years in Japan (5054, men). Median follow-up was 3.7 years. During the study period, 209 functional disabilities occurred in the overall study population. In multivariable analysis, a history of CVD (hazard ratio [HR] 1.57 [95% CI: 1.00-2.45]) and no physical activity habit (HR 1.74 [1.27-2.39]) presented increased risks for functional disability. HRs for functional disability among patients with a CVD history with and without a physical activity habit were 1.68 (0.75-3.74) and 2.65 (1.49-4.71), respectively, compared with individuals without a history of CVD with a physical activity habit. Similar results were observed for CAD. We found no significant difference in the incidence of functional disability between the group with a history of CAD or CVD and physical activity habits and the group with no history of CAD or CVD and without physical activity habits. Physical activity habits had a favorable influence on avoiding functional disability regardless of a history of CAD or CVD. Future prospective studies are needed to clarify these associations.

DOI： 10.1038/s41598-023-47913-z

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"Lifestyle Intervention with Smartphone app and isCGM for People at High Risk of Type 2 Diabetes: Randomized Trial". International journal

Masaru Kitazawa, Yasunaga Takeda, Mariko Hatta, Chika Horikawa, Takaaki Sato, Taeko Osawa, Masahiro Ishizawa, Hiroshi Suzuki, Yasuhiro Matsubayashi, Kazuya Fujihara, Takaho Yamada, Hirohito Sone

The Journal of clinical endocrinology and metabolism 2023.11

Language：English Publishing type：Research paper (scientific journal)

AIMS: Although conventional interventions for people at high risk of developing type 2 diabetes are usually conducted face-to-face, such interventions are burdensome for healthcare providers. We developed a lifestyle intervention program combining lifestyle coaching via a smartphone application augmented by intermittently scanned continuous glucose monitoring (isCGM) without burdening healthcare providers. Its effectiveness for glycemic control and body weight reduction in people at risk of type 2 diabetes was investigated. MATERIALS AND METHODS: For this 12-week randomized unblinded trial with offline recruitment, participants with HbA1c 5.6-6.4% or fasting blood glucose 110-125 mg/dl and body mass index (BMI) > 23 kg/m2 but <40 kg/m2 were randomly assigned to the Intervention group (App) and Control group (C). Primary endpoint was the difference in time in range (TIR) of blood glucose 70-140 mg/dL (3.9-7.8 mmol/L) before and after the study period between the two groups. RESULTS: Among 168 patients (mean age 48.1 y, mean BMI 26.6 kg/m2, and male 80.4%), 82 and 86 were assigned to the App group and C group, respectively. After 12 weeks, TIR of blood glucose 70-140 mg/dL significantly improved in the App group compared to the C group (-2.6 min/day vs. + 31.5 min/day, p = 0.03). Changes in time above range did not differ, whereas time below range (blood glucose <70 mg/dL; + 23.5 min/day vs. -8.9 min/day, p = 0.02) improved in the App group. BMI (-0.26 vs. -0.59, p = 0.017) was reduced in the App group compared to the C group. CONCLUSION: Intervention with a smartphone app and isCGM increased glycemic control accompanied by decreased carbohydrate intake and weight loss. Further trials are needed to confirm whether these interventions can reduce incident type 2 diabetes.

DOI： 10.1210/clinem/dgad639

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Rhomboid protease RHBDL4/RHBDD1 cleaves SREBP-1c at endoplasmic reticulum monitoring and regulating fatty acids. International journal

Song-Iee Han, Masanori Nakakuki, Yoshimi Nakagawa, Yunong Wang, Masaya Araki, Yuta Yamamoto, Hiroaki Tokiwa, Hiroyuki Takeda, Yuhei Mizunoe, Kaori Motomura, Hiroshi Ohno, Kenta Kainoh, Yuki Murayama, Yuichi Aita, Yoshinori Takeuchi, Yoshinori Osaki, Takafumi Miyamoto, Motohiro Sekiya, Takashi Matsuzaka, Naoya Yahagi, Hirohito Sone, Hiroaki Daitoku, Ryuichiro Sato, Hiroyuki Kawano, Hitoshi Shimano

PNAS nexus 2 ( 11 ) pgad351 2023.11

Language：English Publishing type：Research paper (scientific journal)

The endoplasmic reticulum (ER)-embedded transcription factors, sterol regulatory element-binding proteins (SREBPs), master regulators of lipid biosynthesis, are transported to the Golgi for proteolytic activation to tune cellular cholesterol levels and regulate lipogenesis. However, mechanisms by which the cell responds to the levels of saturated or unsaturated fatty acids remain underexplored. Here, we show that RHBDL4/RHBDD1, a rhomboid family protease, directly cleaves SREBP-1c at the ER. The p97/VCP, AAA-ATPase complex then acts as an auxiliary segregase to extract the remaining ER-embedded fragment of SREBP-1c. Importantly, the enzymatic activity of RHBDL4 is enhanced by saturated fatty acids (SFAs) but inhibited by polyunsaturated fatty acids (PUFAs). Genetic deletion of RHBDL4 in mice fed on a Western diet enriched in SFAs and cholesterol prevented SREBP-1c from inducing genes for lipogenesis, particularly for synthesis and incorporation of PUFAs, and secretion of lipoproteins. The RHBDL4-SREBP-1c pathway reveals a regulatory system for monitoring fatty acid composition and maintaining cellular lipid homeostasis.

DOI： 10.1093/pnasnexus/pgad351

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Single-cell transcriptome profiling of pancreatic islets from early diabetic mice identifies Anxa10 for Ca2+ allostasis toward β-cell failure. International journal

Kaori Motomura, Takashi Matsuzaka, Shigeyuki Shichino, Tatsuro Ogawa, Hao Pan, Takuya Nakajima, Yasuhito Asano, Toshitsugu Okayama, Tomoyo Takeuchi, Hiroshi Ohno, Song-Iee Han, Takafumi Miyamoto, Yoshinori Takeuchi, Motohiro Sekiya, Hirohito Sone, Naoya Yahagi, Yoshimi Nakagawa, Tatsuya Oda, Satoshi Ueha, Kazuho Ikeo, Atsushi Ogura, Kouji Matsushima, Hitoshi Shimano

Diabetes 2023.10

Language：English Publishing type：Research paper (scientific journal)

Type 2 diabetes (T2D) is a progressive disorder denoted by hyperglycemia and impaired insulin secretion. Although a decrease in β-cell function and mass is a well-known trigger for diabetes, the comprehensive mechanism is still unidentified. Here we carried out single-cell RNA sequencing (scRNA-seq) of pancreatic islets from prediabetic and diabetic db/db mice, an animal model of T2D. We discovered a diabetes-specific transcriptome landscape of endocrine and nonendocrine cell types with subpopulations of β and α cells. We recognized a new prediabetic gene, Anxa10, that was induced by, and regulated Ca2+ influx from metabolic stresses. Anxa10-overexpressed β cells displayed suppression of glucose-stimulated intracellular Ca2+ elevation and potassiuminduced insulin secretion. Pseudotime analysis of β cells predicted this Ca2+-surge responder-cluster proceeded to mitochondria dysfunction and also endoplasmic reticulum stress. Other trajectories comprised dedifferentiation and transdifferentiation, emphasizing acinar-like cells in diabetic islets. Altogether, our data provides a new insight into Ca2+ allostasis and β cell failure processes.

DOI： 10.2337/db23-0212

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妊娠糖尿病既往女性のフォローアップに関する診療ガイドライン

平松祐司, 杉山隆, 安日一郎, 曽根博仁, 菊池透, 瀧本秀美, 安田和基, 小川佳宏, 荒田尚子, 和栗雅子, 橋本貢士, 宮越敬, 山下洋, 鳴本敬一郎, 青山友子, 山本周美, 川崎麻紀, Obaidur Rahman, 川嵜有紀, 大田えりか, 内潟安子, 川崎英二, 守屋達美, 上塘正人, 田中幹二, 増山寿, 森川守, 楠田聡, 杉原茂孝, 清水一紀, 武田純, 原島伸一, 柳澤慶香, 田中佳代, 人見麻美子, 板倉敦夫, 寺内康夫, 平成30年度日本医療研究開発機構日本医療研究開発機構女性の健康の包括的支援実用化研究事業「妊娠糖尿病女性における出産後の糖尿病・メタボリックシンドローム発症のリスク因子同定と予防介入に関する研究」研究班, 一般社団法人日本糖尿病・妊娠学会

糖尿病と妊娠 23 ( 別冊 ) 1 - 95 2023.10

握力、閉眼片足立ち、立位体前屈による総合体力指標は代謝性疾患のスクリーニングに有用である

佐藤隆明, 藤原和哉, 山田万祐子, 張かおり, 矢口雄大, 山本正彦, 北澤勝, 石黒創, 大澤妙子, 山田貴穂, 加藤公則, 曽根博仁

日本臨床運動療法学会学術集会プログラム・抄録集 42回 61 - 61 2023.10

妊娠糖尿病既往女性のフォローアップに関する診療ガイドライン

糖尿病と妊娠 23 ( 別冊 ) 1 - 95 2023.10

血糖コントロールと妊娠合併症リスクとの量反応関係メタ回帰分析

児玉暁, 山田貴穂, 柳生田紀子, 谷内洋子, 堀川千嘉, 大澤妙子, 北澤勝, 藤原和哉, 西島浩二, 曽根博仁

糖尿病と妊娠 23 ( 3 ) S - 109 2023.10

規制改革特区を活用したGDM妊婦の産後12週以降の管理の全国一律保健適応化の実現

牧尉太, 衛藤英理子, 宮越敬, 曽根博仁, 安日一郎, 杉山隆, 増山寿

糖尿病と妊娠 23 ( 3 ) S - 125 2023.10

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Papers - SONE, Hirohito