Faculty Profiles - SONE, Hirohito

Papers - SONE, Hirohito

Division display 41 - 60 of about 618 ／ All the affair displays >>

写真撮影を含むスマートフォンアプリを用いた自由行動下での利用者及び医療者の負担を最小限とする食事記録方法の検討

北澤勝, 堀川千嘉, 長谷川美代, 武田安永, 松林泰弘, 山田貴穂, 児玉暁, 曽根博仁

日本栄養・食糧学会大会講演要旨集 78回 242 - 242 2024.4

PHRスマートフォンアプリとisCGMを連動させた2型糖尿病発症予防プログラムの有効性検証のためのランダム化比較試験

北澤勝, 武田安永, 治田麻理子, 堀川千嘉, 佐藤隆明, 大澤妙子, 石澤正博, 鈴木浩史, 松林泰弘, 藤原和哉, 山田貴穂, 曽根博仁

糖尿病 67 ( Suppl.1 ) S - 216 2024.4

日本人2型糖尿病患者における,飽和脂肪酸エネルギー比率と心血管疾患発症との関係 JDCP studyの解析から

堀川千嘉, 高原充佳, 片上直人, 武田安永, 竹内瑞希, 藤原和哉, 鈴木浩明, 津田謹輔, 吉岡成人, 島野仁, 佐藤譲, 林野泰明, 田嶼尚子, 西村理明, 山崎義光, 曽根博仁

糖尿病 67 ( Suppl.1 ) S - 169 2024.4

Decade-long WT1-specific CTLs induced by WT1 peptide vaccination.

Tatsuya Suwabe, Yasuhiko Shibasaki, Suguru Tamura, Takayuki Katagiri, Kyoko Fuse, Tori Ida-Kurasaki, Takashi Ushiki, Hirohito Sone, Miwako Narita, Masayoshi Masuko

International journal of hematology 119 ( 4 ) 399 - 406 2024.4

Language：English Publishing type：Research paper (scientific journal)

INTRODUCTION: The peptide-based cancer vaccine targeting Wilms' tumor 1 (WT1) is a promising immunotherapeutic strategy for hematological malignancies. It remains unclear how long and to what extent the WT1-specific CD8 + cytotoxic T cell (CTL) persist after WT1 peptide vaccination. METHODS: The WT1 peptide vaccine was administered with written consent to a patient with CML in the chronic phase who did not respond well to imatinib, and the patient was followed for 12 years after vaccination. Immune monitoring was performed by specific amplification of WT1-specific CTLs using a mixed lymphocyte peptide culture. T-cell receptors (TCRs) of amplified WT1-specific CTLs were analyzed using next-generation sequencing. This study was approved by the Institutional Review Board of our institution. RESULT: WT1-specific CTLs, which were initially detected during WT1 peptide vaccination, persisted at a frequency of less than 5 cells per 1,000,000 CD8 + T cells for more than 10 years. TCR repertoire analysis confirmed the diversity of WT1-specific CTLs 11 years after vaccination. CTLs exhibited WT1 peptide-specific cytotoxicity in vitro. CONCLUSION: The WT1 peptide vaccine induced an immune response that persists for more than 10 years, even after cessation of vaccination in the CML patient.

DOI： 10.1007/s12185-024-03723-1

PubMed

researchmap

詳細な家族歴が2型糖尿病,高血圧,脂質異常症の有病と発症に与える影響の横断縦断的検討

池田和泉, 五十嵐理沙, 藤原和哉, 武田安永, 松林泰弘, 児玉暁, 山田貴穂, 森保道, 門脇孝, 本田律子, 荒瀬康司, 曽根博仁

糖尿病 67 ( Suppl.1 ) S - 194 2024.4

Higher dietary protein/energy ratio is associated with a lower risk for obesity in older women with type 2 diabetes: Cross-sectional analysis of Japanese patients with type 2 diabetes mellitus

Efrem d'Ávila Ferreira, Mariko Hatta, Khin Laymon, Izumi Ikeda, Mizuki Takeuchi, Yasunaga Takeda, Sakiko Yoshizawa Morikawa, Chika Horikawa, Noriko Kato, Hiroshi Maegawa, Kazuya Fujihara, Hirohito Sone

Human Nutrition & Metabolism 200257 - 200257 2024.3

Cross-Sectional and Longitudinal Associations between Forearm Bone Mineral Density and Anthropometry in Adult Japanese Men and Women

Masahiro Ishizawa, Kazuya Fujihara, Junko Yachida, Izumi Ikeda, Takaaki Sato, Takaho Yamada, Ayako Kobayashi, Shiro Tanaka, Yoshimi Nakagawa, Takashi Matsuzaka, Hitoshi Shimano, Minoru Tashiro, Satoru Kodama, Kiminori Kato, Hirohito Sone

Journal of Bone Metabolism 31 ( 1 ) 21 - 30 2024.2

機能性甲状腺結節による甲状腺中毒症を誘因として糖尿病性ケトアシドーシスを来し甲状腺クリーゼを発症した一例

間島貴之, 鈴木浩史, 木村智佑, 佐藤隆明, 山本雅彦, 石黒創, 岩永みどり, 松林泰弘, 山田貴穂, 藤原和哉, 曽根博仁

日本内分泌学会雑誌 99 ( 4 ) 884 - 884 2024.1

機能性甲状腺結節による甲状腺中毒症を誘因として糖尿病性ケトアシドーシスを来し甲状腺クリーゼを発症した一例

間島貴之, 鈴木浩史, 木村智佑, 佐藤隆明, 山本雅彦, 石黒創, 岩永みどり, 松林泰弘, 山田貴穂, 藤原和哉, 曽根博仁

日本内分泌学会雑誌 99 ( 4 ) 884 - 884 2024.1

副交感神経障害を伴わず糖尿病性動眼神経麻痺との鑑別に難渋した下垂体卒中による動眼神経麻痺の一例

深井悠未, 村井幸四郎, 今西明, 矢口雄大, 北澤勝, 鈴木浩史, 松林泰弘, 藤原和哉, 岩永みどり, 山田貴穂, 曽根博仁, 岡田正康

日本内分泌学会雑誌 99 ( 4 ) 895 - 895 2024.1

2型糖尿病患者におけるカリウム摂取量およびナトリウム摂取量と心血管疾患発症リスクの関係 JDCP study

Journal of Epidemiology 34 ( Suppl. ) 163 - 163 2024.1

副交感神経障害を伴わず糖尿病性動眼神経麻痺との鑑別に難渋した下垂体卒中による動眼神経麻痺の一例

深井悠未, 村井幸四郎, 今西明, 矢口雄大, 北澤勝, 鈴木浩史, 松林泰弘, 藤原和哉, 岩永みどり, 山田貴穂, 曽根博仁, 岡田正康

日本内分泌学会雑誌 99 ( 4 ) 895 - 895 2024.1

ACTH産生PitNETの集学的治療戦略と成績

岡田正康, 平石哲也, 米岡有一郎, 石黒創, 北澤勝, 曽根博仁, 大石誠

日本内分泌学会雑誌 99 ( 4 ) 896 - 896 2024.1

Association between screen time, including that for smartphones, and overweight/obesity among children in Japan: NICE EVIDENCE Study 4

Izumi Ikeda, Kazuya Fujihara, Sakiko Morikawa Yoshizawa, Yasunaga Takeda, Hajime Ishiguro, Mayuko Yamada Harada, Chika Horikawa, Yasuhiro Matsubayashi, Takaho Yamada, Yohei Ogawa, Hirohito Sone

Endocrine Journal 2024

isCGMとPHRスマートフォンアプリを用いた糖尿病発症予防プログラムの有効性検証のためのランダム化比較試験

北澤勝, 武田安永, 治田麻理子, 堀川千嘉, 佐藤隆明, 大澤妙子, 石澤正博, 鈴木浩史, 松林泰弘, 藤原和哉, 山田貴穂, 曽根博仁

日本先進糖尿病治療研究会雑誌 17 ( 3 ) 152 - 152 2023.12

トリュフによる血糖上昇抑制効果

鈴木浩史, 渡辺賢一, カク・アンジュ, ウー・シージャ, 石黒創, 井口晃徳, 小西徹也, 曽根博仁

機能性食品と薬理栄養 17 ( 3 ) 201 - 201 2023.12

"Lifestyle Intervention with Smartphone app and isCGM for People at High Risk of Type 2 Diabetes: Randomized Trial". International journal

Masaru Kitazawa, Yasunaga Takeda, Mariko Hatta, Chika Horikawa, Takaaki Sato, Taeko Osawa, Masahiro Ishizawa, Hiroshi Suzuki, Yasuhiro Matsubayashi, Kazuya Fujihara, Takaho Yamada, Hirohito Sone

The Journal of clinical endocrinology and metabolism 2023.11

Language：English Publishing type：Research paper (scientific journal)

AIMS: Although conventional interventions for people at high risk of developing type 2 diabetes are usually conducted face-to-face, such interventions are burdensome for healthcare providers. We developed a lifestyle intervention program combining lifestyle coaching via a smartphone application augmented by intermittently scanned continuous glucose monitoring (isCGM) without burdening healthcare providers. Its effectiveness for glycemic control and body weight reduction in people at risk of type 2 diabetes was investigated. MATERIALS AND METHODS: For this 12-week randomized unblinded trial with offline recruitment, participants with HbA1c 5.6-6.4% or fasting blood glucose 110-125 mg/dl and body mass index (BMI) > 23 kg/m2 but <40 kg/m2 were randomly assigned to the Intervention group (App) and Control group (C). Primary endpoint was the difference in time in range (TIR) of blood glucose 70-140 mg/dL (3.9-7.8 mmol/L) before and after the study period between the two groups. RESULTS: Among 168 patients (mean age 48.1 y, mean BMI 26.6 kg/m2, and male 80.4%), 82 and 86 were assigned to the App group and C group, respectively. After 12 weeks, TIR of blood glucose 70-140 mg/dL significantly improved in the App group compared to the C group (-2.6 min/day vs. + 31.5 min/day, p = 0.03). Changes in time above range did not differ, whereas time below range (blood glucose <70 mg/dL; + 23.5 min/day vs. -8.9 min/day, p = 0.02) improved in the App group. BMI (-0.26 vs. -0.59, p = 0.017) was reduced in the App group compared to the C group. CONCLUSION: Intervention with a smartphone app and isCGM increased glycemic control accompanied by decreased carbohydrate intake and weight loss. Further trials are needed to confirm whether these interventions can reduce incident type 2 diabetes.

DOI： 10.1210/clinem/dgad639

PubMed

researchmap

Rhomboid protease RHBDL4/RHBDD1 cleaves SREBP-1c at endoplasmic reticulum monitoring and regulating fatty acids. International journal

Song-Iee Han, Masanori Nakakuki, Yoshimi Nakagawa, Yunong Wang, Masaya Araki, Yuta Yamamoto, Hiroaki Tokiwa, Hiroyuki Takeda, Yuhei Mizunoe, Kaori Motomura, Hiroshi Ohno, Kenta Kainoh, Yuki Murayama, Yuichi Aita, Yoshinori Takeuchi, Yoshinori Osaki, Takafumi Miyamoto, Motohiro Sekiya, Takashi Matsuzaka, Naoya Yahagi, Hirohito Sone, Hiroaki Daitoku, Ryuichiro Sato, Hiroyuki Kawano, Hitoshi Shimano

PNAS nexus 2 ( 11 ) pgad351 2023.11

Language：English Publishing type：Research paper (scientific journal)

The endoplasmic reticulum (ER)-embedded transcription factors, sterol regulatory element-binding proteins (SREBPs), master regulators of lipid biosynthesis, are transported to the Golgi for proteolytic activation to tune cellular cholesterol levels and regulate lipogenesis. However, mechanisms by which the cell responds to the levels of saturated or unsaturated fatty acids remain underexplored. Here, we show that RHBDL4/RHBDD1, a rhomboid family protease, directly cleaves SREBP-1c at the ER. The p97/VCP, AAA-ATPase complex then acts as an auxiliary segregase to extract the remaining ER-embedded fragment of SREBP-1c. Importantly, the enzymatic activity of RHBDL4 is enhanced by saturated fatty acids (SFAs) but inhibited by polyunsaturated fatty acids (PUFAs). Genetic deletion of RHBDL4 in mice fed on a Western diet enriched in SFAs and cholesterol prevented SREBP-1c from inducing genes for lipogenesis, particularly for synthesis and incorporation of PUFAs, and secretion of lipoproteins. The RHBDL4-SREBP-1c pathway reveals a regulatory system for monitoring fatty acid composition and maintaining cellular lipid homeostasis.

DOI： 10.1093/pnasnexus/pgad351

PubMed

researchmap

Single-cell transcriptome profiling of pancreatic islets from early diabetic mice identifies Anxa10 for Ca2+ allostasis toward β-cell failure. International journal

Kaori Motomura, Takashi Matsuzaka, Shigeyuki Shichino, Tatsuro Ogawa, Hao Pan, Takuya Nakajima, Yasuhito Asano, Toshitsugu Okayama, Tomoyo Takeuchi, Hiroshi Ohno, Song-Iee Han, Takafumi Miyamoto, Yoshinori Takeuchi, Motohiro Sekiya, Hirohito Sone, Naoya Yahagi, Yoshimi Nakagawa, Tatsuya Oda, Satoshi Ueha, Kazuho Ikeo, Atsushi Ogura, Kouji Matsushima, Hitoshi Shimano

Diabetes 2023.10

Language：English Publishing type：Research paper (scientific journal)

Type 2 diabetes (T2D) is a progressive disorder denoted by hyperglycemia and impaired insulin secretion. Although a decrease in β-cell function and mass is a well-known trigger for diabetes, the comprehensive mechanism is still unidentified. Here we carried out single-cell RNA sequencing (scRNA-seq) of pancreatic islets from prediabetic and diabetic db/db mice, an animal model of T2D. We discovered a diabetes-specific transcriptome landscape of endocrine and nonendocrine cell types with subpopulations of β and α cells. We recognized a new prediabetic gene, Anxa10, that was induced by, and regulated Ca2+ influx from metabolic stresses. Anxa10-overexpressed β cells displayed suppression of glucose-stimulated intracellular Ca2+ elevation and potassiuminduced insulin secretion. Pseudotime analysis of β cells predicted this Ca2+-surge responder-cluster proceeded to mitochondria dysfunction and also endoplasmic reticulum stress. Other trajectories comprised dedifferentiation and transdifferentiation, emphasizing acinar-like cells in diabetic islets. Altogether, our data provides a new insight into Ca2+ allostasis and β cell failure processes.

DOI： 10.2337/db23-0212

PubMed

researchmap

妊娠糖尿病既往女性のフォローアップに関する診療ガイドライン

平松祐司, 杉山隆, 安日一郎, 曽根博仁, 菊池透, 瀧本秀美, 安田和基, 小川佳宏, 荒田尚子, 和栗雅子, 橋本貢士, 宮越敬, 山下洋, 鳴本敬一郎, 青山友子, 山本周美, 川崎麻紀, Obaidur Rahman, 川嵜有紀, 大田えりか, 内潟安子, 川崎英二, 守屋達美, 上塘正人, 田中幹二, 増山寿, 森川守, 楠田聡, 杉原茂孝, 清水一紀, 武田純, 原島伸一, 柳澤慶香, 田中佳代, 人見麻美子, 板倉敦夫, 寺内康夫, 平成30年度日本医療研究開発機構日本医療研究開発機構女性の健康の包括的支援実用化研究事業「妊娠糖尿病女性における出産後の糖尿病・メタボリックシンドローム発症のリスク因子同定と予防介入に関する研究」研究班, 一般社団法人日本糖尿病・妊娠学会

糖尿病と妊娠 23 ( 別冊 ) 1 - 95 2023.10

　 PREV - NEXT 　

<SONE, Hirohito>

Papers - SONE, Hirohito