Faculty Profiles - SONE, Hirohito

Papers - SONE, Hirohito

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炭水化物エネルギー比率の算出方法の違いは、糖尿病患者の炭水化物エネルギー比率と心血管疾患発症リスクの関係に影響しうるか

堀川千嘉, 高原充佳, 片上直人, 武田安永, 竹内瑞希, 藤原和哉, 鈴木浩明, 津田謹輔, 吉岡成人, 押田芳治, 島野仁, 佐藤譲, 林野泰明, 田嶼尚子, 西村理明, 山崎義光, 曽根博仁

日本栄養・食糧学会大会講演要旨集 77回 314 - 314 2023.3

Risk of fetal undergrowth in the management of gestational diabetes mellitus in Japan

Hirohito Sone

Journal of Diabetes Investigation 2023.2

エンフォルツマブによる高血糖と回腸導管による代謝性アシドーシスの1例

浅島雄弥, 佐藤隆明, 佐々木知佳, 鈴木浩史, 岩永みどり, 山田貴穂, 藤原和哉, 曾根博仁

新潟医学会雑誌 137 ( 2 ) 71 - 71 2023.2

妊娠初期における母体のヘモグロビン値・赤血球恒数と低出生体重児出産との関連の検討

谷内洋子, 坂本莉菜, 柴崎康彦, 山田貴穂, 生魚薫, 柳生田紀子, 龍野一郎, 曽根博仁

Journal of Epidemiology 33 ( Suppl.1 ) 146 - 146 2023.2

エンフォルツマブによる高血糖と回腸導管による代謝性アシドーシスの1例

浅島雄弥, 佐藤隆明, 佐々木知佳, 鈴木浩史, 岩永みどり, 山田貴穂, 藤原和哉, 曾根博仁

新潟医学会雑誌 137 ( 2 ) 71 - 71 2023.2

ソフトドリンクケトーシス治療中に腎性尿崩症が指摘された一例

日向裕大, 矢口雄大, 砂田大介, 川井千尋, 山本正彦, 石黒創, 北澤勝, 石澤正博, 鈴木浩史, 松林泰弘, 岩永みどり, 山田貴穂, 藤原和哉, 曽根博仁

日本内分泌学会雑誌 98 ( 4 ) 856 - 856 2023.2

Combined effects of blood pressure and glycemic status on risk of heart failure: a population-based study

Hirohito Sone

Journal of Hypertension Publish Ahead of Print 2023.1

Association of the estimated glomerular filtration rate (eGFR) and/or proteinuria to predict the risk of initiation of dialysis in people with and without diabetes

Hirohito Sone

Diabetology International 14 ( 1 ) 86 - 93 2023.1

Language：English Publishing type：Research paper (scientific journal)

AIMS: To determine the associations between combined urinary protein (UP) and a reduced estimated glomerular filtration rate (eGFR) and the risk of starting dialysis with or without diabetes mellitus (DM). METHODS: A nationwide database with claims data on 335,778 people with and without DM aged 19-72 years in Japan was used to elucidate the impact of the severities of UP and eGFR on starting dialysis. Initiation of dialysis was determined from claims using ICD-10 codes and medical procedures. Using multivariate Cox modeling, we investigated the severities of UP and eGFR to predict the initiation of dialysis with and without DM. RESULTS: Both eGFR < 60 and UP(+) were independent predictors for starting dialysis with and without DM, and their values exhibited a synergistic risk of dialysis. eGFR < 60 presented a nearly twofold risk for starting dialysis compared to UP(+) regardless of DM. Risk of starting dialysis was increased with UP(+) and eGFR ≥ 60 accompanied by DM although this association was not observed without DM. Those who had UP(-) and eGFR < 60 had a high risk of starting dialysis regardless of DM. Compared with DM(-)UP(-)eGFR ≥ 60, HRs for starting dialysis for DM(+)UP(+)eGFR ≥ 60, DM(+)UP(-)eGFR < 60 and DM(+)UP(+)eGFR < 60 significantly increased 17.7 (10.6-29.7), 25.5 (13.8-47.1) and 358.1 (239.1-536.5) times, respectively. CONCLUSIONS: eGFR < 60 and UP(+) together presented an extremely high risk of dialysis especially with DM. UP( +) increased the risk of starting dialysis regardless of the eGFR with DM. Both patient education and a treatment strategy by physicians might be helpful to avoid the progression of renal failure.

DOI： 10.1007/S13340-022-00603-Z

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オンライン予防歯科教育動画による企業従業員のヘルスリテラシー向上と行動変容における有効性の検証

植木麻有子, 田村浩平, 木村大地, 木村美樹, 曽根博仁, 小川祐司

口腔衛生学会雑誌 73 ( 1 ) 64 - 64 2023.1

Hypoglycemic Hemiplegia Associated with Reversible Narrowing of the Contralateral Middle Cerebral Artery in a Patient with Adrenal Insufficiency

Hirohito Sone

Internal Medicine 2023

Machine Learning Approach to Drug Treatment Strategy for Diabetes Care

Hirohito Sone

Diabetes & Metabolism Journal 2023

Prediction and prevention of the onset of hypertension from the viewpoint of estimated 24-hour salt excretion and physical fitness test

Hirohito Sone

Journal of Hypertension 2023

Relationship between changes in blood pressure from summer to winter and estimated 24-hour salt excretion using spot urine: the Niigata Wellness Study

Hirohito Sone

Hypertension Research 2023

Effect of dietary fiber-enriched brown rice crackers on suppressing elevation of blood glucose level

Hiroshi Suzuki, Kenichi Watanabe, Izumi Ikeda, Yasunaga Takeda, Mariko Hatta, Chika Horikawa, Efrem D’Avila Ferreira, Wu Sijia, Khin Laymon, Hirohito Sone

Functional Foods in Health and Disease 13 ( 11 ) 595 - 604 2023

Publishing type：Research paper (scientific journal)

Background: Rice crackers are composed of carbohydrates refined from rice and enjoyed as a snack in Japan. Most rice crackers are crafted from white rice, and the potential postprandial blood glucose rise following their consumption may pose a clinical concern. Brown rice contains more dietary fiber than white rice and has been reported to suppress elevations of blood glucose. Dietary fiber-enhanced brown rice crackers have a significantly higher dietary fiber content than regular brown rice crackers and can be expected to suppress blood glucose elevations more reliably. Methods: We conducted a crossover trial in humans using white rice crackers and dietary fiber-enhanced brown rice crackers to investigate the effect of dietary fiber-enhanced brown rice crackers on postprandial blood glucose elevations. Participants ingested the 100 g rice crackers with 200 mL water for 10 min, and blood was collected from the fingertip at 7 time points: baseline, and at 15, 30, 45, 60, 90, and 120 min after ingestion of the rice cracker. The primary outcome measure was the blood glucose levels, and the secondary outcome measure was the incremental area under curve of blood glucose. Results: Glucose levels and incremental areas under curve at 60 min and 120 min after intake were significantly lower with dietary fiber-enhanced brown rice crackers than with white rice crackers. Incremental area under curves at 60 min and 120 min after intake of rice crackers were also significantly lower in dietary fiber-enhanced brown rice crackers than white rice crackers. Conclusions: Ingesting dietary fiber-enhanced brown rice crackers instead of white rice crackers could be useful for achieving better glycemic control.

DOI： 10.31989/ffhd.v13i11.1231

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Machine learning approach to predict body weight in adults International journal

Hirohito Sone

Frontiers in Public Health 11 1090146 - 1090146 2023

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Obesity is an established risk factor for non-communicable diseases such as type 2 diabetes mellitus, hypertension and cardiovascular disease. Thus, weight control is a key factor in the prevention of non-communicable diseases. A simple and quick method to predict weight change over a few years could be helpful for weight management in clinical settings. METHODS: We examined the ability of a machine learning model that we constructed to predict changes in future body weight over 3 years using big data. Input in the machine learning model were three-year data on 50,000 Japanese persons (32,977 men) aged 19-91 years who underwent annual health examinations. The predictive formulas that used heterogeneous mixture learning technology (HMLT) to predict body weight in the subsequent 3 years were validated for 5,000 persons. The root mean square error (RMSE) was used to evaluate accuracy compared with multiple regression. RESULTS: The machine learning model utilizing HMLT automatically generated five predictive formulas. The influence of lifestyle on body weight was found to be large in people with a high body mass index (BMI) at baseline (BMI ≥29.93 kg/m2) and in young people (<24 years) with a low BMI (BMI <23.44 kg/m2). The RMSE was 1.914 in the validation set which reflects ability comparable to that of the multiple regression model of 1.890 (p = 0.323). CONCLUSION: The HMLT-based machine learning model could successfully predict weight change over 3 years. Our model could automatically identify groups whose lifestyle profoundly impacted weight loss and factors the influenced body weight change in individuals. Although this model must be validated in other populations, including other ethnic groups, before being widely implemented in global clinical settings, results suggested that this machine learning model could contribute to individualized weight management.

DOI： 10.3389/FPUBH.2023.1090146

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Identification of key microRNAs regulating ELOVL6 and glioblastoma tumorigenesis

Nurani Istiqamah, Takashi Matsuzaka, Momo Shimizu, Kaori Motomura, Hiroshi Ohno, Shiho Hasebe, Rahul Sharma, Yuka Okajima, Erika Matsuda, Song-Iee Han, Yuhei Mizunoe, Yoshinori Osaki, Yuichi Aita, Hiroaki Suzuki, Hirohito Sone, Yoshinori Takeuchi, Motohiro Sekiya, Naoya Yahagi, Yoshimi Nakagawa, Hitoshi Shimano

BBA Advances 3 100078 - 100078 2023

Citrate synthase insufficiency leads to specific metabolic adaptations in the heart and skeletal muscles upon low-carbohydrate diet feeding in mice(vol 9, 925908, 2022)

Hirohito Sone

Frontiers in Nutrition 9 2023

Publishing type：Research paper (scientific journal) Publisher：Frontiers Media SA

A decrease in TCA cycle activity may lead to impaired nutrition metabolism and cellular energy shortage. Herein, we aimed to characterize the detailed metabolic changes that compensate for energy shortages in energy-consuming organs (heart and skeletal muscles) in mice with knockout of citrate synthase (CS), an important enzyme in the TCA cycle. CS hetero knockout (CS +/−) mice and wild-type mice were fed a low-carbohydrate ketogenic diet (LCKD) or high-fat, high-carbohydrate diet (HFHCD) to induce metabolic changes. Body weight, blood serum parameters, metabolic gene expression, and adenosine triphosphate (ATP) levels were measured in the heart and skeletal muscles. Glycogen content, anabolic and catabolic biomarkers, and morphological changes were also assessed in the skeletal muscles. After diet feeding, there were no differences observed in the body weight and blood serum parameters between wild-type and CS +/− mice. The cardiac expression of genes related to the utilization of fatty acids, monocarboxylates, and branched amino acids increased in LCKD-fed CS +/− mice. In contrast, no significant differences in gene expression were observed in the muscles of LCKD-fed mice or the heart and muscles of HFHCD-fed mice. ATP levels decreased only in the skeletal muscles of LCKD-fed CS +/− mice. Additionally, the decrease in glycogen content, suppression of p70 S6 kinase, and presence of type I fiber atrophy were observed in the muscles of LCKD-fed CS +/− mice. These results suggest that the energy-consuming organs with CS insufficiency may undergo tissue-specific adaption to compensate for energy shortages when the carbohydrate supply is limited.

DOI： 10.3389/FNUT.2023.1193530

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Hepatocyte- or macrophage-specific SREBP-1a deficiency in mice exacerbates methionine- and choline-deficient diet-induced nonalcoholic fatty liver disease. International journal

Masaya Araki, Yoshimi Nakagawa, Hodaka Saito, Yasunari Yamada, Song-Iee Han, Yuhei Mizunoe, Hiroshi Ohno, Takafumi Miyamoto, Motohiro Sekiya, Takashi Matsuzaka, Hirohito Sone, Hitoshi Shimano

American journal of physiology. Gastrointestinal and liver physiology 323 ( 6 ) G627-G639 2022.12

Language：English Publishing type：Research paper (scientific journal)

Sterol regulatory element-binding proteins (SREBPs) are master transcription factors for lipid synthesis, and SREBP-1 is important for fatty acid and triglyceride synthesis. SREBP-1 has two isoforms, SREBP-1a and SREBP-1c, which are splicing variants transcribed from the Srebf1 gene. Although SREBP-1a exhibits stronger transcriptional activity than SREBP-1c, hepatic SREBP-1c is considered more physiologically important. We generated SREBP-1a flox mice using the CRISPR/Cas9 system and hepatocyte- and macrophage-specific SREBP-1a knockout (KO) mice (LKO, liver-knockout; and mΦKO, macrophage-knockout). There were no significant differences among all the mouse genotypes upon feeding with a normal diet. However, feeding with a methionine- and choline-deficient (MCD) diet resulted in exacerbated liver injury in both KO mice. In LKO mice, fatty liver was unexpectedly exacerbated, leading to macrophage infiltration and inflammation. In contrast, in mΦKO mice, the fatty liver state was similar to that in flox mice, but the polarity of the macrophages in the liver was transformed into a proinflammatory M1 subtype, resulting in the exacerbation of inflammation. Taken together, we found that SREBP-1a does not contribute to hepatic lipogenesis, but in either hepatocytes or macrophages distinctly controls the onset of pathological conditions in MCD diet-induced hepatitis.NEW & NOTEWORTHY Hepatocyte- and macrophage-specific SREBP-1a knockout mice were generated for the first time. This study reveals that SREBP-1a does not contribute to hepatic lipogenesis, but in either hepatocytes or macrophages distinctly controls the onset of pathological conditions in methionine- and choline-deficient diet-induced hepatitis.

DOI： 10.1152/ajpgi.00090.2022

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乳酸醗酵酒粕の非アルコール性脂肪性肝炎の進行抑制効果

鈴木浩史, 渡辺賢一, Arumugam Somasundaram, Afrin Rejina, 松林泰弘, 曽根博仁

機能性食品と薬理栄養 16 ( 3 ) 191 - 191 2022.12

デキサメタゾン投与後に周期性四肢麻痺を呈したバセドウ病の一例

浅島雄弥, 佐藤隆明, 滝澤大輝, 日向裕大, 今西明, 橋本浩平, 松林泰弘, 岩永みどり, 山田貴穂, 藤原和哉, 曽根博仁

日本内分泌学会雑誌 98 ( 2 ) 583 - 583 2022.10

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Papers - SONE, Hirohito