Faculty Profiles - SONE, Hirohito

YAP1/TAZ activity maintains vascular integrity and organismal survival. International journal

Shun Uemura, Masayuki Yamashita, Kazumasa Aoyama, Takako Yokomizo-Nakano, Motohiko Oshima, Miki Nishio, Masayoshi Masuko, Jun Takizawa, Hirohito Sone, Yasuhiro Yamada, Akira Suzuki, Atsushi Iwama

Biochemical and biophysical research communications 619 117 - 123 2022.9

Language：English Publishing type：Research paper (scientific journal)

Radiation therapy is one of the major treatment modalities for patients with cancers. However, ionizing radiation (IR) damages not only cancer cells but also the surrounding vascular endothelial cells (ECs). Hippo pathway effector genes Yap1 and Taz are the two transcriptional coactivators that have crucial roles in tissue homeostasis and vascular integrity in various organs. However, their function in adult ECs at the steady state and after IR is poorly understood. Here, we report sex- and context-dependent roles of endothelial YAP1/TAZ in maintaining vascular integrity and organismal survival. EC-specific Yap1/Taz deletion compromised systemic vascular integrity, resulting in lethal circulation failure preferentially in male mice. Furthermore, EC-specific Yap1/Taz deletion induced acute lethality upon sublethal IR that was closely associated with exacerbated systemic vascular dysfunction and circulation failure. Consistent with these findings, RNA-seq analysis revealed downregulation of tight junction genes in Yap1/Taz-deleted ECs. Collectively, our findings highlight the importance of endothelial YAP1/TAZ for maintaining adult vascular function, which may provide clinical implications for preventing organ injury after radiation therapy.

DOI： 10.1016/j.bbrc.2022.06.050

糖尿病性ケトアシドーシス治療中に腎性尿崩症が指摘された一例

握力、閉眼片足立ち、立位体前屈による総合体力指標はメタボリックシンドロームの発症予測に有用である

佐藤隆明, 藤原和哉, 山田万祐子, 張かおり, 矢口雄大, 山本正彦, 北澤勝, 石黒創, 大澤妙子, 山田貴穂, 加藤公則, 曽根博仁

日本臨床運動療法学会学術集会プログラム・抄録集 41回 57 - 57 2022.9

耐糖能およびHDL-C値によるLDL-C値が冠動脈疾患発症に及ぼす影響の検討

山田万祐子, 藤原和哉, 大澤妙子, 北澤勝, 松林泰弘, 矢口雄大, 山本正彦, 佐藤隆明, 三ツ間友里恵, 岩永みどり, 山田貴穂, 児玉暁, 曽根博仁

糖尿病合併症 36 ( Suppl.1 ) 173 - 173 2022.9

日向裕大, 矢口雄大, 砂田大介, 川井千尋, 山本正彦, 石黒創, 北澤勝, 石澤正博, 鈴木浩史, 松林泰弘, 岩永みどり, 山田貴穂, 藤原和哉, 曽根博仁

新潟医学会雑誌 136 ( 9 ) 303 - 303 2022.9

尿細管障害を伴う低カリウム血症の加療中にデノスマブによる著明な低Ca血症をきたした1例

砂田大介, 矢口雄大, 川井千尋, 日向裕大, 山本正彦, 石黒創, 北澤勝, 石澤正博, 鈴木浩史, 松林泰弘, 岩永みどり, 山田貴穂, 藤原和哉, 曽根博仁

新潟医学会雑誌 136 ( 9 ) 303 - 303 2022.9

尿細管障害を伴う低カリウム血症の加療中にデノスマブによる著明な低Ca血症をきたした1例

砂田大介, 矢口雄大, 川井千尋, 日向裕大, 山本正彦, 石黒創, 北澤勝, 石澤正博, 鈴木浩史, 松林泰弘, 岩永みどり, 山田貴穂, 藤原和哉, 曽根博仁

新潟医学会雑誌 136 ( 9 ) 303 - 303 2022.9

糖尿病性ケトアシドーシス治療中に腎性尿崩症が指摘された一例

日向裕大, 矢口雄大, 砂田大介, 川井千尋, 山本正彦, 石黒創, 北澤勝, 石澤正博, 鈴木浩史, 松林泰弘, 岩永みどり, 山田貴穂, 藤原和哉, 曽根博仁

新潟医学会雑誌 136 ( 9 ) 303 - 303 2022.9

成長ホルモン産生下垂体腺腫に対する発現受容体分類に基づく治療の可能性

岡田正康, 米岡有一郎, 大石誠, 石黒創, 山本正彦, 大澤妙子, 伊藤崇子, 曽根博仁, 藤井幸彦

新潟医学会雑誌 136 ( 9 ) 302 - 302 2022.9

Predictors of hemoglobin and its changes focusing on anemia and polycythemia after administration of the SGLT2 inhibitor, tofogliflozin. International journal

Yasuhiro Matsubayashi, Akihiro Yoshida, Hideki Suganami, Momoko Oe, Takaaki Sato, Yuta Yaguchi, Kazuya Fujihara, Takaho Yamada, Shiro Tanaka, Kohei Kaku, Hirohito Sone

Diabetes, obesity & metabolism 24 ( 12 ) 2469 - 2473 2022.8

Fast walking and physical activity are independent contributors to improved physical function. International journal

Haruka Shiozaki, Kazuya Fujihara, Mayuko Yamada-Harada, Masahiko Yamamoto, Yurie Mitsuma, Masaru Kitazawa, Yuta Yaguchi, Yasuhiro Matsubayashi, Midori Iwanaga, Takaho Yamada, Satoru Kodama, Hirohito Sone

Family practice 2022.8

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND AND OBJECTIVES: To clarify whether the presence or absence of fast walking and habitual physical activity are independently associated with the incidence of functional disability. METHODS: This historical cohort study was comprised of 9,652 (4,412 men, mean age 65 years) individuals aged 39-98 years without functional disability at baseline. Functional disability was determined based on the Japanese long-term care insurance system, which specified requirements for assistance in the activities of daily living. The impact of fast walking and habitual physical activity on the incidence of functional disability was analysed by Cox proportional hazards models. RESULTS: The follow-up period was a median of 3.7 years during which 165 patients were newly certified as having functional disability. In the multivariate analysis, baseline age in 5-year increments (hazard ratio 2.42 [95% confidence interval 2.18-2.69]), no habitual physical activity (1.56 [1.07-2.27]), and not fast walking (1.89 [1.32-2.69]) significantly increased the risk of functional disability after adjustment for covariates. The stratified analysis showed that compared with physical activity (+), the impact of physical activity (-) on the incidence of functional disability was observed in those aged ≥75 years regardless of fast walking (+). Fast walking (-) significantly increased the risk of disability compared with fast walking (+) in those aged <75 years regardless of a physical activity habit. CONCLUSION: In Japanese, slow walking speed and lack of a physical activity habit were shown to be independent risk factors for incident functional disability, with their impact differing according to age.

DOI： 10.1093/fampra/cmac087

Two cases of 22q11.2 deletion syndrome with decreased serum calcium during recovery following thyrotoxicosis. International journal

Shota Hiroshima, Chihiro Taniguchi, Mika Inoue, Hirohito Sone, Keisuke Nagasaki

Congenital anomalies 2022.8

Effect of heat-moisture treated brown rice crackers on postprandial flow-mediated dilation in adults with mild endothelial dysfunction. International journal

Kenichi Watanabe, Masao Hirayama, Somasundaram Arumugam, Masayoshi Sugawara, Hisanori Kato, Sumiko Nakamura, Ken'ichi Ohtsubo, Hitoshi Matsumoto, Yuri Nomi, Noriyuki Homma, Yoshifumi Fujii, Naoto Murohashi, Rajarajan A Thandavarayan, Hiroshi Suzuki, Kazuya Fujihara, Satoru Kodama, Hirohito Sone

Heliyon 8 ( 8 ) e10284 2022.8

Language：English Publishing type：Research paper (scientific journal)

Background: Endothelial dysfunction is an early pathophysiological feature and independent predictor of a poor prognosis in most forms of cardiovascular disease. We evaluated the effect of brown rice crackers (BR-C) on endothelial function. Methods: Effect of heat-moisture treated (HMT) -BR-C on postprandial flow-mediated dilation (FMD) in adults with mild endothelial dysfunction was compared with that of BR-C and white rice crackers (WR-C) in 12 adults with mild endothelial dysfunction (less than 7.0% of FMD) by a randomized, single-blind, three-treatment three-period crossover trial (UMIN 000034898). Since we considered that the FMD increase was associated with the treatment of HMT-BR-C, we examined the effect of three possible factors: postprandial glucose levels, polyphenol content, and polyphenol release from the food matrix. Results: Mean pre-intake baseline FMD values of HMT-BR-C, BR-C, and WR-C were 4.9%, 5.1%, and 4.9%, respectively, and those values 1 h post-intake were 6.3%, 5.1%, and 4.8%, respectively. There was no difference in intergroup comparisons of FMD using Dunnett's multiple comparison test. There was a significant increase in FMD only in HMT-BR-C in intragroup comparisons (P = 0.042 by paired-t test). In comparison with BR-C, no significant difference was noted in the postprandial glucose level nor in the content of total polyphenols and ferulic acid derivatives in HMT-BR-C. However, the 70% ethanol extracted from HMT-BR-C contained a significantly larger amount of free and bound ferulic acids than from BR-C. Conclusion: HMT-BR-C intake increased the postprandial FMD response.

DOI： 10.1016/j.heliyon.2022.e10284

Association between Obesity and Intake of Different Food Groups among Japanese with Type 2 Diabetes Mellitus—Japan Diabetes Clinical Data Management Study (JDDM68) International journal

Mariko Hatta, Chika Horikawa, Yasunaga Takeda, Izumi Ikeda, Sakiko Yoshizawa Morikawa, Noriko Kato, Mitsutoshi Kato, Hiroki Yokoyama, Yoshio Kurihara, Hiroshi Maegawa, Kazuya Fujihara, Hirohito Sone

Nutrients 14 ( 15 ) 2022.7

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: We investigated the association between various food groups and obesity in Japanese patients with type 2 diabetes. METHODS: 2070 patients with type 2 diabetes who attended 26 diabetes clinics throughout Japan were analyzed and were divided into obese and non-obese groups. Intakes of food groups determined by a food frequency questionnaire were compared. Odds ratios for obesity for quartiles of individual food groups were calculated using a logistic regression model. RESULTS: Non-obese patients consumed a larger variety of food groups than obese patients, with the diets of non-obese individuals closer to the traditional Japanese diet characterized by fish, seaweed, and soybeans/soy products. Among 21 food groups, low vegetable intake and high sweets intake were the most strongly associated with obesity in both men and women. Low intake of both fruits and vegetables and the combination of high intake of sweets and low intake of fruits were associated with obesity. CONCLUSIONS: Food groups and their combinations that were strongly associated with obesity in Japanese patients with type 2 diabetes were identified. Our findings also suggested an inverse association between the traditional Japanese diet and obesity.

DOI： 10.3390/nu14153034

生活習慣・栄養分野におけるガイドライン2022のトピックスと今後の課題脂質改善・動脈硬化予防のための運動・身体活動

木庭新治, 曽根博仁, 児玉暁, 藤原和哉, 横田裕哉, 宮下政司, 井上茂

日本動脈硬化学会総会プログラム・抄録集 54回 151 - 151 2022.7

Impact of metabolic syndrome and metabolic dysfunction-associated fatty liver disease on cardiovascular risk by the presence or absence of type 2 diabetes and according to sex. International journal

Yasuhiro Matsubayashi, Kazuya Fujihara, Mayuko Yamada-Harada, Yurie Mitsuma, Takaaki Sato, Yuta Yaguchi, Taeko Osawa, Masahiko Yamamoto, Masaru Kitazawa, Takaho Yamada, Satoru Kodama, Hirohito Sone

Cardiovascular diabetology 21 ( 1 ) 90 - 90 2022.6

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: To determine the impact of metabolic syndrome (MetS) and/or metabolic dysfunction-associated fatty liver disease (MAFLD), which are pathophysiologically similar and include insulin resistance, on the development of new-onset cardiovascular disease with and without type 2 diabetes and according to sex. METHODS: This study included 570,426 individuals without a history of cardiovascular disease who were enrolled in a nationwide claims database from 2008 to 2016 and were classified by the presence or absence of MetS and/or MAFLD stratified by the presence or absence of type 2 diabetes and sex. The fatty liver index was used to determine the presence or absence of fatty liver that required a diagnosis of MAFLD. Risks of developing coronary artery disease (CAD) and cerebrovascular disease (CVD) in each category were analyzed using a multivariate Cox proportional hazard model. RESULTS: During a median follow-up of 5.2 years, 2252 CAD and 3128 CVD events occurred. Without type 2 diabetes the hazard ratio (HR) (95% CI) for CAD/CVD compared with neither MAFLD nor MetS was 1.32 (1.17-1.50)/1.41(1.28-1.57) for MAFLD only (without MetS), 1.78 (1.22-2.58)/1.66 (1.34-2.06) for MetS only (without MAFLD), and 2.10 (1.84-2.39)/1.73 (1.54-1.95) for MAFLD + MetS. For those with type 2 diabetes, the HR for CAD for MAFLD only (compared with neither MAFLD nor MetS) was 1.29 (1.06-1.58), for MetS only 1.34 (0.84-2.13), and for MAFLD + MetS 1.22 (1.02-1.47). For CVD, there was a significant increase in HR only in MAFLD + MetS [1.44 (1.18-1.76)]. The results of the analysis stratified by sex showed that MAFLD had a greater impact in men, and MetS had a greater impact in women regarding the development of CAD. CONCLUSIONS: Distinguishing between MetS and/or MAFLD in the presence or absence of type 2 diabetes and according to sex may aid in accurately identifying patients at high risk of cardiovascular disease.

DOI： 10.1186/s12933-022-01518-4