Faculty Profiles - SONE, Hirohito

Papers - SONE, Hirohito

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Factors associated with inappropriate weight loss attempts by early adolescent girls in Japan Reviewed

A. Sugawara, M. Sato, K. Totsuka, K. Saito, S. Kodama, A. Fukushi, Y. Yamanashi, E. Matsushima, Y. Fujiwara, E. Suzuki, K. Kondo, S. Yamamoto, H. Sone

Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity 16 ( 3 ) e157 - e163 2011.9

AMP-activated protein kinase activates neuropeptide Y neurons in the hypothalamic arcuate nucleus to increase food intake in rats. International journal

Daisuke Kohno, Hideyuki Sone, Shigeyasu Tanaka, Hideharu Kurita, Darambazar Gantulga, Toshihiko Yada

Neuroscience letters 499 ( 3 ) 194 - 8 2011.7

Language：English Publishing type：Research paper (scientific journal)

AMP-activated protein kinase (AMPK) is an energy sensor that is activated by the increase of intracellular AMP:ATP ratio. AMPK in the hypothalamic arcuate nucleus (ARC) is activated during fasting and the activation of AMPK stimulates food intake. To clarify the pathway underlying AMPK-induced feeding, we monitored the activity of single ARC neurons by measuring cytosolic Ca(2+) concentration ([Ca(2+)](i)) with fura-2 fluorescence imaging. An AMPK activator, AICA-riboside (AICAR), at 200 μM increased [Ca(2+)](i) in 24% of ARC neurons. AMPK and acetyl CoA carboxylase were phosphorylated in the neurons with [Ca(2+)](i) responses to AICAR. AICAR-induced [Ca(2+)](i) increases were inhibited by Ca(2+)-free condition but not by thapsigargin, suggesting that AICAR increases [Ca(2+)](i) through Ca(2+) influx from extracellular space. Among AICAR-responding ARC neurons, 38% were neuropeptide Y (NPY)-immunoreactive neurons while no proopiomelanocortin (POMC)-immunoreactive neuron was observed. Intracerebroventricular administration of AICAR increased food intake, and the AICAR-induced food intake was abolished by the co-administration of NPY Y1 receptor antagonist, 1229U91. These results indicate that the activation of AMPK leads to the activation of ARC NPY neurons through Ca(2+) influx, thereby causing NPY-dependent food intake. These mechanisms could be implicated in the stimulation of food intake by physiological orexigenic substances.

DOI： 10.1016/j.neulet.2011.05.060

PubMed

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Weight History as a Screening Tool for Identifying Undiagnosed Diabetes and Pre-Diabetes in Japanese Men: The Toranomon Hospital Health Management Center Study (TOPICS) Reviewed

Sakiko Yoshizawa, Yoriko Heianza, Kazuya Fujiwara, Shigeko Hara, Kazumi Saito, Hiroshi Tsuji, Satoru Kodama, Yasuji Arase, Nobuhiro Yamada, Kinori Kosaka, Hirohito Sone

DIABETES 60 A235 - A235 2011.7

Weight History as a Screening Tool for Identifying Undiagnosed Diabetes and Pre-Diabetes in Japanese Men: The Toranomon Hospital Health Management Center Study (TOPICS) Reviewed

Sakiko Yoshizawa, Yoriko Heianza, Kazuya Fujiwara, Shigeko Hara, Kazumi Saito, Hiroshi Tsuji, Satoru Kodama, Yasuji Arase, Nobuhiro Yamada, Kinori Kosaka, Hirohito Sone

DIABETES 60 A235 - A235 2011.7

Nifedipine, a calcium-channel blocker, attenuated glucose intolerance and white adipose tissue dysfunction in type 2 diabetic KK-A y Mice

Masaru Iwai, Harumi Kanno, Shinji Inaba, Izumi Senba, Hisako Sone, Hirotomo Nakaoka, Masatsugu Horiuchi

American Journal of Hypertension 24 ( 2 ) 169 - 174 2011.2

Nanometer resolution stress measurement of the Si gate using illumination-collection-type scanning near-field Raman spectroscopy with a completely metal-inside-coated pyramidal probe.

Hosaka S, Aramomi Y, Sone H, Yin Y, Sato E, Tochigi K

2011.1

[Diabetes mellitus and metabolic syndrome in epidemiological studies]. Reviewed

Sone H

Nihon rinsho. Japanese journal of clinical medicine 69 Suppl 1 93 - 100 2011.1

HbA1c Variability and Risk of Development of Microalbuminuria in Japanese Patients with Type 2 Diabetes: A Pilot Study, Tsukuba Kawai Diabetes Registry 3

Hirohito Sone

Diabetes 2011

Self-Reported Rate of Eating Is Associated with BMI but Not with Glycemic Control Status in Japanese Patients with Type 2 Diabetes

Hirohito Sone

Diabetes 2011

Evaluation of Clinical Predictors of Vulnerable Coronary Plaque Detected by CT Angiography in Asymptomatic Patients with Type 2 Diabetes (T2DM)

Hirohito Sone

Diabetes 2011

[Prevention and management of atherosclerotic complications of diabetes]. Reviewed

Sone H

Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 48 ( 3 ) 253 - 256 2011

Flow-Mediated Dilation is Associated with Microalbuminuria Independent of Cardiovascular Risk Factors in Type 2 Diabetes - Interrelations with Arterial Thickness and Stiffness Reviewed

Hiroki Yokoyama, Hirohito Sone, Kazumi Saito, Daishiro Yamada, Jun Honjo, Masakazu Haneda

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 18 ( 9 ) 744 - 752 2011

[Epidemiology of diabetic microangiopathy in Japan--comparison with Western countries]. Reviewed

Sone H

Nihon rinsho. Japanese journal of clinical medicine 68 Suppl 9 13 - 20 2010.11

Comparison between Fasting and Post-Load Glucose Values as a Continuous Risk Factor for Cardiovascular Disease: A Meta-Analysis Reviewed

Satoru Kodama, Chika Horikawa, Yui Anasako, Kazumi Saito, Reiko Hirasawa, Yoko Ibe, Yoko Yachi, Miho Asumi, Hitoshi Shimano, Nobuhiro Yamada, Hirohito Sone

DIABETES 59 ( Suppl ) A298 - A298 2010.6

Body image: International comparisons: From the symposium held at the 15th international congress of dietetics Reviewed

Ayumi Sugawara, Jun Yanagishita, Ayami Sano, Yueching Wong, Duc Son N.T Le, Jeanne B. Martin, Shigeru Yamamoto, Hirohito Sone

Nutrition Today 45 ( 3 ) 113 - 117 2010.5

Absorption and effectiveness of orally administered low molecular weight collagen hydrolysate in rats.

Watanabe-Kamiyama M, Shimizu M, Kamiyama S, Taguchi Y, Sone H, Morimatsu F, Shirakawa H, Furukawa Y, Komai M

2010.1

Oxygenomics in environmental stress

Hirohito Sone

Redox Report 2010

Low HDL Cholesterol Is Associated With the Risk of Stroke in Elderly Diabetic Individuals Changes in the risk for atherosclerotic diseases at various ages Reviewed

Tosmo Hayashi, Seinosuke Kawashima, Hideki Itoh, Nobuhiro Yamada, Hirohito Sone, Hiroshi Watanabe, Yoshiyuki Hattori, Takashi Ohrui, Koutaro Yokote, Hideki Nomura, Hiroyuki Umegaki, Akihisa Iguchi

DIABETES CARE 32 ( 7 ) 1221 - 1223 2009.7

[Progress in clinical care of cardiovascular diseases complicated with diabetes mellitus]. Reviewed

Sone H, Yamada N

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 98 ( 4 ) 794 - 801 2009.4

1) Current Status of Diabetic Vascular Complication in Japan. from the View Point of the Results of Japan Diabetes Complication Study (JDCS)

Sone Hirohito, Akanuma Yasuo, Yamada Nobuhiro

Nihon Naika Gakkai Kaishi 98 84a - 84a 2009

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Papers - SONE, Hirohito