Faculty Profiles - SONE, Hirohito

Papers - SONE, Hirohito

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Weight History as a Screening Tool for Identifying Undiagnosed Diabetes and Pre-Diabetes in Japanese Men: The Toranomon Hospital Health Management Center Study (TOPICS) Reviewed

Sakiko Yoshizawa, Yoriko Heianza, Kazuya Fujiwara, Shigeko Hara, Kazumi Saito, Hiroshi Tsuji, Satoru Kodama, Yasuji Arase, Nobuhiro Yamada, Kinori Kosaka, Hirohito Sone

DIABETES 60 A235 - A235 2011.7

Nifedipine, a calcium-channel blocker, attenuated glucose intolerance and white adipose tissue dysfunction in type 2 diabetic KK-A y Mice

Masaru Iwai, Harumi Kanno, Shinji Inaba, Izumi Senba, Hisako Sone, Hirotomo Nakaoka, Masatsugu Horiuchi

American Journal of Hypertension 24 ( 2 ) 169 - 174 2011.2

Language：English Publishing type：Research paper (scientific journal)

BackgroundTo explore the metabolic actions of nifedipine on diabetes, we examined glucose intolerance and white adipose tissue changes in type 2 diabetic KK-A y mice.MethodsMale KK-A y mice were treated with nifedipine (1.5mg/kg/day in lab chow) for 5 weeks, which did not affect blood pressure or feeding of KK-A y mice.ResultsAfter treatment with nifedipine, body weight tended to decrease and the weight of white adipose tissue was reduced. Without food restriction, nifedipine decreased plasma insulin level, while plasma glucose level tended to decrease. In oral glucose tolerance test, nifedipine suppressed the increase in glucose level after a glucose load without affecting plasma insulin concentration. Nifedipine also improved the result of insulin tolerance test. In white adipose tissue, nifedipine increased adipocyte number and the expression of peroxisome proliferator-activated receptor-γ (PPARγ) and adipocyte fatty acid-binding protein related to adipocyte differentiation. In addition, expression of adiponectin, insulin receptor, insulin receptor substrate-1, and glucose transporter type-4 was also increased by nifedipine. Nifedipine also increased the expression of NO synthase in white adipose tissue. Nifedipine did not affect expression of angiotensin II type 1 (AT 1) and type 2 (AT 2) receptors in white adipose tissue. Such changes in white adipose tissue were apparent in retroperitoneal adipose tissue. Nifedipine did not change the expression of angiotensin receptors, renin receptor, and angiotensinogen in white adipose tissue. Moreover, nifedipine attenuated nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity and increased superoxide dismutase (SOD) activity in white adipose tissue.ConclusionThese results suggest that nifedipine can enhance insulin sensitivity and reduce white adipose tissue, possibly related to stimulation of adipocyte differentiation. © 2011 American Journal of Hypertension, Ltd.

DOI： 10.1038/ajh.2010.198

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Nanometer resolution stress measurement of the Si gate using illumination-collection-type scanning near-field Raman spectroscopy with a completely metal-inside-coated pyramidal probe.

Hosaka S, Aramomi Y, Sone H, Yin Y, Sato E, Tochigi K

2011.1

[Diabetes mellitus and metabolic syndrome in epidemiological studies]. Reviewed

Sone H

Nihon rinsho. Japanese journal of clinical medicine 69 Suppl 1 93 - 100 2011.1

HbA1c Variability and Risk of Development of Microalbuminuria in Japanese Patients with Type 2 Diabetes: A Pilot Study, Tsukuba Kawai Diabetes Registry 3

Hirohito Sone

Diabetes 2011

Self-Reported Rate of Eating Is Associated with BMI but Not with Glycemic Control Status in Japanese Patients with Type 2 Diabetes

Hirohito Sone

Diabetes 2011

Evaluation of Clinical Predictors of Vulnerable Coronary Plaque Detected by CT Angiography in Asymptomatic Patients with Type 2 Diabetes (T2DM)

Hirohito Sone

Diabetes 2011

[Prevention and management of atherosclerotic complications of diabetes]. Reviewed

Sone H

Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 48 ( 3 ) 253 - 256 2011

Flow-Mediated Dilation is Associated with Microalbuminuria Independent of Cardiovascular Risk Factors in Type 2 Diabetes - Interrelations with Arterial Thickness and Stiffness Reviewed

Hiroki Yokoyama, Hirohito Sone, Kazumi Saito, Daishiro Yamada, Jun Honjo, Masakazu Haneda

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 18 ( 9 ) 744 - 752 2011

Language：English Publishing type：Research paper (scientific journal) Publisher：JAPAN ATHEROSCLEROSIS SOC

Aims: To investigate whether endothelial dysfunction assessed by brachial artery flow-mediated dilation (FMD) is associated with urinary albumin excretion (UAE) and is interrelated with carotid intima-media thickness (IMT) and pulse-wave velocity (PWV) in type 2 diabetes.Methods: We measured FMD, IMT and PWV in 158 subjects with type 2 diabetes (normo- 49, micro- 64, macroalbuminuria 45), explored the determinants of FMD, and analyzed the relationship of FMD with traditional cardiovascular risk factors according to IMT and PWV levels.Results: Microalbuminuria was significantly associated with lower FMD, higher IMT and higher PWV compared to normoalbuminuria (p<0.001 for all). FMD was significantly correlated with IMT and PWV, and also with traditional risk factors, UAE, glomerular filtration rate, diabetic retinopathy, and neuropathy. Multivariate regression analysis revealed that UAE remained a significant determinant of FMD independent of traditional risk factors, metabolic control, and renal function. The relationship of FMD with IMT and PWV was less pronounced in subjects with increased IMT and PWV.Conclusions: In individuals with type 2 diabetes, FMD is impaired in subjects with microalbuminuria and is associated with IMT and PWV only when these values are not increased, i.e., at an early stage of atherosclerosis.

DOI： 10.5551/jat.7526

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[Epidemiology of diabetic microangiopathy in Japan--comparison with Western countries]. Reviewed

Sone H

Nihon rinsho. Japanese journal of clinical medicine 68 Suppl 9 13 - 20 2010.11

Comparison between Fasting and Post-Load Glucose Values as a Continuous Risk Factor for Cardiovascular Disease: A Meta-Analysis Reviewed

Satoru Kodama, Chika Horikawa, Yui Anasako, Kazumi Saito, Reiko Hirasawa, Yoko Ibe, Yoko Yachi, Miho Asumi, Hitoshi Shimano, Nobuhiro Yamada, Hirohito Sone

DIABETES 59 ( Suppl ) A298 - A298 2010.6

[Japan Diabetes Complications Study (JDCS)]. Reviewed

Sone H, Yamada N

Nihon rinsho. Japanese journal of clinical medicine 70 Suppl 3 281 - 289 2010.5

Body image: International comparisons: From the symposium held at the 15th international congress of dietetics Reviewed

Ayumi Sugawara, Jun Yanagishita, Ayami Sano, Yueching Wong, Duc Son N.T Le, Jeanne B. Martin, Shigeru Yamamoto, Hirohito Sone

Nutrition Today 45 ( 3 ) 113 - 117 2010.5

Authorship：Corresponding author Language：English Publishing type：Research paper (international conference proceedings)

To be thin is the desire of many young women because of idealized body images in the media as well as cultural factors. This review summarizes the content of the symposium, "International Comparison of Body Image," which was part of the 15th International Congress of Dietetics held in Yokohama, Japan, on September 8 to 11, 2008. Body image is a term that refers to one's perception of his/her own physical appearance and how that body appears to others. A negative body image usually has unfavorable consequences, such as the development of an eating disorder. The desire for thinness is widespread, even in non-Western countries. For example, young Japanese women have an even stronger desire to be thin than their American or Vietnamese counterparts. Abnormal eating behaviors are common among adolescents in both Western and non-Western countries. Therefore, we should monitor inappropriate weight loss attempts, especially by adolescents in all countries. Copyright © 2010 Lippincott Williams &amp
Wilkins.

DOI： 10.1097/NT.0b013e3181dec6bb

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Absorption and effectiveness of orally administered low molecular weight collagen hydrolysate in rats.

Watanabe-Kamiyama M, Shimizu M, Kamiyama S, Taguchi Y, Sone H, Morimatsu F, Shirakawa H, Furukawa Y, Komai M

2010.1

Oxygenomics in environmental stress

Hirohito Sone

Redox Report 2010

Low HDL Cholesterol Is Associated With the Risk of Stroke in Elderly Diabetic Individuals Changes in the risk for atherosclerotic diseases at various ages Reviewed

Tosmo Hayashi, Seinosuke Kawashima, Hideki Itoh, Nobuhiro Yamada, Hirohito Sone, Hiroshi Watanabe, Yoshiyuki Hattori, Takashi Ohrui, Koutaro Yokote, Hideki Nomura, Hiroyuki Umegaki, Akihisa Iguchi

DIABETES CARE 32 ( 7 ) 1221 - 1223 2009.7

Language：English Publishing type：Research paper (scientific journal) Publisher：AMER DIABETES ASSOC

OBJECTIVE - To clarify the relationship between lipid levels and ischemic heart disease (IHD) and cerebrovascular disease (CVD) in diabetic individuals.
RESEARCH DESIGN AND METHODS - The Japan Cholesterol and Diabetes Mellitus Study is a prospective cohort study of 4,014 type 2 diabetic patients (1,936 women; mean +/- SD age 67.4 +/- 9.5 years). Lipid and glucose levels and other factors were investigated in relation to occurrence of IHD or CVD.
RESULTS - IHD and CVD occurred in 1.59 and 1.43% of participants, respectively, over a 2-year period. The relation of lower HDL or higher LDL cholesterol to occurrence of IHD in subjects <65 years old was significant. Lower HDL cholesterol was also significantly related to CVD in subjects :65 years old and especially in those >75 years old (n = 1,016 odds ratio 0.511 [95% CI 0.239-0.918]; P < 0.05). Stepwise multiple regression analysis with onset of CVD as a dependent variable showed the same result.
CONCLUSIONS - Lower HDL cholesterol is an important risk factor for not only IHD but also CVD, especially in diabetic elderly individuals.

DOI： 10.2337/dc08-1677

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[Progress in clinical care of cardiovascular diseases complicated with diabetes mellitus]. Reviewed

Sone H, Yamada N

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 98 ( 4 ) 794 - 801 2009.4

1) Current Status of Diabetic Vascular Complication in Japan. from the View Point of the Results of Japan Diabetes Complication Study (JDCS)

Sone Hirohito, Akanuma Yasuo, Yamada Nobuhiro

Nihon Naika Gakkai Kaishi 98 84a - 84a 2009

Effect of low-intensity exercise training on glucose and lipid metabolism and cardiorespiratory fitness in the elderly Reviewed

Kodama Satoru, Miao Shu, Kazumi Saito, Haruka Murakami, Tomohiro Okura, Kiyoji Tanaka, Shinya Kuno, Ryuichi Ajisaka, Nobuhiro Yamada, Hirohito Sone

JOURNAL OF AGING AND PHYSICAL ACTIVITY 16 ( Suppl. S ) S111 - S112 2008.7

Effect of different dietary carbohydrate/fat ratios on glucose metabolism in type 2 diabetic patients: A meta-analysis Reviewed

Satoru Kodama, Kazumi Saito, Yoko Yachi, Yoko Ibe, Mihoko Asumi, Miho Maki, Emiko Suzuki, Hitoshi Shimano, Nobuhiro Yamada, Hirohito Sone

DIABETES 57 A470 - A470 2008.6

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Papers - SONE, Hirohito