Faculty Profiles - SONE, Hirohito

アレルギーの食餌制限によりヨード欠乏症を来した成人男性の一例

日本人2型糖尿病患者における、年齢層別に見た食塩摂取量と心血管疾患発症との関係 J-EDIT・JDCSの解析から

堀川千嘉, 相田麗, 田中司朗, 鎌田智英実, 田中佐知子, 吉村幸雄, 小寺玲美, 藤原和哉, 守屋達美, 井藤英喜, 赤沼安夫, 荒木厚, 曽根博仁

糖尿病 65 ( Suppl.1 ) S - 142 2022.4

日本人2型糖尿病患者における食品群摂取量と肥満の関連 JDDMにおける検討

治田麻理子, 堀川千嘉, 武田安永, 池田泉, 森川咲子, 加藤則子, 加藤光敏, 横山宏樹, 栗原義夫, 前川聡, 藤原和哉, 曽根博仁, 糖尿病データマネジメント研究会

糖尿病 65 ( Suppl.1 ) S - 131 2022.4

妊娠中期における糖代謝状態と低出生体重児出産との関連の検討

谷内洋子, 山田貴穂, 藤原和哉, 生魚薫, 堀川千嘉, 田中康弘, 龍野一郎, 曽根博仁

糖尿病 65 ( Suppl.1 ) S - 214 2022.4

肥満における各野菜摂取頻度と遺伝子・環境相互作用の検討

藤原和哉, 野川駿, 齋藤憲司, 堀川千嘉, 武田安永, 張かおり, 石黒創, 児玉暁, 曽根博仁

糖尿病 65 ( Suppl.1 ) S - 160 2022.4

滝澤大輝, 日向裕大, 橋本浩平, 松林泰弘, 岩永みどり, 山田貴穂, 藤原和哉, 長崎啓祐, 曽根博仁

日本内分泌学会雑誌 98 ( 1 ) 349 - 349 2022.4

肥満傾向または肥満を合併した2型糖尿病高リスクを有する男性に対する血糖自己測定SMBGと栄養教育ツールを併用した栄養教育の効果

長谷川美代, 堀川千嘉, 田代稔, 鈴木沙織, 藤原和哉, 北澤勝, 加藤公則, 田中司朗, 曽根博仁

日本栄養士会雑誌 65 ( 3 ) 159 - 168 2022.3

Language：Japanese Publisher：(公社)日本栄養士会

肥満傾向または肥満を合併した2型糖尿病高リスク者において、摂取した食事の全体量、食べ方を振り返り、食後血糖との関連を把握できるための栄養教育とSMBGとの併用効果が血糖コントロールやBMIの改善に有効であるかを検討した。対象は、医療機関未受診の20〜69歳男性でHbA1c5.6%以上6.5%未満かつBMI24kg/m2以上の者31人を介入群15人、対照群16人に無作為化クラスター割り付けした。介入群には半年間週2回夕食2時間後にSMBGを行い、食事摂取と食後血糖の関係を認識するよう促し、その間管理栄養士と保健師が3回の栄養教育を実施し、対照群には3回の栄養教育のみ行った。解析条件を満たした者は介入群11人、対照群10人であった。介入群と対照群のHbA1cとBMIは、介入前後の変化量に有意差は認められなかった(p=0.09、0.44)。炭水化物エネルギー比は、介入群のみ介入後の比率が増える傾向にあった(p=0.06)。介入群では、内的誘惑に対する統制感が有意に改善した(p=0.01)。また、「食事量」の行動において介入群、対照群共に有意な改善が見られた(p=0.02、p=0.01)。SMBGと本栄養教育の併用が、1食における3大栄養素や食品群の適量を把握し、「栄養素が血糖に変わる速度と割合」の理解につながること、行動の振り返りと問題点の改善が自己効力感を高め、前向きな行動変容につながることが示唆された。(著者抄録)

Leisure-time physical activity and incidence of objectively assessed hearing loss: The Niigata Wellness Study. International journal

Ryoko Kawakami, Susumu S Sawada, Kiminori Kato, Yuko Gando, Haruki Momma, Hideaki Oike, Motohiko Miyachi, I-Min Lee, Minoru Tashiro, Chika Horikawa, Hajime Ishiguro, Yasuhiro Matsubayashi, Kazuya Fujihara, Hirohito Sone

Scandinavian journal of medicine & science in sports 32 ( 2 ) 435 - 445 2022.2

Language：English Publishing type：Research paper (scientific journal)

Previous cohort study reported that high physical activity was associated with a low risk of self-reported hearing loss in women. However, no studies have examined the association between physical activity and the development of hearing loss as measured using an objective assessment of hearing loss in men and women. Here, we used cohort data to examine the association between leisure-time physical activity and incidence of objectively assessed hearing loss in men and women. Participants included 27 537 Japanese adults aged 20-80 years without hearing loss, who completed a self-administered physical activity questionnaire between April 2001 and March 2002. The participants were followed up for the development of hearing loss as measured by audiometry between April 2002 and March 2008. During follow-up, 3691 participants developed hearing loss. Compared with the none physical activity group, multivariable adjusted hazard ratios (HRs) for developing hearing loss were 0.93 (95% confidence interval (CI), 0.86-1.01) and 0.87 (0.81-0.95) for the medium (<525 MET-min/week) and high (≥525 MET-min/week) physical activity groups, respectively (p for trend = 0.001). The magnitude of risk reduction was slightly greater in vigorous-intensity activity than in moderate-intensity activity (p for interaction = 0.01). Analysis by sound frequency showed that the amount of physical activity was inversely associated with high frequency hearing loss development (p for trend <0.001), but not with low frequency hearing loss development (p for trend = 0.19). Higher level of leisure-time physical activity was associated with lower incidence of hearing loss, particularly for vigorous-intensity activities and high sound frequencies.

DOI： 10.1111/sms.14089

Morphological and functional adaptation of pancreatic islet blood vessels to insulin resistance is impaired in diabetic db/db mice. International journal

Yuka Okajima, Takashi Matsuzaka, Shun Miyazaki, Kaori Motomura, Hiroshi Ohno, Rahul Sharma, Takuya Shimura, Nurani Istiqamah, Song-Iee Han, Yuhei Mizunoe, Yoshinori Osaki, Hitoshi Iwasaki, Shigeru Yatoh, Hiroaki Suzuki, Hirohito Sone, Takafumi Miyamoto, Yuichi Aita, Yoshinori Takeuchi, Motohiro Sekiya, Naoya Yahagi, Yoshimi Nakagawa, Tsutomu Tomita, Hitoshi Shimano

Biochimica et biophysica acta. Molecular basis of disease 1868 ( 4 ) 166339 - 166339 2022.1

Language：English Publishing type：Research paper (scientific journal)

The pancreatic islet vasculature is of fundamental importance to the β-cell response to obesity-associated insulin resistance. To explore islet vascular alterations in the pathogenesis of type 2 diabetes, we evaluated two insulin resistance models: ob/ob mice, which sustain large β-cell mass and hyperinsulinemia, and db/db mice, which progress to diabetes due to secondary β-cell compensation failure for insulin secretion. Time-dependent changes in islet vasculature and blood flow were investigated using tomato lectin staining and in vivo live imaging. Marked islet capillary dilation was observed in ob/ob mice, but this adaptive change was blunted in db/db mice. Islet blood flow volume was augmented in ob/ob mice, whereas it was reduced in db/db mice. The protein concentrations of total and phosphorylated endothelial nitric oxide synthase (eNOS) at Ser1177 were increased in ob/ob islets, while they were diminished in db/db mice, indicating decreased eNOS activity. This was accompanied by an increased retention of advanced glycation end-products in db/db blood vessels. Amelioration of diabetes by Elovl6 deficiency involved a restoration of capillary dilation, blood flow, and eNOS phosphorylation in db/db islets. Our findings suggest that the disability of islet capillary dilation due to endothelial dysfunction impairs local islet blood flow, which may play a role in the loss of β-cell function and further exacerbate type 2 diabetes.

DOI： 10.1016/j.bbadis.2022.166339

Higher Iron Intake Is Independently Associated with Obesity in Younger Japanese Type-2 Diabetes Mellitus Patients International journal

Efrem d'Ávila, Mariko Hatta, Yasunaga Takeda, Chika Horikawa, Mizuki Takeuchi, Noriko Kato, Hiroki Yokoyama, Yoshio Kurihara, Koichi Iwasaki, Kazuya Fujihara, Hiroshi Maegawa, Hirohito Sone

Nutrients 14 ( 1 ) 2022.1

Language：English Publishing type：Research paper (scientific journal)

We aimed to analyze the association between dietary iron intake and obesity assessed by BMI after adjustment for nutrient intake (macronutrients and fiber) and food groups. The study design was cross-sectional. Patients with type-2 diabetes (n = 1567; 63.1% males; mean age 62.3 ± 11.6 years) were included in the study. To assess diet, consumption of typical food groups was determined by a food frequency questionnaire. Obesity was defined as BMI ≥ 25 kg/m2. We performed a binary regression analysis between quartiles of iron intake and obesity by quartiles of age group. A direct linear association was found for the highest quartile of iron intake and obesity in the younger age group of 30 to 54 years (OR = 3.641, 95% CI = 1.020-12.990; p trend = 0.011). Multivariate analysis using food groups as opposed to nutrients revealed a positive trend for obesity in the younger age group after adjusting for lifestyle factors, energy intake and bean and vegetable intake (p trend = 0.023). In all participants, an inverse association was observed before adjustment by vegetable intake (OR = 0.453, 95% CI = 0.300-0.684; p trend = 0.001). Higher iron intake was associated with obesity independent of macronutrient and fiber intake but only in the youngest quartile of age group examined.

DOI： 10.3390/nu14010211