研究者詳細 - 寺井　崇二

論文 - 寺井　崇二

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膵癌早期発見を目指した新潟県膵癌ネットワーク(Phoenix Study)の構築と膵癌病態解析に関する多施設後方視的観察研究

五十嵐聡, 林和直, 寺井崇二

日本消化器病学会雑誌 117 ( 臨増総会 ) A258 - A258 2020年7月

当院におけるIgG4関連硬化性胆管炎の診断の現状と課題

田中裕登, 林和直, 五十嵐聡, 寺井崇二

日本消化器病学会雑誌 117 ( 臨増総会 ) A298 - A298 2020年7月

EUS-FNAが術前診断に有用であった十二指腸Brunner腺過誤腫出血の1切除例

荒生祥尚, 小林正明, 池見雅俊, 塩路和彦, 清野智, 阿部寛幸, 岩城孝和, 田口貴博, 谷優佑, 寺井崇二

Gastroenterological Endoscopy 62 ( 7 ) 778 - 784 2020年7月

肝胆膵疾患における血清DPPIV解析

林和直, 五十嵐聡, 土屋淳紀, 寺井崇二

日本消化器病学会雑誌 117 ( 臨増総会 ) A387 - A387 2020年7月

消化器疾患における移植医療の現状と問題点本県の急性肝不全診療におけるネットワーク構築の取り組み

薛徹, 土屋淳紀, 寺井崇二

日本消化器病学会雑誌 117 ( 臨増総会 ) A73 - A73 2020年7月

肝硬変に対する間葉系幹細胞由来エクソソーム治療のライブイメージング技術、Single cell RNA-seqを用いたメカニズム解析

土屋淳紀, 竹内卓, 寺井崇二

日本消化器病学会雑誌 117 ( 臨増総会 ) A238 - A238 2020年7月

肝硬変患者のQOL・予後の改善と基盤研究の最前線 IFN-γ刺激下間葉系幹細胞由来エクソソームの肝線維化改善における効果・メカニズムの検証

土屋淳紀, 竹内卓, 寺井崇二

日本消化器病学会雑誌 117 ( 臨増総会 ) A97 - A97 2020年7月

胃瘻造設によりS状結腸間膜穿孔をきたした一例

吉田悠紀, 川田雄三, 永山逸夫, 野澤良祐, 冨永顕太郎, 薛徹, 横尾健, 水野研一, 寺井崇二

ENDOSCOPIC FORUM for digestive disease 36 ( 1 ) 46 - 46 2020年7月

肝癌治療に対する内科外科のすみわけと連携における放射線治療の役割

上村顕也, 柴田理, 大越麻理奈, 寺井崇二

日本消化器病学会雑誌 117 ( 臨増総会 ) A292 - A292 2020年7月

非アルコール性脂肪性肝疾患(NAFLD)の病態進行における自律神経を介した臓器間ネットワークの関与

高昌良, 上村顕也, 名古屋拓郎, 酒井規裕, 坂牧僚, 横尾健, 寺井崇二

日本門脈圧亢進症学会雑誌 26 ( 2 ) 143 - 146 2020年7月

消化器疾患における共生微生物叢研究の新たな知見 NAFLDの病態における自律神経ネットワークを介した腸内細菌叢の関与

高昌良, 上村顕也, 寺井崇二

日本消化器病学会雑誌 117 ( 臨増総会 ) A78 - A78 2020年7月

肝癌分子標的薬治療時の鰹だし併用による肝予備能維持効果

小関洋平, 上村顕也, 坂牧僚, 大越麻理奈, 田中裕登, 寺井崇二

日本消化器病学会雑誌 117 ( 臨増総会 ) A296 - A296 2020年7月

臨床応用に向けた肝癌の病態解明放射線照射によるDNA損傷時のHHMの役割

丹羽佑輔, 上村顕也, 寺井崇二

日本消化器病学会雑誌 117 ( 臨増総会 ) A161 - A161 2020年7月

Cytapheresis for pyoderma gangrenosum associated with inflammatory bowel disease: A review of current status. 査読国際誌

Kentaro Tominaga, Kenya Kamimura, Hiroki Sato, Masayoshi Ko, Yuzo Kawata, Takeshi Mizusawa, Junji Yokoyama, Shuji Terai

World journal of clinical cases 8 ( 11 ) 2092 - 2101 2020年6月

記述言語：英語掲載種別：研究論文（学術雑誌）

Pyoderma gangrenosum (PG) is a neutrophilic dermatosis clinically characterized by the presence of painful skin ulcerations with erythematous. As it is frequently associated with inflammatory bowel diseases, including ulcerative colitis, gastroenterologists should be familiar with the disease including therapeutic options. Therefore, we have conducted a review focusing on the cytapheresis for PG in cases of inflammatory bowel diseases. A literature search was conducted to extract studies published in the last 20 years, with information on demographics, clinical symptoms, treatment, and the clinical course from a total of 22 cases reported and our recent case. In most patients, cytapheresis was associated with improvement or resolution of PG after failure of conventional therapeutic options such as corticosteroids, antibiotics, immunosuppressive agents and immunoglobulin. Based on the information summarized, cytapheresis is helpful in the majority of patients with PG refractory to medical treatment associated with inflammatory bowel diseases and could be further studied in a multicenter, randomized trial.

DOI： 10.12998/wjcc.v8.i11.2092

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Development of a non-alcoholic steatohepatitis model with rapid accumulation of fibrosis, and its treatment using mesenchymal stem cells and their small extracellular vesicles. 査読国際誌

Takayuki Watanabe, Atsunori Tsuchiya, Suguru Takeuchi, Shunsuke Nojiri, Tomoaki Yoshida, Masahiro Ogawa, Michiko Itoh, Masaaki Takamura, Takayoshi Suganami, Yoshihiro Ogawa, Shuji Terai

Regenerative therapy 14 252 - 261 2020年6月

記述言語：英語掲載種別：研究論文（学術雑誌）

Introduction: Currently, there are no approved drugs for treating non-alcoholic steatohepatitis (NASH); however, mesenchymal stem cells (MSCs) and their small extracellular vesicles (sEVs), which possess immunomodulatory activities, are potential candidates. This study aimed to develop a mouse model of NASH with rapid accumulation of fibrosis using the pre-established melanocortin type-4 receptor knockout (Mc4r-KO) NASH mouse model and lipopolysaccharide (LPS), and to evaluate the therapeutic effect of MSCs and their sEVs. Methods: Mc4r-KO mice (8 weeks old, male) were fed a western diet (WD) for 8 weeks. Next, the mice were intraperitoneally injected with lipopolysaccharide (LPS) twice a week for 4 weeks while continuing the WD. To confirm the therapeutic effect of MSCs and sEVs, human adipose tissue-derived MSCs or their sEVs were administered 12 weeks after initiation of the WD, and serum testing, quantitative analysis of fibrosis, and quantitative reverse transcription-polymerase chain reaction qRT-PCR were performed. Results: By providing a WD combined with LPS treatment, we successfully developed a NASH model with rapid accumulation of fibrosis. Both human MSCs and their sEVs decreased serum alanine transaminase levels and inflammatory markers based on qRT-PCR. Histological analysis showed that MSC or sEV treatment did not affect fat accumulation. However, an improvement in fibrosis in the groups treated with MSCs and their sEVs was observed. Furthermore, after administering MSCs and sEVs, there was a significant increase in anti-inflammatory macrophages in the liver. Conclusion: We successfully developed a NASH model with rapid accumulation of fibrosis and confirmed the anti-inflammatory and anti-fibrotic effects of MSCs and their sEVs, which may be options for future therapy.

DOI： 10.1016/j.reth.2020.03.012

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A rare case of peliosis hepatis in a patient with chronic renal failure and renal cell carcinoma.

Hiroki Maruyama, Kazuya Takahashi, Natsuki Ishikawa, Kazunori Hosaka, Daisuke Kumaki, Yukio Aruga, Masashi Yamakawa, Masaaki Hirano, Kazuhiro Funakoshi, Shuji Terai

Clinical journal of gastroenterology 13 ( 3 ) 403 - 407 2020年6月

記述言語：英語掲載種別：研究論文（学術雑誌）

Peliosis hepatis (PH) is a rare disease characterized by the presence of sinusoidal dilation and blood-filled cysts throughout the hepatic parenchyma. We report a case of PH in a 49-year-old woman with chronic renal failure (CRF) on hemodialysis and with renal cell carcinoma (RCC). Dynamic contrast-enhanced computed tomography (CT) showed a 35-mm-diameter, hypervascular tumor in the liver and RCC in the right renal cyst. Ultrasound and superparamagnetic iron oxide-enhanced magnetic resonance imaging were also performed; however, the liver tumor could not be distinguished from the metastasis of RCC. Therefore, echo-guided biopsy of the liver tumor using an 18-G Majima needle was performed. Histological evaluation of the specimen showed irregular sinusoidal dilatation and blood-filled cavities without malignant cells. She was ultimately diagnosed with PH. Subsequently, she underwent total right nephrectomy for RCC and was diagnosed with RCC stage 1 (pT1N0M0). A follow-up CT performed 4 months after nephrectomy showed no growth of PH. Although the development of PH in patients with CRF or RCC who do not undergo renal transplantation is extremely rare, it should be considered in the differential diagnosis to distinguish PH from the metastasis of RCC.

DOI： 10.1007/s12328-019-01068-5

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【幹細胞治療と疾患】間葉系幹細胞は"指揮細胞"としてマクロファージに作用し肝硬変の肝線維化改善、再生を誘導する自己骨髄細胞投与療法から他家脂肪組織由来間葉系幹細胞投与へ

寺井崇二, 土屋淳紀

BIO Clinica 35 ( 5 ) 406 - 410 2020年5月

Small Intestinal Bacterial Overgrowth Diagnosed by a Breath Test and Improved by Rifaximin in a Patient with Hepatic Encephalopathy and Alcoholic Liver Cirrhosis: A Case Report. 査読

Akira Sakamaki, Kunihiko Yokoyama, Fusako Yamazaki, Hiroteru Kamimura, Kenya Kamimura, Masaaki Takamura, Junji Yokoyama, Shuji Terai

Internal medicine (Tokyo, Japan) 59 ( 15 ) 1849 - 1853 2020年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

A 66-year-old Japanese man was admitted to our hospital with grade 2 hepatic encephalopathy (HE). Abdominal computed tomography and laboratory examinations revealed decompensated liver cirrhosis. Intravenous administration of branched-chain amino acids immediately ameliorated the HE, and lactulose was initiated. However, a breath test revealed small intestinal bacterial overgrowth (SIBO); therefore, rifaximin was additionally initiated. The breath test was repeated after discharge, when no evidence of SIBO or overt HE was identified. This case suggested that a breath test is effective for the identification of SIBO and that the administration of a poorly absorbed antibiotic should be considered in SIBO-positive HE patients taking lactulose.

DOI： 10.2169/internalmedicine.4593-20

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Effect of methionine/choline-deficient diet and high-fat diet-induced steatohepatitis on mitochondrial homeostasis in mice. 査読国際誌

Yoshihisa Arao, Hirokazu Kawai, Kenya Kamimura, Takamasa Kobayashi, Oki Nakano, Manabu Hayatsu, Tatsuo Ushiki, Shuji Terai

Biochemical and biophysical research communications 527 ( 2 ) 365 - 371 2020年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

Considering the increase in cases of non-alcoholic steatohepatitis (NASH), the use of appropriate animal model of NASH is essential to understand the underlying pathogenesis mechanism. To date, several mice models have been used; however, significant differences in the etiologies and food administered affected the results, with inconsistent conclusions. Therefore, it is necessary to understand these models and their differences to be able to choose appropriate models. Inspired by the fact that mitochondrial (mt)DNA content is changed in non-alcoholic fatty liver disease in humans, we investigated the mtDNA copy number in the NASH mice models induced by high-fat diet (HFD) and methionine/choline-deficient diet (MCD) to understand the differences between these models. Megamitochondria were observed in both MCD and HFD groups. However, the MCD group showed significant decrease in liver mtDNA content compared with that in the HFD group. These changes were associated with significant upregulation of mitochondrial biogenesis- and degradation-related genes in MCD model than in HFD model. Thus, stability of mtDNA is associated with the differences between MCD and HFD-induced NASH models often used in studies; these findings could help in choosing appropriate models for studies on NASH.

DOI： 10.1016/j.bbrc.2020.03.180

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Rare Genotype of His/His in NUDT15 Codon 139 and Thiopurine-associated Adverse Events in a Case of Ulcerative Colitis. 査読

Kei Tomiyoshi, Hiroki Sato, Kentaro Tominaga, Yuzo Kawata, Daisuke Okamoto, Yoichi Kakuta, Junji Yokoyama, Shuji Terai

Internal medicine (Tokyo, Japan) 59 ( 13 ) 1611 - 1613 2020年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

Thiopurine drugs are commonly used to treat immunologic diseases. However, the narrow therapeutic safety margin demands evidence-based precision medicine approaches. NUDT15 variants are associated with thiopurine-induced adverse events, particularly in Asians. We herein report a rare genotype of His/His in NUDT15 codon 139 in a case of ulcerative colitis and review the relevant literature. The patient experienced severe thiopurine-associated adverse events, including leukopenia and alopecia. There is no literature on the His/His genotype in NUDT15 codon 139, and our case suggests cautious use or the contraindication of thiopurines for patients with this genotype.

DOI： 10.2169/internalmedicine.4261-19

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