研究者詳細 - 寺井　崇二

論文 - 寺井　崇二

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Magnifying image-enhanced endoscopy for collagenous colitis. 査読

Kobayashi M, Hoshi T, Morita SI, Kanefuji T, Suda T, Hasegawa G, Terai S

Endoscopy international open 5 ( 11 ) E1069 - E1073 2017年11月

Live image and mechanistic analysis of Mesenchymal stem cells (MSCs) and induced bone marrow derived macrophages (id-BMMs) combination therapy for liver cirrhosis in mice 査読

Yusuke Watanabe, Atsunori Tsuchiya, Satoshi Seino, Syunzou Ikarashi, Suguru Takeuchi, Takayuki Watanabe, Kenya Kamimura, Masaaki Takamura, Satoshi Yamagiwa, Shuji Terai

HEPATOLOGY 66 76A - 76A 2017年10月

Effectiveness and safety of tolvaptan in liver cirrhosis patients with edema: Interim results of post-marketing surveillance of tolvaptan in liver cirrhosis (START study) 査読

Isao Sakaida, Shuji Terai, Masayuki Kurosaki, Moriyoshi Yasuda, Mitsuru Okada, Kosuke Bando, Yasuhiko Fukuta

HEPATOLOGY RESEARCH 47 ( 11 ) 1137 - 1146 2017年10月

Usefulness of follicular helper T cell subset frequencies in the diagnosis of autoimmune hepatitis 査読

Naruhiro Kimura, Satoshi Yamagiwa, Ryoko Horigome, Hiroteru Kamimura, Kenya Kamimura, Atsunori Tsuchiya, Masaaki Takamura, Hirokazu Kawai, Shuji Terai

HEPATOLOGY 66 687A - 688A 2017年10月

Persistent reduction of mucosal-associated invariant T cells in primary biliary cholangitis 査読

Toru Setsu, Satoshi Yamagiwa, Naruhiro Kimura, Hiroteru Kamimura, Atsunori Tsuchiya, Masaaki Takamura, Shuji Terai

HEPATOLOGY 66 166A - 166A 2017年10月

A Case of Hepatorenal Syndrome and Abdominal Compartment Syndrome with High Renal Congestion. 査読国際誌

Hiroteru Kamimura, Takayuki Watanabe, Tomoyuki Sugano, Nao Nakajima, Junji Yokoyama, Kenya Kamimura, Atsunori Tsuchiya, Masaaki Takamura, Hirokazu Kawai, Takashi Kato, Gen Watanabe, Satoshi Yamagiwa, Shuji Terai

The American journal of case reports 18 1000 - 1004 2017年9月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND Hepatorenal syndrome (HRS) is a reversible renal impairment that occurs in patients with acute liver failure and advanced liver cirrhosis. HRS is due to a renal vasoconstriction that results from extreme vasodilatation. It is therefore a functional disorder, not associated with structural kidney damage. On the other hand, end-stage liver diseases are often complicated by massive ascites. Massive ascites may cause abdominal compartment syndrome (ACS), which includes impairment of renal blood flow, but there are no reports indicating that kidney lesions caused by ACS may pathologically contribute to end-stage liver diseases. CASE REPORT A 40-year-old man with acute liver failure was admitted to our hospital. He was diagnosed with type 1 HRS and showed ACS at the same time. He died 30 days after admission. There were signs of congestion in the kidneys upon dissection and advanced erythroid fullness in the renal tubules. CONCLUSIONS We report an autopsy case with HRS and ACS diagnosed with a clinical and histopathological consideration of liver and kidney. Further clinical studies are needed to improve management of renal failure in patients with acute liver failure and advanced liver cirrhosis.

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A canine liver fibrosis model to develop a therapy for liver cirrhosis using cultured bone marrow-derived cells. 査読国際誌

Takashi Matsuda, Taro Takami, Ryo Sasaki, Tatsuro Nishimura, Yuki Aibe, Bruno Diaz Paredes, Luiz Fernando Quintanilha, Toshihiko Matsumoto, Tsuyoshi Ishikawa, Naoki Yamamoto, Kenji Tani, Shuji Terai, Yasuho Taura, Isao Sakaida

Hepatology communications 1 ( 7 ) 691 - 703 2017年9月

記述言語：英語掲載種別：研究論文（学術雑誌）

We have been developing a therapy for liver cirrhosis using cultured autologous bone marrow-derived mesenchymal stem cells (BMSCs). Before human clinical trials can be considered, the safety and efficacy of BMSC infusion in medium to large animals must be confirmed; thus, we developed a canine liver fibrosis model. A small amount of bone marrow fluid was aspirated from the canine humerus to assess the characteristics of BMSCs. We implanted a venous catheter in the stomach and a subcutaneous infusion port in the back of the neck of each canine. Repeated injection of CCl4 through the catheter was performed to induce liver cirrhosis. After 10 weeks of CCl4 injection, eight canines were equally divided into two groups: no cell infusion (control group) and autologous BMSC infusion through the peripheral vein (BMSC group). A variety of assays were carried out before and 4 weeks after the infusion. The area of liver fibrosis stained with sirius red was significantly reduced in the BMSC group 4 weeks after BMSC infusion, consistent with a significantly shortened half-life of indocyanine green and improved liver function. Conclusion: We established a useful canine liver fibrosis model and confirmed that cultured autologous BMSC infusion improved liver fibrosis without adverse effects. (Hepatology Communications 2017;1:691-703).

DOI： 10.1002/hep4.1071

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A Huge Abdominal Tumor Abdominal Abscess 査読

Norihiro Sakai, Kenya Kamimura, Shuji Terai

GASTROENTEROLOGY 153 ( 3 ) E5 - E6 2017年9月

HHMの肝発癌における分子生物学的メカニズムの解明

小川光平, 上村顕也, 後藤諒, 井上良介, 品川陽子, 酒井規裕, 名古屋拓郎, 小林雄司, 阿部寛幸, 阿部聡司, 坂牧僚, 横尾健, 川合弘一, 山際訓, 高見太郎, 山本直樹, 坂井田功, 寺井崇二

日本消化器病学会雑誌 114 ( 臨増大会 ) A732 - A732 2017年9月

Innovative therapeutic endoscopy 膵仮性嚢胞・感染性WONに対する内視鏡的治療重症急性膵炎後Walled-off necrosisの自然軽快に関連する因子

五十嵐聡, 林和直, 寺井崇二

Gastroenterological Endoscopy 59 ( Suppl.2 ) 2103 - 2103 2017年9月

Innovative therapeutic endoscopy 膵仮性嚢胞・感染性WONに対する内視鏡的治療重症急性膵炎後Walled-off necrosisの自然軽快に関連する因子

五十嵐聡, 林和直, 寺井崇二

日本消化器病学会雑誌 114 ( 臨増大会 ) A689 - A689 2017年9月

当院におけるBordeline resectable膵癌の治療の現況

林和直, 五十嵐聡, 水野研一, 橋本哲, 横山純二, 山際訓, 寺井崇二

日本消化器病学会雑誌 114 ( 臨増大会 ) A832 - A832 2017年9月

YAP determines the cell fate of injured mouse hepatocytes in vivo (vol 8, 16017, 2017) 査読

Norio Miyamura, Shoji Hata, Tohru Itoh, Minoru Tanaka, Miki Nishio, Michiko Itoh, Yoshihiro Ogawa, Shuji Terai, Isao Sakaida, Akira Suzuki, Atsushi Miyajima, Hiroshi Nishina

NATURE COMMUNICATIONS 8 16146 2017年8月

An Automated Self-Learning Quantification System to Identify Visible Areas in Capsule Endoscopy Images 査読

Shinichi Hashimoto, Hiroyuki Ogihara, Masato Suenaga, Yusuke Fujita, Shuji Terai, Yoshihiko Hamamoto, Isao Sakaida

JOURNAL OF MEDICAL SYSTEMS 41 ( 8 ) 119 2017年8月

YAP determines the cell fate of injured mouse hepatocytes in vivo 査読

Norio Miyamura, Shoji Hata, Tohru Itoh, Minoru Tanaka, Miki Nishio, Michiko Itoh, Yoshihiro Ogawa, Shuji Terai, Isao Sakaida, Akira Suzuki, Atsushi Miyajima, Hiroshi Nishina

NATURE COMMUNICATIONS 8 1 - 9 2017年7月

The use of clip anchoring to ensure safe transgastric puncture during endoscopic ultrasound-guided transmural drainage 査読

Shinichi Morita, Kazuo Hara, Takeshi Suda, Susumu Hijioka, Nozomi Okuno, Masaaki Kobayashi, Shuji Terai

ENDOSCOPY 49 ( 7 ) E186 - E187 2017年7月

Risk of metastasis in adenocarcinoma of the esophagus: a multicenter retrospective study in a Japanese population 査読

Ryu Ishihara, Tsuneo Oyama, Seiichiro Abe, Hiroaki Takahashi, Hiroyuki Ono, Junko Fujisaki, Mitsuru Kaise, Kenichi Goda, Kenro Kawada, Tomoyuki Koike, Manabu Takeuchi, Rie Matsuda, Dai Hirasawa, Masayoshi Yamada, Junichi Kodaira, Masaki Tanaka, Masami Omae, Akira Matsui, Takashi Kanesaka, Akiko Takahashi, Shinichi Hirooka, Masahiro Saito, Yosuke Tsuji, Yuki Maeda, Hiroharu Yamashita, Ichiro Oda, Yasuhiko Tomita, Takashi Matsunaga, Shuji Terai, Soji Ozawa, Tatsuyuki Kawano, Yasuyuki Seto

JOURNAL OF GASTROENTEROLOGY 52 ( 7 ) 800 - 808 2017年7月

Lusutrombopag increases hematocytes in a compensated liver cirrhosis patient 査読

Akira Sakamaki, Takayuki Watanabe, Satoshi Abe, Kenya Kamimura, Atsunori Tsuchiya, Masaaki Takamura, Hirokazu Kawai, Satoshi Yamagiwa, Shuji Terai

Clinical Journal of Gastroenterology 10 ( 3 ) 261 - 264 2017年6月

Spontaneous regression of hepatocellular carcinoma: A mini-review 査読

Akira Sakamaki, Kenya Kamimura, Satoshi Abe, Atsunori Tsuchiya, Masaaki Takamura, Hirokazu Kawai, Satoshi Yamagiwa, Shuji Terai

WORLD JOURNAL OF GASTROENTEROLOGY 23 ( 21 ) 3797 - 3804 2017年6月

Effect of double platinum agents, combination of miriplatintransarterial oily chemoembolization and cisplatinhepatic arterial infusion chemotherapy, in patients with hepatocellular carcinoma: Report of two cases 査読

Kohei Ogawa, Kenya Kamimura, Yukari Watanabe, Yosuke Motai, Daisuke Kumaki, Ryoya Seki, Akira Sakamaki, Satoshi Abe, Hirokazu Kawai, Takeshi Suda, Satoshi Yamagiwa, Shuji Terai

WORLD JOURNAL OF CLINICAL CASES 5 ( 6 ) 238 - 246 2017年6月

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論文 - 寺井　崇二