研究者詳細 - 寺井　崇二

論文 - 寺井　崇二

分割表示 1,167 件中 521 - 540 件目／全件表示 >>

【間葉系幹細胞の基礎と臨床応用】疾患治療他家脂肪組織由来間葉系幹細胞投与療法の開発

寺井崇二, 土屋淳紀

医学のあゆみ 272 ( 10 ) 1032 - 1039 2020年3月

Effect of Diphtheria Toxin-Based Gene Therapy for Hepatocellular Carcinoma. 査読国際誌

Kenya Kamimura, Takeshi Yokoo, Hiroyuki Abe, Norihiro Sakai, Takuro Nagoya, Yuji Kobayashi, Masato Ohtsuka, Hiromi Miura, Akira Sakamaki, Hiroteru Kamimura, Norio Miyamura, Hiroshi Nishina, Shuji Terai

Cancers 12 ( 2 ) 2020年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

Hepatocellular carcinoma (HCC) is a major global malignancy, responsible for >90% of primary liver cancers. Currently available therapeutic options have poor performances due to the highly heterogeneous nature of the tumor cells; recurrence is highly probable, and some patients develop resistances to the therapies. Accordingly, the development of a novel therapy is essential. We assessed gene therapy for HCC using a diphtheria toxin fragment A (DTA) gene-expressing plasmid, utilizing a non-viral hydrodynamics-based procedure. The antitumor effect of DTA expression in HCC cell lines (and alpha-fetoprotein (AFP) promoter selectivity) is assessed in vitro by examining HCC cell growth. Moreover, the effect and safety of the AFP promoter-selective DTA expression was examined in vivo using an HCC mice model established by the hydrodynamic gene delivery of the yes-associated protein (YAP)-expressing plasmid. The protein synthesis in DTA transfected cells is inhibited by the disappearance of tdTomato and GFP expression co-transfected upon the delivery of the DTA plasmid; the HCC cell growth is inhibited by the expression of DTA in HCC cells in an AFP promoter-selective manner. A significant inhibition of HCC occurrence and the suppression of the tumor marker of AFP and des-gamma-carboxy prothrombin can be seen in mice groups treated with hydrodynamic gene delivery of DTA, both 0 and 2 months after the YAP gene delivery. These results suggest that DTA gene therapy is effective for HCC.

DOI： 10.3390/cancers12020472

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On-line HDFを急性肝不全の患者に施行する際の診療ガイド

井上和明, 織田成人, 安部隆三, 滝川康裕, 中山伸朗, 加藤直也, 藤原慶一, 安井伸, 寺井崇二, 井戸章雄, 坂井田功, 玄田拓哉, 清水雅仁, 持田智, 滝川一

肝臓 61 ( 2 ) 47 - 60 2020年2月

Septicemic listeriosis during adalimumab- and golimumab-based treatment for ulcerative colitis: case presentation and literature review. 査読

Ryoko Horigome, Hiroki Sato, Terasu Honma, Shuji Terai

Clinical journal of gastroenterology 13 ( 1 ) 22 - 25 2020年2月

記述言語：英語

Listeria monocytogenes is a common bacterium that can trigger an episode of amphixenosis from the consumption of contaminated food. It survives in the host as an intracellular parasite and can get reactivated when the host's immune system is compromised. The use of anti-tumor necrosis factor-α (TNF-α) blockers is reported to increase the risk of L. monocytogenes infections. In the field of gastroenterology, the use of TNF-α blockers is on the rise due to remarkable efficacy in select patients with inflammatory bowel diseases (IBDs) such as ulcerative colitis and Crohn's disease and the rise in the incidence and prevalence of IBDs. There are few case reports on this topic, despite the rapid development of novel TNF-α blockers. Here, we report two cases of septicemic listeriosis encountered during treatment with the more recent TNF-α blockers, namely, adalimumab and golimumab, in ulcerative colitis and review the published literature on the topic.

DOI： 10.1007/s12328-019-01005-6

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Rare paradoxical adverse event in Crohn's disease: a case report. 査読国際誌

Marina Okoshi, Hiroki Sato, Terasu Honma, Shuji Terai

Annals of translational medicine 8 ( 4 ) 133 - 133 2020年2月

記述言語：英語

An 18-year-old male adolescent diagnosed with ileocolitis-type Crohn's disease received therapy involving an anti-tumor necrosis factor-α (TNF-α) blocker, which resulted in remission for 2 years. The patient presented with fever, stomatitis, and cough with respiratory distress. Chest radiography revealed bilateral hilar lymphadenopathy; bronchoalveolar lavage showed high lymphocyte level: 40.8% and CD4/8 value: 3.9. Transbronchial lung biopsy identified multiple non-caseating granulomas fused to each other with connective tissue septa, leading to the diagnosis of sarcoidosis. The sarcoidosis was defined as a paradoxical adverse event (PAE) due to the use of TNF-α blocker; therefore, cessation of TNF-α blocker administration was sufficient to induce remission. We report a rare case of PAE on Crohn's disease. The characteristics and distinguishing histologies of PAE and Crohn's disease are described. Biological agent therapy has been reported to cause several PAEs during the treatment of immune-mediated inflammatory disorders. PAEs are defined as pathological conditions that occur during biological agent therapy usually effective in treatment. The laboratory, radiography, and histological findings shown in this case are useful for differential diagnosis and management of PAE.

DOI： 10.21037/atm.2019.12.122

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肝癌に対する局所療法としての放射線療法の安全性と有効性の検証

大越麻理奈, 上村顕也, 柴田修, 森田慎一, 坂牧僚, 田中裕登, 小関洋平, 寺井崇二

日本内科学会雑誌 109 ( Suppl. ) 155 - 155 2020年2月

Ghrelin-insulin-like growth factor-1 axis is activated via autonomic neural circuits in the non-alcoholic fatty liver disease. 査読国際誌

Takuro Nagoya, Kenya Kamimura, Ryosuke Inoue, Masayoshi Ko, Takashi Owaki, Yusuke Niwa, Norihiro Sakai, Toru Setsu, Akira Sakamaki, Takeshi Yokoo, Hiroteru Kamimura, Yuka Nakamura, Masaki Ueno, Shuji Terai

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 32 ( 5 ) e13799 2020年1月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: The correlation of the growth hormone (GH) and insulin-like growth factor-1 (IGF-1) with non-alcoholic fatty liver disease (NAFLD) has been reported in epidemiological studies. However, the mechanisms of molecular and inter-organ systems that render these factors to influence on NAFLD have not been elucidated. In this study, we examined the induction of ghrelin which is the GH-releasing hormone and IGF-1, and involvement of autonomic neural circuits, in the pathogenesis of NAFLD. METHODS: The expression of gastric and hypothalamic ghrelin, neural activation in the brain, and serum IGF-1 were examined in NAFLD models of choline-deficient defined l-amino-acid diet-fed, melanocortin 4 receptor knockout mice, and partial hepatectomy mice with or without the blockades of autonomic nerves to test the contribution of neural circuits connecting the brain, liver, and stomach. KEY RESULTS: The fatty changes in the liver increased the expression of gastric ghrelin through the autonomic pathways which sends the neural signals to the arcuate nucleus in the hypothalamus through the afferent vagal nerve which reached the pituitary gland to release GH and then stimulate the IGF-1 release from the liver. In addition, high levels of ghrelin expression in the arcuate nucleus were correlated with NAFLD progression regardless of the circuits. CONCLUSIONS: Our study demonstrated that the fatty liver stimulates the autonomic nervous signal circuits which suppress the progression of the disease by activating the gastric ghrelin expression, the neural signal transduction in the brain, and the release of IGF-1 from the liver.

DOI： 10.1111/nmo.13799

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Prostaglandin E2 and its receptor EP2 trigger signaling that contributes to YAP-mediated cell competition. 査読国際誌

Erika Ishihara, Yuya Nagaoka, Toshiaki Okuno, Satoshi Kofuji, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Kenya Kamimura, Shuji Terai, Takehiko Yokomizo, Yukihiko Sugimoto, Yasuyuki Fujita, Akira Suzuki, Hiroshi Nishina

Genes to cells : devoted to molecular & cellular mechanisms 25 ( 3 ) 197 - 214 2020年1月

記述言語：英語掲載種別：研究論文（学術雑誌）

Cell competition is a biological process by which unfit cells are eliminated from "cell society." We previously showed that cultured mammalian epithelial Madin-Darby canine kidney (MDCK) cells expressing constitutively active YAP were eliminated by apical extrusion when surrounded by "normal" MDCK cells. However, the molecular mechanism underlying the elimination of active YAP-expressing cells was unknown. Here, we used high-throughput chemical compound screening to identify cyclooxygenase-2 (COX-2) as a key molecule triggering cell competition. Our work shows that COX-2-mediated PGE2 secretion engages its receptor EP2 on abnormal and nearby normal cells. This engagement of EP2 triggers downstream signaling via an adenylyl cyclase-cyclic AMP-PKA pathway that, in the presence of active YAP, induces E-cadherin internalization leading to apical extrusion. Thus, COX-2-induced PGE2 appears a warning signal to both abnormal and surrounding normal cells to drive cell competition.

DOI： 10.1111/gtc.12750

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Usefulness of autotaxin for the complications of liver cirrhosis. 国際誌

Xue Shao, Haruki Uojima, Toru Setsu, Tomomi Okubo, Masanori Atsukawa, Yoshihiro Furuichi, Yoshitaka Arase, Hisashi Hidaka, Yoshiaki Tanaka, Takahide Nakazawa, Makoto Kako, Tatehiro Kagawa, Katsuhiko Iwakiri, Shuji Terai, Wasaburo Koizumi

World journal of gastroenterology 26 ( 1 ) 97 - 108 2020年1月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Autotaxin (ATX) has been reported as a direct biomarker for estimating the evaluation of liver fibrosis. But available data on ATX as a useful biomarker for the complications of liver cirrhosis (LC) are scant. AIM: To assess the clinical usefulness of ATX for assessing the complications of LC. METHODS: This multicenter, retrospective study was conducted at six locations in Japan. We include patients with LC, n = 400. The ATX level was evaluated separately in men and women because of its high level in female patients. To assess the clinical usefulness of ATX for the complications of LC, the area under the curve (AUC) of ATX assessing for the severe complications was analyzed in comparison with the model for end-stage liver disease score, albumin-bilirubin (ALBI) score, fibrosis-4 index, and aspartate aminotransferase-to-platelet ratio index. RESULTS: The mean age was 68.4 ± 11.4 years, 240 patients (60.0%) were male. A total of 213 (53.3%) and 187 (46.8%) patients were compensated and decompensated, respectively. The numbers of patients with varix rupture, hepatic ascites, and hepatic encephalopathy were 35 (8.8%), 131 (32.8%), and 103 (25.8%), respectively. The AUCs of ATX in men for hepatic encephalopathy, hepatic ascites, and varix ruptures were 0.853, 0.816, and 0.706, respectively. The AUCs of ATX in women for hepatic encephalopathy, hepatic ascites, and varix rupture were 0.759, 0.717, and 0.697, respectively. The AUCs of ATX in men were higher than those in women, as were all the other biomarkers used to detect encephalopathy and varix ruptures. However, for detecting ascites, the AUC of ALBI in men was more effective than using ATX. CONCLUSION: ATX in men was more effective than any other biomarkers for detecting hepatic encephalopathy and varix ruptures.

DOI： 10.3748/wjg.v26.i1.97

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Achalasia in a Patient with Myotonic Dystrophy. 査読

Hiroki Sato, Ken-Ichi Mizuno, Satoru Hashimoto, Masafumi Takatsuna, Shuji Terai

Internal medicine (Tokyo, Japan) 59 ( 1 ) 67 - 68 2020年1月

記述言語：英語

Myotonic dystrophy is a progressive disorder mainly affecting the voluntary muscles. We herein report a rare case of myotonic dystrophy complicated with high-resolution manometry-defined achalasia, the pathology of which is absent relaxation of the smooth muscles of lower esophageal sphincter (LES). In the present case, achalasia was considered a complication of myotonic dystrophy instead of sporadic achalasia, as on performing high-resolution manometry, the finding of an impaired LES relaxation (myotonic phase) changed to a totally emaciated LES function (muscle weakness phase) as myotonic dystrophy progressed.

DOI： 10.2169/internalmedicine.3360-19

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Rare Brain Metastasis From a Pancreatobiliary Subtype of Intraductal Papillary Mucinous Neoplasm. 査読国際誌

Arao Y, Kamimura K, Ikemi M, Hayashi K, Takaki M, Takahashi S, Seino S, Abe H, Tsuboguchi S, Otsu Y, Sanpei K, Kohisa J, Kondo S, Tani Y, Ito J, Toyoshima Y, Kakita A, Ajioka Y, Terai S

Pancreas 49 ( 1 ) e8 - e11 2020年1月

Endoscopic diverticulectomy for Zenker's diverticulum with heterotopic gastric mucosa. 査読国際誌

Hiroki Sato, Manabu Takeuchi, Shuji Terai

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society 32 ( 1 ) 145 - 145 2020年1月

Loss of autophagy impairs physiological steatosis by accumulation of NCoR1. 国際誌

Shun-Saku Takahashi, Yu-Shin Sou, Tetsuya Saito, Akiko Kuma, Takayuki Yabe, Yuki Sugiura, Hyeon-Cheol Lee, Makoto Suematsu, Takehiko Yokomizo, Masato Koike, Shuji Terai, Noboru Mizushima, Satoshi Waguri, Masaaki Komatsu

Life science alliance 3 ( 1 ) 2020年1月

記述言語：英語掲載種別：研究論文（学術雑誌）

Lipid droplets (LDs) are dynamic organelles that store neutral lipids during times of energy excess, such as after a meal. LDs serve as an energy reservoir during fasting and have a buffering capacity that prevents lipotoxicity. Autophagy and the autophagic machinery have been proposed to play a role in LD biogenesis, but the underlying molecular mechanism remains unclear. Here, we show that when nuclear receptor co-repressor 1 (NCoR1), which inhibits the transactivation of nuclear receptors, accumulates because of autophagy suppression, LDs decrease in size and number. Ablation of ATG7, a gene essential for autophagy, suppressed the expression of gene targets of liver X receptor α, a nuclear receptor responsible for fatty acid and triglyceride synthesis in an NCoR1-dependent manner. LD accumulation in response to fasting and after hepatectomy was hampered by the suppression of autophagy. These results suggest that autophagy controls physiological hepatosteatosis by fine-tuning NCoR1 protein levels.

DOI： 10.26508/lsa.201900513

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Therapeutic potential of mesenchymal stem cells and their exosomes in severe novel coronavirus disease 2019 (COVID-19) cases. 査読国際誌

Atsunori Tsuchiya, Suguru Takeuchi, Takahiro Iwasawa, Masaru Kumagai, Takeki Sato, Satoko Motegi, Yui Ishii, Youhei Koseki, Kei Tomiyoshi, Kazuki Natsui, Nobutaka Takeda, Yuki Yoshida, Fusako Yamazaki, Yuichi Kojima, Yusuke Watanabe, Naruhiro Kimura, Kentaro Tominaga, Hiroteru Kamimura, Masaaki Takamura, Shuji Terai

Inflammation and regeneration 40 14 - 14 2020年

記述言語：英語掲載種別：研究論文（学術雑誌）

The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19) and the ensuing worldwide pandemic. The spread of the virus has had global effects such as activity restriction, economic stagnation, and collapse of healthcare infrastructure. Severe SARS-CoV-2 infection induces a cytokine storm, leading to acute respiratory distress syndrome (ARDS) and multiple organ failure, which are very serious health conditions and must be mitigated or resolved as soon as possible. Mesenchymal stem cells (MSCs) and their exosomes can affect immune cells by inducing anti-inflammatory macrophages, regulatory T and B cells, and regulatory dendritic cells, and can inactivate T cells. Hence, they are potential candidate agents for treatment of severe cases of COVID-19. In this review, we report the background of severe cases of COVID-19, basic aspects and mechanisms of action of MSCs and their exosomes, and discuss basic and clinical studies based on MSCs and exosomes for influenza-induced ARDS. Finally, we report the potential of MSC and exosome therapy in severe cases of COVID-19 in recently initiated or planned clinical trials of MSCs (33 trials) and exosomes (1 trial) registered in 13 countries on ClinicalTrials.gov.

DOI： 10.1186/s41232-020-00121-y

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10年目を迎えた新潟県肝疾患相談センターの現況査読

上村博輝, 高村昌昭, 五十嵐正人, 青栁豊, 菊田玲, 渡辺和仁, 中山均, 田村務, 寺井崇二, 薛徹, 荒生祥尚, 廣川光, 澤栗裕美, 渡邊文子, 小師優子, 坂牧僚, 土屋淳紀

肝臓 61 ( 5 ) 245 - 254 2020年

記述言語：日本語出版者・発行元：一般社団法人日本肝臓学会

<p>平成21年に設立された新潟大学医歯学総合病院肝疾患相談センターは令和元年に10年目を迎え，236万人の新潟県民や医療従事者に対するウイルス性肝炎の情報の提供，啓発活動，助成制度のサポート等を新潟県健康対策課，厚生労働省健康局がん・疾病対策課肝炎対策室，国立国際医療センター肝炎情報センターとともに行ってきた．新潟県内の各種肝炎ウイルスの発生動向の報告，助成対象人数の把握や非受検者に対する啓発活動を各年度で行ってきた．C型肝炎については他県と同じく新規治療者数については減少段階にある．しかし，肝炎ウイルスは世界最大級の感染症であることにかわりなく，A型肝炎のエンデミック，B型肝炎ウイルスに対する耐性ウイルス発生や核酸アナログ製剤の長期利用による諸問題，E型肝炎の報告例の増加などについては今後も監視が必要である．また肝炎検査未受検者も多く，啓発活動を行う肝疾患相談センターの存在意義は今後も重要である．</p>

DOI： 10.2957/kanzo.61.245

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Obesity and accumulation of subcutaneous adipose tissue are poor prognostic factors in patients with alcoholic liver cirrhosis. 国際誌

Akira Sakamaki, Kunihiko Yokoyama, Kyutaro Koyama, Shinichi Morita, Hiroyuki Abe, Kenya Kamimura, Masaaki Takamura, Shuji Terai

PloS one 15 ( 11 ) e0242582 2020年

記述言語：英語掲載種別：研究論文（学術雑誌）

In alcoholic liver cirrhosis (LC) patients, obesity has become a problem that progresses into liver dysfunction. Herein, we investigated the relationship between the prognosis of steatohepatitis and body weight, along with fat accumulation in patients with alcoholic LC. We conducted a single-center retrospective study, enrolled 104 alcoholic LC patients without hepatocellular carcinoma (HCC) based on histological and clinical evidence, and investigated factors related to poor prognosis using multivariate Cox regression and cluster analyses. Cox regression analysis revealed three independent relevant factors: subcutaneous adipose tissue (SAT) index (median 34.8 cm2/m2, P = 0.009, hazard ratio [HR] 1.017, 95% confidence interval [CI] 1.004-1.030), total bilirubin level (median 1.7 mg/dL, P = 0.003, HR 1.129, 95% CI 1.042-1.223), and prothrombin time value (median 64%, P = 0.007, HR 0.967, 95% CI 0.943-0.991). In the cluster analysis, we categorized the patients into three groups: no adipose tissue accumulation (NAT group), SAT prior accumulation (SAT group), and visceral adipose tissue prior accumulation (VAT group). The results of the three groups revealed that the SAT group displayed a significantly poor prognosis of the Kaplan-Meier curve (67.1 vs 21.2 vs 65.3, P<0.001) of a 5-year survival rate. Propensity score matching analysis of the SAT and VAT groups was performed to adjust the patient's background, but no significant differences were found between them; however, the prognosis was poorer (21.2 vs 66.3, P<0.001), and hemostatic factors were still at a lower level in the SAT group. These findings suggest that SAT accumulation type of obesity is a poor prognostic factor in alcoholic LC patients without HCC, and the hemorrhagic tendency might worsen the poor prognosis in such cases.

DOI： 10.1371/journal.pone.0242582

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Nationwide epidemiological survey of autoimmune pancreatitis in Japan in 2016

Masamune, A., Kikuta, K., Hamada, S., Tsuji, I., Takeyama, Y., Shimosegawa, T., Okazaki, K., Kanno, A., Sano, T., Uchida, K., Ikeura, T., Fujimori, N., Nakai, Y., Kamisawa, T., Kubota, K., Motoya, M., Shimizu, K., Ushijima, T., Fukasawa, M., Naitoh, I., Ueno, M., Okuwaki, K., Uza, N., Asada, M., Mukai, T., Kudo, Y., Uetsuki, K., Mitoro, A., Watanabe, H., Terai, S., Hayashi, K., Imamura, Y., Haba, S., Hara, K., Fujisawa, T., Iwasaki, E., Okumura, F., Kawaji, Y., Kitano, M., Nishino, T., Nagahama, M., Hirano, A., Aruga, Y., Yamamoto, S., Inui, K., Kubota, Y., Takahashi, K., Sakagami, J., Kobayashi, T., Miraki, T., Watanabe, T., Sato, H., Takeda, Y., Satoh, M., Kobashigawa, K., Chiba, M., Tamura, T., Sawada, N., Mizukami, K., Sekine, M., Unno, J., Ishizawa, T., Funayama, H., Hatayama, K., Miyakawa, H., Sakai, T., Kuwatani, M., Toki, M., Toyokawa, T., Hashimoto, S., Itoi, T., Iwashita, Y., Sato, A., Kato, H., Takatori, H., Iizawa, Y., Iwashita, T., Kondo, H., Sato, Y., Tanabe, M., Ogura, T., Yamamoto, K., Masaka, T., Setsuda, M., Sano, T., Matsubara, S., Kitamura, K., Iwata, K., Shirahata, N., Hagiwara, H., Yoshida, M., Yokota, T., Shigoka, H., Kaneko, N., Abue, M., Tsuruoka, N.

Journal of Gastroenterology 55 ( 4 ) 2020年

Nationwide epidemiological survey of chronic pancreatitis in Japan: introduction and validation of the new Japanese diagnostic criteria 2019

Masamune, A., Kikuta, K., Kume, K., Hamada, S., Tsuji, I., Takeyama, Y., Shimosegawa, T., Okazaki, K., Miura, S., Takikawa, T., Hongo, S., Nakano, E., Nabeshima, T., Matsumoto, R., Tanaka, Y., Ueno, M., Mukai, T., Matsumoto, M., Kudo, Y., Azuma, S., Okuwaki, K., Yamamoto, S., Inui, K., Kobashigawa, K., Unno, J., Fujimori, N., Kitamura, K., Miyakawa, H., Takahashi, K., Ikeura, T., Takenaka, M., Fukasawa, M., Funayama, H., Mitoro, A., Takagi, T., Sekine, M., Suwa, K., Sakagami, J., Ishida, M., Ohtsuka, M., Kagawa, S., Muraki, T., Watanabe, T., Watanabe, T., Yamamoto, K., Masaka, T., Nagahama, M., Sato, A., Aruga, Y., Nakai, Y., Iwasaki, E., Itoi, T., Kawaji, Y., Kitano, M., Mizukami, K., Iwasaki, S., Mori, M., Kaneko, N., Kodama, Y., Sato, H., Yoshida, N., Hatayama, K., Kobayashi, T., Hirano, A., Kaino, M., Fujisawa, T., Ushijima, T., Chiba, M., Shimizu, K., Ota, H., Toki, M., Nishikawa, T., Yoshida, Y., Tanaka, K., Uetsuki, K., Motoya, D., Muro, S., Watanabe, H., Imamura, Y., Ishizawa, T., Kamisawa, T., Tsuruoka, M., Hayashi, K., Terai, S., Iwatsuka, K., Iwata, K., Yoshida, M., Takagi, T., Goto, M., Oza, N., Takeda, Y., Hagiwara, H., Tadano, T., Sakai, T., Sumimoto, K., Nishimura, N., Irisawa, A., Kuwatani, M., Shirahata, N., Satoh, M., Fujikawa, T., Iizawa, Y., Watanabe, N., Ishiguro, H., Sawada, N., Katada, K., Kondo, H., Sakakihara, I., Nishida, J., Tamura, T., Dairaku, N., Kamezaki, H., Okano, H., Suzuki, S., Okamoto, T., Matsugu, Y., Imamura, M., Honjo, M., Sugiyama, G., Ohta, H., Higashide, S., Ishii, S., Hoshi, T., Takagi, Y., Satoh, A., Yamaji, N., Nishimura, N., Shibasaki, M., Tamura, H., Iwashita, T., Motoya, M., Tanisaka, Y., Ryozawa, S., Takatori, H., Tsuruoka, N., Hashimoto, S., Suzuki, N., Sato, Y., Tamai, H., Hara, K., Ashida, K., Yokota, T., Tsuji, T., Abue, M., Tomaki, H., Fukunishi, M., Koga, H., Takehara, Y., Kawamura, H., Shimokawahara, N., Otsu, N., Kimura, Y., Ishido, K., Kofunato, Y., Shiihara, M., Sakaguchi, T., Masui, T., Eguchi, H., Suzumura, K., Ide, T., Inomata, M., Maemura, K., Iizawa, H., Nakajima, A., Uyama, S., Shiozaki, S., Yokoyama, S., Wakabayashi, T., Furuuchi, T., Gushima, T., Satoh, S., Shioya, T., Nakazawa, K., Takahashi, Y., Fukuba, N., Matsubara, S.

Journal of Gastroenterology 55 ( 11 ) 2020年

Usefulness of endoscopic ultrasound (EUS)-fine needle aspiration (FNA) for local excision of brunner's gland hamartoma with hemorrhage: A case report and literature review,EUS-FNA が術前診断に有用であった十二指腸 Brunner 腺過誤腫出血の <sub>1</sub> 切除例

Arao, Y., Kobayashi, M., Ikemi, M., Shioji, K., Seino, S., Abe, H., Iwaki, T., Taguchi, T., Tani, Y., Terai, S.

Gastroenterological Endoscopy 62 ( 7 ) 2020年

Practical guide on on-line hemodiafiltration for acute liver failure

Inoue, K., Oda, S., Abe, R., Takikawa, Y., Nakayama, N., Kato, N., Fujiwara, K., Yasui, S., Terai, S., Ido, A., Sakaida, I., Genda, T., Shimizu, M., Mochida, S., Takikawa, H.

Kanzo/Acta Hepatologica Japonica 61 ( 2 ) 2020年

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