研究者詳細 - 寺井　崇二

論文 - 寺井　崇二

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アルコール性肝硬変の予後における、るいそうおよび肥満の影響

坂牧僚, 横山邦彦, 上村顕也, 高村昌昭, 寺井崇二

肥満研究 25 ( Suppl. ) 304 - 304 2019年10月

マウス肝線維化進展予防薬の探索及びレトロゾールによる線維化進展予防効果の検証

酒井規裕, 上村顕也, 名古屋拓郎, 丹羽佑輔, 高昌良, 薛徹, 横尾健, 坂牧僚, 榎本初音, 立木秀尚, 寺井崇二

肝臓 60 ( Suppl.2 ) A680 - A680 2019年10月

NASHモデルマウスにおける自律神経系を介したグレリンの関与

名古屋拓郎, 上村顕也, 井上良介, 酒井規裕, 後藤諒, 高昌良, 丹羽佑輔, 坂牧僚, 寺井崇二

肝臓 60 ( Suppl.2 ) A682 - A682 2019年10月

Wavy mucosal tear in the sigmoid colon. 査読国際誌

Kentaro Tominaga, Junji Yokoyama, Kazunao Hayashi, Atsunori Tsuchiya, Shuji Terai

Clinical case reports 7 ( 9 ) 1825 - 1826 2019年9月

記述言語：英語掲載種別：研究論文（学術雑誌）

Although linear mucosal tears have been reported, we found a relatively rare case of wavy mucosal tear in collagenous colitis. This may be related to the mutual weak adhesiveness between the epithelium and collagen band. This complication necessitates great care to be taken while performing colonoscopy in patients suspected of collagenous colitis.

DOI： 10.1002/ccr3.2275

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Inhibition of sodium-glucose cotransporter 2 ameliorated renal injury in a novel medaka model of nonalcoholic steatohepatitis-related kidney disease. 査読国際誌

Nagoya T, Kamimura K, Goto R, Shinagawa-Kobayashi Y, Niwa Y, Kimura A, Sakai N, Ko M, Nishina H, Terai S

FEBS open bio 9 ( 12 ) 2016 - 2024 2019年9月

NSTによる消化器内科病変の発見により自宅退院まで改善した症例

小師優子, 村山稔子, 上村博輝, 小山諭, 寺井崇二

学会誌JSPEN 1 ( Suppl. ) 1331 - 1331 2019年9月

非ウイルス性肝硬変時代の門亢症〜ウイルス性との共通点・相違点を中心に〜原発性胆汁性胆管炎における食道・胃静脈瘤の検討

薛徹, 横山純二, 高綱将史, 荒生祥尚, 上村輝博, 坂牧僚, 横尾健, 上村顕也, 土屋淳紀, 高村昌昭, 寺井崇二

日本門脈圧亢進症学会雑誌 25 ( 3 ) 110 - 110 2019年9月

門亢症に伴う慢性肝不全の臓器関連〜脳・腎・腸〜 NASHの病態進行との自律神経を介した臓器間ネットワークの関与

高昌良, 上村顕也, 名古屋拓郎, 大脇崇史, 井上良介, 酒井規裕, 丹羽祐輔, 坂牧僚, 横尾健, 寺井崇二

日本門脈圧亢進症学会雑誌 25 ( 3 ) 77 - 77 2019年9月

Change in body composition in patients with achalasia before and after peroral endoscopic myotomy. 査読国際誌

Takeshi Mizusawa, Hiroki Sato, Kenya Kamimura, Satoru Hashimoto, Ken-Ichi Mizuno, Hiroteru Kamimura, Satoshi Ikarashi, Kazunao Hayashi, Masaaki Takamura, Junji Yokoyama, Shuji Terai

Journal of gastroenterology and hepatology 35 ( 4 ) 601 - 608 2019年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND AND AIM: Patients with achalasia experience weight loss because of dysphagia caused by impaired relaxation of the lower esophageal sphincter. This study aimed to use dual bioelectrical impedance analysis (BIA) to determine the change in bodyweight and body composition in patients with achalasia before and after peroral endoscopic myotomy (POEM). METHODS: Patients with achalasia who underwent POEM from 2013 to 2018 (n = 72) were retrospectively analyzed for change in bodyweight before and after 3 months. Additionally, change in body composition was prospectively investigated in the final 10 of 72 patients using non-radiation dual BIA. RESULTS: Twenty patients (27.8%) were underweight (body mass index < 18.5) before undergoing POEM. No clinical parameters were identified to be associated with the underweight condition before POEM and be predictive of an increase in bodyweight after POEM. Low visceral fat volume observed on dual BIA correlated closely with the result obtained using computed tomography (Pearson correlation coefficient: r = 0.850, P < 0.01). Patients with achalasia had a statistically significant increase in visceral (P < 0.01) and subcutaneous fat volumes (P < 0.01) after POEM. Skeletal muscle mass index slightly increased (P = 0.02), although the value after POEM was still low. No blood biomarkers were indicators for low bodyweight or low visceral fat volume. CONCLUSIONS: Dual BIA is an effective non-invasive tool to evaluate the change in body composition of underweight patients with achalasia. Skeletal muscle volume was not enough after POEM, although a rapid increase in the intra-abdominal fat volume was observed. Additional studies are warranted to understand the pathological implications.

DOI： 10.1111/jgh.14847

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Methotrexate-Associated Lymphoproliferative Disorder: A Rare Case of Large Liver Tumors. 国際誌

Saori Watanabe, Kazuya Takahashi, Kazuhiro Funakoshi, Shuji Terai

Hepatology (Baltimore, Md.) 70 ( 2 ) 748 - 750 2019年8月

Epidemiological analysis of achalasia in Japan using a large-scale claims database 査読

Sato, H., Yokomichi, H., Takahashi, K., Tominaga, K., Mizusawa, T., Kimura, N., Kawata, Y., Terai, S.

Journal of Gastroenterology 54 ( 7 ) 621 - 627 2019年7月

Case of early-stage gastric cancer identified in the gastric mucosa with lanthanum phosphate deposition. 査読

Takatsuna M, Takeuchi M, Usuda H, Terai S

Endoscopy international open 7 ( 7 ) E893 - E895 2019年7月

Colorectal neuroendocrine carcinoma: A case report and review of the literature. 査読国際誌

Yoshida T, Kamimura K, Hosaka K, Doumori K, Oka H, Sato A, Fukuhara Y, Watanabe S, Sato T, Yoshikawa A, Tomidokoro T, Terai S

World journal of clinical cases 7 ( 14 ) 1865 - 1875 2019年7月

Delayed pancreatic ductal leakage after EUS-FNA for autoimmune pancreatitis. 査読

Ikarashi S, Tsuchiya A, Hayashi K, Terai S

Endoscopic ultrasound 8 ( 4 ) 277 - 278 2019年7月

肝癌薬剤耐性におけるエクソソームの有用性および課題

松田康伸, 寺井崇二

BIO Clinica 34 ( 7 ) 737 - 740 2019年7月

記述言語：日本語出版者・発行元：(株)北隆館

エクソソームは、細胞-細胞間コミュニケーションを司る機能をもつ不溶性粒子である。近年ではエクソソームががん診断・治療に有用な生体ツールであることが明らかにされて以降、その実用性に関する注目が集まっている。肝がんは化学療法耐性を伴う、予後不良な悪性疾患であり、エクソソームを用いた治療への期待は高い。肝がん由来のエクソソームはがん進展や転移能を促進し、薬剤耐性獲得にも関与しているため、今後はエクソソーム分泌阻害剤による肝がん治療法の開発が待たれている。(著者抄録)

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A case report of psychiatric symptoms following direct-acting antiviral and ribavirin combination therapy for chronic hepatitis C in a patient with innate anxiety. 査読国際誌

Akira Sakamaki, Kenya Kamimura, Naoki Fukui, Haruka Watanabe, Norihiro Sakai, Kentaro Tominaga, Kenichi Mizuno, Masaaki Takamura, Hirokazu Kawai, Takuro Sugai, Satoshi Yamagiwa, Toshiyuki Someya, Shuji Terai

BMC gastroenterology 19 ( 1 ) 85 - 85 2019年6月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Direct-acting antivirals (DAAs) result in a highly sustained virological response rate and better patient tolerance. However, this therapeutic approach may, on rare occasions, give rise to psychiatric symptoms. We describe a case requiring discontinuation of DAA and ribavirin combination therapy due to psychiatric symptoms in a patient with congenital anxious personality traits. The information summarized here will be helpful to physicians treating chronic hepatitis C virus (HCV) infection in patients with underlying psychiatric problems. CASE PRESENTATION: A 57-year-old Japanese woman diagnosed with chronic HCV infection was prescribed DAA and ribavirin combination therapy. She had a history of mild innate anxiety and development of psychiatric symptoms due to interferon (IFN) therapy 8 years prior, which subsided with discontinuation of the therapy. Similar psychiatric symptoms such as enervation, palpitations, an episode of hyperventilation, and consciousness disturbances with myotonia were observed after the administration of the antiviral agents. No abnormal findings related to her symptoms were observed on laboratory or imaging results. Psychiatrists diagnosed the patient as having a somatization disorder induced by the antiviral agents on the basis of innate anxiety. After the discontinuation of therapy, her symptoms gradually improved. CONCLUSIONS: Although DAAs were not causative factors for psychiatric symptoms in phase 3 studies, a post-marketing study reported psychiatric symptoms such as depression in patients with underlying psychiatric problems. Our case suggests psychiatric symptoms might worsen after DAA and ribavirin administration in patients with underlying psychiatric disorders, and therefore, close monitoring is necessary for these patients, especially if they have a history of psychiatric symptoms after IFN.

DOI： 10.1186/s12876-019-1013-1

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Evaluating the effect of injecting triamcinolone acetonide in two sessions for preventing esophageal stricture after endoscopic submucosal dissection. 査読国際誌

Satoru Hashimoto, Ken-Ichi Mizuno, Kazuya Takahashi, Hiroki Sato, Junji Yokoyama, Manabu Takeuchi, Yuichi Sato, Masaaki Kobayashi, Shuji Terai

Endoscopy international open 7 ( 6 ) E764-E770 - E770 2019年6月

記述言語：英語掲載種別：研究論文（学術雑誌）

Background and study aims Several previous reports indicate that endoscopic injection of triamcinolone acetonide (TA) after widespread endoscopic submucosal dissection (ESD) is effective for preventing esophageal stricture. We investigated the efficacy of injecting TA in two sessions for preventing stricture formation post-ESD. Patients and methods Sixty-six consecutive patients with widespread mucosal defects that affected more than three-fourths of the circumference of the esophagus were included. The study group (n = 40) received TA injections over two sessions: immediately after and 14 days after ESD. The control group (n = 26) did not receive a TA injection. This study was performed retrospectively against historical controls. The primary endpoint of this study was frequency of stricture after TA injection. The secondary endpoint was number of required endoscopic balloon dilations (EBDs) after TA injection. Results The post-ESD stricture rate among patients who had subcircumferential mucosal defects was 45.7 % in the study group (16/35 patients), which was significantly lower than the rate of 73.9 % in the control group (17/23 patients; P = 0.031). The number of EBD procedures required was significantly lower in the study group (median 0, range 0 - 7) than in the control group (median 4, range 0 - 20; P < 0.001). There was no significant difference between the study and control groups among the patients who had full circumferential mucosal defects. Conclusion This study showed that performing two sessions of TA injection is an effective and safe treatment for prevention of esophageal stricture following subcircumferential ESD.

DOI： 10.1055/a-0894-4374

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医学・医療におけるシミュレータの進歩と普及(Vol.23) 消化器領域超音波のシミュレータ腹部超音波/超音波内視鏡

林和直, 五十嵐聡, 寺井崇二

医学のあゆみ 269 ( 12 ) 945 - 948 2019年6月

記述言語：日本語出版者・発行元：医歯薬出版(株)

腹部超音波はその非侵襲性と簡便性のため、検診的なスクリーニングから緊急時のスクリーニング、造影超音波や穿刺治療など、幅広い場面で日常診療において使用されている。したがって、腹部超音波の技術の習得は実臨床において非常に重要である。腹部超音波診断ファントムは、生体と同じようにプローベを当てることができ、腹部臓器の基本描出の習得に有用である。また、バーチャル技術を用いたシミュレータでは超音波画像と周囲臓器の超音波の断面を同時に見ることができ、超音波検査における臓器の解剖学的位置関係の理解や技術習得の助けとなる。また、近年では腹部消化器領域、とくに胆膵領域の診断と治療において超音波内視鏡が必須となってきている。超音波内視鏡の画像読影と技術の習得には修練を要するが、専用のファントムやバーチャル技術を用いたシミュレータが使用可能となってきており、技術の習得が、より容易になることが期待される。(著者抄録)

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その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J00060&link_issn=&doc_id=20190624030012&doc_link_id=%2Faa7ayuma%2F2019%2F026912%2F013%2F0945-0948%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Faa7ayuma%2F2019%2F026912%2F013%2F0945-0948%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

ダブルバルーン内視鏡で診断に至った消化管重複症の成人例

丹羽佑輔, 上村顕也, 小林隆昌, 高橋一也, 冨永顕太郎, 河久順志, 阿部聡司, 川合弘一, 横山純二, 杉野英明, 梅津哉, 寺井崇二

ENDOSCOPIC FORUM for digestive disease 35 ( 1 ) 44 - 44 2019年6月

FDG-PETが重粒子線治療の効果判定に有用であった、若年者切除不能肝内胆管癌の1例

渡邉緑, 柴田理, 上村顕也, 安住里映, 渋谷圭, 大野達也, 寺井崇二

日本消化器病学会甲信越支部例会抄録集 64回 34 - 34 2019年6月

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