研究者詳細 - 寺井　崇二

論文 - 寺井　崇二

分割表示 1,167 件中 801 - 820 件目／全件表示 >>

Vonoprazan 20 mg <i>vs</i> lansoprazole 30 mg for endoscopic submucosal dissection-induced gastric ulcers. 査読国際誌

Takahashi K, Sato Y, Kohisa J, Watanabe J, Sato H, Mizuno K, Hashimoto S, Terai S

World journal of gastrointestinal endoscopy 8 ( 19 ) 716 - 722 2016年11月

Case of severe alcoholic hepatitis treated with granulocytapheresis 査読

Yukari Watanabe, Kenya Kamimura, Tomohiro Iwasaki, Hiroyuki Abe, Shunsaku Takahashi, Ken-ichi Mizuno, Manabu Takeuchi, Atsushi Eino, Ichiei Narita, Shuji Terai

WORLD JOURNAL OF CLINICAL CASES 4 ( 11 ) 369 - 374 2016年11月

[Series: Diagnosis at a Glance]. 査読

Kobayashi T, Tsuchiya A, Kuraoka N, Yamamoto T, Honda Y, Yokoyama J, Kawai H, Yamagiwa S, Suda T, Terai S

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 105 ( 11 ) 2263 - 2267 2016年11月

Significance of hepatic progenitor cell marker-positive hepatocellular carcinoma and its possible prediction by AFP-L3 査読

Atsunori Tsuchiya, Yuichi Kojima, Satoshi Seino, Yusuke Watanabe, Kenya Kamimura, Masaaki Takamura, Hirokazu Kawai, Satoshi Yamagiwa, Shuji Terai

HEPATOLOGY 64 669A - 670A 2016年10月

Liver-targeted hydrodynamic gene therapy: Recent advances in the technique 査読

Takeshi Yokoo, Kenya Kamimura, Hiroyuki Abe, Yuji Kobayashi, Tsutomu Kanefuji, Kohei Ogawa, Ryo Goto, Masafumi Oda, Takeshi Suda, Shuji Terai, Masafumi Oda

WORLD JOURNAL OF GASTROENTEROLOGY 22 ( 40 ) 8862 - 8868 2016年10月

Platinum-based transhepatic arterial chemotherapy using a combination of miriplatin and CDDP powder in patients with hepatocellular carcinoma 査読

Kohei Ogawa, Kenya Kamimura, Takeshi Suda, Takeshi Yokoo, Akira Sakamaki, Satoshi Abe, Hiroteru Kamimura, Atsunori Tsuchiya, Masaaki Takamura, Hirokazu Kawai, Nobuo Waguri, Toru Ishikawa, Satoshi Yamagiwa, Shuji Terai

HEPATOLOGY 64 652A - 652A 2016年10月

Biological significance of a disintegrin and metalloproteinase 21 expression in hepatocellular carcinoma 査読

Masaaki Takamura, Hiroki Honda, Satoshi Yamagiwa, Naruhiro Kimura, Toru Setsu, Kentaro Tominaga, Hiroteru Kamimura, Takuya Genda, Yasunobu Matsuda, Toshifumi Wakai, Shuji Terai

HEPATOLOGY 64 639A - 639A 2016年10月

Myofibroblasts of the muscle layer stimulate the malignant potential of colorectal cancer 査読

Masafumi Takatsuna, Satoko Morohashi, Tadashi Yoshizawa, Hideaki Hirai, Toshihiro Haga, Rie Ota, Yunyan Wu, Hajime Morohashi, Kenichi Hakamada, Shuji Terai, Hiroshi Kijima

ONCOLOGY REPORTS 36 ( 3 ) 1251 - 1257 2016年9月

Assessments of histologic changes after peroral endoscopic myotomy. 査読

Sato H, Sagara S, Suzuki K, Terai S, Yahagi N

Gastrointestinal endoscopy 84 ( 2 ) 377 - 378 2016年8月

Management of gastric and duodenal neuroendocrine tumors 査読

Yuichi Sato, Satoru Hashimoto, Ken-ichi Mizuno, Manabu Takeuchi, Shuji Terai

WORLD JOURNAL OF GASTROENTEROLOGY 22 ( 30 ) 6817 - 6828 2016年8月

Effects of Fibrotic Tissue on Liver-targeted Hydrodynamic Gene Delivery 査読

Yuji Kobayashi, Kenya Kamimura, Hiroyuki Abe, Takeshi Yokoo, Kohei Ogawa, Yoko Shinagawa-Kobayashi, Ryo Goto, Ryosuke Inoue, Masato Ohtsuka, Hiromi Miura, Tsutomu Kanefuji, Takeshi Suda, Masanori Tsuchida, Yutaka Aoyagi, Guisheng Zhang, Dexi Liu, Shuji Terai

MOLECULAR THERAPY-NUCLEIC ACIDS 5 ( 8 ) e359 2016年8月

A novel training model composed of nonbiological materials for endoscopic submucosal dissection. 査読

Mizuno K, Sato H, Hashimoto S, Sato Y, Terai S

Gastrointestinal endoscopy 84 ( 2 ) 373 - 374 2016年8月

Novel ex-vivo training model for peroral endoscopic myotomy using hydrogel 査読

Hiroki Sato, Ken-ichi Mizuno, Shuji Terai

DIGESTIVE ENDOSCOPY 28 ( 5 ) 620 - 620 2016年7月

Pivotal Role of Carbohydrate Sulfotransferase 15 in Fibrosis and Mucosal Healing in Mouse Colitis 査読

Kenji Suzuki, Somasundaram Arumugam, Junji Yokoyama, Yusuke Kawauchi, Yutaka Honda, Hiroki Sato, Yutaka Aoyagi, Shuji Terai, Kazuichi Okazaki, Yasuo Suzuki, Shuji Mizumoto, Kazuyuki Sugahara, Raja Atreya, Markus F. Neurath, Kenichi Watanabe, Taishi Hashiguchi, Hiroyuki Yoneyama, Hitoshi Asakura

PLOS ONE 11 ( 7 ) e0158967 2016年7月

Therapeutic or spontaneous Helicobacter pylori eradication can obscure magnifying narrow-band imaging of gastric tumors. 査読

Kobayashi M, Hashimoto S, Mizuno K, Takeuchi M, Sato Y, Watanabe G, Ajioka Y, Azumi M, Akazawa K, Terai S

Endoscopy international open 4 ( 6 ) E665 - 72 2016年6月

Deferasirox, an oral iron chelator, prevents hepatocarcinogenesis and adverse effects of sorafenib 査読

Naoki Yamamoto, Takahiro Yamasaki, Taro Takami, Koichi Uchida, Koichi Fujisawa, Toshihiko Matsumoto, Issei Saeki, Shuji Terai, Isao Sakaida

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION 58 ( 3 ) 202 - 209 2016年5月

Effective prevention of hand-foot syndrome by the consumption of dried bonito broth 査読

Kenya Kamimura, Yoko Shinagawa, Kohei Ogawa, Yuji Kobayashi, Hiroyuki Abe, Takeshi Yokoo, Hiroteru Kamimura, Hirokazu Kawai, Takeshi Suda, Satoshi Yamagiwa, Hiroshi Baba, Shuji Terai

Japanese Journal of Cancer and Chemotherapy 43 ( 4 ) 463 - 465 2016年4月

当院における悪性胃十二指腸狭窄に対する内視鏡的ステント留置術の有用性の検討

林和直, 山本幹, 水野研一, 本田穣, 橋本哲, 横山純二, 竹内学, 佐藤祐一, 寺井崇二

Gastroenterological Endoscopy 58 ( Suppl.1 ) 790 - 790 2016年4月

Modulation of anti-cancer drug sensitivity through the regulation of mitochondrial activity by adenylate kinase 4 査読国際誌

Fujisawa Koichi, Terai Shuji, Takami Taro, Yamamoto Naoki, Yamasaki Takahiro, Matsumoto Toshihiko, Yamaguch Kazuhito, Owada Yuji, Nishina Hiroshi, Takafumi Noma, Sakaida Isao

Journal of Experimental & Clinical Cancer Research Vol.35 ( No.1 ) 48 - 48 2016年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

Background: Adenylate kinase is a key enzyme in the high-energy phosphoryl transfer reaction in living cells. Anisoform of this enzyme, adenylate kinase 4 (AK4), is localized in the mitochondrial matrix and is believed to beinvolved in stress, drug resistance, malignant transformation in cancer, and ATP regulation. However, the molecularbasis for the AK4 functions remained to be determined.Methods: HeLa cells were transiently transfected with an AK4 small interfering RNA (siRNA), an AK4 short hairpinRNA (shRNA) plasmid, a control shRNA plasmid, an AK4 expression vector, and a control expression vector toexamine the effect of the AK4 expression on cell proliferation, sensitivity to anti-cancer drug, metabolome, geneexpression, and mitochondrial activity.Results: AK4 knockdown cells treated with short hairpin RNA increased ATP production and showed greatersensitivity to hypoxia and anti-cancer drug, cis-diamminedichloro-platinum (II) (CDDP). Subcutaneous grafting AK4knockdown cells into nude mice revealed that the grafted cells exhibited both slower proliferation and reduced thetumor sizes in response to CDDP. AK4 knockdown cell showed a increased oxygen consumption rate with FCCPtreatment, while AK4 overexpression lowered it. Metabolome analysis showed the increased levels of thetricarboxylic acid cycle intermediates, fumarate and malate in AK4 knockdown cells, while AK4 overexpressionlowered them. Electron microscopy detected the increased mitochondrial numbers in AK4 knockdown cells.Microarray analysis detected the increased gene expression of two key enzymes in TCA cycle, succinatedehydrogenase A (SDHA) and oxoglutarate dehydrogenease L (OGDHL), which are components of SDH complexand OGDH complex, supporting the metabolomic results.Conclusions: We found that AK4 was involved in hypoxia tolerance, resistance to anti-tumor drug, and theregulation of mitochondrial activity. These findings provide a new potential target for efficient anticancer therapiesby controlling AK4 expression.

DOI： 10.1186/s13046-016-0322-2

PubMed

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Modulation of anti-cancer drug sensitivity through the regulation of mitochondrial activity by adenylate kinase 4. 査読国際誌

Fujisawa K, Terai S, Takami T, Yamamoto N, Yamasaki T, Matsumoto T, Yamaguchi K, Owada Y, Nishina H, Noma T, Sakaida I

Journal of experimental & clinical cancer research : CR 35 48 - 48 2016年3月

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