研究者詳細 - 寺井　崇二

論文 - 寺井　崇二

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Methotrexate-Associated Lymphoproliferative Disorder: A Rare Case of Large Liver Tumors. 国際誌

Saori Watanabe, Kazuya Takahashi, Kazuhiro Funakoshi, Shuji Terai

Hepatology (Baltimore, Md.) 70 ( 2 ) 748 - 750 2019年8月

Epidemiological analysis of achalasia in Japan using a large-scale claims database 査読

Sato, H., Yokomichi, H., Takahashi, K., Tominaga, K., Mizusawa, T., Kimura, N., Kawata, Y., Terai, S.

Journal of Gastroenterology 54 ( 7 ) 621 - 627 2019年7月

Case of early-stage gastric cancer identified in the gastric mucosa with lanthanum phosphate deposition. 査読

Takatsuna M, Takeuchi M, Usuda H, Terai S

Endoscopy international open 7 ( 7 ) E893 - E895 2019年7月

Colorectal neuroendocrine carcinoma: A case report and review of the literature. 査読国際誌

Yoshida T, Kamimura K, Hosaka K, Doumori K, Oka H, Sato A, Fukuhara Y, Watanabe S, Sato T, Yoshikawa A, Tomidokoro T, Terai S

World journal of clinical cases 7 ( 14 ) 1865 - 1875 2019年7月

Delayed pancreatic ductal leakage after EUS-FNA for autoimmune pancreatitis. 査読

Ikarashi S, Tsuchiya A, Hayashi K, Terai S

Endoscopic ultrasound 8 ( 4 ) 277 - 278 2019年7月

肝癌薬剤耐性におけるエクソソームの有用性および課題

松田康伸, 寺井崇二

BIO Clinica 34 ( 7 ) 737 - 740 2019年7月

A case report of psychiatric symptoms following direct-acting antiviral and ribavirin combination therapy for chronic hepatitis C in a patient with innate anxiety. 査読国際誌

Akira Sakamaki, Kenya Kamimura, Naoki Fukui, Haruka Watanabe, Norihiro Sakai, Kentaro Tominaga, Kenichi Mizuno, Masaaki Takamura, Hirokazu Kawai, Takuro Sugai, Satoshi Yamagiwa, Toshiyuki Someya, Shuji Terai

BMC gastroenterology 19 ( 1 ) 85 - 85 2019年6月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Direct-acting antivirals (DAAs) result in a highly sustained virological response rate and better patient tolerance. However, this therapeutic approach may, on rare occasions, give rise to psychiatric symptoms. We describe a case requiring discontinuation of DAA and ribavirin combination therapy due to psychiatric symptoms in a patient with congenital anxious personality traits. The information summarized here will be helpful to physicians treating chronic hepatitis C virus (HCV) infection in patients with underlying psychiatric problems. CASE PRESENTATION: A 57-year-old Japanese woman diagnosed with chronic HCV infection was prescribed DAA and ribavirin combination therapy. She had a history of mild innate anxiety and development of psychiatric symptoms due to interferon (IFN) therapy 8 years prior, which subsided with discontinuation of the therapy. Similar psychiatric symptoms such as enervation, palpitations, an episode of hyperventilation, and consciousness disturbances with myotonia were observed after the administration of the antiviral agents. No abnormal findings related to her symptoms were observed on laboratory or imaging results. Psychiatrists diagnosed the patient as having a somatization disorder induced by the antiviral agents on the basis of innate anxiety. After the discontinuation of therapy, her symptoms gradually improved. CONCLUSIONS: Although DAAs were not causative factors for psychiatric symptoms in phase 3 studies, a post-marketing study reported psychiatric symptoms such as depression in patients with underlying psychiatric problems. Our case suggests psychiatric symptoms might worsen after DAA and ribavirin administration in patients with underlying psychiatric disorders, and therefore, close monitoring is necessary for these patients, especially if they have a history of psychiatric symptoms after IFN.

DOI： 10.1186/s12876-019-1013-1

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Evaluating the effect of injecting triamcinolone acetonide in two sessions for preventing esophageal stricture after endoscopic submucosal dissection. 査読国際誌

Satoru Hashimoto, Ken-Ichi Mizuno, Kazuya Takahashi, Hiroki Sato, Junji Yokoyama, Manabu Takeuchi, Yuichi Sato, Masaaki Kobayashi, Shuji Terai

Endoscopy international open 7 ( 6 ) E764-E770 - E770 2019年6月

記述言語：英語掲載種別：研究論文（学術雑誌）

Background and study aims Several previous reports indicate that endoscopic injection of triamcinolone acetonide (TA) after widespread endoscopic submucosal dissection (ESD) is effective for preventing esophageal stricture. We investigated the efficacy of injecting TA in two sessions for preventing stricture formation post-ESD. Patients and methods Sixty-six consecutive patients with widespread mucosal defects that affected more than three-fourths of the circumference of the esophagus were included. The study group (n = 40) received TA injections over two sessions: immediately after and 14 days after ESD. The control group (n = 26) did not receive a TA injection. This study was performed retrospectively against historical controls. The primary endpoint of this study was frequency of stricture after TA injection. The secondary endpoint was number of required endoscopic balloon dilations (EBDs) after TA injection. Results The post-ESD stricture rate among patients who had subcircumferential mucosal defects was 45.7 % in the study group (16/35 patients), which was significantly lower than the rate of 73.9 % in the control group (17/23 patients; P = 0.031). The number of EBD procedures required was significantly lower in the study group (median 0, range 0 - 7) than in the control group (median 4, range 0 - 20; P < 0.001). There was no significant difference between the study and control groups among the patients who had full circumferential mucosal defects. Conclusion This study showed that performing two sessions of TA injection is an effective and safe treatment for prevention of esophageal stricture following subcircumferential ESD.

DOI： 10.1055/a-0894-4374

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医学・医療におけるシミュレータの進歩と普及(Vol.23) 消化器領域超音波のシミュレータ腹部超音波/超音波内視鏡

林和直, 五十嵐聡, 寺井崇二

医学のあゆみ 269 ( 12 ) 945 - 948 2019年6月

ダブルバルーン内視鏡で診断に至った消化管重複症の成人例

丹羽佑輔, 上村顕也, 小林隆昌, 高橋一也, 冨永顕太郎, 河久順志, 阿部聡司, 川合弘一, 横山純二, 杉野英明, 梅津哉, 寺井崇二

ENDOSCOPIC FORUM for digestive disease 35 ( 1 ) 44 - 44 2019年6月

FDG-PETが重粒子線治療の効果判定に有用であった、若年者切除不能肝内胆管癌の1例

渡邉緑, 柴田理, 上村顕也, 安住里映, 渋谷圭, 大野達也, 寺井崇二

日本消化器病学会甲信越支部例会抄録集 64回 34 - 34 2019年6月

Rational arrangement of measuring shear wave speed in the liver. 査読国際誌

Takeshi Yokoo, Tsutomu Kanefuji, Takeshi Suda, Itsuo Nagayama, Takahiro Hoshi, Satoshi Abe, Shinichi Morita, Hiroteru Kamimura, Kenya Kamimura, Atsunori Tsuchiya, Masaaki Takamura, Kazuyoshi Yagi, Shuji Terai

World journal of gastroenterology 25 ( 20 ) 2503 - 2513 2019年5月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Shear wave speed has been widely applied to quantify a degree of liver fibrosis. However, there is no standardized procedure, which makes it difficult to utilize the speed universally. AIM: To provide procedural standardization of shear wave speed measurement. METHODS: Point shear wave elastography (pSWE) was measured in 781 patients, and two-dimensional shear wave elastography (2dSWE) was measured on the same day in 18 cases. Regions-of-interest were placed at 12 sites, and the median and robust coefficient-of-variation (CVR) were calculated. A residual sum-of-square (Σdi2) was computed for bootstrap values of 1000 iterations in 18 cases with each assumption of 1 to 12 measurements. The proportion of the Σdi2 (%Σdi2) was calculated as the ratio of Σdi2 to pSWE after converting it based on the correlation between pSWE and 2dSWE. RESULTS: The CVR showed a significantly broader distribution in the left lobe (P < 0.0001), and the smallest CVR in the right anterior segment that covered 95% cases was 40.4%. pSWE was significantly higher in the left lobe than in the right lobe (1.63 ± 0.78 m/s vs 1.61 ± 0.78 m/s, P = 0.0004), and the difference between the lobes became further discrete when the subjects were limited to the cases with a CVR less than 40.4% in any segment (1.76 ± 0.80 m/s vs 1.70 ± 0.82 m/s, P < 0.0001). The highest values of the CVR in every 0.1 m/s interval were plotted in convex upward along pSWE and peaked at 1.93 m/s. pSWE and 2dSWE were significantly correlated (P < 0.0001, r = 0.95). In 216000 resamples from 18 cases, the %Σdi2 of 12 sites was 8.0% and gradually increased as the acquisition sites decreased to reach a significant difference with a %Σdi2 of 7 sites (P = 0.027). CONCLUSION: These data suggest that shear wave speed should be measured at 8 or more sites of spreading in both lobes.

DOI： 10.3748/wjg.v25.i20.2503

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Utility of measuring paraesophageal varices using computed tomography to select endoscopic treatment for patients with esophageal varices 査読

Kimura, N., Yokoyama, J., Terai, S.

Digestive Endoscopy 31 ( 3 ) 335 - 335 2019年5月

Efficacy and safety of ribavirin therapy for chronic hepatitis E after kidney transplantation. 査読国際誌

Yoshida T, Takamura M, Goto R, Takeuchi S, Tsuchiya A, Kamimura K, Tasaki M, Nakagawa Y, Saito K, Tomita Y, Terai S

Hepatology research : the official journal of the Japan Society of Hepatology 49 ( 10 ) 1244 - 1248 2019年5月

Multiple Endocrine Neoplasia Type 1-Related Acute Pancreatitis. 査読

Takahashi S, Kamimura K, Abe H, Watanabe Y, Hayashi K, Mizuno K, Yamamoto T, Takeuchi M, Natsui M, Terai S

Pancreas 48 ( 5 ) e35 - e38 2019年5月

A rare duodenal carcinosarcoma: A case report and literature review 査読

Arao, Y., Kamimura, K., Ikemi, M., Takaki, M., Takahashi, S., Seino, S., Abe, H., Kohisa, J., Kato, T., Ajioka, Y., Terai, S.

Internal Medicine 58 ( 9 ) 1273 - 1278 2019年5月

Endoscopic ultrasound-guided hepaticogastrostomy using a novel covered metallic stent with a fine-diameter delivery system 査読

Morita, S., Yagi, K., Terai, S.

Digestive Endoscopy 31 ( 3 ) e60 - e61 2019年5月

Submucosal painting for gastroduodenal stent placement. 査読国際誌

Morita S, Suda T, Terai S

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society 31 ( 3 ) e64 - e65 2019年5月

膵癌術前胆道ドレナージにおける大口径プラスチックステントの役割

五十嵐聡, 林和直, 寺井崇二, 水澤健, 川田雄三, 冨永顕太郎, 佐藤裕樹, 水野研一, 橋本哲, 横山純二, 高村昌昭

Gastroenterological Endoscopy 61 ( Suppl.1 ) 981 - 981 2019年5月

慢性膵炎による膵管狭窄に対するステント治療の現状と課題

林和直, 五十嵐聡, 寺井崇二, 水澤健, 冨永顕太郎, 佐藤裕樹, 水野研一, 橋本哲, 横山純二

Gastroenterological Endoscopy 61 ( Suppl.1 ) 1000 - 1000 2019年5月

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