研究者詳細 - 寺井　崇二

論文 - 寺井　崇二

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肝癌診療ガイドライン2017を再検証する肝癌に対する放射線治療の検討

上村顕也, 柴田理, 寺井崇二

肝臓 60 ( Suppl.1 ) A132 - A132 2019年4月

NASH/NAFLDの病態解明に向けた基礎的検討 NASH/NAFLDの病態における自律神経を介した消化管ホルモンの関与

上村顕也, 名古屋拓郎, 寺井崇二

肝臓 60 ( Suppl.1 ) A146 - A146 2019年4月

肝癌に対する分子標的薬の有害事象の発症予測

上村顕也, 寺井崇二

肝臓 60 ( Suppl.1 ) A487 - A487 2019年4月

免疫チェックポイント阻害薬による免疫関連有害事象と考えられる肝障害を呈した2例

坂牧僚, 上村顕也, 寺井崇二

肝臓 60 ( Suppl.1 ) A488 - A488 2019年4月

メダカを用いた食品・医薬品の機能性評価基盤の構築メダカモデルを用いた薬物スクリーニングと医学研究応用

寺井崇二, 上村顕也

日本栄養・食糧学会大会講演要旨集 73回 174 - 174 2019年4月

Esophageal diverticulum: New perspectives in the era of minimally invasive endoscopic treatment. 査読国際誌

Hiroki Sato, Manabu Takeuchi, Satoru Hashimoto, Ken-Ichi Mizuno, Koichi Furukawa, Akito Sato, Junji Yokoyama, Shuji Terai

World journal of gastroenterology 25 ( 12 ) 1457 - 1464 2019年3月

記述言語：英語

Esophageal diverticula are rare conditions that cause esophageal symptoms, such as dysphagia, regurgitation, and chest pain. They are classified according to their location and characteristic pathophysiology into three types: epiphrenic diverticulum, Zenker's diverticulum, and Rokitansky diverticulum. The former two disorders take the form of protrusions, and symptomatic cases require interventional treatment. However, the esophageal anatomy presents distinct challenges to surgical resection of the diverticulum, particularly when it is located closer to the oral orifice. Since the condition itself is not malignant, minimally invasive endoscopic approaches have been developed with a focus on alleviation of symptoms. Several types of endoscopic devices and techniques are currently employed, including peroral endoscopic myotomy (POEM). However, the use of minimally invasive endoscopic approaches, like POEM, has allowed the development of new disorder called iatrogenic esophageal diverticula. In this paper, we review the pathophysiology of each type of diverticulum and the current state-of-the-art treatment based on our experience.

DOI： 10.3748/wjg.v25.i12.1457

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M2-polarized macrophages relate the clearance of gastric lanthanum deposition 査読

Nakamura, T., Tsuchiya, A., Kobayashi, M., Naito, M., Terai, S.

Clinical Case Reports 7 ( 3 ) 570 - 572 2019年3月

Diverse perspectives to address for the future treatment of heterogeneous hepatocellular carcinoma. 査読国際誌

Tsuchiya A, Ogawa M, Watanabe T, Takeuchi S, Kojima Y, Watanabe Y, Kimura N, Hayashi K, Yokoyama J, Terai S

Heliyon 5 ( 3 ) e01325 2019年3月

当院における切除不能局所進行膵癌の治療の現況

林和直, 五十嵐聡, 水澤健, 川田雄三, 冨永顕太郎, 佐藤裕樹, 水野研一, 橋本哲, 横山純二, 寺井崇二

日本消化器病学会雑誌 116 ( 臨増総会 ) A468 - A468 2019年3月

術後再建腸管例におけるEUS-FNAの現状と工夫

五十嵐聡, 林和直, 水澤健, 川田雄三, 冨永顕太郎, 佐藤裕樹, 水野研一, 橋本哲, 横山純二, 高村昌昭, 寺井崇二

日本消化器病学会雑誌 116 ( 臨増総会 ) A299 - A299 2019年3月

当院における肝癌に対する放射線治療の検討

柴田理, 上村顕也, 木村成宏, 薛徹, 横尾健, 坂牧僚, 上村博輝, 土屋淳紀, 高村昌昭, 丸山克也, 太田篤, 海津元樹, 青山英史, 寺井崇二

日本消化器病学会雑誌 116 ( 臨増総会 ) A456 - A456 2019年3月

難治性潰瘍性大腸炎の治療戦略における外科と内科のコラボレーション難治性潰瘍性大腸炎に対する治療と今後の課題

横山純二, 冨永顕太郎, 寺井崇二

日本消化器病学会雑誌 116 ( 臨増総会 ) A53 - A53 2019年3月

消化器領域における腸内細菌研究と臨床応用空置腸炎に対宇る自家糞便移植の有用性と腸内細菌叢への影響の解明

冨永顕太郎, 横山純二, 寺井崇二

日本消化器病学会雑誌 116 ( 臨増総会 ) A161 - A161 2019年3月

メタボリックシンドロームとしての脂肪肝 SGLT2阻害薬によるNASH進展抑制効果の検証メダカNASHモデルを用いて

上村顕也, 後藤諒, 寺井崇二

日本消化器病学会雑誌 116 ( 臨増総会 ) A142 - A142 2019年3月

Radial incision and cutting for refractory benign esophageal stricture. 国際誌

Takeshi Mizusawa, Masaaki Kobayashi, Shuji Terai

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society 31 ( 2 ) e46-e47 2019年3月

肝線維化研究の展開と臨床応用マウス肝線維化進展予防薬の探索及びレトロゾールによる線維化進展予防効果の検証

酒井規裕, 上村顕也, 寺井崇二

日本消化器病学会雑誌 116 ( 臨増総会 ) A214 - A214 2019年3月

高齢肝癌症例におけるソラフェニブの効果と有用性

横尾健, 森田真一, 木村成宏, 薛徹, 坂牧僚, 上村博輝, 上村顕也, 土屋淳紀, 高村昌昭, 寺井崇二

日本消化器病学会雑誌 116 ( 臨増総会 ) A413 - A413 2019年3月

Co-existent ulcerative colitis and Guillain-Barré syndrome: a case report and literature review. 査読

Tominaga K, Tsuchiya A, Sato H, Kimura A, Oda C, Hosaka K, Kawata Y, Kimura N, Hayashi K, Yokoyama J, Terai S

Clinical journal of gastroenterology 12 ( 3 ) 243 - 246 2019年2月

Clinical and pathological profile of eosinophilic gastroenteritis. 査読国際誌

Hiroki Sato, Terasu Honma, Takashi Owaki, Kentaro Tominaga, Junji Yokoyama, Shuji Terai

European journal of gastroenterology & hepatology 31 ( 2 ) 157 - 162 2019年2月

記述言語：英語

BACKGROUND: Eosinophilic gastroenteritis (EoGE) can be diagnosed on the basis of histologic criteria; however, the pathology is considered to be heterogeneous. There is no consensus on the management of this enigmatic disorder with an unknown etiology. PATIENTS AND METHODS: Data for patients diagnosed with EoGE and followed up over a 1-year period were analyzed. Their symptoms, patterns of flares, and type of treatment were documented. The shift in peripheral blood eosinophil levels was also examined. RESULTS: A total of 10 (mean age, 44 years; range: 31-70 years; women, 5) patients were diagnosed with EoGE. The most frequent presenting symptom was abdominal pain, and eight patients were classified with mucosal type of EoGE. Chronic disease or multiple flares were observed in seven out of 10 (70.0%) patients, and all of them had a history of allergy. Four were corticosteroid dependent (three relapsed during corticosteroid tapering and one following corticosteroid withdrawal). One of them received anti-IL5 monoclonal antibody that enabled corticosteroid dose tapering. In four patients with highly elevated initial eosinophil levels at diagnosis, the peripheral eosinophil level correlated with the amelioration and deterioration of their symptoms. The remaining three patients had a single flare without relapse. Two had no history of allergy. CONCLUSION: EoGE is a unique disorder with a variable clinical course. Although further studies are required to confirm our observations, the presence of other allergic disorders is associated with chronicity or multiple flares. Peripheral eosinophil level may be an effective biomarker for recurrence in patients with severe systemic disorders at diagnosis.

DOI： 10.1097/MEG.0000000000001241

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A cut-off value of shear wave speed to distinguish nonalcoholic steatohepatitis candidates 査読

Suda, T., Kanefuji, T., Abe, A., Nagayama, I., Hoshi, T., Morita, S., Yagi, K., Hatakeyama, S., Hayatsu, M., Hasegawa, N., Terai, S.

Medicine (United States) 98 ( 2 ) e13958 2019年1月

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