Faculty Profiles - YOSHIHARA Akihiro

Serum albumin (SA) levels and 10-year mortality in a community-dwelling 70-year-old population Reviewed

Yutaka Takata, Toshihiro Ansai, Akihiro Yoshihara, Hideo Miyazaki

ARCHIVES OF GERONTOLOGY AND GERIATRICS 54 ( 1 ) 39 - 43 2012.1

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER IRELAND LTD

Although an association between SA concentrations and mortality in the patients is well known, this association is not conclusive in elderly community-dwelling populations. We therefore attempted to determine whether this association could be extended to a Japanese 70-year-old community-dwelling population. Seventy-year-old subjects residing in Niigata City, Japan participated. Baseline examinations including a determination of SA concentrations were performed in June 1998 in 600 participants, and they were followed for 10 years. During the 10-year follow up, 80 subjects died. Albumin levels were divided into four groups (highest > 45 g/l, higher 43-44 g/l, lower 41-42 g/l, lowest < 40 g/l). The survival rate using Kaplan-Meier methods was longer in the highest and higher albumin groups than in the lowest and lower groups. No differences were found between the four groups in the mortalities from cancer, cardiovascular disease (CVD) or pneumonia. Individuals with the lowest albumin levels had 2.7 or 2.9 times higher total mortality, whether adjusted with confounding factors or not, using Cox regression analysis. The mortality hazard ratio (HR) found in the lowest group was compared to the highest group. In an elderly 70-year-old Japanese community-dwelling population, lower SA concentrations were an independent predictor of total mortality, but not mortality due to cancer, CVD, or pneumonia. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.archger.2011.02.018

Serum albumin (SA) levels and 10-year mortality in a community-dwelling 70-year-old population

Yutaka Takata, Toshihiro Ansai, Akihiro Yoshihara, Hideo Miyazaki

ARCHIVES OF GERONTOLOGY AND GERIATRICS 54 ( 1 ) 39 - 43 2012.1

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER IRELAND LTD

DOI： 10.1016/j.archger.2011.02.018

乳幼児健診に併設し実施する個別指導による歯科保健行動の変容

坂入久美子, 葭原明弘, 金子昇, 林悠子, 藤山友紀, 宮崎秀夫

口腔衛生学会雑誌 62 ( 1 ) 63 - 64 2012.1

高齢者における咀嚼能力と体力およびうつ傾向との関係について

瀧口知彌, 葭原明弘, 小川祐司, 山賀孝之, 宮崎秀夫

口腔衛生学会雑誌 62 ( 1 ) 64 - 64 2012.1

Association Between Glucan Synthesis by Streptococcus mutans and Caries Incidence in Schoolchildren Receiving a Fluoride Mouth Rinse Reviewed

Umetsu, Hidehiro, Kaneko, Noboru, Yoshihara, Akihiro, Sakuma, Shihoko, Hanada, Nobuhiro, Miyazaki, Hideo

ORAL HEALTH & PREVENTIVE DENTISTRY 10 ( 2 ) 161 - 166 2012

Language：English Publishing type：Research paper (scientific journal) Publisher：QUINTESSENCE PUBLISHING CO INC

Purpose: To determine whether variation in glucan synthesis by Streptococcus mutans isolates is associated with caries development in children receiving a fluoride mouth rinse (FMR).Materials and Methods: Of 122 children (aged 9 to 10 years), 64 had received FMR (FMR(+) group) and the remaining 58 children had not (FMR() group). The number of decayed and filled teeth (DFT) and increases in the number of DFT in 1 year (dDFT) were recorded. Saliva samples were collected to isolate the clinical S. mutans strains. The isolates were incubated in heart infusion broth supplemented with 1% sucrose, then the amount of water-insoluble glucan (WIG) formed on a glass tube surface was evaluated.Results: In the FMR() group, children carrying S. mutans had a higher DFT (P = 0.039) and tended to have a higher dDFT (P = 0.080) than the others. In the FMR(+) group, although the differences between children with and without S. mutans were not significant, children carrying S. mutans that produced a high amount of WIG had higher dDFT than the other S. mutans-positive children (P = 0.034).Conclusions: This study revealed that the variation in glucan synthesis by S. mutans is associated with caries development in children receiving a FMR.

The relationship between masticatory ability and assessment items of metabolic syndrome in adults aged 60's years old Reviewed

Takahashi Junko, Yoshihara Akihiro, Hayami Ryu

42 ( 1 ) 21 - 26 2012

Association of dental status with vegetable intake in an elderly population Reviewed

T Hirotomi, A Yoshihara, H Ogawa, H Miyazaki

The Journal of Aging Research & Clinical Practice 1 84 - 87 2012

Association between Masticatory Performance and One-leg Standing Time with Eyes Open in Community-dwelling Elderly Women Reviewed

IWASAKI Masanori, YOSHIHARA Akihiro, MIYAZAKI Hideo

62 ( 3 ) 289 - 295 2012

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Society for Dental Health

The one-leg standing test has been widely practiced as an equilibrium function test in the elderly because of its simple evaluation method. Previous studies confirmed that those who cannot maintain a one-leg standing position with eyes open for 30 seconds had a significantly increased risk of falls. Falls in the elderly can cause fracture, gait disturbance, hospital admission, and death. Mean-while, the study results regarding oral function and physical strength in the elderly showed that the one-leg standing time and number of teeth present/occlusal support area are closely associated. A color-changeable chewing gum test for masticatory performance is a simple method that can evaluate a subject's masticatory performance in a short period of time. The results of this test show a significant correlation with the number of teeth present or occlusal support area. This study examined the association between masticatory performance using a color-changeable chewing gum and the one-leg standing time with eyes open in community-dwelling elderly women. The subjects were 138 women aged between 65 and 74 years who participated in the surveys conducted in 2009 and 2010, and consented to undergo a medical interview, body measurement, one-leg standing test with eyes open, and oral examination. Color-changeable chewing gum was used to measure the masticatory performance. The color of the gum after chewing for 2 minutes was assessed using a color chart, and the masticatory ability was evaluated using a 5-point rating scale (score of 1-5). Based on the scores, the subjects were divided into three groups (high performance group: 5 points; moderate performance group: 4 points; low performance group: 1-3 points). Denture wearers underwent tests with their dentures in. Logistic regression analyses were performed, with masticatory performance using a color-changeable chewing gum as the main variable, to estimate its influence on the ability to stand on one leg with eyes open for 30 seconds. Tested potential confounders included the number of teeth present, age, and motor function. A lower masticatory performance was significantly associated with the inability to stand on one leg with eyes open for 30 seconds (adjusted odds ratio [95% CI] = 2.34 [0.91-6.01] in moderate performance and 3.61 [1.14-11.4] in low performance groups). A decrease in the motor function was also significantly associated with the inability to stand on one leg with eyes open for 30 seconds (adjusted odds ratio [95%CI] = 5.00 [1.30-19.1]). The results indicated that there was a significant association between the masticatory performance using a color-changeable chewing gum and one-leg standing time with eyes open in community-dwelling elderly women.

DOI： 10.5834/jdh.62.3_289

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Other Link： http://search.jamas.or.jp/link/ui/2012304189

Association Between Glucan Synthesis by Streptococcus mutans and Caries Incidence in Schoolchildren Receiving a Fluoride Mouth Rinse

Umetsu, Hidehiro, Kaneko, Noboru, Yoshihara, Akihiro, Sakuma, Shihoko, Hanada, Nobuhiro, Miyazaki, Hideo

ORAL HEALTH & PREVENTIVE DENTISTRY 10 ( 2 ) 161 - 166 2012

Language：English Publishing type：Research paper (scientific journal) Publisher：QUINTESSENCE PUBLISHING CO INC

Association between Masticatory Performance and One-leg Standing Time with Eyes Open in Community-dwelling Elderly Women

IWASAKI Masanori, YOSHIHARA Akihiro, MIYAZAKI Hideo

J Dent Hlth 62 ( 3 ) 289 - 295 2012

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Society for Oral Health

DOI： 10.5834/jdh.62.3_289

CiNii Article

CiNii Books

The Relationship between Articulation Function Evaluated by Oral Diadochokinesis and Speech Mechanism Disorder Reviewed

62 ( 5 ) 445 - 453 2012

Relationship between root caries and cardiac dysrhythmia Reviewed

Masayuki Kaneko, Akihiro Yoshihara, Hideo Miyazaki

GERODONTOLOGY 28 ( 4 ) 289 - 295 2011.12

Relationship between root caries and cardiac dysrhythmia

Masayuki Kaneko, Akihiro Yoshihara, Hideo Miyazaki

GERODONTOLOGY 28 ( 4 ) 289 - 295 2011.12

Mineral content of calcium and magnesium in the serum and longitudinal periodontal progression in Japanese elderly smokers Reviewed

Akihiro Yoshihara, Masanori Iwasaki, Hideo Miyazaki

JOURNAL OF CLINICAL PERIODONTOLOGY 38 ( 11 ) 992 - 997 2011.11

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY-BLACKWELL

Objective: Evidence from physiological and clinical studies regarding the mechanism by which calcium and magnesium are associated with periodontal disease, adjusted for smoking habits, is lacking. This longitudinal study evaluated the association of serum calcium levels and the calcium/magnesium (Ca/Mg) ratio with periodontal disease progression among smokers and non-smokers.
Material and Methods: A total of 309 subjects aged 73 years were included. Followup surveys were carried out every year for 6 years. After dividing subjects into smokers and non-smokers, multiple logistic regression analysis for men was performed to evaluate the relationship between the serum Ca/Mg ratio and periodontal disease progression. We used the 25th percentile of periodontal disease events for 6 years as the dependent variable and seven other variables, including quartiles for serum Ca/Mg ratios, as independent variables.
Results: There was a clear dose-response relationship of Ca/Mg ratio quartiles for periodontal disease events among smokers. Significant differences in odds ratios in the first and second quartiles were seen compared with the fourth quartile (reference): 6.28 (p = 0.014) and 5.96 (p = 0.022), respectively. However, there was no significant dose-response relationship among non-smokers.
Conclusion: A low serum Ca/Mg ratio was significantly associated with periodontal disease progression in Japanese elderly smokers.

DOI： 10.1111/j.1600-051X.2011.01769.x

Mineral content of calcium and magnesium in the serum and longitudinal periodontal progression in Japanese elderly smokers

Akihiro Yoshihara, Masanori Iwasaki, Hideo Miyazaki

JOURNAL OF CLINICAL PERIODONTOLOGY 38 ( 11 ) 992 - 997 2011.11

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY-BLACKWELL

DOI： 10.1111/j.1600-051X.2011.01769.x

Physical activity and 5-year changes in physical performance tests and bone mineral density in postmenopausal women: The Yokogoshi Study Reviewed

Kaori Kitamura, Kazutoshi Nakamura, Ryosaku Kobayashi, Rieko Oshiki, Toshiko Saito, Mari Oyama, Shunsuke Takahashi, Tomoko Nishiwaki, Masanori Iwasaki, Akihiro Yoshihara

MATURITAS 70 ( 1 ) 80 - 84 2011.9

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER IRELAND LTD

Objective: The effect of physical activity on musculoskeletal health in older adults is not completely understood. The aim of this study was to determine the relationship between physical activity and 5-year changes in physical performance tests and bone mineral density (BMD) in postmenopausal women.
Study design: The design was a 5-year cohort study.
Main outcome measures: Subjects were 507 women (55-74 years old) living in a rural community in Japan. Physical activity assessed included housework, farm work, and moderate leisure-time physical activity within the previous week. Measurements at baseline included handgrip strength, walking time (timed "Up & Go" test) and BMD of the femoral neck and vertebrae. Five-year changes in these measures (outcome variables) were compared among groups with different levels of physical activity by analysis of covariance.
Results: Women who did not do housework performed worse in changes in handgrip strength (difference = 2.22 kg, P = 0.0201) and worse in changes in the walking time (difference = 0.54 s, P = 0.0072) than those who did housework alone. Women who spent at least 9 h per week (median = 24) doing farm work performed better in changes in handgrip strength (difference = 0.28 kg, P= 0.0334), but worse in changes in the walking time (difference = 0.66 s, P<0.0001) than those who did not do farm work. However, leisure-time activity was not associated with changes in any outcome variable, and none of the physical activities predicted BMD changes.
Conclusions: Engaging in housework and farm work are determinants of physical function in postmenopausal women, which may help them maintain independence in daily living. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.maturitas.2011.06.014

Physical activity and 5-year changes in physical performance tests and bone mineral density in postmenopausal women: The Yokogoshi Study

Kaori Kitamura, Kazutoshi Nakamura, Ryosaku Kobayashi, Rieko Oshiki, Toshiko Saito, Mari Oyama, Shunsuke Takahashi, Tomoko Nishiwaki, Masanori Iwasaki, Akihiro Yoshihara

MATURITAS 70 ( 1 ) 80 - 84 2011.9

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER IRELAND LTD

DOI： 10.1016/j.maturitas.2011.06.014

縦断調査からみた歯列欠損形態と咀嚼能力の経年変化

佐藤直子, 野村修一, 昆はるか, 櫻井直樹, 葭原明弘, 宮崎秀夫, 河野正司

老年歯科医学 26 ( 2 ) 171 - 172 2011.9

Relationships among bone turnover, renal function and periodontal disease in elderly Japanese Reviewed

A. Yoshihara, Y. Hayashi, H. Miyazaki

JOURNAL OF PERIODONTAL RESEARCH 46 ( 4 ) 491 - 496 2011.8

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY-BLACKWELL

Background and Objective: We hypothesized that renal function is associated with the relationship between periodontal disease and bone metabolism. The present study evaluated the relationship of bone formation and resorption markers to periodontal disease, taking renal function into consideration, in elderly Japanese subjects.
Material and Methods: We selected 148 subjects aged 77 years. The periodontal examination included the assessment of clinical attachment level (CAL). We measured two bone formation markers (serum bone-specific alkaline phosphatase and serum osteocalcin) and two bone resorption markers (urinary deoxypyridinoline and urinary cross-linked N-telopeptide of type I collagen). Creatinine clearance per 24 h, as a measure of renal function, was also determined. The correlations between mean CAL or percentage of sites with >= 6 mm CAL (6+ mm CAL) and bone turnover markers, and between bone turnover markers and creatinine clearance levels, were performed by multiple linear regression analysis.
Results: There were significant negative relationships between mean CAL or 6+ mm CAL and serum osteocalcin levels adjusted for gender, smoking habits and oral care habits (beta - -0.25, p - 0.014 and beta - -0.35, p - 0.001, respectively). In addition, there was a negative relationship between serum osteocalcin and creatinine clearance levels adjusted for gender and smoking habits (beta = -0.45, p < 0.0001).
Conclusion: Results from the present study suggest that serum osteocalcin was significantly associated with renal function and periodontal disease. The low systemic bone metabolism, which might be caused by low renal function, is associated with periodontal disease.

DOI： 10.1111/j.1600-0765.2011.01365.x