Faculty Profiles - YOSHIHARA Akihiro

縦断調査から見た地域高齢者の咀嚼能力

佐藤直子, 野村修一, 昆はるか, 櫻井直樹, 河野正司, 葭原明弘, 宮崎秀夫

日本老年歯科医学会総会・学術大会プログラム・抄録集 21回 107 - 107 2010.6

Relationship between the mandibular inferior cortex and bone stiffness in elderly Japanese people Reviewed

B. Kiswanjaya, A. Yoshihara, T. Deguchi, N. Hanada, H. Miyazaki

OSTEOPOROSIS INTERNATIONAL 21 ( 3 ) 433 - 438 2010.3

Language：English Publishing type：Research paper (scientific journal) Publisher：SPRINGER LONDON LTD

This study assessed the relationship between the mandibular inferior cortex (MIC) and bone stiffness in elderly Japanese subjects. Results suggest that MIC classification may be useful for screening patients for the possibility of osteoporosis by measuring bone stiffness with ultrasound bone densitometry.
The prevention of fractures is a priority for patients with osteoporosis. Dental panoramic radiographs are frequently taken for the examination of teeth and jaws in general dental practice worldwide. This study assessed the relationship between the mandibular inferior cortex (MIC) and bone stiffness in elderly Japanese subjects.
This study included 519 healthy subjects (263 men and 256 women) aged 70 years old. We evaluated the relationship between MIC classification and bone stiffness using Scheffe's multiple comparison test. Multiple linear regression analysis was used to assess the relationship between MIC classification and bone stiffness after controlling for confounding factors.
A significant correlation was found between MIC classification and bone stiffness in men (C1 vs C2: p < 0.05) and women (C1 vs C2: p = NS, C1 vs C3: p < 0.01, C2 vs C3: p < 0.05). MIC classification was significantly associated with bone stiffness on multiple linear regression analysis after controlling for sex, body mass index, regular exercise, and smoking (beta = -0.11, p < 0.01, R (2) = 0.387, p < 0.001).
Our study suggests that MIC classification may be useful for screening patients for the possibility of osteoporosis by measuring bone stiffness with ultrasound bone densitometry.

DOI： 10.1007/s00198-009-0996-9

A Quick Statistically Accurate Diagnosis for Caries Risk in the Elderly

Hidenobu Senpuku, Hideo Miyazaki, Saori Yoneda, Akihiro Yoshihara, Akio Tada

CLINICAL LABORATORY 56 ( 11-12 ) 505 - 512 2010

Language：English Publishing type：Research paper (scientific journal) Publisher：CLIN LAB PUBL

Background: In the elderly, the necessity to promote oral health is increasing to improve their quality of life. The prediction of dental caries risk makes it possible to prolong the life span of teeth. To develop a quick diagnosis system for caries risk, two methods, the modified Saliva Check SM (TM) and Saliva Check sIgA, were investigated in elderly patients.
Methods: We developed a caries risk quick assessment system using Saliva Check sIgA that specifically recognizes secretory IgA (sIgA) in saliva against the binding site of the mutans streptococci (MS) to the salivary-coated tooth surface; and combined it with a modified Saliva Check SM (TM) to determine the number of MS. One hundred eighty three patients (80 females, 103 males) who participated in 2005 (average age 77 years) and in 2006 (average age 78 years) were assessed for caries risk using the systems in this cohort study.
Results: Subjects with a positive Saliva Check sIgA showed a significantly lower increment of decayed and filled teeth number (DFT) on the coronal surface; whereas those testing negative had root decay and increased filled teeth numbers (RDFT) at the root surface during the following year. The combination of Saliva Check sIgA and modified Saliva Check SM (TM) showed the subjects with Saliva Check sIgA positive and modified Saliva Check SM (TM) negative had less than half of the increment of DFT than other groups. In the other groups, Saliva Check sIgA negative and modified Saliva Check SM (TM) positive detected >90% of the subjects with an MS level of >5 x 10(5)/mL of saliva in patients that were assessed in 2006. This suggests these subjects may need extensive care.
Conclusions: This new combination system significantly evaluates the caries risk to predict future incidence for dental caries on the coronal surface and may be useful for risk diagnosis of caries during a visit to the dental office. (Clin. Lab. 2010;56:505-512)

高齢者の口腔乾燥感と神経症症状および服薬との関連 Reviewed

船山さおり, 伊藤加世子, 濃野要, 五十嵐敦子, 井上誠, 葭原明弘, 宮﨑秀夫

日本口腔衛生学会雑誌 60 ( 5 ) 575 - 583 2010

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：(一社)日本口腔衛生学会

高齢者の口腔乾燥感は主に薬剤の副作用によって生じると言われている。高齢者はストレスへの耐性が低いが、神経症症状と口腔乾燥感との関連を検討した報告は少ない。また、服薬および神経症症状と口腔乾燥感に関して、同じ対象者において同時に検討した報告も少ない。よって本研究では、高齢者における口腔乾燥感の自覚頻度を明らかにするとともに、服薬および神経症症状と口腔乾燥感の関連について検討することを目的とした。高齢者398名を対象として、質問紙や面接聞き取り等により口腔乾燥感、服薬状況および神経症症状を調査した。神経症症状の評価には、日本版GHQ30を用いた。口腔乾燥感を有する者は60.4%、神経症症状を有する者は27.6%であった。服薬中の者は72.3%、服薬数の最頻値は2剤であった。口渇高頻度薬剤の服用者は18.7%、服薬数の最頻値は1剤であった。口腔乾燥感を従属変数、性、神経症症状および口渇高頻度薬剤の服用を説明変数としたロジスティック回帰分析を行った結果、神経症症状のある者(オッズ比:2.059、p<0.05)および口渇高頻度薬剤の服用者(オッズ比:2.552、p<0.05)は、そうでない者と比べ統計学的に有意に口腔乾燥感のある者の割合が高かった。以上により、高齢者において神経症症状が、服薬と同様に口腔乾燥感に関連していることが示唆された。(著者抄録)

DOI： 10.5834/jdh.60.5_575

Other Link： https://search.jamas.or.jp/default/link?pub_year=2010&ichushi_jid=J00440&link_issn=&doc_id=20101109220004&doc_link_id=%2Fdk1dehea%2F2010%2F006005%2F005%2F0575-0583%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdk1dehea%2F2010%2F006005%2F005%2F0575-0583%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

A study of oral health in Vientiane, Lao PDR Reviewed

M Kaneko, H Ogawa, A Yoshihara, N Murayama, S Ladparkdy, K Phommavongsa, B Boupha, H Miyazaki

The international Journal of Oral Health 6 1 - 7 2010

The Effects of Medication and Psychological Well-being on Subjective Oral Dryness in the Elderly

FUNAYAMA Saori, ITO Kayoko, NOHNO Kaname, IGARASHI Atsuko, INOUE Makoto, YOSHIHARA Akihiro, MIYAZAKI Hideo

J Dent Hlth 60 ( 5 ) 575 - 583 2010

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Society for Oral Health

Objective: One of the main causes of subjective oral dryness in the elderly is the side effects of medication. In addition, the elderly's tolerance to stress is low, and stress may induce many symptoms including mouth dryness. Thus, it is necessary to examine their psychological well-being. However, few reports have considered the relationship between subjective oral dryness and psychological well-being. Furthermore, few reports have examined subjective oral dryness, medication use, and psychological well-being simultaneously. The purpose of this study was to investigate the rate of subjective oral dryness and effects of psychological well-being and medication in the elderly. Methods: A questionnaire survey and interview concerning subjective oral dryness, medication use, and psychological symptoms were conducted involving 398 elderly aged 77-78 years old in Japan. The rates of the side effect of subjective oral dryness caused by medication and drug efficacy were investigated using the book 'Drugs in Japan'. The Japanese version of a general health questionnaire (GHQ 30), a self-entry type questionnaire, was used to evaluate psychological well-being. The elderly with scores greater

DOI： 10.5834/jdh.60.5_575

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高齢者における咀嚼回数と食品群別摂取量および栄養素等摂取量との関連 Reviewed

岩崎正則, 葭原明弘, 村松芳多子, 渡邊令子, 宮崎秀夫

日本口腔衛生学会雑誌 60 128 - 138 2010

Correlation between Oral Care and Fever in General Ward Patients Reviewed

Ryoko Hori, Naoko Takano, Akihiro Yoshihara, Hideo Miyazaki

Japanese Journal of Environmental Infections 25 ( 2 ) 85 - 90 2010

Language：English Publishing type：Research paper (scientific journal)

Many studies have examined the preventive effects of oral care provided by dental professionals against aspiration pneumonia in elderly nursing home residents who require care. However, few reports have evaluated routine oral care provided by nurses to inpatients. Therefore, we investigated the correlation between oral care provided to general ward patients and the incidence of fever and the detection of the etiologic agents of hospital-acquired pneumonia in the oral cavity in 69 in-patients, aged 40 years or older, who were admitted to four hospitals in Niigata and required assistance in oral care. The number and details of oral care procedures were recorded. The presence of Staphylococcus aureus, MRSA, and Pseudomonas aeruginosa in the oral cavity were quantified, and fevers of 37.5°C or higher over the previous week were recorded. The subjects were divided into two groups based on oral intake (oral intake and non-oral intake groups), and Fisher's direct probability test was used to compare their results. For the oral intake group, the incidence of fever and the detection rate of S. Aureus were significantly lower for subjects who received oral care three times a day. On the other hand, for the non-oral intake group, the ratio of patients with fevers was significantly lower for those who received oral care using toothbrushes. These findings suggest that, for inpatients who ingest food orally, frequent oral care can prevent fever and opportunistic pathogen colonization in the oral cavity, and that for inpatients who do not ingest food orally, fever can be prevented by mechanical oral care using a toothbrush. © 2010, Japanese Society for Infection Prevention and Control. All rights reserved.

DOI： 10.4058/jsei.25.85

Scopus

A Quick Statistically Accurate Diagnosis for Caries Risk in the Elderly Reviewed

Hidenobu Senpuku, Hideo Miyazaki, Saori Yoneda, Akihiro Yoshihara, Akio Tada

CLINICAL LABORATORY 56 ( 11-12 ) 505 - 512 2010

Language：English Publishing type：Research paper (scientific journal) Publisher：CLIN LAB PUBL

The Relationship between the Speed of Eating and Nutritional Intake of Japanese Aged 80 Years Old Based on Responses to a Brief-type Self-administered Diet History Questionnaire Reviewed

小規模障害者施設における心身障害者のう蝕および歯周病の罹患状況に関する研究 Reviewed

杉浦貴美子, 葭原明弘, 藤山友紀, 岡田匠, 宮﨑秀夫

日本口腔衛生学会雑誌 60 112 - 118 2010

IWASAKI Masanori, YOSHIHARA Akihiro, MURAMATSU Kanako, WATANABE Reiko, MIYAZAKI Hideo

Journal of dental health 60 ( 1 ) 30 - 37 2010

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Society for Dental Health

A brief-type self-administered diet history questionnaire (BDHQ) is a validated method of dietary assessment. This study investigated the relationship between the speed of eating, which is considered an eating behavior, and the estimated nutrient intake using the BDHQ in community-dwelling Japanese aged 80 years old. Three hundred and fifty-four participants (174 males and 180 females) aged 80 years old who participated in both dental examinations and BDHQ assessment conducted in 2008 were included in the analysis. The speed of eating was self-reported by giving a response chosen from five qualitative categories: 'very fast', 'relatively fast', 'medium', 'relatively slowly', and 'very slowly'. The five categories were classified into two categories for statistical analysis, that is, participants who answered 'very fast' and 'relatively fast' were defined as 'eating fast', while those who answered 'medium', 'relatively slowly', and 'very slowly' were defined as 'eating slowly'. The nutrient intake was calculated from the BDHQ using the ad-hoc program developed for nutrient calculation based on BDHQ responses. The estimated nutrient intake was compared between the two groups defined as eating 'fast' or 'slowly'. Furthermore, multivariable linear regression analysis was conducted using the speed of eating, gender, BMI, number of teeth, and masticatory function as independent variables to assess the influence on the estimated nutrient intake. The participants defined as eating 'fast' consumed significantly more zinc, copper, cryptoxanthin, and vitamin C than participants defined as eating 'slowly' (p=0.012, p=0.022, p=0.007, and p=0.049, respectively; Student's t-test). Moreover, the zinc, copper, cryptoxanthin, and vitamin C intakes of participants defined as eating 'fast' remained significantly higher than those of participants defined as eating 'slowly' after simultaneously adjusting for possible confounders (p=0.027, p=0.039, p=0.004, and p=0.043, respectively). The findings of this study suggest that Japanese people aged 80 years old who define themselves as eating fast consume higher levels of nutrients that are included in meat, fish, shellfish, vegetables, and fruits.

DOI： 10.5834/jdh.60.1_30

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Evaluation of Personalized Oral Health Program for Mothers Provided with Screening Examination at their Infants' Medical and Dental Check-ups Reviewed

Other Link： http://search.jamas.or.jp/link/ui/2010121408

YOSHIHARA Akihiro, KANEKO Noboru, SUGIMOTO Tomoko, SEIDA Yoshikazu, SATO Toru, MIYAZAKI Hideo

Journal of dental health 60 ( 1 ) 11 - 16 2010

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Society for Dental Health

Dental examinations are often conducted in cities, towns, and villages as part of an oral health program for adults. However, in many places, a low percentage of subjects participate in these programs. This study evaluated the effects of a prevention program on periodontal disease focusing on personal education for adults, assessing whether or not the percentage of subjects who use interdental brushes or dental floss daily increase. Seventy-three mothers were surveyed in S city in Niigata Prefecture. Clinical examinations were performed for mothers who visited their local health centers while taking their children for their 1- or 2.5- year medical and dental check-ups. Subjects were divided into 2 groups: test group (n=29, mean age=32.7±5.1) and control group (n=44, mean age=30.2±5.2). For the test group, a chewing function test using chewing gum and a saliva bleeding test employing stimulated saliva as a screening examination, as well as personal education regarding dental care, were conducted by dental hygienists. The instruction was provided to improve the following two items: (1) the use of dental floss or interdental brushes, and (2) regular professional dental check-ups. We used a jaw model, booklets, and dental floss to support the personal instruction. For the control group, a dental examination using a probe and mirror was conducted, and tooth-brushing instructions were provided. Changes in oral health conditions and oral health behavior were evaluated over a 3-month period. The results showed that the rate of subjects who used dental floss or interdental brushes increased from 41.4% (baseline) to 62.1% (3 months) in the test group (20.7% change, P<0.001) compared with 34.1% (baseline) to 47.7% (3 months) in the control group (13.6% change, P<0.001). These results demonstrate that personal instruction with, a screening examination for mothers who bring their children for medical and dental check-ups may improve oral hygiene.

DOI： 10.5834/jdh.60.1_11

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Other Link： http://search.jamas.or.jp/link/ui/2010121405

Economic Evaluation of a School-based Combined Program with a Targeted Pit and Fissure Sealant and Fluoride Mouth Rinse in Japan.

Sakuma S, Yoshihara A, Miyazaki H, Kobayashi S

The open dentistry journal 4 230 - 6 2010

特定高齢者における口腔機能向上プログラムの効果 Reviewed

薄波清美, 髙野尚子, 葭原明弘, 宮﨑秀夫

新潟歯学会雑誌 40 33 - 37 2010

Low calcium intake is associated with increased bone resorption in postmenopausal Japanese women: Yokogoshi Study Reviewed

Kazutoshi Nakamura, Toshiko Saito, Akihiro Yoshihara, Miki Ishikawa, Yasuo Tsuchiya, Rieko Oshiki, Ryosaku Kobayashi, Keiko Maruyama, Keiko Hyodo, Mitsue Nashimoto, Naoko Tsugawa, Toshio Okano, Mari Oyama, Masaharu Yamamoto

PUBLIC HEALTH NUTRITION 12 ( 12 ) 2366 - 2370 2009.12

Language：English Publishing type：Research paper (scientific journal) Publisher：CAMBRIDGE UNIV PRESS

Objective: Low Ca intake is common among Japanese women, but its effect Oil bone metabolism has not been fully elucidated. The aim Of the present study was to determine the relationship between Ca intake and serum markers of bone turnover ill postmenopausal Japanese women.
Design: A cross-sectional study.
Setting: A community setting.
Subjects: Subjects were 595 home-dwelling postmenopausal Japanese women. Ca intake was assessed by a validated FFQ, Serum type I collagen cross-linked N-telopeptides (NTX) and osteocalcin Were measured as markers of bone turnover. The relationships between demographic characteristics, lifestyles, serum Ca, vitamin D and intact serum parathyroid hormone and bone turnover were also assessed.
Results: The average age of the subjects was 64.5 (SD 5.8) years and the mean Ca intake was 527 (SD 160) mg/d. Ca intake was significantly associated with serum NTX (P=0.0104); but not with serum osteocalcin. Mean serum NTX concentration in the lowest quartile of Ca intake (<417 mg/d) was significantly higher than in the fourth, referent quartile. Among these Japanese postmenopausal women, very low Ca intake (less than similar to 400 mg/d) was associated with increased bone resorption but not one formation.
Conclusions: Increased bone resorption may be one mechanism by which this Ca-depleted population normalizes bone metabolism and prevents osteoporosis.

DOI： 10.1017/S1368980009005084

Low calcium intake is associated with increased bone resorption in postmenopausal Japanese women: Yokogoshi Study

PUBLIC HEALTH NUTRITION 12 ( 12 ) 2366 - 2370 2009.12

Language：English Publishing type：Research paper (scientific journal) Publisher：CAMBRIDGE UNIV PRESS

DOI： 10.1017/S1368980009005084

日本における集団応用でのフッ化物洗口に関する実態調査施設別、都道府県別の普及状況(2008) Reviewed

木本一成, 田浦勝彦, 田口千恵子, 相田潤, 晴佐久悟, 葭原明弘, 安藤雄一, 荒川浩久, 境脩

口腔衛生学会雑誌 59 ( 5 ) 586 - 595 2009.10

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：(一社)日本口腔衛生学会

NPO法人日本むし歯予防フッ素推進会議は、2008年3月現在の全国での集団応用フッ化物(F)洗口実施状況を、(財)8020推進財団、WHO口腔保健協力センターと共同調査した。F洗口実施率は、全国の施設総数の9.0%、児童生徒総数(4歳〜15歳未満)の5.1%と低かった。各施設(保育所、幼稚園、小学校、中学校、特別支援学校等)でF洗口実施人数の約50%を1割程度の自治体が占め、普及に都道府県間の格差を認めた。洗口回数は、保育所、幼稚園で週5回が、小学校、中学校、特別支援学校等で週1回が多かった。使用洗口液F濃度は、年齢が上がるにつれて900ppmFの割合が多いものの、特別支援学校等では450ppmFが多かった。洗口剤は保育所、幼稚園、特別支援学校で市販F洗口製剤が、小学校、中学校でフッ化ナトリウム試薬の使用割合が高かった。経費負担者・団体は、いずれの施設でも行政や教育委員会が最も多かった。「健康日本21の地方計画」にF応用が組み込まれず、F洗口の目標値のない自治体の存在や、実施状況に都道府県間の格差がみられたことから、格差是正に向け、公衆衛生施策としてF洗口を検討すべきである。本調査がF洗口の目標(数値目標)を検討するための基礎データとして利用され、2010〜2012年度に行われる「健康日本21」最終評価で、F洗口の目標や数値目標の設定を採択し、2013年度以降の運動推進に反映されるように提言する。(著者抄録)

DOI： 10.5834/jdh.59.5_586

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Long-term follow-up of the effects of a school-based caries preventive programme involving fluoride mouth rinse and targeted fissure sealant: Evaluation at 20 years old

Aya Nakamura, Shihoko Sakuma, Akihiro Yoshihara, Tomoya Deguchi, Minoru Yagi, Hideo Miyazaki

INTERNATIONAL DENTAL JOURNAL 59 ( 4 ) 215 - 221 2009.8

Language：English Publishing type：Research paper (scientific journal) Publisher：F D I WORLD DENTAL PRESS LTD

Aims: The evaluation of long-term effects five years after the completion of a school-based caries prevention programme combined with fluoride mouth rinse (FMR) and targeted sealant application (TS). Participants: 46 subjects in the FMR+TS group and 55 subjects in the FMR group, who were 20 -21 years old, were analysed. They had participated in each 11-year programme, underwent a dental examination at the age of 20 years and answered a self-administered questionnaire. Methods: The caries prevalence and mean DMFT were calculated, and differences between the two groups were analysed by the X(2) test and Mann-Whitney test, respectively. Logistic and multiple regression analyses were performed using sex, group, and five questionnaire items as independent variables. Results: The caries prevalence and mean DMFT (SD) was 28.3%, 1.56 (3.00) in the FMR+TS group and 60.0%, 2.20 (2.44) in the FMR group, and the difference was significant respectively. In the logistic regression analysis the odds ratio of the FMR+TS group to the FMR group was 0.28 (p < 0.05). Conclusions: The caries-preventive effects of a school-based combined programme with FMR and TS continued for more than five years after the programme until the age of 20 years.

DOI： 10.1922/IDJ_2233Sakuma07