Faculty Profiles - YOSHIHARA Akihiro

Relationship between metabolic syndrome and periodontitis in 80-year-old Japanese subjects Reviewed

K. Minagawa, M. Iwasaki, H. Ogawa, A. Yoshihara, H. Miyazaki

JOURNAL OF PERIODONTAL RESEARCH 50 ( 2 ) 173 - 179 2015.4

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY

Background and ObjectivePotentially significant associations between metabolic syndrome (MetS) and periodontitis have been reported in recent studies; however, there are limited data on their association in the very old. The aim of this cross-sectional study was to investigate the association between MetS and periodontitis among 80-year-old Japanese subjects.
Material and MethodsThe subjects were 234 Japanese aged 80years old who participated in a health and periodontal examination in June 2008 in Niigata city, Japan, and were classified into three groups: (i) severe periodontitis: having six or more interproximal sites with clinical attachment level 6mm and three or more interproximal sites with probing pocket depth (PPD) 5mm (not on the same tooth) (n=19); (ii) moderate periodontitis: having six or more interproximal sites with clinical attachment level 4mm or six or more interproximal sites with PPD 5mm (not on the same tooth) (n=162); and (iii) no or mild periodontitis: neither moderate nor severe periodontitis (n=53). MetS was defined using the modified criteria of the guidelines for the diagnosis of MetS in Japan. An ordinal logistic regression model was used to evaluate the association between MetS and periodontitis. Adjustments for gender, income, education, smoking status, dental visiting patterns, brushing frequency, exercise habits and dietary energy and food intake were considered.
ResultsOverall, 57 individuals (24.4%) were diagnosed as having MetS. MetS was associated with the presence and severity of periodontitis (crude odds ratio=2.24, 95% confidence interval=1.14-4.41). This association remained statistically significant after multivariate adjustments (adjusted odds ratio=2.10, 95% confidence interval=1.03-4.28).
ConclusionOur findings provide evidence of an association between MetS and periodontitis in elderly Japanese.

DOI： 10.1111/jre.12190

Longitudinal Relationship Between Metabolic Syndrome and Periodontal Disease Among Japanese Adults Aged >= 70 Years: The Niigata Study

Masanori Iwasaki, Misuzu Sato, Kumiko Minagawa, Michael C. Manz, Akihiro Yoshihara, Hideo Miyazaki

JOURNAL OF PERIODONTOLOGY 86 ( 4 ) 491 - 498 2015.4

Language：English Publishing type：Research paper (scientific journal) Publisher：AMER ACAD PERIODONTOLOGY

Background: There has been little evaluation in longitudinal epidemiologic studies of the effect of metabolic syndrome (MetS) on periodontal status. The specific aim of this longitudinal study is to investigate whether MetS in the Japanese population could be a risk factor for periodontal disease.
Methods: A total of 125 older adults from Japan for whom data were available for the years 2003 to 2006 were selected for the current study. Full-mouth periodontal status, measured as clinical attachment level (CAL), was recorded at baseline and in follow-up examinations. Development of periodontal disease was considered to be >= 2 teeth demonstrating a longitudinal loss of proximal attachment of >= 3 mm at the follow-up dental examination. A multivariable Poisson regression model with robust error variance was used to evaluate the association of MetS defined by the modified National Cholesterol Education Program Adult Treatment Panel III criteria with development of periodontal disease. Adjustments for sex, income, education, smoking status, number of teeth at baseline, mean CAL at baseline, pattern of visits to a dentist, and brushing frequency were considered.
Results: The prevalence of MetS was 21.6% (27/125). Study participants with MetS were approximately 2.6 times more likely to develop periodontal disease (adjusted relative risk 2.58, 95% confidence interval 1.17 to 5.67) after simultaneous adjustment for other covariates.
Conclusions: These findings support the hypothesis that MetS may be a risk factor for periodontal disease in older Japanese individuals. Additional studies with larger, more diverse populations and more complete information are needed to substantiate the findings.

DOI： 10.1902/jop.2015.140398

地域在住高齢者における歯・口腔の健康が認知機能検査スコアに与える影響 Reviewed

岩崎正則, 葭原明弘, 小川祐司, 山賀孝之, 佐藤美寿々, 安細敏弘, 宮崎秀夫

口腔衛生学会雑誌 65 ( 2 ) 195 - 195 2015.4

歯科医師および歯科衛生士数と医院の担える診療内容との関連

皆川久美子, 葭原明弘, 荒井節男, 清田義和, 宮崎秀夫

口腔衛生学会雑誌 65 ( 2 ) 255 - 255 2015.4

成人女性に対する歯周病予防の取り組みへの提案

皆川久美子, 葭原明弘, 宮崎秀夫

口腔衛生学会雑誌 65 ( 1 ) 53 - 53 2015.1

Association between dental status and food diversity among older Japanese Reviewed

Masanori Iwasaki, Y. Kimura, A. Yoshihara, H. Ogawa, T. Yamaga, T. Takiguchi, T. Wada, R. Sakamoto, Y. Ishimoto, E. Fukutomi, W. Chen, H. Imai, M. Fujisawa, K. Okumiya, M. C. Manz, H. Miyazaki, K. Matsubayashi

Community Dental Health 32 ( 2 ) 104 - 110 2015

Language：English Publishing type：Research paper (scientific journal) Publisher：Dennis Barber Ltd

Objective: To investigate the relationship of dental status to food diversity among older Japanese. Design and Setting: A community-based cross-sectional study conducted in the town of Tosa, Kochi Prefecture, Japan. Methods: The study participants were 252 Japanese (84 men and 168 women, average age 81.2 years) and dentate participants were classified into three groups: 1-9 teeth, 10-19 teeth and 20 or more teeth. Food diversity was assessed as a validated measure of dietary quality using the 11-item Food Diversity Score Kyoto (FDSK-11), which evaluates frequency of consumption of 11 main food groups. Multivariable analysis of the differences in FDSK-11 score ranging from 0 to 11, with a higher score indicating greater food diversity, among the three dental status groups was conducted using general linear models. All the performed analyses were stratified by gender. Results: There was no association between dental status and food diversity score in models for men. In contrast, women with ≤9 teeth and with 10-19 teeth had significantly lower FDSK-11 scores than women with ≥20 teeth after adjusting for confounders (p&lt
0.001 and p=0.009, respectively). Additionally, there was a trend toward lower scores for FDSK-11 with fewer teeth (p=0.001). Conclusion: A less varied diet, as indicated by low FDSK-11 score, was observed in female participants with fewer teeth. Tooth loss was associated with poor diet quality among older Japanese women.

DOI： 10.1922/CDH_3502Iwasaki07

Scopus

Low dietary diversity among older Japanese adults with impaired dentition Reviewed

Iwasaki M, Kimura Y, Yoshihara A, Ogawa H, Yamaga T, Wada T, Sakamoto R, Ishimoto Y, Fukutomi E, Vhen WL, Imai H, Fujisawa M, Okumiya K, Manz MC, Ansai T, Miyazaki H, Matsubayashi K

Journal of Dentistry and Oral Hygiene 7 ( 4 ) 40 - 43 2015

Analysis of tooth brushing cycles Reviewed

Yuki Tosaka, Kuniko Nakakura-Ohshima, Nozomi Murakami, Rikako Ishii, Issei Saitoh, Yoko Iwase, Akihiro Yoshihara, Akitsugu Ohuchi, Haruaki Hayasaki

CLINICAL ORAL INVESTIGATIONS 18 ( 8 ) 2045 - 2053 2014.11

Language：English Publishing type：Research paper (scientific journal) Publisher：SPRINGER HEIDELBERG

The aim of this study was to demonstrate the effectiveness of an analysis of tooth brushing cycles using a system that measures tooth brushing motion and brushing force with an accelerometer and strain tension gage attached to a toothbrush.
Mechanical plaque removal with a manual toothbrush remains the primary method of maintaining good oral hygiene for the majority of the population. Because toothbrush motion has not been fully understood, it should be clarified by analysis of tooth brushing cycles.
Twenty healthy female dental hygienists participated in this study. Their tooth brushing motions were measured and analyzed using an American Dental Association-approved manual toothbrush to which a three-dimensional (3-D) accelerometer and strain tension gage were attached. 3-D motion and brushing force on the labial surface of the mandibular right central incisor and the lingual surface of the mandibular left first molar were measured, analyzed, and compared. Multilevel linear model analysis was applied to estimate variables and compare motion and forces related to the two tooth surfaces.
The analysis of tooth brushing cycles was feasible, and significant differences were detected for durations and 3-D ranges of toothbrush motion as well as brushing force between the two tooth surfaces.
The analysis used in this study demonstrated an ability to detect characteristics of tooth brushing motion, showing tooth brushing motion to change depending on the brushed location. These results also suggest that more detailed instructions might be required according to patient's oral condition.

DOI： 10.1007/s00784-013-1172-3

Analysis of tooth brushing cycles Reviewed

Yuki Tosaka, Kuniko Nakakura-Ohshima, Nozomi Murakami, Rikako Ishii, Issei Saitoh, Yoko Iwase, Akihiro Yoshihara, Akitsugu Ohuchi, Haruaki Hayasaki

CLINICAL ORAL INVESTIGATIONS 18 ( 8 ) 2045 - 2053 2014.11

Language：English Publishing type：Research paper (scientific journal) Publisher：SPRINGER HEIDELBERG

DOI： 10.1007/s00784-013-1172-3

Oral health status: relationship to nutrient and food intake among 80-year-old Japanese adults Reviewed

Masanori Iwasaki, George W. Taylor, Michael C. Manz, Akihiro Yoshihara, Misuzu Sato, Kanako Muramatsu, Reiko Watanabe, Hideo Miyazaki

COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY 42 ( 5 ) 441 - 450 2014.10

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY-BLACKWELL

ObjectivesThe aim of this cross-sectional study was to investigate the relationship of oral health status defined on the basis of presence of posterior occluding pairs (POPs) and adequacy of removable denture fit as determined by self-report to nutrient and food intake among older Japanese.
MethodsThe subjects were 353 Japanese aged 80years in 2008 and were classified into four groups according to the number of POPs, defined as pairs of occluding natural, restored, or fixed prosthetic postcanine teeth (range: 0-8) and removable denture status. The groups were: (i) good dentition (n=56; 8 POPs and no removable prosthesis), (ii) well-fitting dentures (n=158; <8 POPs with self-reported good-fitting dentures), (iii) ill-fitting dentures (n=70; <8 POPs with self-reported ill-fitting dentures), and (iv) compromised dentition (n=69; <8 POPs and no removable prosthesis). Multivariable analysis of the differences in nutrient and food intake outcome variables which were collected via validated food frequency questionnaire among the four oral health status groups was conducted using general linear models.
ResultsIntake of multiple nutrients was significantly (P<0.05) lower in the group with ill-fitting dentures or compromised dentition than in the good dentition group. Vegetable, fish, and shellfish consumption was significantly lower in the ill-fitting dentures or compromised dentition groups. No significant differences were seen in dietary intake between the well-fitting dentures and good dentition groups.
ConclusionsDietary intake was poorer in those with self-perceived ill-fitting dentures or fewer POPs than among those having all POPs. Regular dental care to maintain intact dentition, as well as dental treatment to replace missing teeth and ensure adequate denture fit and function, may be important to the diet intake and subsequent nutritional status of older Japanese.

DOI： 10.1111/cdoe.12100

Oral health status: relationship to nutrient and food intake among 80-year-old Japanese adults Reviewed

Masanori Iwasaki, George W. Taylor, Michael C. Manz, Akihiro Yoshihara, Misuzu Sato, Kanako Muramatsu, Reiko Watanabe, Hideo Miyazaki

COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY 42 ( 5 ) 441 - 450 2014.10

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY-BLACKWELL

DOI： 10.1111/cdoe.12100

Comparison of periodontal conditions among three elderly populations in Japan and Germany Reviewed

Toshinobu Hirotomi, Thomas Kocher, Akihiro Yoshihara, Reiner Biffar, Wolfgang Micheelis, Thomas Hoffmann, Hideo Miyazaki, Birte Holtfreter

JOURNAL OF CLINICAL PERIODONTOLOGY 41 ( 7 ) 633 - 642 2014.7

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY-BLACKWELL

Aim: There is a growing interest in comparing periodontal conditions between countries. This study compared periodontal disease conditions in three elderly populations- one from Japan and two from Germany.
Materials and Methods: We compared periodontal data of 70-year-old subjects from the Niigata Study with 65-74-year-old subjects from the Study of Health in Pomerania (SHIP) and from West Germany (DMS III). A total of 489, 399 and 549 dentate subjects were analysed, respectively. Recording protocols were standardized. Linear or logistic models were used to compare Niigata Study with SHIP.
Results: Elderly German subjects in SHIP and DMS III had significantly more severe periodontal conditions and fewer remaining teeth compared to those in Niigata Study, though differences were less pronounced for DMS III. German subjects showed a significantly different pattern of various periodontal risk factors compared to Japanese subjects. Even after adjustment for putative periodontal risk factors, SHIP subjects still presented significantly higher adjusted values for most periodontal parameters compared to Niigata Study subjects (p < 0.05).
Conclusions: Periodontitis was more prevalent in SHIP compared with Niigata Study, even after comprehensive risk factor adjustment. Only to a very small extent, differences between studies could be explained by the risk factors explored.

DOI： 10.1111/jcpe.12267

Comparison of periodontal conditions among three elderly populations in Japan and Germany Reviewed

Toshinobu Hirotomi, Thomas Kocher, Akihiro Yoshihara, Reiner Biffar, Wolfgang Micheelis, Thomas Hoffmann, Hideo Miyazaki, Birte Holtfreter

JOURNAL OF CLINICAL PERIODONTOLOGY 41 ( 7 ) 633 - 642 2014.7

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY-BLACKWELL

DOI： 10.1111/jcpe.12267

Association between low renal function and tooth loss over 5 years Reviewed

Akihiro Yoshihara, Masanori Iwasaki, Hideo Miyazaki, Kazutoshi Nakamura

GERODONTOLOGY 31 ( 2 ) 111 - 116 2014.6

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY-BLACKWELL

ObjectivesThis longitudinal study evaluated the relationship between low renal function and tooth loss in elderly subjects.
Material and methodsSubjects comprised 406 female subjects (55-74years old) who agreed to participate in a baseline examination and a follow-up examination after 5years. Serum cystatin C levels were used to assess renal function. Multiple logistic regression analysis was used to evaluate the relationship between tooth loss and change in serum cystatin C levels over 5years. Tooth loss over 5years (0: no, 1: yes) was used as the dependent variable. Seven variables were used as independent variables, including change in serum cystatin C levels over 5years.
ResultsResults of multiple logistic regression analysis showed that cystatin C change over 5years, age, number of remaining teeth at baseline, number of sites with 4mm clinical attachment level at baseline and serum 25-hydroxyvitamin D levels at baseline were significantly associated with tooth loss. The odds ratio for tooth loss with cystatin C change over 5years was 7.70 (p=0.029).
ConclusionThis study indicates a relationship between serum cystatin C levels and number of missing teeth, and thus suggests that low renal function is associated with tooth loss.

DOI： 10.1111/ger.12015

Association between low renal function and tooth loss over 5 years Reviewed

Akihiro Yoshihara, Masanori Iwasaki, Hideo Miyazaki, Kazutoshi Nakamura

GERODONTOLOGY 31 ( 2 ) 111 - 116 2014.6

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY-BLACKWELL

DOI： 10.1111/ger.12015

高齢者における歯周病が医療費に及ぼす影響

佐藤美寿々, 岩崎正則, 葭原明弘, 宮崎秀夫

新潟歯学会雑誌 44 ( 1 ) 56 - 56 2014.6

The interaction between beta-3 adrenergic receptor polymorphism and obesity to periodontal disease in community-dwelling elderly Japanese Reviewed

Akihiro Yoshihara, Noriko Sugita, Masanori Iwasaki, Hideo Miyazaki, Kazutoshi Nakamura

JOURNAL OF CLINICAL PERIODONTOLOGY 41 ( 5 ) 460 - 466 2014.5

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY-BLACKWELL

Objectives
The purpose of this study was to elucidate whether the association between beta-3 adrenergic receptor polymorphism and periodontal disease is modified by body weight.
Material and Methods
We enrolled 332 postmenopausal women and determined their HbA1C levels (%) and beta-3 adrenergic receptor (rs4994) genotypes. Periodontal parameters including clinical attachment level (CAL) were measured. After selecting subjects for each body mass index (BMI) level, the prevalence rate ratio (PRR) by multiple Poisson regression analysis was calculated to evaluate the relationship between periodontal disease and beta-3 adrenergic receptor polymorphism. The number of sites with CAL >= 6mm was used as a dependent variable, and beta-3 adrenergic receptor genotype [categorized as Arg non-carriers (reference) or Arg carriers], age (y) and HbA1C (%) were adopted as independent variables. We converted the number of probing sites (n) to an offset variable.
Results
The PRR of the beta-3 adrenergic receptor genotype for the number of sites of CAL >= 6mm showed a positive association in subjects with BMI >= 25.0 and increased markedly with BMI. The PRR in subjects with BMI >= 30 was 3.10 (p<0.0001).
Conclusion
This study indicates a positive association between periodontal disease and the beta-3 adrenergic receptor genotype in obese individuals.

DOI： 10.1111/jcpe.12235

The interaction between beta-3 adrenergic receptor polymorphism and obesity to periodontal disease in community-dwelling elderly Japanese Reviewed

Akihiro Yoshihara, Noriko Sugita, Masanori Iwasaki, Hideo Miyazaki, Kazutoshi Nakamura

JOURNAL OF CLINICAL PERIODONTOLOGY 41 ( 5 ) 460 - 466 2014.5

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY-BLACKWELL

DOI： 10.1111/jcpe.12235