Faculty Profiles - YOSHIHARA Akihiro

保育園児に対する口腔機能向上訓練の構音機能への効果について Reviewed

平野真弓, 葭原明弘, 宮﨑秀夫

新潟歯学会雑誌 44 27 - 32 2014

Serum antibody to Porphyromonas gingivalis in metabolic syndrome among an older Japanese population Reviewed

M Iwasaki, K Minagawa, M Sato, N Kaneko, S Imai, A Yoshihara, H Miyazaki

Gerodontology 2014

臨床指針 Reviewed

八重垣健, 秋房住郎, 天野敦雄, 薄井由枝, 葭原明弘

日本口腔衛生学会雑誌 64 296 - 298 2014

High serum 25-hydroxyvitamin D levels do not retard postmenopausal bone loss in Japanese women: the Yokogoshi study Reviewed

Kaori Kitamura, Kazutoshi Nakamura, Toshiko Saito, Ryosaku Kobayashi, Rieko Oshiki, Tomoko Nishiwaki, Masanori Iwasaki, Akihiro Yoshihara

ARCHIVES OF OSTEOPOROSIS 8 ( 1-2 ) 153 2013.12

Language：English Publishing type：Research paper (scientific journal) Publisher：SPRINGER LONDON LTD

We conducted a cohort study exploring an association between serum 25-hydroxyvitamin D (serum 25(OH)D) and parathyroid hormone (PTH) levels and 5-year changes in bone mineral density (BMD) in 482 postmenopausal women. High serum 25(OH)D levels do not retard postmenopausal bone loss within the lumbar spine or femoral neck, and high PTH levels potentially increase hip bone loss.
Purpose The aim of this study was to explore an association between serum 25(OH)D levels and 5-year changes in BMD in postmenopausal women.
Methods This 5-year cohort study included 482 women between 55 and 74 years of age who lived in a community in Japan. Medical examinations were conducted in 2005 and 2010. Data were obtained on baseline serum 25(OH)D and intact parathyroid hormone (iPTH) levels. Outcomes of this study were 5-year changes in BMDs of the lumbar spine and femoral neck. Covariates included years since menopause, body mass index (BMI), lifestyle factors, and weight change. Changes in BMDs among quartiles of serum 25(OH)D were compared with analysis of covariance.
Results The mean age of subjects was 63.1 years, and mean serum25(OH)D levelswere 56.0 nmol/L. Age and decrease in weight were significantly associated with decreases in BMDs of both the lumbar spine (P for trend<0.001 and =0.002, respectively) and femoral neck (P for trend=0.026 and <0.001, respectively); low BMI was associated with a decrease in lumbar spine BMD (P for trend<0.001). No significant associations were found between serum 25(OH)D levels and changes in BMDs. High serum iPTH levels were associated with a greater decrease in femoral neck BMD (P for trend=0.026).
Conclusions High serum 25(OH)D levels do not retard postmenopausal bone loss within the lumbar spine or femoral neck, and high PTH levels potentially increase hip bone loss.

DOI： 10.1007/s11657-013-0153-0

Association between low bone mineral density and clinical attachment loss in Japanese postmenopausal females Reviewed

Masanori Iwasaki, George W. Taylor, Kazutoshi Nakamura, Akihiro Yoshihara, Hideo Miyazaki

Journal of Periodontology 84 ( 12 ) 1708 - 1716 2013.12

Language：English Publishing type：Research paper (scientific journal)

Background: Previous studies have shown conflicting results as to whether low bone mineral density (BMD) is associated with severe clinical attachment loss (AL). The effect of dental restoration on AL was not considered in most studies. In addition, studies of this association in Japanese individuals are limited. The aim of this crosssectional study is to evaluate the possible association between BMD and AL with dental restoration information in Japanese community-dwelling postmenopausal females. Methods: The participants were 397 females (average age: 68.2 years). BMDs of the lumbar spine and right proximal femur were measured by the dual-energy x-ray absorptiometry method. Based on lower BMD/young adult mean (YAM) among the two sites measured, participants were classified into three groups: 1) normal: BMD = 80% YAM or higher (n = 161)
2) osteopenia: BMD = 70% to 80% YAM (n = 136)
and 3) osteoporosis: BMD = &lt
70% YAM (n = 100). Multivariable analyses of the differences in AL values among three BMD groups was conducted using general linear models. Adjustments for the percentage of teeth restored and other covariates were considered. Results: Individuals with osteopenia had significantly higher average AL than individuals with normal BMD (P = 0.022). Additionally, the osteoporosis group displayed significantly higher average AL (P = 0.003) and higher percentages of sites with AL ≥4 mm (P = 0.007). Conclusion: The results of the present study indicate that low systemic BMD was associated with severe AL in Japanese community-dwelling postmenopausal females.

DOI： 10.1902/jop.2013.120613

Scopus

High serum 25-hydroxyvitamin D levels do not retard postmenopausal bone loss in Japanese women: the Yokogoshi study

Kaori Kitamura, Kazutoshi Nakamura, Toshiko Saito, Ryosaku Kobayashi, Rieko Oshiki, Tomoko Nishiwaki, Masanori Iwasaki, Akihiro Yoshihara

ARCHIVES OF OSTEOPOROSIS 8 ( 1-2 ) 153 2013.12

Language：English Publishing type：Research paper (scientific journal) Publisher：SPRINGER LONDON LTD

DOI： 10.1007/s11657-013-0153-0

Serum albumin levels and 10-year tooth loss in a 70-year-old population Reviewed

A. Yoshihara, M. Iwasaki, H. Ogawa, H. Miyazaki

JOURNAL OF ORAL REHABILITATION 40 ( 9 ) 678 - 685 2013.9

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY-BLACKWELL

Serum albumin levels are a practical marker of general health status in the elderly and have been used to determine the severity of underlying diseases and the risk for death. This longitudinal study evaluated the relationship between serum albumin concentrations and tooth loss over 10years in elderly subjects, after controlling for confounding factors. A sample of 554 dentate subjects among enrolled subjects (n=600) was involved in this planned longitudinal study with follow-up examinations after 5 and 10years. At the 5-year follow-up, 373 (673%), subjects were available for re-examination. In addition, 331 (597%) were available at the 10-year follow-up. Multiple Poisson regression analysis was conducted to evaluate the relationship between the number of missing teeth over 5 or 10years and serum albumin levels at baseline after adjusting for 10 variables: gender, serum markers levels at baseline, dental status, smoking habits and educational years and oral health behaviour. The number of missing teeth over 5 or 10years was significantly negatively associated with serum albumin levels at baseline [incidence rate ratios (IRR)=0373, P<00001 for 5years; IRR=0570, P<00001 for 10years]. We conclude that elderly subjects with hypoalbuminemia are at high risk for 5- and 10-year tooth loss.

DOI： 10.1111/joor.12083

Evaluation of chewing ability and its relationship with activities of daily living, depression, cognitive status and food intake in the community-dwelling elderly Reviewed

Yumi Kimura, Hiroshi Ogawa, Akihiro Yoshihara, Takayuki Yamaga, Tomoya Takiguchi, Taizo Wada, Ryota Sakamoto, Yasuko Ishimoto, Eriko Fukutomi, Wenling Chen, Michiko Fujisawa, Kiyohito Okumiya, Kuniaki Otsuka, Hideo Miyazaki, Kozo Matsubayashi

GERIATRICS & GERONTOLOGY INTERNATIONAL 13 ( 3 ) 718 - 725 2013.7

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY-BLACKWELL

Aim: The aim of this study was to assess chewing ability using color-changeable chewing gum and to show the association between chewing ability and geriatric functions, as well as dietary status in the community-dwelling elderly.
Methods: The study population consisted of 269 community-dwelling elderly aged >= 75 living in Tosa, Japan. Assessment of chewing ability was carried out by a dentist using color-changeable chewing gum. Activities of daily living (ADL), depression and subjective quality of life (QOL) were assessed by questionnaire. Cognitive status was assessed by; Mini-Mental State Examination (MMSE), Hasegawa Dementia Scale-Revised (HDS-R) and Frontal Assessment Battery (FAB) during the check-up. Food diversity was assessed using the 11-item Food Diversity Score Kyoto (FDSK-11).
Results: Number of teeth was significantly related to chewing ability (P < 0.001). The participants with low chewing ability had significantly lower ADL scores in the items of self-maintenance (P = 0.029) and intellectual activity (P = 0.021). There was a significant association between low chewing ability and depression (P < 0.001). Lower cognitive functions were significantly related to low chewing ability; MMSE (P = 0.022), HDSR (P = 0.017) and FAB (P = 0.002). The participants with low chewing ability had lower food variety (P < 0.001), and less frequent intake of beans, vegetables, seaweed and nuts, than the participants with high chewing ability.
Conclusion: Low chewing ability evaluated by color-changeable gum was associated with lower ADL, lower cognitive functioning, depression and food insufficiency in the community-dwelling elderly. More attention should be paid to assessing chewing ability of elderly persons in community settings. Geriatr Gerontol Int 2013; 13: 718-725.

DOI： 10.1111/ggi.12006

Peroxisome proliferator-activated receptor (PPAR) gamma polymorphism, vitamin D, bone mineral density and periodontitis in postmenopausal women Reviewed

Y. Wang, N. Sugita, A. Yoshihara, M. Iwasaki, H. Miyazaki, K. Nakamura, H. Yoshie

ORAL DISEASES 19 ( 5 ) 501 - 506 2013.7

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY-BLACKWELL

OBJECTIVES: PPARg regulates bone metabolism and inflammation. Our previous study suggested PPARg Pro12Ala polymorphism to represent a susceptibility factor for periodontitis in pregnant Japanese women. Several recent papers have drawn attention to a possible link between low bone mineral density (BMD) and periodontitis in postmenopausal women. Since the pathogenesis for both involve bone remodeling, they might share common risk factors such as gene polymorphisms and vitamin D level. The present study investigated possible associations between the PPARgPro12Ala polymorphism, periodontitis, BMD and serum 25(OH)D in postmenopausal Japanese women.
MATERIALS AND METHODS: PPARgPro12Ala genotypes of 359 women were determined by PCR-RFLP. BMD and periodontal parameters of each woman were measured. Serum 25(OH)D levels were determined by radioimmunoassay.
RESULTS: PPARgPro12Ala polymorphism was not associated with periodontitis or BMD as an independent factor. Serum 25(OH)D was significantly higher in Ala allele carriers compared to non-carriers. Only in the Ala allele carriers, positive correlations were found between mean clinical attachment level and BMD, between BMD and 25(OH)D, and between percentage of sites with probing depth >= 4 mm and 25(OH)D.
CONCLUSIONS: PPARgPro12Ala polymorphism was not independently associated with periodontitis or BMD. However, the polymorphism might be a modulator of the relationship between the two conditions in postmenopausal Japanese women.

DOI： 10.1111/odi.12032

Evaluation of chewing ability and its relationship with activities of daily living, depression, cognitive status and food intake in the community-dwelling elderly

GERIATRICS & GERONTOLOGY INTERNATIONAL 13 ( 3 ) 718 - 725 2013.7

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY-BLACKWELL

DOI： 10.1111/ggi.12006

口腔衛生学における疫学研究のエビデンスとその応用(ポストドクトリアルセミナー)

八重垣健, 葭原明弘

口腔衛生学会雑誌 63 ( 2 ) 133 - 134 2013.4

O-10 地域在住女性高齢者における腎機能と歯周組織の炎症部位面積に関する横断調査(一般口演)

岩崎正則, 葭原明弘, 宮崎秀夫

口腔衛生学会雑誌 63 ( 2 ) 148 - 148 2013.4

Dietary antioxidants and periodontal disease in community-based older Japanese: a 2-year follow-up study Reviewed

Masanori Iwasaki, Paula Moynihan, Michael C. Manz, George W. Taylor, Akihiro Yoshihara, Kanako Muramatsu, Reiko Watanabe, Hideo Miyazaki

PUBLIC HEALTH NUTRITION 16 ( 2 ) 330 - 338 2013.2

Language：English Publishing type：Research paper (scientific journal) Publisher：CAMBRIDGE UNIV PRESS

Objective: To investigate the longitudinal relationship between the intake of dietary antioxidants and periodontal disease in community-dwelling older Japanese.
Design: A retrospective cohort study, with a follow-up of 2 years (2003-2005). Intakes of dietary antioxidants (vitamin C, vitamin E, alpha-carotene and beta-carotene) were assessed with a validated FFQ. Participants were classified by tertile of antioxidant intake. Full-mouth periodontal status, measured as the clinical attachment level, was recorded at baseline and follow-up examinations. Periodontal disease progression was considered as loss of attachment of 3mm or greater over the study period at the interproximal site for each tooth. Finally, the number of teeth with periodontal disease progression per person was calculated and was used as the outcome. Poisson regression analysis was conducted, with dietary antioxidants as the main exposure, to estimate their influence on the number of teeth with periodontal disease progression.
Setting: Niigata City (Japan).
Subjects: Dentate individuals aged 75 years in 2003, for whom data were available, were included in the analyses (n 264).
Results: A higher intake of dietary antioxidants was inversely associated with the number of teeth with periodontal disease progression, controlling for other variables. The multivariate-adjusted incidence rate ratios in the first, second and third tertiles were 1.00, 0.76 (95% CI 0.60, 0.97) and 0.72 (95% CI 0.56, 0.93) for vitamin C; 1.00, 0.79 (95% CI 0.62, 0.99) and 0.55 (95% CI 0.42, 0.72), for vitamin E; and 1.00, 1.02 (95% CI 0.81, 1.29) and 0.73 (95% CI 0.56, 0.95) for beta-carotene.
Conclusions: The study results suggest that higher intake of antioxidants may mitigate periodontal disease in community-dwelling older Japanese.

DOI： 10.1017/S1368980012002637

Dietary antioxidants and periodontal disease in community-based older Japanese: a 2-year follow-up study

Masanori Iwasaki, Paula Moynihan, Michael C. Manz, George W. Taylor, Akihiro Yoshihara, Kanako Muramatsu, Reiko Watanabe, Hideo Miyazaki

PUBLIC HEALTH NUTRITION 16 ( 2 ) 330 - 338 2013.2

Language：English Publishing type：Research paper (scientific journal) Publisher：CAMBRIDGE UNIV PRESS

DOI： 10.1017/S1368980012002637

Questionnaire Survey on Oral Symptoms of Menopausal Women and Cooperation Between Doctors and Dentists. Reviewed

高齢者における咀嚼能力と体力の関係について

瀧口知彌, 小川祐司, 葭原明弘, 山賀孝之, 宮崎秀夫

口腔衛生学会雑誌 63 ( 1 ) 44 - 44 2013.1

Matsuki, T, Ito, K, Funayama, S, Yoshihara, A, Masumi, S

Int J Oral-Med Sci 12 ( 1 ) 21 - 28 2013

Language：English Publisher：Research Institute of Oral Science, Nihon University School of Dentistry at Matsudo

Objective: Xerostomia, temporomandibular disorder, and periodontal disease are frequently seen in menopausal women. However, few studies have reported the prevalence of oralsymptoms during menopause or the cooperation between doctors at outpatient clinics for women and dentists. The purpose of this study was to investigate the frequency of oral symptoms and the cooperation between doctors at outpatient clinics for women and dentists. Methods: A questionnaire was sent to 380 outpatient clinics for women in Japan. The questionnaire included characteristics for the person completing it, staff structure,cooperation with medicalspecialists, the existence of oralsymptoms, details of these symptoms, cooperation with dentists, and space for free responses. Results: The survey response rate was 57.9% (220 of 380 institutions). Most respondents (81.6%) thought that female sex hormones influenced the mouth, and 79.4% had encountered oralsymptoms. The most frequently encountered symptoms were oral dryness, taste disorder, and burning sensation of the mouth. The necessity of cooperation between doctors and dentists was recognized by 63.1%. Staff that recognised the influence of female hormones on the mouth were significantly more likely than others to acknowledge the importance of cooperation (p<0.01). However, as only half of the staff had referred patients to a dental clinic, it seems possible that patients whose symptoms could have been alleviated by dentists were not appropriately managed. Conclusion: Although oral symptoms can relate to menopause, the cooperation between doctors and dentists is poor. Improved cooperation may relieve not only oral complaints but also systemic menopausal symptoms.

DOI： 10.5466/ijoms.12.21

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