Papers - YOSHIHARA Akihiro

A polymorphism rs6815464 in the macrophage erythroblast attacher gene is associated with low bone mineral density in postmenopausal Japanese women. Reviewed International journal

Yulan Che, Noriko Sugita, Akihiro Yoshihara, Masanori Iwasaki, Hideo Miyazaki, Kazutoshi Nakamura, Hiromasa Yoshie

Gene   700   1 - 6   2019.6

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Language：English   Publishing type：Research paper (scientific journal)  

BACKGROUND AND PURPOSES: Osteoporosis and osteopenia are multifactorial diseases characterized by low bone mineral density (BMD) and are susceptible to genetic and environmental risk factors. The macrophage erythroblast attacher (MAEA) was discovered as a protein to mediate the attachment of erythroid cells to macrophages and is essential for bone marrow hematopoiesis. MAEA is expressed in a wide range of cells and tissues including osteoblasts and osteoclasts. Recent studies have shown that a single nucleotide polymorphism (SNP) rs6815464 (C/G) in the MAEA gene increases the susceptibility of type 2 diabetes mellitus. However, the contribution of MAEA to bone metabolism remains unknown. Therefore, we performed this study to evaluate the association between MAEA polymorphism and low BMD. METHODS: In a cross-sectional study with postmenopausal Japanese women living in the Yokogoshi area, Niigata City, we evaluated whether rs6815464 was associated with low BMD. Blood samples were collected from 353 subjects (age 63.8 ± 5.4 years). The MAEA genotype was determined by TaqMan assay. BMD was assessed by dual-energy X-ray absorptiometry at the lumbar spine (L2-L4), hip and femoral neck. Low BMD was defined as a T-score <-1. RESULTS: The percentage of subjects with low BMD in the lumbar spine, total hip and femoral neck were 71%, 75% and 84% respectively. After adjusting age, BMI, HbA1c, smoking and alcohol consumption, the G-allele carriage was found to be associated with low BMD of total hip (odds ratio = 2.11, 95% CI: 1.14-3.91, P = 0.018), but not of the lumbar spine or femoral neck. CONCLUSION: The MAEA gene polymorphism rs6815464 was associated with low hip BMD in postmenopausal Japanese women.

DOI： 10.1016/j.gene.2019.03.027

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MAEA rs6815464 polymorphism and periodontitis in postmenopausal Japanese females: A cross-sectional study. Reviewed International journal

Yulan Che, Noriko Sugita, Akihiro Yoshihara, Masanori Iwasaki, Hideo Miyazaki, Kazutoshi Nakamura, Hiromasa Yoshie

Archives of oral biology   102   128 - 134   2019.6

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Language：English   Publishing type：Research paper (scientific journal)  

OBJECTIVES: Macrophage erythroblast attacher (MAEA) is a membrane protein that regulates the development of mature macrophages by mediating attachment with erythroblasts. A polymorphism rs6815464 (C/G) in MAEA gene was reported to be associated with type II diabetes. Along with diabetes, osteoporosis shows an increased prevalence in postmenopausal females, and both diseases have been reported to be associated with periodontitis. Therefore, we explored the relevance of the MAEA polymorphism to periodontitis, bone mineral density (BMD) and haemoglobin A1c (HbA1c). DESIGN: This was a cross-sectional study with the final sample comprised of 344 postmenopausal Japanese females. Probing pocket depth (PPD) and clinical attachment level (CAL) were measured. Genotype was determined by TaqMan assay. Blood biochemical parameters and BMD of the lumbar spine were evaluated. RESULTS: No differences were found in age, body mass index, HbA1c, BMD, number of teeth, bone metabolism parameters between the genotypes. Mean CAL and percentage of sites with PPD or CAL ≥ 5 mm were higher in the G-allele carriers than in the non-carriers. Multiple logistic regression analyses revealed that G-allele carriage was associated with severe periodontitis (odds ratio = 3.73, 95% CI = 1.36-10.19). CONCLUSION: Our results suggested that the MAEA gene polymorphism was independently associated with severe periodontitis.

DOI： 10.1016/j.archoralbio.2019.04.008

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Interaction between beta-3 adrenergic receptor genotype and environmental factors on periodontal progression. Reviewed International journal

Akihiro Yoshihara, Noboru Kaneko, Kaname Nohno, Masanori Iwasaki

Journal of clinical periodontology   46 ( 6 )   623 - 630   2019.6

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OBJECTIVES: The purpose of this longitudinal study was to evaluate the relationship between beta-3 adrenergic receptor polymorphism and environmental factors such as smoking on periodontal disease by considering effect modification. MATERIALS AND METHODS: A total of 294 subjects who participated in all follow-up surveys over the 6-year study period were analysed. After dividing subjects into tertiles according to the number of years exposed to smoking, we conducted Poisson regression analysis to compare the incidence rate ratio (IRR) for periodontal disease events during the 6-year study period with beta-3 adrenergic receptor genotype (1: Arg allele carriers, 2: Arg allele non-carriers) for each tertile adjusted for other four variables. RESULTS: The number of years exposed to smoking (mean ± standard deviation) for the 1st, 2nd and 3rd tertiles was 0 ± 0, 20.1 ± 9.1 and 45.3 ± 7.7 years, respectively. The IRRs ± SE were 0.89 ± 0.08 (p = 0.218) for the 1st tertile, 1.93 ± 0.36 (p < 0.001) for the 2nd tertile and 2.56 ± 0.23 (p < 0.001) for the 3rd tertile. CONCLUSION: There was a clear dose-response relationship between beta-3 adrenergic receptor genotype and periodontal disease progression based on the number of years exposed to smoking.

DOI： 10.1111/jcpe.13115

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地域在住高齢者における高次生活機能の加齢変化パターンと歯の本数の関連 10年間の前向きコホート研究

岩崎 正則, 佐藤 美寿々, 葭原 明弘

日本老年歯科医学会総会・学術大会プログラム・抄録集   30回   P一般 - 089   2019.6

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Language：Japanese   Publisher：(一社)日本老年歯科医学会  

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Rising rural body-mass index is the main driver of the global obesity epidemic in adults

Honor Bixby, James Bentham, Bin Zhou, Mariachiara Di Cesare, Christopher J. Paciorek, James E. Bennett, Cristina Taddei, Gretchen A. Stevens, Andrea Rodriguez-Martinez, Rodrigo M. Carrillo-Larco, Young-Ho Khang, Maroje Sorić, Edward W. Gregg, J. Jaime Miranda, Zulfiqar A. Bhutta, Stefan Savin, Marisa K. Sophiea, Maria L. C. Iurilli, Bethlehem D. Solomon, Melanie J. Cowan, Leanne M. Riley, Goodarz Danaei, Pascal Bovet, Adela Chirita-Emandi, Ian R. Hambleton, Alison J. Hayes, Nayu Ikeda, Andre P. Kengne, Avula Laxmaiah, Yanping Li, Stephen T. McGarvey, Aya Mostafa, Martin Neovius, Gregor Starc, Ahmad A. Zainuddin, Leandra Abarca-Gómez, Ziad A. Abdeen, Shynar Abdrakhmanova, Suhaila Abdul Ghaffar, Zargar Abdul Hamid, Jamila Abubakar Garba, Niveen M. Abu-Rmeileh, Benjamin Acosta-Cazares, Robert J. Adams, Wichai Aekplakorn, Kaosar Afsana, Imelda A. Agdeppa, Carlos A. Aguilar-Salinas, Charles Agyemang, Mohamad Hasnan Ahmad, Noor Ani Ahmad, Naser Ahmadi, Alireza Ahmadvand, Wolfgang Ahrens, Kamel Ajlouni, Fadia AlBuhairan, Shahla AlDhukair, Hazzaa M. Al-Hazzaa, Mohamed M. Ali, Osman Ali, Alaa Alkerwi, Amani Rashed Al-Othman, Rajaa Al-Raddadi, Mar Alvarez-Pedrerol, Eman Aly, Deepak N. Amarapurkar, Philippe Amouyel, Antoinette Amuzu, Lars Bo Andersen, Sigmund A. Anderssen, Lars H. Ängquist, Ranjit Mohan Anjana, Alireza Ansari-Moghaddam, Hajer Aounallah-Skhiri, Joana Araújo, Inger Ariansen, Tahir Aris, Raphael E. Arku, Nimmathota Arlappa, Krishna K. Aryal, Thor Aspelund, Felix K. Assah, Maria Cecília F. Assunção, May Soe Aung, Juha Auvinen, Mária Avdicová, Ana Azevedo, Fereidoun Azizi, Mehrdad Azmin, Bontha V. Babu, Azli Baharudin, Suhad Bahijri, Jennifer L. Baker, Nagalla Balakrishna, Mohamed Bamoshmoosh, Maciej Banach, Piotr Bandosz, José R. Banegas, Carlo M. Barbagallo, Alberto Barceló, Amina Barkat, Aluisio J. D. Barros, Mauro V. G. Barros, Iqbal Bata, Anwar M. Batieha, Rosangela L. Batista, Zhamilya Battakova, Assembekov Batyrbek, Louise A. Baur, Robert Beaglehole, Silvia Bel-Serrat, Habiba Ben Romdhane, Judith Benedics, Mikhail Benet, Salim Berkinbayev, Antonio Bernabe-Ortiz, Gailute Bernotiene, Heloisa Bettiol, Aroor Bhagyalaxmi, Sumit Bharadwaj, Santosh K. Bhargava, Hongsheng Bi, Yufang Bi, Anna Biehl, Elysée Claude Bika Lele, Mukharram Bikbov, Bihungum Bista, Dusko J. Bjelica, Peter Bjerregaard, Espen Bjertness, Marius B. Bjertness, Cecilia Björkelund, Anneke Blokstra, Simona Bo, Martin Bobak, Lynne M. Boddy, Bernhard O. Boehm, Heiner Boeing, Jose G. Boggia, Carlos P. Boissonnet, Marialaura Bonaccio, Vanina Bongard, Matthias Bopp, Rossana Borchini, Herman Borghs, Lien Braeckevelt, Lutgart Braeckman, Marjolijn C. E. Bragt, Imperia Brajkovich, Francesco Branca, Juergen Breckenkamp, João Breda, Hermann Brenner, Lizzy M. Brewster, Garry R. Brian, Lacramioara Brinduse, Graziella Bruno, H. Bas Bueno-de-Mesquita, Anna Bugge, Marta Buoncristiano, Genc Burazeri, Con Burns, Antonio Cabrera de León, Joseph Cacciottolo, Hui Cai, Tilema Cama, Christine Cameron, José Camolas, Gamze Can, Günay Can, Ana Paula C. Cândido, Felicia Cañete, Mario V. Capanzana, Eduardo Capuano, Vincenzo Capuano, Viviane C. Cardoso, Axel C. Carlsson, Esteban Carmuega, Maria J. Carvalho, Felipe F. Casanueva, Juan-Pablo Casas, Carmelo A. Caserta, Ertugrul Celikcan, Laura Censi, Juraci A. Cesar, Snehalatha Chamukuttan, Angelique W. Chan, Queenie Chan, Himanshu K. Chaturvedi, Nishi Chaturvedi, Norsyamlina Che Abdul Rahim, Chien-Jen Chen, Fangfang Chen, Huashuai Chen, Shuohua Chen, Zhengming Chen, Ching-Yu Cheng, Yiling J. Cheng, Angela Chetrit, Ekaterina Chikova-Iscener, Arnaud Chiolero, Shu-Ti Chiou, María-Dolores Chirlaque, Belong Cho, Yumi Cho, Kaare Christensen, Diego G. Christofaro, Jerzy Chudek, Renata Cifkova, Michelle Cilia, Eliza Cinteza, Frank Claessens, Janine Clarke, Els Clays, Hans Concin, Susana C. Confortin, Cyrus Cooper, Tara C. Coppinger, Simona Costanzo, Dominique Cottel, Chris Cowell, Cora L. Craig, Amelia C. Crampin, Ana B. Crujeiras, Juan J. Cruz, Alexandra Cucu, Liufu Cui, Jean Dallongeville, Albertino Damasceno, Camilla T. Damsgaard, Rachel Dankner, Thomas M. Dantoft, Graziella D’Arrigo, Parasmani Dasgupta, Saeed Dastgiri, Luc Dauchet, Kairat Davletov, Guy De Backer, Dirk De Bacquer, Amalia De Curtis, Giovanni de Gaetano, Stefaan De Henauw, Paula Duarte de Oliveira, Karin De Ridder, Susanne R. de Rooij, Delphine De Smedt, Mohan Deepa, Alexander D. Deev, Abbas Dehghan, Hélène Delisle, Francis Delpeuch, Elaine Dennison, Valérie Deschamps, Klodian Dhana, Meghnath Dhimal, Augusto F. Di Castelnuovo, Juvenal Soares Dias-da-Costa, Alejandro Diaz, Zivka Dika, Shirin Djalalinia, Ha T. P. Do, Annette J. Dobson, Maria Benedetta Donati, Chiara Donfrancesco, Silvana P. Donoso, Angela Döring, Maria Dorobantu, Ahmad Reza Dorosty, Eleonora d’Orsi, Kouamelan Doua, Wojciech Drygas, Jia Li Duan, Charmaine A. Duante, Rosemary B. Duda, Vesselka Duleva, Virginija Dulskiene, Samuel C. Dumith, Vilnis Dzerve, Elzbieta Dziankowska-Zaborszczyk, Ricky Eddie, Eruke E. Egbagbe, Robert Eggertsen, Gabriele Eiben, Ulf Ekelund, Jalila El Ati, Denise Eldemire-Shearer, Marie Eliasen, Paul Elliott, Reina Engle-Stone, Rajiv T. Erasmus, Cihangir Erem, Louise Eriksen, Johan G. Eriksson, Jorge Escobedo-de la Peña, Alun Evans, David Faeh, Caroline H. Fall, Victoria Farrugia Sant’Angelo, Farshad Farzadfar, Mohammad R. Fattahi, Francisco J. Felix-Redondo, Trevor S. Ferguson, Romulo A. Fernandes, Daniel Fernández-Bergés, Daniel Ferrante, Marika Ferrari, Catterina Ferreccio, Eldridge Ferrer, Jean Ferrieres, Anna Fijalkowska, Günther Fink, Krista Fischer, Eric Monterubio Flores, Bernhard Föger, Leng Huat Foo, Ann-Sofie Forslund, Maria Forsner, Heba M. Fouad, Damian K. Francis, Maria do Carmo Franco, Oscar H. Franco, Guillermo Frontera, Flavio D. Fuchs, Sandra C. Fuchs, Yuki Fujita, Takuro Furusawa, Zbigniew Gaciong, Mihai Gafencu, Daniela Galeone, Fabio Galvano, Jingli Gao, Manoli Garcia-de-la-Hera, Dickman Gareta, Sarah P. Garnett, Jean-Michel Gaspoz, Magda Gasull, Louise Gates, Andrea Gazzinelli, Harald Geiger, Johanna M. Geleijnse, Ali Ghanbari, Erfan Ghasemi, Anoosheh Ghasemian, Oana-Florentina Gheorghe-Fronea, Simona Giampaoli, Francesco Gianfagna, Tiffany K. Gill, Jonathan Giovannelli, Glen Gironella, Aleksander Giwercman, Justyna Godos, Sibel Gogen, Rebecca A. Goldsmith, David Goltzman, Helen Gonçalves, Angel R. Gonzalez, David A. Gonzalez-Chica, Marcela Gonzalez-Gross, Margot González-Leon, Juan P. González-Rivas, María-Elena González-Villalpando, Frederic Gottrand, Antonio Pedro Graça, Sidsel Graff-Iversen, Dušan Grafnetter, Aneta Grajda, Maria G. Grammatikopoulou, Ronald D. Gregor, Tomasz Grodzicki, Anders Grøntved, Giuseppe Grosso, Gabriella Gruden, Dongfeng Gu, Emanuela Gualdi-Russo, Elias F. Gudmundsson, Vilmundur Gudnason, Ramiro Guerrero, Idris Guessous, Andre L. Guimaraes, Martin C. Gulliford, Johanna Gunnlaugsdottir, Marc Gunter, Xiuhua Guo, Yin Guo, Prakash C. Gupta, Rajeev Gupta, Oye Gureje, Beata Gurzkowska, Laura Gutierrez, Felix Gutzwiller, Farzad Hadaegh, Charalambos A. Hadjigeorgiou, Rosa Haghshenas, Jytte Halkjær, Rebecca Hardy, Rachakulla Hari Kumar, Maria Hassapidou, Jun Hata, Teresa Haugsgjerd, Jiang He, Yuna He, Regina Heidinger-Felso, Mirjam Heinen, Tatjana Hejgaard, Marleen Elisabeth Hendriks, Ana Henriques, Leticia Hernandez Cadena, Sauli Herrala, Victor M. Herrera, Isabelle Herter-Aeberli, Ramin Heshmat, Allan G. Hill, Sai Yin Ho, Suzanne C. Ho, Michael Hobbs, Albert Hofman, Wilma M. Hopman, Andrea R. V. R. Horimoto, Claudia M. Hormiga, Bernardo L. Horta, Leila Houti, Christina Howitt, Thein Thein Htay, Aung Soe Htet, Maung Maung Than Htike, Yonghua Hu, José María Huerta, Ilpo Tapani Huhtaniemi, Constanta Huidumac Petrescu, Martijn Huisman, Abdullatif Husseini, Chinh Nguyen Huu, Inge Huybrechts, Nahla Hwalla, Jolanda Hyska, Licia Iacoviello, Jesús M. Ibarluzea, Mohsen M. Ibrahim, Norazizah Ibrahim Wong, M. Arfan Ikram, Vilma E. Irazola, Takafumi Ishida, Muhammad Islam, Aziz al-Safi Ismail, Vanja Ivkovic, Masanori Iwasaki, Tuija Jääskeläinen, Rod T. Jackson, Jeremy M. Jacobs, Hashem Jaddou, Tazeen Jafar, Kenneth James, Kazi M. Jamil, Konrad Jamrozik, Imre Janszky, Edward Janus, Juel Jarani, Marjo-Riitta Jarvelin, Grazyna Jasienska, Ana Jelakovic, Bojan Jelakovic, Garry Jennings, Seung-lyeal Jeong, Chao Qiang Jiang, Ramon O. Jimenez, Michel Joffres, Mattias Johansson, Jari J. Jokelainen, Jost B. Jonas, Torben Jørgensen, Pradeep Joshi, Dragana P. Jovic, Jacek Józwiak, Anne Juolevi, Gregor Jurak, Vesna Juresa, Rudolf Kaaks, Anthony Kafatos, Eero O. Kajantie, Ofra Kalter-Leibovici, Nor Azmi Kamaruddin, Yves Kameli, Efthymios Kapantais, Khem B. Karki, Amir Kasaeian, Marzieh Katibeh, Joanne Katz, Peter T. Katzmarzyk, Jussi Kauhanen, Prabhdeep Kaur, Maryam Kavousi, Gyulli Kazakbaeva, Ulrich Keil, Lital Keinan-Boker, Sirkka Keinänen-Kiukaanniemi, Roya Kelishadi, Cecily Kelleher, Han C. G. Kemper, Alina Kerimkulova, Mathilde Kersting, Timothy Key, Yousef Saleh Khader, Davood Khalili, Mohammad Khateeb, Kay-Tee Khaw, Bahareh Kheiri, Alireza Khosravi, Ilse M. S. L. Khouw, Stefan Kiechl, Ursula Kiechl-Kohlendorfer, Japhet Killewo, Jeongseon Kim, Yeon-Yong Kim, Jeannette Klimont, Jurate Klumbiene, Michael Knoflach, Bhawesh Koirala, Elin Kolle, Patrick Kolsteren, Jürgen König, Raija Korpelainen, Paul Korrovits, Magdalena Korzycka, Seppo Koskinen, Katsuyasu Kouda, Viktoria A. Kovacs, Sudhir Kowlessur, Slawomir Koziel, Wolfgang Kratzer, Susi Kriemler, Peter Lund Kristensen, Steinar Krokstad, Daan Kromhout, Herculina S. Kruger, Ruzena Kubinova, Renata Kuciene, Diana Kuh, Urho M. Kujala, Enisa Kujundzic, Zbigniew Kulaga, R. Krishna Kumar, Marie Kunešová, Pawel Kurjata, Yadlapalli S. Kusuma, Kari Kuulasmaa, Catherine Kyobutungi, Quang Ngoc La, Fatima Zahra Laamiri, Tiina Laatikainen, Carl Lachat, Youcef Laid, Tai Hing Lam, Maja Lang Morovic, Vera Lanska, Georg Lappas, Bagher Larijani, Tint Swe Latt, Lars E. Laugsand, Laura Lauria, Maria Lazo-Porras, Khanh Le Nguyen Bao, Agnès Le Port, Tuyen D. Le, Jeannette Lee, Jeonghee Lee, Paul H. Lee, Terho Lehtimäki, Daniel Lemogoum, Naomi S. Levitt, Christa L. Lilly, Wei-Yen Lim, M. Fernanda Lima-Costa, Hsien-Ho Lin, Xu Lin, Lars Lind, Allan Linneberg, Lauren Lissner, Mieczyslaw Litwin, Jing Liu, Helle-Mai Loit, Luis Lopes, Tania Lopez, Esther López-García, Roberto Lorbeer, Paulo A. Lotufo, José Eugenio Lozano, Dalia Luksiene, Annamari Lundqvist, Robert Lundqvist, Nuno Lunet, Per Lytsy, Guansheng Ma, Jun Ma, George L. L. Machado-Coelho, Aristides M. Machado-Rodrigues, Suka Machi, Stefania Maggi, Dianna J. Magliano, Emmanuella Magriplis, Bernard Maire, Marjeta Majer, Marcia Makdisse, Fatemeh Malekzadeh, Reza Malekzadeh, Rahul Malhotra, Sofia Malyutina, Lynell V. Maniego, Yannis Manios, Jim I. Mann, Enzo Manzato, Paula Margozzini, Anastasia Markaki, Oonagh Markey, Eliza Markidou Ioannidou, Larissa Pruner Marques, Pedro Marques-Vidal, Jaume Marrugat, Rosemarie Martin, Yves Martin-Prevel, Reynaldo Martorell, Eva Martos, Stefano Marventano, Shariq R. Masoodi, Ellisiv B. Mathiesen, Prashant Mathur, Alicia Matijasevich, Tandi E. Matsha, Artur Mazur, Jean Claude N. Mbanya, Shelly R. McFarlane, Martin McKee, Stela McLachlan, Rachael M. McLean, Scott B. McLean, Breige A. McNulty, Safiah Md Yusof, Sounnia Mediene-Benchekor, Jurate Medzioniene, Parinaz Mehdipour, Aline Meirhaeghe, Jørgen Meisfjord, Christa Meisinger, Ana Maria B. Menezes, Geetha R. Menon, Gert B. M. Mensink, Alibek Mereke, Indrapal I. Meshram, Andres Metspalu, Haakon E. Meyer, Jie Mi, Kim F. Michaelsen, Nathalie Michels, Kairit Mikkel, Jody C. Miller, Cláudia S. Minderico, Juan Francisco Miquel, Daphne Mirkopoulou, Erkin Mirrakhimov, Marjeta Misigoj-Durakovic, Antonio Mistretta, Veronica Mocanu, Pietro A. Modesti, Sahar Saeeidi Moghaddam, Bahram Mohajer, Mostafa K. Mohamed, Kazem Mohammad, Noushin Mohammadifard, Viswanathan Mohan, Salim Mohanna, Muhammad Fadhli Mohd Yusoff, Farnam Mohebi, Marie Moitry, Drude Molbo, Line T. Møllehave, Niels C. Møller, Dénes Molnár, Amirabbas Momenan, Charles K. Mondo, Eric A. Monterrubio, Kotsedi Daniel K. Monyeki, Jin Soo Moon, Leila B. Moreira, Alain Morejon, Luis A. Moreno, Karen Morgan, Suzanne Morin, Erik Lykke Mortensen, George Moschonis, Malgorzata Mossakowska, Jorge Mota, Anabela Mota-Pinto, Mohammad Esmaeel Motlagh, Jorge Motta, Kelias P. Msyamboza, Thet Thet Mu, Magdalena Muc, Boban Mugoša, Maria Lorenza Muiesan, Parvina Mukhtorova, Martina Müller-Nurasyid, Neil Murphy, Jaakko Mursu, Elaine M. Murtagh, Sanja Music Milanovic, Vera Musil, Iraj Nabipour, Shohreh Naderimagham, Gabriele Nagel, Balkish M. Naidu, Harunobu Nakamura, Jana Námešná, Ei Ei K. Nang, Vinay B. Nangia, Martin Nankap, Sameer Narake, Paola Nardone, Matthias Nauck, Eva Maria Navarrete-Muñoz, William A. Neal, Keiu Nelis, Liis Nelis, Ilona Nenko, Flavio Nervi, Chung T. Nguyen, Nguyen D. Nguyen, Quang Ngoc Nguyen, Ramfis E. Nieto-Martínez, Guang Ning, Toshiharu Ninomiya, Sania Nishtar, Marianna Noale, Oscar A. Noboa, Teresa Norat, Sawada Norie, Davide Noto, Mohannad Al Nsour, Eha Nurk, Moffat Nyirenda, Galina Obreja, Angélica M. Ochoa-Avilés, Eiji Oda, Kyungwon Oh, Kumiko Ohara, Ryutaro Ohtsuka, Örn Olafsson, Maria Teresa Anselmo Olinto, Isabel O. Oliveira, Maciej Oltarzewski, Mohd Azahadi Omar, Altan Onat, Terence W. O’Neill, Sok King Ong, Lariane M. Ono, Pedro Ordunez, Dermot O’Reilly, Rui Ornelas, Ana P. Ortiz, Pedro J. Ortiz, Merete Osler, Clive Osmond, Sergej M. Ostojic, Afshin Ostovar, Johanna A. Otero, Kim Overvad, Ellis Owusu-Dabo, Fred Michel Paccaud, Cristina Padez, Ioannis Pagkalos, Elena Pahomova, Andrzej Pająk, Domenico Palli, Alberto Palloni, Luigi Palmieri, Wen-Harn Pan, Songhomitra Panda-Jonas, Arvind Pandey, Francesco Panza, Dimitrios Papandreou, Soon-Woo Park, Winsome R. Parnell, Mahboubeh Parsaeian, Ionela M. Pascanu, Nikhil D. Patel, Ivan Pecin, Mangesh S. Pednekar, Nasheeta Peer, Sergio Viana Peixoto, Markku Peltonen, Alexandre C. Pereira, Cynthia M. Pérez, Napoleon Perez-Farinos, Annette Peters, Astrid Petersmann, Janina Petkeviciene, Ausra Petrauskiene, Niloofar Peykari, Son Thai Pham, Daniela Pierannunzio, Iris Pigeot, Hynek Pikhart, Aida Pilav, Lorenza Pilotto, Francesco Pistelli, Freda Pitakaka, Aleksandra Piwonska, Pedro Plans-Rubió, Bee Koon Poh, Hermann Pohlabeln, Raluca M. Pop, Stevo R. Popovic, Miquel Porta, Marileen L. P. Portegies, Georg Posch, Dimitrios Poulimeneas, Hamed Pouraram, Akram Pourshams, Hossein Poustchi, Rajendra Pradeepa, Alison J. Price, Jacqueline F. Price, Jardena J. Puder, Iveta Pudule, Soile E. Puhakka, Maria Puiu, Margus Punab, Radwan F. Qasrawi, Mostafa Qorbani, Tran Quoc Bao, Madhari S. Radhika, Ivana Radic, Ricardas Radisauskas, Mahfuzar Rahman, Mahmudur Rahman, Olli Raitakari, Manu Raj, Hemalatha Rajkumar, Sherali Rakhmatulloev, Sudha Ramachandra Rao, Ambady Ramachandran, Jacqueline Ramke, Elisabete Ramos, Rafel Ramos, Lekhraj Rampal, Sanjay Rampal, Kodavanti Mallikharjuna Rao, Ramon A. Rascon-Pacheco, Mette Rasmussen, Josep Redon, Paul Ferdinand M. Reganit, Valéria Regecová, Luis Revilla, Lourdes Ribas-Barba, Robespierre Ribeiro, Elio Riboli, Fernando Rigo, Natascia Rinaldo, Tobias F. Rinke de Wit, Ana Rito, Raphael M. Ritti-Dias, Juan A. Rivera, Cynthia Robitaille, Daniela Rodrigues, Fernando Rodríguez-Artalejo, María del Cristo Rodriguez-Perez, Laura A. Rodríguez-Villamizar, Rosalba Rojas-Martinez, Nipa Rojroongwasinkul, Dora Romaguera, Annika Rosengren, Ian Rouse, Joel G. R. Roy, Adolfo Rubinstein, Frank J. Rühli, Jean-Bernard Ruidavets, Emma Ruiz Moreno, Blanca Sandra Ruiz-Betancourt, Paola Russo, Petra Rust, Marcin Rutkowski, Charumathi Sabanayagam, Harshpal S. Sachdev, Saeid Safiri, Olfa Saidi, Benoit Salanave, Eduardo Salazar-Martinez, Diego Salmerón, Veikko Salomaa, Jukka T. Salonen, Massimo Salvetti, Jose Sánchez-Abanto, Sandjaja, Susana Sans, Loreto Santa-Marina, Diana A. Santos, Ina S. Santos, Osvaldo Santos, Rute Santos, Sara Santos Sanz, Jouko L. Saramies, Luis B. Sardinha, Nizal Sarrafzadegan, Kai-Uwe Saum, Savvas Savva, Mathilde Savy, Marcia Scazufca, Angelika Schaffrath Rosario, Herman Schargrodsky, Anja Schienkiewitz, Karin Schindler, Sabine Schipf, Carsten O. Schmidt, Ida Maria Schmidt, Ben Schöttker, Constance Schultsz, Aletta E. Schutte, Sylvain Sebert, Aye Aye Sein, Rusidah Selamat, Vedrana Sember, Abhijit Sen, Idowu O. Senbanjo, Sadaf G. Sepanlou, Victor Sequera, Luis Serra-Majem, Jennifer Servais, Svetlana A. Shalnova, Sanjib K. Sharma, Jonathan E. Shaw, Lela Shengelia, Kenji Shibuya, Hana Shimizu-Furusawa, Dong Wook Shin, Youchan Shin, Alfonso Siani, Rosalynn Siantar, Abla M. Sibai, Antonio M. Silva, Diego Augusto Santos Silva, Mary Simon, Judith Simons, Leon A. Simons, Khairil Si-Ramlee, Agneta Sjöberg, Michael Sjöström, Jolanta Slowikowska-Hilczer, Przemyslaw Slusarczyk, Liam Smeeth, Marieke B. Snijder, Hung-Kwan So, Eugène Sobngwi, Stefan Söderberg, Moesijanti Y. E. Soekatri, Agustinus Soemantri, Vincenzo Solfrizzi, Emily Sonestedt, Yi Song, Thorkild I. A. Sørensen, Charles Sossa Jérome, Aïcha Soumaré, Angela Spinelli, Igor Spiroski, Jan A. Staessen, Hanspeter Stamm, Maria G. Stathopoulou, Kaspar Staub, Bill Stavreski, Jostein Steene-Johannessen, Peter Stehle, Aryeh D. Stein, George S. Stergiou, Jochanan Stessman, Doris Stöckl, Tanja Stocks, Jakub Stokwiszewski, Gareth Stratton, Karien Stronks, Maria Wany Strufaldi, Lela Sturua, Ramón Suárez-Medina, Chien-An Sun, Johan Sundström, Yn-Tz Sung, Jordi Sunyer, Paibul Suriyawongpaisal, Boyd A. Swinburn, Rody G. Sy, René Charles Sylva, Lucjan Szponar, E. Shyong Tai, Mari-Liis Tammesoo, Abdonas Tamosiunas, Eng Joo Tan, Xun Tang, Frank Tanser, Yong Tao, Mohammed Rasoul Tarawneh, Jakob Tarp, Carolina B. Tarqui-Mamani, Radka Taxová Braunerová, Anne Taylor, Félicité Tchibindat, William R. Tebar, Grethe Tell, Tania Tello, Holger Theobald, Xenophon Theodoridis, Lutgarde Thijs, Betina H. Thuesen, Lubica Tichá, Erik J. Timmermans, Anne Tjonneland, Hanna K. Tolonen, Janne S. Tolstrup, Murat Topbas, Roman Topór-Madry, María José Tormo, Michael J. Tornaritis, Maties Torrent, Stefania Toselli, Pierre Traissac, Dimitrios Trichopoulos, Antonia Trichopoulou, Oanh T. H. Trinh, Atul Trivedi, Yu-Hsiang Tsao, Lechaba Tshepo, Maria Tsigga, Shoichiro Tsugane, Marshall K. Tulloch-Reid, Fikru Tullu, Tomi-Pekka Tuomainen, Jaakko Tuomilehto, Maria L. Turley, Per Tynelius, Themistoklis Tzotzas, Christophe Tzourio, Peter Ueda, Eunice E. Ugel, Flora A. M. Ukoli, Hanno Ulmer, Belgin Unal, Hannu M. T. Uusitalo, Justina Vaitkeviciute, Gonzalo Valdivia, Susana Vale, Damaskini Valvi, Yvonne T. van der Schouw, Koen Van Herck, Hoang Van Minh, Lenie van Rossem, Natasja M. Van Schoor, Irene G. M. van Valkengoed, Dirk Vanderschueren, Diego Vanuzzo, Gregorio Varela-Moreiras, Patricia Varona-Pérez, Lars Vatten, Tomas Vega, Toomas Veidebaum, Gustavo Velasquez-Melendez, Biruta Velika, Giovanni Veronesi, W. M. Monique Verschuren, Cesar G. Victora, Giovanni Viegi, Lucie Viet, Paolo Vineis, Jesus Vioque, Jyrki K. Virtanen, Marjolein Visser, Sophie Visvikis-Siest, Bharathi Viswanathan, Tiina Vlasoff, Peter Vollenweider, Henry Völzke, Ari Voutilainen, Sari Voutilainen, Martine Vrijheid, Tanja G. M. Vrijkotte, Alisha N. Wade, Aline Wagner, Thomas Waldhör, Janette Walton, Wan Mohamad Wan Bebakar, Wan Nazaimoon Wan Mohamud, Rildo S. Wanderley, Ming-Dong Wang, Qian Wang, Xiangjun Wang, Ya Xing Wang, Ying-Wei Wang, S. Goya Wannamethee, Nicholas Wareham, Adelheid Weber, Deepa Weerasekera, Daniel Weghuber, Wenbin Wei, Peter H. Whincup, Kurt Widhalm, Indah S. Widyahening, Andrzej Wiecek, Alet H. Wijga, Rainford J. Wilks, Johann Willeit, Peter Willeit, Tom Wilsgaard, Bogdan Wojtyniak, Jyh Eiin Wong, Tien Yin Wong, Roy A. Wong-McClure, Jean Woo, Mark Woodward, Frederick C. Wu, Jianfeng Wu, Shouling Wu, Haiquan Xu, Liang Xu, Uruwan Yamborisut, Weili Yan, Ling Yang, Xiaoguang Yang, Yang Yang, Nazan Yardim, Mehdi Yaseri, Xingwang Ye, Panayiotis K. Yiallouros, Agneta Yngve, Moein Yoosefi, Akihiro Yoshihara, Qi Sheng You, San-Lin You, Novie O. Younger-Coleman, Ahmad Faudzi Yusoff, Luciana Zaccagni, Vassilis Zafiropulos, Farhad Zamani, Sabina Zambon, Antonis Zampelas, Hana Zamrazilová, Maria Elisa Zapata, Ko Ko Zaw, Tomasz Zdrojewski, Tajana Zeljkovic Vrkic, Yi Zeng, Dong Zhao, Wenhua Zhao, Wei Zheng, Yingfeng Zheng, Bekbolat Zholdin, Maigeng Zhou, Dan Zhu, Baurzhan Zhussupov, Esther Zimmermann, Julio Zuñiga Cisneros, Majid Ezzati, NCD Risk Factor Collaboration (NCD-RisC)

Nature   569 ( 7755 )   260 - 264   2019.5

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Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities1,2. This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity3–6. Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean BMI segregated by place of residence (a rural or urban area) from 1985 to 2017. We show that, contrary to the dominant paradigm, more than 55% of the global rise in mean BMI from 1985 to 2017—and more than 80% in some low- and middle-income regions—was due to increases in BMI in rural areas. This large contribution stems from the fact that, with the exception of women in sub-Saharan Africa, BMI is increasing at the same rate or faster in rural areas than in cities in low- and middle-income regions. These trends have in turn resulted in a closing—and in some countries reversal—of the gap in BMI between urban and rural areas in low- and middle-income countries, especially for women. In high-income and industrialized countries, we noted a persistently higher rural BMI, especially for women. There is an urgent need for an integrated approach to rural nutrition that enhances financial and physical access to healthy foods, to avoid replacing the rural undernutrition disadvantage in poor countries with a more general malnutrition disadvantage that entails excessive consumption of low-quality calories.

DOI： 10.1038/s41586-019-1171-x

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Predicting gingivitis using visual gingival redness examination on 11 years old Japanese schoolchildren: A ROC analysis Reviewed

Lisdrianto Hanindriyo, Akihiro Yoshihara, Hiro-O. Ito, Kana Suwama, Satoko Kakuta, Makoto Fukui, Masanori Iwasaki, Naofumi Tamaki, Toshihiro Ansai

Pediatric Dental Journal   29 ( 2 )   66 - 71   2019.5

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Perioperative changes in knowledge and attitude toward oral health by oral health education. Reviewed International journal

Nakata H, Matsuo K, Suzuki H, Yoshihara A

Oral diseases   25 ( 4 )   1214 - 1220   2019.5

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OBJECTIVES: Perioperative oral health care can prevent postoperative complications, but it is also important to maintain oral health afterward to avoid later adverse events. This study examined (a) the relationship between knowledge and attitude toward oral health (KAOH) and oral/periodontal status (OPS) in patients receiving surgery, and (b) the changes in KAOH by perioperative oral health care and education. METHODS: Patients receiving surgery who visited our hospital's dental clinic beforehand were prospectively recruited. All participants received oral health care and education. In questionnaires assessing KAOH before and after surgery, respondent answers were generally classified as positive or negative. OPS was assessed before surgery. Associations between KAOH and OPS and perioperative changes in KAOH were statistically tested. RESULTS: A total of 507 patients answered the questionnaire before surgery, among whom 324 patients also completed it afterward. Preoperative OPS was significantly worse in the negative than in the positive KAOH group. Positive answers for KAOH increased significantly from 68.6% to 92.2% during the perioperative period. CONCLUSIONS: We found that patients with poor KAOH also had poor OPS, but KAOH could be improved by perioperative oral health care and education, suggesting that perioperative oral health management could improve oral health knowledge and attitudes.

DOI： 10.1111/odi.13048

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地域在宅超高齢者の食事パターンと栄養状態、栄養素摂取量および嚥下との関連

濱嵜 朋子, 岩崎 正則, 角田 聡子, 片岡 正太, 濃野 要, 葭原 明弘, 小川 祐司, 安細 敏弘, 宮崎 秀夫

口腔衛生学会雑誌   69 ( 増刊 )   161 - 161   2019.4

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職域における歯科健診と個別保健指導による行動変容 Reviewed

金子昇, 葭原 明弘, 濃野 要, 山賀 孝之, 財津 崇, 川口 陽子, 宮崎 秀夫

口腔衛生会誌 J Dent Hlth69   69 ( 1 )   27 - 33   2019.1

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職域における歯科保健事業として、疾病の早期発見を目的とした歯科健診が主に行われてきた。こうした従来型の歯科健診から、行動・環境リスク発見型・行動変容支援型歯科健診への転換を目的として、日本歯科医師会で「標準的な成人健診プログラム・保健指導マニュアル」(生活歯援プログラム)が策定された。本調査ではこのプログラムに基づいた歯科健診と保健指導が、歯科健診単独に比べてどの程度優れているのか検討を行った。新潟市内の3企業の従業員129名(44.6±11.5歳)を対象としてランダムに2群に分け、介入群には生活歯援プログラムに準じた歯科健診と保健指導を、対照群には歯科健診のみを行った。保健行動を把握するための質問紙調査をベースライン時、3ヵ月後、6ヵ月後および1年後に行い、この間の行動変容を調べた。その結果、介入群と対照群のいずれにおいても「職場や外出先での歯磨き」や「フッ素入りの歯磨剤の使用」、「歯間ブラシ・フロスの使用」が有意に改善していた。ただ、介入群では1年後まですべての時点でベースライン時に比べ有意に改善していたのに対し、対照群では一部の時点で有意な改善がみられたのみであった。したがって、従来型の歯科健診でも保健行動の変容がある程度期待できるが、その期間は限定的であること、歯科健診に加え生活歯援プログラムに準じた保健指導を行うことで行動変容はより確実となり、効果が少なくとも1年間持続することが明らかとなった。(著者抄録)

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小児の歯肉炎評価におけるGCFの応用に関する検討 Reviewed

角田 聡子, 邵 仁浩, 葭原 明弘, 福井 誠, 岩崎 正則, 諏訪間 加奈, 鶴田 実穂, 平山 綾, 片岡 正太, 茂山 博代, 横田 誠, 牛島 直文, 玉木 直文, 伊藤 博夫, 安細 敏弘

口腔衛生学会雑誌   69 ( 1 )   19 - 26   2019.1

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歯肉炎の評価は視診もしくはプロービングによる方法が一般的であり、検診の場で使用可能な非侵襲的で簡便性、客観性、再現性を併せもつ検査方法はないのが現状である。本研究では、歯肉溝滲出液(GCF)中の成分が歯肉炎バイオマーカーとして有用であるかを検討した。対象は北九州市内某小学校5、6年生107名である。ブロッティングブラシ(以下、ブラシ)で採取したGCF中のα-1アンチトリプシン(A1AT)、ラクトフェリン(Lf)他4成分(AST、ALT、ALP、LDH)を定量し、PMA index(PMA)、プラーク付着状態(PlI)との比較を行った。PMA、PlIを低値群と高値群に2値化し、GCF成分との比較を行ったところ、PMAではすべての成分、PlIではLDH以外の成分で有意(p<0.05)に関連していた。さらに、ROC曲線から求めたPMA、PlIに対する各成分のカットオフ値はそれぞれ、A1ATが283.8、248.3、Lfが152.1、114.4、ASTが4.5、2.5、ALTはともに1.5、ALPは2.5、PMAでのLDHが26.0であった。陽性尤度比は1.5から3.0程度となった。以上の結果からGCF中A1AT、Lf、AST、ALTおよびALPは小児を対象とした歯肉炎スクリーニングのバイオマーカーとして有用であることが示唆された。(著者抄録)

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歯科医師および歯科衛生士数と歯科診療所で担うことのできる診療内容との関連(平成24年新潟県歯科医療機能連携実態調査より)

皆川 久美子, 葭原 明弘, 佐藤 美寿々, 荒井 節男, 清田 義和, 宮崎 秀夫

口腔衛生学会雑誌   69 ( 1 )   10 - 18   2019.1

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高齢化が進み、有病者への対応や医療連携体制の必要性が高まる現在、診療所は一次医療機関として、多岐にわたる患者への対応および地域における多職種連携等が求められている。本調査の目的は、新潟県の診療所に勤務する各業種の従事状況と、診療所で担える診療内容の関連について評価することである。平成24年8月1日現在、新潟県で開設されている県内すべての歯科診療所(1,186施設)を対象に調査を行い、平成24年7月の1ヵ月間の実施状況について、質問紙による調査で回答を得た。欠損値のない950施設を分析対象とした。診療所に勤務している歯科医師数あるいは歯科衛生士数を説明変数とし、歯科業務補助者数、技工士数、事務職数を共変量に在宅歯科医療サービスの実施状況についてロジスティック回帰分析、障害者および摂食嚥下指導への対応状況については順序ロジスティック回帰分析を行った。その結果、歯科衛生士数のみと関連がみられたのは在宅歯科医療サービス、施設への歯科訪問診療、訪問歯科衛生指導、障害者への対応(それぞれ調整済オッズ比[95%信頼区間]=1.12[1.03-1.23]、1.11[1.01-1.23]、1.31[1.16-1.47]、1.27[1.16-1.40])であった。一方、摂食嚥下指導への対応については歯科医師数(1.24[1.04-1.48])とのみ関連がみられた。診療所の多岐にわたる患者への対応や病診連携を推進するには、まずは歯科医師の意識向上が前提であり、それを基に診療所における歯科医師および歯科衛生士の人材確保が必要である。(著者抄録)

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主観的評価による現在歯数調査の妥当性について

星野 剛志, 皆川 久美子, 葭原 明弘, 深井 穫博, 安藤 雄一, 嶋崎 義浩, 神原 正樹, 宮崎 秀夫

口腔衛生学会雑誌   69 ( 1 )   50 - 51   2019.1

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歯科受診者における受診理由と主観的全身健康観の関連

市川 優, 皆川 久美子, 葭原 明弘, 深井 穫博, 安藤 雄一, 嶋崎 義浩, 神原 正樹, 宮崎 秀夫

口腔衛生学会雑誌   69 ( 1 )   51 - 51   2019.1

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Association between the Numbers of Dentists/Dental Hygienists Working in Dental Clinics and Their Service Contents -From the Survey on the Cooperation of Dentistry Medical Function in Niigata-

MINAGAWA Kumiko, YOSHIHARA Akihiro, SATO Misuzu, ARAI Setsuo, SEIDA Yoshikazu, MIYAZAKI Hideo

JOURNAL OF DENTAL HEALTH   69 ( 1 )   10 - 18   2019

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<p> With advanced aging, there are growing demands for the management of sick persons and medical liaison systems. In such a situation, clinics are expected to play roles as primary medical institutions, such as dealing with diverse patients and promoting community-based multi-professional collaboration. To clarify the association between the statuses of different types of professionals working in dental clinics and their service contents, a questionnaire survey was conducted, involving all dental clinics in Niigata Prefecture (1,186 as of August 1, 2012), along with examination of their service provision in July of the same year. Among these clinics, 950 that responded to the questionnaire without missing values were analyzed. With the number of dentists or dental hygienists working in the study clinics as an explanatory variable and those of dental assistants and clerks as covariances, logistic regression analysis was performed to analyze the contents of home dental care services. Ordered logistic regression analysis was also used to examine the management of patients with disabilities and the provision of feeding/swallowing guidance.</p><p> The items only associated with the number of dental hygienists were home dental care services, visits to care facilities, dental hygiene guidance for care facilities, and the management of patients with disabilities (adjusted odds ratio [95% confidence interval]=1.12 [1.03-1.23], 1.11 [1.03-1.23], 1.31 [1.16-1.47], and 1.27 [1.16-1.40], respectively). The provision of feeding/swallowing guidance was only associated with the number of dentists (1.24 [1.04-1.48]).</p><p> In order to promote the management of diverse patients in dental clinics and their liaison with hospitals, it may be necessary to enhance dentists' awareness as a premise and basis for ensuring sufficient numbers of dentists and dental hygienists working in such clinics.</p>

DOI： 10.5834/jdh.69.1_10

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Self-Feeding Ability as a Predictor of Mortality Japanese Nursing Home Residents: A Two-Year Longitudinal Study. Reviewed

Sakamoto M, Watanabe Y, Edahiro A, Motokawa K, Shirobe M, Hirano H, Ito K, Kanehisa Y, Yamada R, Yoshihara A

The journal of nutrition, health & aging   23 ( 2 )   157 - 164   2019

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DOI： 10.1007/s12603-018-1125-2

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The number of remaining teeth as a risk indicator of cognitive impairment: A cross-sectional clinical study in Sado Island. Reviewed International journal

Ayumi Kuroki, Noriko Sugita, Shigeki Komatsu, Minako Wakasugi, Akio Yokoseki, Akihiro Yoshihara, Tetsuo Kobayashi, Kazutoshi Nakamura, Takeshi Momotsu, Naoto Endo, Kenji Sato, Ichiei Narita, Hiromasa Yoshie

Clinical and experimental dental research   4 ( 6 )   291 - 296   2018.12

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Most studies that have demonstrated an association between number of remaining teeth and cognitive impairment have treated teeth as a continuous variable, although the relationship is nonlinear. The aim of this cross-sectional study was to determine the critical number of remaining teeth in hospital outpatients at which the association with cognitive impairment becomes apparent. Japanese adults living on Sado Island who visited Sado General Hospital were invited to participate in Project in Sado for Total Health. In total, 2,530 adults were interviewed and had their teeth counted; 1,476 of these individuals also completed the Mini-Mental State Examination (MMSE) and underwent measurement of their serum high-sensitivity C-reactive protein (hsCRP) levels. Patients on dialysis and those with hsCRP ≥ 10 mg/L were excluded. The final study group consisted of 565 adults (290 men and 275 women) of mean age 69.8 (range 29-91) years. An MMSE score < 24 was considered to indicate cognitive impairment. The subjects were categorized according to whether they had an edentulous jaw or one to 10, 11-20, 21-27, or ≥28 remaining teeth. One hundred twenty-eight of the 565 study participants were diagnosed to have cognitive impairment. Multiple logistic regression analysis revealed associations of cognitive impairment with older age, ischemic heart disease, smoking, and alcohol consumption. After adjustment for covariates, having one to 10 remaining teeth was significantly associated with cognitive impairment. There is a significant association between having only one to 10 remaining teeth and cognitive impairment in hospital outpatients.

DOI： 10.1002/cre2.147

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一般地域住民における主観的な歯や歯肉の健康状態と全身健康状態との関連 8020推進財団「一般地域住民を対象とした歯・口腔の健康に関する調査研究」より

皆川 久美子, 葭原 明弘, 佐藤 美寿々, 深井 穫博, 安藤 雄一, 嶋崎 義浩, 古田 美智子, 相田 潤, 神原 正樹, 宮崎 秀夫

口腔衛生学会雑誌   68 ( 4 )   198 - 206   2018.10

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Language：Japanese   Publisher：(一社)日本口腔衛生学会  

健康の評価方法として、歯科保健の分野においても主観的評価による健康度を評価指標にした調査が報告されている。しかし、主観的健康観についての調査対象は高齢者が多く、65歳未満の者を対象とした調査はほとんど行われていない。そのため本研究は、一般地域住民を対象に、歯や歯肉の健康状態と全身健康状態との関連を主観的健康観により明らかにすることを目的とした。全国から20〜79歳の5,000人を抽出し、質問紙による調査で回答を得た2,465人(有効回収率49.3%)の中から、分析に用いる変数に欠損値のない1,972人を分析対象者とした。対象者を年齢によって壮年(20〜39歳)・中年(40〜59歳)・高年(60〜79歳)の3区分に分け、それぞれの群において歯や歯肉の健康状態と全身健康状態の主観的健康観の回答をそれぞれカテゴリー化した後、相互の関連を順序ロジスティック回帰分析を用いて分析した。共変量として、現在歯数、性別、仕事の有無、主観的経済状況、就学年数、治療中の疾患の有無、相談相手の有無、BMIを使用した。その結果、すべての年齢群において歯や歯肉の健康状態が良いと回答した者は全身的な健康状態がより良好であると回答していた(調整済オッズ比[95%信頼区間]=壮年期12.41[7.22-21.34]、中年期11.77[7.50-18.48]、老年期10.07[6.55-15.50])。一般住民において属性や関連要因を調整した分析で、いずれの年代においても主観的な歯や歯肉の健康状態と全身健康状態との間には明確な関連性が認められた。(著者抄録)

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Hyposalivation and 10-year all-cause mortality in an elderly Japanese population

Masanori Iwasaki, Wenche S. Borgnakke, Akihiro Yoshihara, Kayoko Ito, Hiroshi Ogawa, Kaname Nohno, Misuzu Sato, Kumiko Minagawa, Toshihiro Ansai, Hideo Miyazaki

Gerodontology   35 ( 2 )   87 - 94   2018.6

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Blackwell Munksgaard  

Objective: To evaluate the association of salivary flow rate with all-cause mortality among older Japanese adults. We hypothesised that hyposalivation would be a marker for mortality. Background: Hyposalivation, which is an objectively measurable decrease in salivary flow, is highly prevalent among older adults. It is associated with malnutrition and poor general health. Methods: The study population comprised 600 community-dwelling Japanese adults (306 men and 294 women), who were 70 years old at baseline. They underwent stimulated salivary flow rate (SSFR) measurements and were followed up during a 10-year study period. After stratification by sex, the hazard ratios of all-cause mortality were estimated using Cox proportional hazards regression analysis comparing groups with and without hyposalivation (ie, SSFR &lt
 0.7 mL/min). Results: The baseline prevalence of hyposalivation was 27.8% (85/306) among men and 47.3% (139/294) among women. During a mean (standard deviation) follow-up period of 104 (27) months, 80 deaths occurred: 60 (75.0%) deaths among men and 20 (25.0%) deaths among women. After adjusting for the number of remaining teeth, smoking status, exercise, hypoalbuminemia, diabetes and cardiovascular disease, hyposalivation at baseline was significantly associated with all-cause mortality among men (adjusted hazard ratio, 1.71
95% confidence interval, 1.01-2.89). In contrast, no association between SSFR and all-cause mortality existed among women. Conclusion: Hyposalivation could be a marker for all-cause mortality among older community-dwelling Japanese men. Future studies investigating the association between SSFR and cause-specific mortality are warranted.

DOI： 10.1111/ger.12319

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Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: a pooled analysis of 1018 population-based measurement studies with 88.6 million participants

Bin Zhou, James Bentham, Mariachiara Di Cesare, Honor Bixby, Goodarz Danaei, Kaveh Hajifathalian, Cristina Taddei, Rodrigo M Carrillo-Larco, Shirin Djalalinia, Shahab Khatibzadeh, Charles Lugero, Niloofar Peykari, Wan Zhu Zhang, James Bennett, Ver Bilano, Gretchen A Stevens, Melanie J Cowan, Leanne M Riley, Zhengming Chen, Ian R Hambleton, Rod T Jackson, Andre Pascal Kengne, Young-Ho Khang, Avula Laxmaiah, Jing Liu, Reza Malekzadeh, Hannelore K Neuhauser, Maroje Sorić, Gregor Starc, Johan Sundström, Mark Woodward, Majid Ezzati, Leandra Abarca-Gómez, Ziad A Abdeen, Niveen M Abu-Rmeileh, Benjamin Acosta-Cazares, Robert J Adams, Wichai Aekplakorn, Kaosar Afsana, Carlos A Aguilar-Salinas, Charles Agyemang, Noor Ani Ahmad, Alireza Ahmadvand, Wolfgang Ahrens, Kamel Ajlouni, Nazgul Akhtaeva, Rajaa Al-Raddadi, Mohamed M Ali, Osman Ali, Ala'a Alkerwi, Eman Aly, Deepak N Amarapurkar, Philippe Amouyel, Antoinette Amuzu, Lars Bo Andersen, Sigmund A Anderssen, Lars H Ängquist, Ranjit Mohan Anjana, Daniel Ansong, Hajer Aounallah-Skhiri, Joana Araújo, Inger Ariansen, Tahir Aris, Nimmathota Arlappa, Dominique Arveiler, Krishna K Aryal, Thor Aspelund, Felix K Assah, Maria Cecília F Assunção, Mária Avdicová, Ana Azevedo, Fereidoun Azizi, Bontha V Babu, Suhad Bahijri, Nagalla Balakrishna, Mohamed Bamoshmoosh, Maciej Banach, Piotr Bandosz, José R Banegas, Carlo M Barbagallo, Alberto Barceló, Amina Barkat, Aluisio J D Barros, Mauro V Barros, Iqbal Bata, Anwar M Batieha, Assembekov Batyrbek, Louise A Baur, Robert Beaglehole, Habiba Ben Romdhane, Mikhail Benet, Lowell S Benson, Antonio Bernabe-Ortiz, Gailute Bernotiene, Heloisa Bettiol, Aroor Bhagyalaxmi, Sumit Bharadwaj, Santosh K Bhargava, Yufang Bi, Mukharram Bikbov, Bihungum Bista, Peter Bjerregaard, Espen Bjertness, Marius B Bjertness, Cecilia Björkelund, Anneke Blokstra, Simona Bo, Martin Bobak, Heiner Boeing, Jose G Boggia, Carlos P Boissonnet, Vanina Bongard, Rossana Borchini, Pascal Bovet, Lutgart Braeckman, Imperia Brajkovich, Francesco Branca, Juergen Breckenkamp, Hermann Brenner, Lizzy M Brewster, Graziella Bruno, H B(as) Bueno-de-Mesquita, Anna Bugge, Con Burns, Michael Bursztyn, Antonio Cabrera de León, Joseph Cacciottolo, Hui Cai, Christine Cameron, Günay Can, Ana Paula C Cândido, Vincenzo Capuano, Viviane C Cardoso, Axel C Carlsson, Maria J Carvalho, Felipe F Casanueva, Juan-Pablo Casas, Carmelo A Caserta, Snehalatha Chamukuttan, Angelique W Chan, Queenie Chan, Himanshu K Chaturvedi, Nishi Chaturvedi, Chien-Jen Chen, Fangfang Chen, Huashuai Chen, Shuohua Chen, Zhengming Chen, Ching-Yu Cheng, Imane Cherkaoui Dekkaki, Angela Chetrit, Arnaud Chiolero, Shu-Ti Chiou, Adela Chirita-Emandi, María-Dolores Chirlaque, Belong Cho, Yumi Cho, Diego G Christofaro, Jerzy Chudek, Renata Cifkova, Eliza Cinteza, Frank Claessens, Els Clays, Hans Concin, Cyrus Cooper, Rachel Cooper, Tara C Coppinger, Simona Costanzo, Dominique Cottel, Chris Cowell, Cora L Craig, Ana B Crujeiras, Juan J Cruz, Graziella D'Arrigo, Eleonora d'Orsi, Jean Dallongeville, Albertino Damasceno, Goodarz Danaei, Rachel Dankner, Thomas M Dantoft, Luc Dauchet, Kairat Davletov, Guy De Backer, Dirk De Bacquer, Giovanni de Gaetano, Stefaan De Henauw, Paula Duarte de Oliveira, Delphine De Smedt, Mohan Deepa, Abbas Dehghan, Hélène Delisle, Valérie Deschamps, Klodian Dhana, Augusto F Di Castelnuovo, Juvenal Soares Dias-da-Costa, Alejandro Diaz, Ty T Dickerson, Shirin Djalalinia, Ha T P Do, Chiara Donfrancesco, Silvana P Donoso, Angela Döring, Maria Dorobantu, Kouamelan Doua, Wojciech Drygas, Virginija Dulskiene, Aleksandar Džakula, Vilnis Dzerve, Elzbieta Dziankowska-Zaborszczyk, Robert Eggertsen, Ulf Ekelund, Jalila El Ati, Paul Elliott, Roberto Elosua, Rajiv T Erasmus, Cihangir Erem, Louise Eriksen, Johan G Eriksson, Jorge Escobedo-de la Peña, Alun Evans, David Faeh, Caroline H Fall, Farshad Farzadfar, Francisco J Felix-Redondo, Trevor S Ferguson, Romulo A Fernandes, Daniel Fernández-Bergés, Daniel Ferrante, Marika Ferrari, Catterina Ferreccio, Jean Ferrieres, Joseph D Finn, Krista Fischer, Bernhard Föger, Leng Huat Foo, Ann-Sofie Forslund, Maria Forsner, Heba M Fouad, Damian K Francis, Maria do Carmo Franco, Oscar H Franco, Guillermo Frontera, Flavio D Fuchs, Sandra C Fuchs, Yuki Fujita, Takuro Furusawa, Zbigniew Gaciong, Fabio Galvano, Manoli Garcia-de-la-Hera, Dickman Gareta, Sarah P Garnett, Jean-Michel Gaspoz, Magda Gasull, Louise Gates, Johanna M Geleijnse, Anoosheh Ghasemian, Anup Ghimire, Simona Giampaoli, Francesco Gianfagna, Tiffany K Gill, Jonathan Giovannelli, Rebecca A Goldsmith, Helen Gonçalves, Marcela Gonzalez-Gross, Juan P González-Rivas, Mariano Bonet Gorbea, Frederic Gottrand, Sidsel Graff-Iversen, Dušan Grafnetter, Aneta Grajda, Maria G Grammatikopoulou, Ronald D Gregor, Tomasz Grodzicki, Anders Grøntved, Giuseppe Grosso, Gabriella Gruden, Vera Grujic, Dongfeng Gu, Ong Peng Guan, Elias F Gudmundsson, Vilmundur Gudnason, Ramiro Guerrero, Idris Guessous, Andre L Guimaraes, Martin C Gulliford, Johanna Gunnlaugsdottir, Marc Gunter, Prakash C Gupta, Rajeev Gupta, Oye Gureje, Beata Gurzkowska, Laura Gutierrez, Felix Gutzwiller, Farzad Hadaegh, Jytte Halkjær, Ian R Hambleton, Rebecca Hardy, Rachakulla Hari Kumar, Jun Hata, Alison J Hayes, Jiang He, Yuna He, Marleen Elisabeth, Ana Henriques, Leticia Hernandez Cadena, Sauli Herrala, Ramin Heshmat, Ilpo Tapani Hihtaniemi, Sai Yin Ho, Suzanne C Ho, Michael Hobbs, Albert Hofman, Gonul Horasan Dinc, Andrea R V R Horimoto, Claudia M Hormiga, Bernardo L Horta, Leila Houti, Christina Howitt, Thein Thein Htay, Aung Soe Htet, Maung Maung Than Htike, Yonghua Hu, José María Huerta, Martijn Huisman, Abdullatif S Husseini, Inge Huybrechts, Nahla Hwalla, Licia Iacoviello, Anna G Iannone, Mohsen M Ibrahim, Norazizah Ibrahim Wong, Nayu Ikeda, M Arfan Ikram, Vilma E Irazola, Muhammad Islam, Aziz al-Safi Ismail, Vanja Ivkovic, Masanori Iwasaki, Rod T Jackson, Jeremy M Jacobs, Hashem Jaddou, Tazeen Jafar, Konrad Jamrozik, Imre Janszky, Grazyna Jasienska, Ana Jelaković, Bojan Jelaković, Garry Jennings, Seung-lyeal Jeong, Chao Qiang Jiang, Michel Joffres, Mattias Johansson, Jari J Jokelainen, Jost B Jonas, Torben Jørgensen, Pradeep Joshi, Jacek Jóźwiak, Anne Juolevi, Gregor Jurak, Vesna Jureša, Rudolf Kaaks, Anthony Kafatos, Eero O Kajantie, Ofra Kalter-Leibovici, Nor Azmi Kamaruddin, Khem B Karki, Amir Kasaeian, Joanne Katz, Jussi Kauhanen, Prabhdeep Kaur, Maryam Kavousi, Gyulli Kazakbaeva, Ulrich Keil, Lital Keinan Boker, Sirkka Keinänen-Kiukaanniemi, Roya Kelishadi, Han C G Kemper, Andre P Kengne, Alina Kerimkulova, Mathilde Kersting, Timothy Key, Yousef Saleh Khader, Davood Khalili, Young-Ho Khang, Mohammad Khateeb, Kay-Tee Khaw, Ursula Kiechl-Kohlendorfer, Stefan Kiechl, Japhet Killewo, Jeongseon Kim, Yeon-Yong Kim, Jurate Klumbiene, Michael Knoflach, Elin Kolle, Patrick Kolsteren, Paul Korrovits, Seppo Koskinen, Katsuyasu Kouda, Sudhir Kowlessur, Slawomir Koziel, Susi Kriemler, Peter Lund Kristensen, Steinar Krokstad, Daan Kromhout, Herculina S Kruger, Ruzena Kubinova, Renata Kuciene, Diana Kuh, Urho M Kujala, Zbigniew Kulaga, R Krishna Kumar, Pawel Kurjata, Yadlapalli S Kusuma, Kari Kuulasmaa, Catherine Kyobutungi, Tiina Laatikainen, Carl Lachat, Tai Hing Lam, Orlando Landrove, Vera Lanska, Georg Lappas, Bagher Larijani, Lars E Laugsand, Avula Laxmaiah, Khanh Le Nguyen Bao, Tuyen D Le, Catherine Leclercq, Jeannette Lee, Jeonghee Lee, Terho Lehtimäki, Luz M León-Muñoz, Naomi S Levitt, Yanping Li, Christa L Lilly, Wei-Yen Lim, M Fernanda Lima-Costa, Hsien-Ho Lin, Xu Lin, Lars Lind, Allan Linneberg, Lauren Lissner, Mieczyslaw Litwin, Jing Liu, Roberto Lorbeer, Paulo A Lotufo, José Eugenio Lozano, Dalia Luksiene, Annamari Lundqvist, Nuno Lunet, Per Lytsy, Guansheng Ma, Jun Ma, George L L Machado-Coelho, Suka Machi, Stefania Maggi, Dianna J Magliano, Emmanuella Magriplis, Marjeta Majer, Marcia Makdisse, Reza Malekzadeh, Rahul Malhotra, Kodavanti Mallikharjuna Rao, Sofia Malyutina, Yannis Manios, Jim I Mann, Enzo Manzato, Paula Margozzini, Pedro Marques-Vidal, Larissa Pruner Marques, Jaume Marrugat, Reynaldo Martorell, Ellisiv B Mathiesen, Alicia Matijasevich, Tandi E Matsha, Jean Claude N Mbanya, Anselmo J Mc Donald Posso, Shelly R McFarlane, Stephen T McGarvey, Stela McLachlan, Rachael M McLean, Scott B McLean, Breige A McNulty, Sounnia Mediene-Benchekor, Jurate Medzioniene, Aline Meirhaeghe, Christa Meisinger, Ana Maria B Menezes, Geetha R Menon, Indrapal I Meshram, Andres Metspalu, Haakon E Meyer, Jie Mi, Kairit Mikkel, Jody C Miller, Cláudia S Minderico, Juan Francisco, J Jaime Miranda, Erkin Mirrakhimov, Marjeta Mišigoj-Durakovic, Pietro A Modesti, Mostafa K Mohamed, Kazem Mohammad, Noushin Mohammadifard, Viswanathan Mohan, Salim Mohanna, Muhammad Fadhli Mohd Yusoff, Line T Møllehave, Niels C Møller, Dénes Molnár, Amirabbas Momenan, Charles K Mondo, Kotsedi Daniel K Monyeki, Jin Soo Moon, Leila B Moreira, Alain Morejon, Luis A Moreno, Karen Morgan, George Moschonis, Malgorzata Mossakowska, Aya Mostafa, Jorge Mota, Mohammad Esmaeel Motlagh, Jorge Motta, Kelias P Msyamboza, Thet Thet Mu, Maria L Muiesan, Martina Müller-Nurasyid, Neil Murphy, Jaakko Mursu, Vera Musil, Iraj Nabipour, Gabriele Nagel, Balkish M Naidu, Harunobu Nakamura, Jana Námešná, Ei Ei K Nang, Vinay B Nangia, Sameer Narake, Matthias Nauck, Eva Maria Navarrete-Muñoz, Ndeye Coumba Ndiaye, William A Neal, Ilona Nenko, Martin Neovius, Flavio Nervi, Hannelore K Neuhauser, Chung T Nguyen, Nguyen D Nguyen, Quang Ngoc Nguyen, Quang V Nguyen, Ramfis E Nieto-Martínez, Teemu J Niiranen, Guang Ning, Toshiharu Ninomiya, Sania Nishtar, Marianna Noale, Oscar A Noboa, Ahmad Ali Noorbala, Teresa Norat, Davide Noto, Mohannad Al Nsour, Dermot O'Reilly, Eiji Oda, Glenn Oehlers, Kyungwon Oh, Kumiko Ohara, Maria Teresa A Olinto, Isabel O Oliveira, Mohd Azahadi Omar, Altan Onat, Sok King Ong, Lariane M Ono, Pedro Ordunez, Rui Ornelas, Clive Osmond, Sergej M Ostojic, Afshin Ostovar, Johanna A Otero, Kim Overvad, Ellis Owusu-Dabo, Fred Michel Paccaud, Cristina Padez, Elena Pahomova, Andrzej Pajak, Domenico Palli, Luigi Palmieri, Wen-Harn Pan, Songhomitra Panda-Jonas, Francesco Panza, Dimitrios Papandreou, Soon-Woo Park, Winsome R Parnell, Mahboubeh Parsaeian, Nikhil D Patel, Ivan Pecin, Mangesh S Pednekar, Nasheeta Peer, Petra H Peeters, Sergio Viana Peixoto, Markku Peltonen, Alexandre C Pereira, Annette Peters, Astrid Petersmann, Janina Petkeviciene, Niloofar Peykari, Son Thai Pham, Iris Pigeot, Hynek Pikhart, Aida Pilav, Lorenza Pilotto, Freda Pitakaka, Aleksandra Piwonska, Pedro Plans-Rubió, Ozren Polašek, Miquel Porta, Marileen L P Portegies, Akram Pourshams, Hossein Poustchi, Rajendra Pradeepa, Mathur Prashant, Jacqueline F Price, Jardena J Puder, Maria Puiu, Margus Punab, Radwan F Qasrawi, Mostafa Qorbani, Tran Quoc Bao, Ivana Radic, Ricardas Radisauskas, Mahfuzar Rahman, Olli Raitakari, Manu Raj, Sudha Ramachandra Rao, Ambady Ramachandran, Elisabete Ramos, Lekhraj Rampal, Sanjay Rampal, Daniel A Rangel Reina, Josep Redon, Paul Ferdinand M Reganit, Robespierre Ribeiro, Elio Riboli, Fernando Rigo, Tobias F Rinke de Wit, Raphael M Ritti-Dias, Sian M Robinson, Cynthia Robitaille, Fernando Rodríguez-Artalejo, María del Cristo Rodriguez-Perez, Laura A Rodríguez-Villamizar, Rosalba Rojas-Martinez, Dora Romaguera, Kimmo Ronkainen, Annika Rosengren, Joel G R Roy, Adolfo Rubinstein, Blanca Sandra Ruiz-Betancourt, Marcin Rutkowski, Charumathi Sabanayagam, Harshpal S Sachdev, Olfa Saidi, Sibel Sakarya, Benoit Salanave, Eduardo Salazar Martinez, Diego Salmerón, Veikko Salomaa, Jukka T Salonen, Massimo Salvetti, Jose Sánchez-Abanto, Susana Sans, Diana A Santos, Ina S Santos, Renata Nunes dos Santos, Rute Santos, Jouko L Saramies, Luis B Sardinha, Giselle Sarganas, Nizal Sarrafzadegan, Kai-Uwe Saum, Savvas Savva, Marcia Scazufca, Herman Schargrodsky, Sabine Schipf, Carsten O Schmidt, Ben Schöttker, Constance Schultsz, Aletta E Schutte, Aye Aye Sein, Abhijit Sen, Idowu O Senbanjo, Sadaf G Sepanlou, Sanjib K Sharma, Jonathan E Shaw, Kenji Shibuya, Dong Wook Shin, Youchan Shin, Khairil Si-Ramlee, Rosalynn Siantar, Abla M Sibai, Diego Augusto Santos Silva, Mary Simon, Judith Simons, Leon A Simons, Michael Sjöström, Sine Skovbjerg, Jolanta Slowikowska-Hilczer, Przemyslaw Slusarczyk, Liam Smeeth, Margaret C Smith, Marieke B Snijder, Hung-Kwan So, Eugène Sobngwi, Stefan Söderberg, Vincenzo Solfrizzi, Emily Sonestedt, Yi Song, Thorkild I A Sørensen, Maroje Soric, Charles Sossa Jérome, Aicha Soumare, Jan A Staessen, Gregor Starc, Maria G Stathopoulou, Bill Stavreski, Jostein Steene-Johannessen, Peter Stehle, Aryeh D Stein, George S Stergiou, Jochanan Stessman, Jutta Stieber, Doris Stöckl, Tanja Stocks, Jakub Stokwiszewski, Karien Stronks, Maria Wany Strufaldi, Chien-An Sun, Johan Sundström, Yn-Tz Sung, Paibul Suriyawongpaisal, Rody G Sy, E Shyong Tai, Mari-Liis Tammesoo, Abdonas Tamosiunas, Eng Joo Tan, Xun Tang, Frank Tanser, Yong Tao, Mohammed Rasoul Tarawneh, Carolina B Tarqui-Mamani, Oana-Florentina Tautu, Anne Taylor, Holger Theobald, Xenophon Theodoridis, Lutgarde Thijs, Betina H Thuesen, Anne Tjonneland, Hanna K Tolonen, Janne S Tolstrup, Murat Topbas, Roman Topór-Madry, María José Tormo, Maties Torrent, Pierre Traissac, Dimitrios Trichopoulos, Antonia Trichopoulou, Oanh T H Trinh, Atul Trivedi, Lechaba Tshepo, Marshall K Tulloch-Reid, Fikru Tullu, Tomi-Pekka Tuomainen, Jaakko Tuomilehto, Maria L Turley, Per Tynelius, Christophe Tzourio, Peter Ueda, Eunice E Ugel, Hanno Ulmer, Hannu M T Uusitalo, Gonzalo Valdivia, Damaskini Valvi, Yvonne T van der Schouw, Koen Van Herck, Hoang Van Minh, Lenie van Rossem, Natasja M Van Schoor, Irene G M van Valkengoed, Dirk Vanderschueren, Diego Vanuzzo, Lars Vatten, Tomas Vega, Gustavo Velasquez-Melendez, Giovanni Veronesi, W M Monique Verschuren, Roosmarijn Verstraeten, Cesar G Victora, Lucie Viet, Eira Viikari-Juntura, Paolo Vineis, Jesus Vioque, Jyrki K Virtanen, Sophie Visvikis-Siest, Bharathi Viswanathan, Tiina Vlasoff, Peter Vollenweider, Sari Voutilainen, Alisha N Wade, Aline Wagner, Janette Walton, Wan Mohamad Wan Bebakar, Wan Nazaimoon Wan Mohamud, Rildo S Wanderley, Ming-Dong Wang, Qian Wang, Ya Xing Wang, Ying-Wei Wang, S Goya Wannamethee, Nicholas Wareham, Niels Wedderkopp, Deepa Weerasekera, Peter H Whincup, Kurt Widhalm, Indah S Widyahening, Andrzej Wiecek, Alet H Wijga, Rainford J Wilks, Johann Willeit, Peter Willeit, Emmanuel A Williams, Tom Wilsgaard, Bogdan Wojtyniak, Roy A Wong-McClure, Justin Y Y Wong, Tien Yin Wong, Jean Woo, Mark Woodward, Aleksander Giwercman Wu, Frederick C Wu, Shouling Wu, Haiquan Xu, Weili Yan, Xiaoguang Yang, Xingwang Ye, Panayiotis K Yiallouros, Akihiro Yoshihara, Novie O Younger-Coleman, Ahmad Faudzi Yusoff, Ahmad Ali Zainuddin, Sabina Zambon, Antonis Zampelas, Tomasz Zdrojewski, Yi Zeng, Dong Zhao, Wenhua Zhao, Wei Zheng, Yingfeng Zheng, Dan Zhu, Baurzhan Zhussupov, Esther Zimmermann, Julio Zuñiga Cisneros

International Journal of Epidemiology   47 ( 3 )   872 - 883i   2018.6

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Publishing type：Research paper (scientific journal)   Publisher：Oxford University Press (OUP)  

DOI： 10.1093/ije/dyy016

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Relationship between vitamin D receptor gene polymorphism and susceptibility to chronic kidney disease and periodontal disease in community-dwelling elderly. Reviewed International journal

Akihiro Yoshihara, Noboru Kaneko, Masanori Iwasaki, Kaname Nohno, Hideo Miyazaki

Journal of clinical periodontology   45 ( 6 )   672 - 679   2018.6

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Language：English   Publishing type：Research paper (scientific journal)  

OBJECTIVES: The aim of this study was to investigate the possible correlation between vitamin D receptor (VDR) gene polymorphism and susceptibility to chronic kidney disease (CKD) and periodontal disease. MATERIAL AND METHODS: This study analysed 345 participants, who were all 79 years of age. Kidney function levels were determined based on the estimated glomerular filtration rate (eGFR; non-reduced function: ≥60 and reduced function: <60 ml min-1  1.73 m-2 ). VDR TaqI genotyping was also studied. We calculated the periodontal inflamed surface area (PISA). After classifying participants into quartile groups according to eGFR or PISA values, the subjects were then split into two groups (highest quartile versus the other three groups combined). Multiple logistic regression analysis was performed to evaluate the odds ratios between the eGFR and VDR TaqI genotype with the different PISA groups. The eGFR was set as the dependent variable while the VDR TaqI genotype, HbA1C, gender, smoking habits and body mass index were defined as independent variables. RESULTS: A significant association was observed between the VDR TaqI genotype and eGFR in the PISA high group (odds ratio = 3.97, p = .027). CONCLUSION: Study results suggest that VDR TaqI genotype might be associated with CKD during inflammatory conditions caused by periodontal disease.

DOI： 10.1111/jcpe.12896

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