Faculty Profiles - YOSHIHARA Akihiro

Dietary ratio of n-6 to n-3 polyunsaturated fatty acids and periodontal disease in community-based older Japanese: A 3-year follow-up study Reviewed

Masanori Iwasaki, George W. Taylor, Paula Moynihan, Akihiro Yoshihara, Kanako Muramatsu, Reiko Watanabe, Hideo Miyazaki

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS 85 ( 2 ) 107 - 112 2011.8

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCI LTD

DOI： 10.1016/j.plefa.2011.04.002

Relationship between Saturated Fatty Acids and Periodontal Disease Reviewed

M. Iwasaki, M. C. Manz, P. Moynihan, A. Yoshihara, K. Muramatsu, R. Watanabe, H. Miyazaki

JOURNAL OF DENTAL RESEARCH 90 ( 7 ) 861 - 867 2011.7

Language：English Publishing type：Research paper (scientific journal) Publisher：SAGE PUBLICATIONS INC

Saturated fatty acids (SFAs) produce an inflammatory response. Hyperinflammation is now recognized as one of the key underlying etiologic factors in periodontal disease. The longitudinal relationship between dietary SFAs and periodontal disease in 264 Japanese individuals, aged 75 years, for whom data were available for the years 2003-2004, was investigated. SFA intake was assessed with a brief self-administered diet history questionnaire. Participants were classified by quartiles of SFA intake. Full-mouth periodontal status, measured as the clinical attachment level (CAL), was recorded at baseline and follow-up examinations. The number of teeth with a loss of CAL >= 3 mm at any site over a year was calculated as 'periodontal disease events'. Poisson regression analysis was conducted, with dietary SFAs as the primary predictor of interest, to estimate their influence on periodontal disease events. High dietary SFA intake was significantly associated with a greater number of periodontal disease events among nonsmokers. The multivariate adjusted relative risk (95% confidence intervals) in the 1st, 2nd, 3rd, and 4th quartiles of dietary SFAs was 1.00, 1.19 (0.72-1.97), 1.55 (0.95-2.52), and 1.92 (1.19-3.11), respectively. These findings suggest an independent association of dietary SFA intake to the progression of periodontal disease in older Japanese non-smokers.

DOI： 10.1177/0022034511405384

Relationship between bone fragility of the mandibular inferior cortex and tooth loss related to periodontal disease in older people Reviewed

A. Yoshihara, T. Deguchi, H. Miyazaki

COMMUNITY DENTAL HEALTH 28 ( 2 ) 165 - 169 2011.6

Language：English Publishing type：Research paper (scientific journal) Publisher：F D I WORLD DENTAL PRESS LTD

Objective: The purpose of this study was to evaluate the relationship between bone fragility of the mandibular inferior cortex and tooth loss in older adults by accounting for periodontal disease and bone metabolism markers. Research Design: A total of 177 subjects aged 77 years participated in this study. We counted the number of remaining teeth. The mandibular cortex condition was examined using the mandibular inferior cortex classification (MICC) on dental panoramic radiographs. The mandibular inferior cortex was detected on both sides of the mandible, distally from the mental foramen (C1, normal; C2, mild/moderate erosion; C3, severe erosion). Multiple linear regression analysis was performed to assess the relationship between the mandibular cortex condition with the MICC and the number of remaining teeth after controlling for confounding factors such as gender, the percentage of sites with >= 4 mm clinical attachment levels, and serum osteocalcin levels. Results: The mean +/- SD number of remaining teeth of MICC C1, C2 and C3 were 20.7+/-7.5, 14.6+/-8.1 and 4.0+/-0.0 for males, and MICC C1, C2, and C3 were 21.7+/-7.6, 17.2+/-8.0, and 16.2+/-10.4 for females. The MICC was significantly associated with the number of remaining teeth using multiple linear regression analysis (beta= -0.21, p=0.031). Conclusion: This study suggests that there is a relationship between bone fragility of the mandibular inferior cortex and tooth loss related to periodontal disease.

DOI： 10.1922/CDH_2532Yoshihara05

Relationships between the amount of saliva and medications in elderly individuals

Kana Ichikawa, Shihoko Sakuma, Akihiro Yoshihara, Hideo Miyazaki, Saori Funayama, Kayoko Ito, Atsuko Igarashi

GERODONTOLOGY 28 ( 2 ) 116 - 120 2011.6

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY-BLACKWELL

Objective:
To investigate medications that are related to volume of saliva in the elderly.
Background data:
In the elderly, many cases of mouth dryness may represent side effects of medication.
Materials and methods:
The volume of unstimulated saliva was measured for 30 s (cotton roll test), and with stimulation for 3 min (gum test) in 368 subjects 79-80 years old (177 men, 191 women). Medications were investigated using subject's medication notebooks.
Results:
Mean volumes of unstimulated and stimulated saliva were 0.14 +/- 0.13 and 4.30 +/- 2.54 ml respectively. Significant differences were seen between gender and mean volume of saliva. The volume of unstimulated saliva was 0.16 +/- 0.15 ml for men and 0.11 +/- 0.10 ml for women. The volume of stimulated saliva was 4.99 +/- 2.67 ml for men and 3.67 +/- 2.25 ml for women. The percentage of subjects taking medication was 64.7% (238/368). Mean number of medications was 2.08 +/- 2.26, with no significant difference with gender (2.01 +/- 2.37 for men, 2.16 +/- 2.16 for women). In a stepwise multiple regression analysis with volume of saliva as the objective variable and number of drugs by category as explanatory variables, significant explanatory variables in addition to gender and number of medications were blood-coagulating agents, Ca antagonists and peptic ulcer drugs for volume of unstimulated saliva, and diabetes medications and peptic ulcer drugs for volume of stimulated saliva.
Conclusion:
These findings suggest that differences exist between gender in volume of saliva for elderly individuals, and that the volume of saliva is affected by the number and type of medications.

DOI： 10.1111/j.1741-2358.2009.00358.x

Relationships between the amount of saliva and medications in elderly individuals Reviewed

Kana Ichikawa, Shihoko Sakuma, Akihiro Yoshihara, Hideo Miyazaki, Saori Funayama, Kayoko Ito, Atsuko Igarashi

GERODONTOLOGY 28 ( 2 ) 116 - 120 2011.6

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY-BLACKWELL

DOI： 10.1111/j.1741-2358.2009.00358.x

Glomerular filtration rate and 10-year mortality in a 70-year-old community-dwelling Japanese population Reviewed

Yutaka Takata, Toshihiro Ansai, Akihiro Yoshihara, Hideo Miyazaki

AGING CLINICAL AND EXPERIMENTAL RESEARCH 23 ( 3 ) 223 - 230 2011.6

Language：English Publishing type：Research paper (scientific journal) Publisher：EDITRICE KURTIS S R L

Background and aims: The equation for Japanese estimated glomeruiar filtration rate (eGFR) was revised by measuring GFR by inulin clearance. The association of the new eGFR with all-cause mortality and mortality from cardiovascular disease (CVD) was assessed in an elderly Japanese population. Methods: Seventy-year-old subjects, residents of Niigata, Japan, participated. Baseline examinations were carried out in June 1998. The new eGFR measure, 194 x (serum creatinine)(-1.094) x Age(-0.287) x (0.739 if female), was calculated. According to eGFR results, subjects were classified into normal or slightly impaired (>= 60 mL/min/1.73 me), moderately impaired (40-59 mL/min/1.73 m(2)) and severely impaired (<40 mL/min/1.73 m(2)). Participants were under survey for 10 years. Results: The overall survival rate with the Kaplan-Meier method was shorter in subjects with severely impaired eGFR than in those with normal, slightly or moderately impaired eGFR. Similarly, mortality from CVD was higher for individuals with severely impaired eGFR than those with normal or slightly impaired eGFR. There were no associations of mortality from cancer or pneumonia with eGFR. The hazard ratio by the Cox proportional regression model for total mortality was 3.9 times higher in the severely impaired group than in normal or slightly impaired groups, with adjustment for confounding factors. Mortality from CVD was 13.6 times higher in the former than in the latter, with adjustment. Conclusions: There is an association of the new Japanese eGFR with total mortality and CVD mortality, suggesting that the new equation may be independently predictive of all-cause mortality and mortality from CVD in the general 70-year-old Japanese population. (Aging Clin Exp Res 2011; 23: 223-230) (c) 2011, Editrice Kurtis

DOI： 10.3275/7207

Glomerular filtration rate and 10-year mortality in a 70-year-old community-dwelling Japanese population

Yutaka Takata, Toshihiro Ansai, Akihiro Yoshihara, Hideo Miyazaki

AGING CLINICAL AND EXPERIMENTAL RESEARCH 23 ( 3 ) 223 - 230 2011.6

Language：English Publishing type：Research paper (scientific journal) Publisher：EDITRICE KURTIS S R L

DOI： 10.3275/7207

縦断調査からみた歯列欠損形態と咀嚼能力の経年変化

佐藤直子, 野村修一, 昆はるか, 桜井直樹, 河野正司, 葭原明弘, 宮崎秀夫

日本老年歯科医学会総会・学術大会プログラム・抄録集 22回 152 - 152 2011.6

Influence of dental occlusion on physical fitness decline in a healthy Japanese elderly population

Naoko Okuyama, Takayuki Yamaga, Akihiro Yoshihara, Kaname Nohno, Yutaka Yoshitake, Yasuo Kimura, Mieko Shimada, Naoki Nakagawa, Mamoru Nishimuta, Masaharu Ohashi, Hideo Miyazaki

ARCHIVES OF GERONTOLOGY AND GERIATRICS 52 ( 2 ) 172 - 176 2011.3

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER IRELAND LTD

The aim of this study was to clarify the relationship between dental occlusion and physical fitness by a longitudinal survey. A sample of 348 subjects (171 men and 177 women) aged 71 was investigated by Eichner index (EI) as an occlusal condition (Class A: no loss; Class B: partial loss; Class C: complete loss) and five types of physical fitness tests and were re-examined 8 years later. The upper 50% were sampled to analyze the correlation between each physical fitness decline and the EI at the baseline by logistic regression models. Logistic regression analyses revealed that leg extensor power (Class B vs. Class A; odds ratio = OR = 4.61, p = 0.010) and one-leg standing time with eyes open (Class C vs. Class A; OR = 4.27, p = 0.031) showed significant correlations with the EI at the baseline. In this study, partial or complete loss of occlusion was associated with a decline in leg extensor power or a decrease in one-leg standing time with eyes open. These findings suggest that maintenance of dental occlusion may prevent a decrease in activities of daily living in the elderly. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.archger.2010.03.011

特定健診対象者における歯周疾患スクリーニングテストとメタボリックシンドロームとの関連性 Reviewed

岩﨑正則, 葭原明弘, 宮﨑秀夫

日本口腔衛生学会雑誌 61 573 - 580 2011

Long-term caries preventive effects of a school-based Fluoride Mouth Rinse program in adulthood Reviewed

Y. Neko-Uwagawa, A. Yoshihara, H. Miyazaki

Open Dentistry Journal 5 ( 1 ) 24 - 28 2011

Language：English Publishing type：Research paper (scientific journal)

The purpose of this study was to evaluate the long-term caries preventive effects of school-based fluoride mouth rinse (FMR) program in adults aged 20 years and older. 637 mothers aged from 20 to 39 years were surveyed. Clinical examinations were carried out for subjects to obtain data on dental caries prevalence when they visited local health centers to take their children for medical and dental check-ups at 1.5- or 3-years old. We also obtained information regarding the FMR program: the duration that the subjects participated between nursery school and junior high school. When analyzing data, subjects were divided into 4 groups: FMR from nursery to junior high school group (N-JH group, n=22), FMR limited to the elementary school group (El group, n=62), FMR no-experience group (n=545), and other subjects whose FMR experience is not clear (n=8). For evaluation of the FMR program effect, multiple regression analysis was used. As independent variable, the FMR program patterns were converted into dummy data, and mean DMFT was used as dependent variable. The results of multiple regression analysis between mean DMFT and FMR program patterns showed that the N-JH group and El group were negatively associated with the mean DMFT (ß=-0.20, p&lt
0.001 for N-JH group and ß=-0.11, p=0.003 for El group). The positive caries preventive effects of school-based FMR program from nursery school to junior high school can continue in adults aged 20 years and older. © Neko-Uwagawa et al.

DOI： 10.2174/1874210601105010024

Scopus

Relationship between periodontal disease and bone metabolism in the elderly Invited

Economic evaluation of a school-based combined program with a targeted pit and fissure sealant and fluoride mouth rinse in Japan Reviewed

Y Neko-Uwagawa, A Yoshihara, H Miyazaki

The Open Dentistry Journal 5 24 - 28 2011

成人期および高齢期における咀嚼回数と体格の関連 Reviewed

岩﨑正則, 葭原明弘, 宮﨑秀夫

日本口腔衛生学会雑誌 61 318 - 328 2011

用語委員会報告口腔衛生関連学術用語の統一に関する見解 Reviewed

千葉逸朗, 尾崎哲則, 加藤一夫, 日野出大輔, 平田幸夫, 葭原明弘

日本口腔衛生学会 61 563 - 572 2011

A Yoshihara

Journal of Dental Health 61 178 - 182 2011

Longitudinal relationship between dietary omega-3 fatty acids and periodontal disease

Masanori Iwasaki, Akihiro Yoshihara, Paula Moynihan, Reiko Watanabe, George W. Taylor, Hideo Miyazaki

NUTRITION 26 ( 11-12 ) 1105 - 1109 2010.11

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCIENCE INC

Objective: Fish oil has anti-inflammatory actions that may benefit periodontal health. We investigated the longitudinal relation between dietary omega-3 fatty acids (FAs), docosahexaenoic acid, (DHA), and eicosapentaenoic acid (EPA) to periodontal disease in community-dwelling elderly.
Methods: Fifty-five participants aged 74 y were randomly selected from a longitudinal interdisciplinary study of aging. Dietary intake data were obtained by a 3-d weighed food intake. The dietary intakes of energy, DHA, and EPA were calculated based on the Standard Food Composition Tables in Japan. Dental examinations were carried out at baseline and once a year for 5 y. The number of teeth with periodontal progression over 5 y per person was calculated as "periodontal disease events." Negative binomial regression analysis was conducted, which included DHA, EPA, and other covariates as independent variables to estimate the influence on periodontal disease events. Longitudinal data were analyzed for participants for whom data were available for 5 y (n = 36).
Results: Low DHA intake was significantly associated with more periodontal disease events. The mean number of periodontal disease events for participants who consumed the lowest tertile of DHA was approximately 1.5 times larger (lowest tertile, incidence rate ratio 1.49, 95% confidence interval 1.01-2.21) than the reference group (highest tertile of DHA consumption), after simultaneously adjusting for possible confounders.
Conclusion: The findings suggest there may be an inverse, independent relation of dietary DHA intake to the progression of periodontal disease in older people. (C) 2010 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.nut.2009.09.010

Longitudinal relationship between dietary omega-3 fatty acids and periodontal disease Reviewed

Masanori Iwasaki, Akihiro Yoshihara, Paula Moynihan, Reiko Watanabe, George W. Taylor, Hideo Miyazaki

NUTRITION 26 ( 11-12 ) 1105 - 1109 2010.11

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCIENCE INC

DOI： 10.1016/j.nut.2009.09.010

Dietary omega-3 fatty acid may control periodontal disease Low dietary docosahexaenoic acid might be a significant risk factor of periodontal disease progression Reviewed

Masanori Iwasaki, Akihiro Yoshihara, Paula Moynihan, Reiko Watanabe, Hideo Miyazaki

AGRO FOOD INDUSTRY HI-TECH 21 ( 6 ) 34 - 37 2010.11

Language：English Publishing type：Research paper (scientific journal) Publisher：TEKNOSCIENZE PUBL

Objective: we investigated the longitudinal relation of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) to periodontal disease. Methods: dietary intake data were obtained by a 3-day weighed food intake. Dental examinations were carried out at baseline and once a year for 5 years in 36 participants. The number of teeth with periodontal progression per person was calculated as "periodontal disease events". Results: negative binomial regression analysis revealed that the mean number of periodontal disease events for participants who consumed the lowest tertile of DHA was approximately 1.5 times larger than the reference group (highest tertile), after simultaneously adjusting for possible confounders. Conclusion: within the limitations of the reported study, an inverse, independent relationship between dietary DHA intake and the progression of periodontal disease was found. Further studies are necessary to confirm these findings.

フッ化物洗口の都道府県別にみた普及の推移国の政策が果たした役割の検討 Reviewed

田浦勝彦, 相田潤, 安藤雄一, 晴佐久悟, 田口千恵子, 木本一成, 葭原明弘, 筒井昭仁, 眞木吉信, 荒川浩久, 飯島洋一, 磯崎篤則, 小林清吾, 小関健由

口腔衛生学会雑誌 60 ( 5 ) 556 - 562 2010.10

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：(一社)日本口腔衛生学会

2003年1月に厚生労働省はフッ化物洗口ガイドラインを都道府県知事宛に通知した。これに先行して「健康日本21」の歯の健康項目の策定と「8020運動推進特別事業」が展開されてきた。これらの施策がその後の都道府県全体における集団フッ化物洗口の普及にどのような影響を及ぼしたかを検討したところ、国の施策実施前後の2000年頃を境に全国の約4分の1にあたる府県で集団フッ化物洗口の増加を認めた。また、1994年から2008年のデータをもとにフッ化物洗口実施率を目的変数としたマルチレベル分析を行ったところ、調査年度間と都道府県間に統計学的に有意な差を認めた。調査年ごとに平均0.48%の実施率の上昇、およびガイドライン実施後はそれに加えて1.31%の実施率の上昇が認められた。よって、フッ化物洗口ガイドラインは集団フッ化物洗口の拡大に有意に影響を及ぼし始めていることが推定された。以上のように、歯の健康づくりに国の各種施策が果たした役割は大きいことが示唆された。(著者抄録)

DOI： 10.5834/jdh.60.5_556