Faculty Profiles - YOSHIHARA Akihiro

The carriage of Candida species on the dorsal surface of the tongue: the correlation with the dental, periodontal and prosthetic status in elderly subjects.

Wang J, Ohshima T, Yasunari U, Namikoshi S, Yoshihara A, Miyazaki H, Maeda N

Gerodontology 23 ( 3 ) 157 - 63 2006.9

フッ化物洗口プログラムをベースとした選択的シーラント応用の20歳成人におけるう蝕予防効果

中村文, 佐久間汐子, 葭原明弘, 八木稔, 出口知也, 宮崎秀夫

口腔衛生学会雑誌 = JOURNAL OF DENTAL HEALTH 56 ( 4 ) 520 - 520 2006.8

Association between commensal bacteria and opportunistic pathogens in the dental plaque of elderly individuals Reviewed

A Tada, H Senpuku, Y Motozawa, A Yoshihara, N Hanada, H Tanzawa

CLINICAL MICROBIOLOGY AND INFECTION 12 ( 8 ) 776 - 781 2006.8

Language：English Publishing type：Research paper (scientific journal) Publisher：BLACKWELL PUBLISHING

Opportunistic infections in the oral cavity of the elderly may increase the incidence of systemic disease. The objective of this study was to investigate the differences in the oral bacterial flora between dependent elderly (inpatients) and independent elderly (community-dwelling residents). After multiple variables were taken into account, inpatients had significantly lower detection rates than community-dwelling residents for alpha-streptococci (p < 0.001) and Neisseria (p 0.004), and higher detection rates for Pseudomonas aeruginosa (p 0.024), methicillin-resistant Staphylococcus aureus (MRSA) (p 0.011) and Actinomyces spp. (p 0.005). Among inpatients, the requirement for a high degree of care was related negatively to detection of alpha-streptococci, but was related significantly to detection of P. aeruginosa (p 0.018) or MRSA (p 0.004). Tube-fed inpatients had a significantly lower detection rate for alpha-streptococci (p 0.041) and a higher detection rate for P. aeruginosa (p 0.004) than those who did not require tube feeding. Inpatients with a history of antibiotic use had a significantly lower detection rate for alpha-streptococci (p 0.049) and a higher detection rate for MRSA (p 0.007) than those without a history of antibiotic use. The detection rates for P. aeruginosa or MRSA in inpatients without alpha-streptococci were higher than in inpatients with alpha-streptococci after controlling for age and gender (P. aeruginosa, p 0.006; MRSA, p 0.001). Overall, detection of alpha-streptococci had an inverse correlation with the detection of P. aeruginosa and MRSA in the oral cavity and is likely to be an indicator of pathogenic bacterial infection.

DOI： 10.1111/j.1469-0691.2006.01497.x

Association between serum albumin and periodontal disease in community-dwelling elderly Reviewed

H Ogawa, A Yoshihara, N Amarasena, T Hirotomi, H Miyazaki

JOURNAL OF CLINICAL PERIODONTOLOGY 33 ( 5 ) 312 - 316 2006.5

Language：English Publishing type：Research paper (scientific journal) Publisher：BLACKWELL PUBLISHING

Aim: The purpose of this study was to evaluate the relationship between periodontal disease and general health status in community-dwelling elderly using serum albumin concentration as a criterion index of the severity of an underlying disease and nutrition status.
Methods: Serum albumin level was detected by the bromcresol green albumin (BCG) method and the data for serum albumin were available in 368 subjects aged 75 years. Pressure-sensitive probes were used to measure loss of attachment (LA) on six sites of all teeth present. Information relevant to gender and smoking habit was obtained by means of a personal interview, while body mass index (BMI) and biochemical serum markers were investigated.
Results: Serum albumin concentration ranged from 3.2 to 4.8 g/dl with a mean of 4.1 +/- 0.2. More than 70% of subjects had at least one site with LA 6+ mm, while 91 exhibited 10% or more sites with LA 6+ mm. Using a multiple regression analysis, we found that sites of LA 6+ mm had a significant effect on serum albumin level (correlation coefficient=-0.14; p < 0.05), which was independent of the other covariates.
Conclusions: The findings of the present study indicated that there might be an inverse relationship between periodontal disease and serum albumin concentration in these elderly subjects.

DOI： 10.1111/j.1600-051X.2005.00901.x

Association between serum albumin and periodontal disease in community-dwelling elderly

H Ogawa, A Yoshihara, N Amarasena, T Hirotomi, H Miyazaki

JOURNAL OF CLINICAL PERIODONTOLOGY 33 ( 5 ) 312 - 316 2006.5

Language：English Publishing type：Research paper (scientific journal) Publisher：BLACKWELL PUBLISHING

DOI： 10.1111/j.1600-051X.2005.00901.x

介護認定申請者における要介護度別歯科疾患の実態および歯科的治療ニーズに関する研究 Reviewed

鈴木昭, 河野正司, 野村修一, 伊藤加代子, 豊里晃, 田巻元子, 八木稔, 葭原明弘, 大内章嗣

新潟歯学会雑誌 35 ( 2 ) 209 - 214 2006.1

Language：Japanese Publisher：新潟歯学会

介護認定者の歯科疾患の実態と歯科的治療ニーズを把握・評価するため,要介護度を踏まえた検討を行った.対象は新潟県内の同一保険医療福祉圏内の7市町村に在住し,2002年10月から12月の間に介護認定申請をした368名(平均年齢81歳)で,調査結果を分析し,以下の結論を得た.1)平均残存歯数と要介護度には相関関係はない,2)要介護度が上がると要抜去歯が有意に増加する傾向がある,3)歯科的治療ニーズ患者割合(要歯科治療・要専門的口腔ケアは89.4%),4)要介護状態になってから歯科を受診した患者割合は35.3%.以上より,歯科治療の必要性と実際の受診状況には大きな隔たりがあることが分かった

Influence of a fluoride mouthrinse on mutans streptococci in schoolchildren

Noboru Kaneko, Akihiro Yoshihara, Hirohisa Ida, Yoshiaki Nomura, Susumu Imai, Toshiki Nisizawa, Shihoko Sakuma, Nobuhiro Hanada, Hideo Miyazaki

CARIES RESEARCH 40 ( 6 ) 501 - 507 2006

Language：English Publishing type：Research paper (scientific journal) Publisher：KARGER

This study aimed to determine whether the long-term use of a fluoride mouthrinse affects the salivary levels of mutans streptococci. Two hundred and fifteen schoolchildren (aged 9-10 years) participated. One hundred and forty-nine of these children had used a fluoride mouthrinse since 5 years of age at nursery school, and the remaining 66 children had not. DFT (decayed and filled teeth) was recorded, and the salivary levels of Streptococcus mutans and Streptococcus sobrinus were measured using mitis salivarius bacitracin agar. The group that had used a fluoride mouthrinse had a significantly lower prevalence of both S. mutans and S. sobrinus (p = 0.038) and a significantly lower DFT score (p = 0.001) than the other group. Using logistic regression analysis including caries experience at baseline as a dependent variable, the odds ratio of carrying S. mutans alone was 8.0 (p = 0.066) and that of carrying both S. mutans and S. sobrinus was 16.5 (p = 0.022) in the group that had not used the fluoride mouthrinse. Children carrying both S. mutans and S. sobrinus had a higher caries incidence in 1 year than the others, with odds ratios of 5.73 ( p = 0.067) in the group with a fluoride mouthrinse and 3.47 (p = 0.035) in the group without it. These results show that the long-term use of a fluoride mouthrinse is associated with reduced salivary levels of mutans streptococci and this bacterial reduction may partly contribute to the suppression of dental caries in children using a long-term fluoride mouthrinse. Copyright (c) 2006 S. Karger AG, Basel

DOI： 10.1159/000095649

Influence of a fluoride mouthrinse on mutans streptococci in schoolchildren Reviewed

Noboru Kaneko, Akihiro Yoshihara, Hirohisa Ida, Yoshiaki Nomura, Susumu Imai, Toshiki Nisizawa, Shihoko Sakuma, Nobuhiro Hanada, Hideo Miyazaki

CARIES RESEARCH 40 ( 6 ) 501 - 507 2006

Language：English Publishing type：Research paper (scientific journal) Publisher：KARGER

DOI： 10.1159/000095649

National Survey on the School-based Fluoride Mouthrinsing Program in Japan : Proposition Regarding Intermediate Assessment of Healthy Japan 21 in 2005 Reviewed

義歯の装着と咬合力および噛める食品との関係 Reviewed

岩舩素子, 五十嵐直子, 河野正司, 清田義和, 葭原明弘, 宮秀夫

新潟歯学会誌 34 ( 2 ) 213 - 218 2005.12

The relationship between dietary intake and the number of teeth in elderly Japanese subjects Reviewed

Akihiro Yoshihara, Reiko Watanabe, Mamoru Nishimuta, Nobuhiro Hanada, Hideo Miyazaki

Gerodontology 22 211 - 218 2005.12

KIMOTO Kazunari, HARESAKU Satoru, TAURA Katsuhiko, SHIMURA Masayo, FUJINO Etsuo, YAMAMOTO Takeo, YOSHIHARA Akihiro, ISOZAKI Atsunori, ARAKAWA Hirohisa, KOBAYASHI Seigo, SAKAI Osamu

JOURNAL OF DENTAL HEALTH 55 ( 3 ) 199 - 203 2005.12

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Society for Oral Health

The purpose of this investigation is to clarify the spread of the school-based fluoride mouthrinsing program over the past twenty years throughout Japan. Data were collected by questionnaire surveys regarding the schools and children participating in the program, frequency of rinsing, mouthrinsing agent used, fluoride concentration of the rinsing solution and financial support for the program. Questionnaires were sent to the key persons and dentists of the non-profit Japanese Conference on the Promotion of the Use of Fluoride in Caries Prevention (NPO-JPUF) by mail or e-mail every two years. Of the 47 prefectures in Japan, the fluoride mouthrinsing program started in a single prefecture in 1970, and spread to 32 by 1992 and to 45 by 2004. In 2004, the total numbers of schools and individuals participating in the program were 3,923 and 396,702, respectively. Although the numbers of schools and children participating in the program are increasing, they remain modest. In 2010, the numbers of schools and individuals participating in the school-based fluoride mouthrinsing program in Japan is estimated to be 8,782 and 896,916, respectively. We propose that the school-based fluoride mouthrinsing program, an important item with regarding caries prevention in Japanese children, should be included in Healthy Japan 21 at the intermediate assessment in 2005.

DOI： 10.5834/jdh.55.3_199

CiNii Article

CiNii Books

Other Link： https://search.jamas.or.jp/link/ui/2005231337

公診連携を目指した8020育成事業の評価 Reviewed

葭原明弘, 片岡照二郎, 濃野要, 峯田和彦, 高徳幸男, 河内博, 片山修, 清田義和, 石上和男, 宮秀夫

口腔衛生会誌 55 113 - 117 2005.12

The relationship between dietary intake and the number of teeth in elderly Japanese subjects.

Yoshihara A, Watanabe R, Nishimuta M, Hanada N, Miyazaki H

Gerodontology 22 ( 4 ) 211 - 8 2005.12

介護認定申請者における要介護度別歯科疾患の実態および歯科的治療ニーズに関する研究

鈴木昭, 河野正司, 野村修一, 伊藤加代子, 豊里晃, 田巻元子, 八木稔, 葭原明弘, 大内章嗣

新潟歯学会誌 35 ( 2 ) 25 - 30 2005.12

Relationship between bleeding on probing and periodontal disease progression in community-dwelling older adults Reviewed

A. Rahardjo, A. Yoshihara, N. Amarasena, H. Ogawa, K. Nakashima, H. Miyazaki

Journal of Clinical Periodontology 32 ( 11 ) 1129 - 1133 2005.11

Language：English Publishing type：Research paper (scientific journal)

Objective: The main objective of this study was to determine the relationship between bleeding on probing (BOP) and periodontal disease progression in community-dwelling older adults. Methods: A 3-year longitudinal study was carried out in 229 non-smoking healthy older adults aged 70 years. Using pressure-controlled periodontal probes, BOP, pocket depth and attachment level at 13,289 sites were measured annually. Periodontal disease progression was defined as an increase in attachment loss of ≥ 3 mm from the baseline to the final examination. The backward stepwise logistic regression analysis was performed to assess the relationship between the total number of sites with BOP in the four examinations and periodontal progression. Results: Logistic regression analysis showed that the odds ratios of BOP frequency for periodontal disease progression ranged from 1.4 to 6.2 after controlling for pocket depth ≥ 4 mm at baseline, number of missing teeth, jaw type and tooth site. Conclusion: Increasing frequencies of bleeding might increase the probability of periodontal disease progression in community-dwelling older adults. © Blackwell Munksgaard 2005.

DOI： 10.1111/j.1600-051X.2005.00834.x

The relationship between bone mineral density and the number of remaining teeth in community-dwelling older adults Reviewed

A. Yoshihara, Y. Seida, N. Hanada, K. Nakashima, H. Miyazaki

Journal of Oral Rehabilitation 32 ( 10 ) 735 - 740 2005.10

Language：English Publishing type：Research paper (scientific journal)

Tooth loss and osteoporosis may share common aetiologic agents which influence the process of both diseases. The purpose of this study was to evaluate the relationship between bone mineral density (BMD) of the os calcis and the number of remaining teeth, controlling the known confounding factors. Among all 70-year-old inhabitants in Niigata City, Japan, 600 people were selected randomly in order to have approximately the same number of each gender. We analysed 460 subjects. We evaluated the BMD of the os calcis using an ultrasound bone densitometer, then we counted the number of remaining teeth excluding the third molars. Stiffness is a clinical index which is calculated by the spread speed of supersonic waves. To monitor the general health condition of the subjects, serum levels of disease markers and smoking habits were also investigated. The mean number of remaining teeth for the osteopenia group (OG) and the no-osteopenia group (NOG) was 15.97 ± 9.98 and 18.31 ± 8.06, respectively in females, and 16.32 ± 9.93 and 18.12 ± 9.33, respectively in males (OG versus NOG, P = 0.047 by two-way ANOVA). In addition, stiffness was significantly associated with the number of remaining teeth (CV = -0.157, P = 0.005) using linear multiple regression analysis adjusted by four other variables. In this study, there was a significant relationship between the number of remaining teeth and BMD of the os calcis. © 2005 Blackwell Publishing Ltd.

DOI： 10.1111/j.1365-2842.2005.01491.x

Periodontal conditions in an elderly Japanese population influenced by smoking status and serum immunoglobulin G2 levels

K Nakashima, T Kobayashi, A Yoshihara, J Fujiwara, H Miyazaki, Y Kowashi

JOURNAL OF PERIODONTOLOGY 76 ( 4 ) 582 - 589 2005.4

Language：English Publishing type：Research paper (scientific journal) Publisher：AMER ACAD PERIODONTOLOGY

Background: A Japanese population residing in the same area may be suitable for evaluation of the association among IgG subclass levels, smoking status, and periodontal disease due to similar racial and environmental factors, as these factors can interact to influence serum IgG subclass levels. The present cross-sectional investigation attempted to examine the influence of serum IgG subclass levels and smoking status on periodontal condition in a population of elderly Japanese subjects.
Methods: Elderly individuals (N = 451, age, 71 years) residing in Niigata City, Japan participated in the present study. Clinical evaluations, which consisted of probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), and calculus, and serological determinations including serum IgG subclass levels and anti - Porphyromonas gingivalis fimbriae IgG subclass titers were conducted. All participants were asked to complete questionnaires regarding smoking status and were then divided into one of three groups: never smoker, former smoker, or current smoker.
Results: Distributions of the number of teeth did not differ significantly across the groups. The proportion of sites with CAL &GE; 4 mm (%CAL4) in current smokers was significantly higher in comparison with never smokers. Multiple linear regression analysis revealed that %CAL4 was influenced by number of teeth, serum IgG2 levels, gender, and smoking status (R-2 = 0.253, P &LT; 0.001). The effect of IgG2 was greater than that of smoking status. Distribution of IgG2 was not significantly different across the three groups.
Conclusion: These data indicate that serum IgG2 levels influences periodontal conditions in an elderly Japanese population independent of smoking status.

DOI： 10.1902/jop.2005.76.4.582

Periodontal conditions in an elderly Japanese population influenced by smoking status and serum immunoglobulin G2 levels Reviewed

Keisuke Nakashima, Takao Kobayashi, Akihiro Yoshihara, Jun Fujiwara, Hideo Miyazaki, Yusuke Kowashi

Journal of Periodontology 76 ( 4 ) 582 - 589 2005.4

Language：English Publishing type：Research paper (scientific journal)

Background: A Japanese population residing in the same area may be suitable for evaluation of the association among IgG subclass levels, smoking status, and periodontal disease due to similar racial and environmental factors, as these factors can interact to influence serum IgG subclass levels. The present cross-sectional investigation attempted to examine the influence of serum IgG subclass levels and smoking status on periodontal condition in a population of elderly Japanese subjects. Methods: Elderly individuals (N = 451, age, 71 years) residing in Niigata City, Japan participated in the present study. Clinical evaluations, which consisted of probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), and calculus, and serological determinations including serum IgG subclass levels and anti-Porphyromonas gingivalis fimbriae IgG subclass titers were conducted. All participants were asked to complete questionnaires regarding smoking status and were then divided into one of three groups: never smoker, former smoker, or current smoker. Results: Distributions of the number of teeth did not differ significantly across the groups. The proportion of sites with CAL ≥4 mm (%CAL4) in current smokers was significantly higher in comparison with never smokers. Multiple linear regression analysis revealed that %CAL4 was influenced by number of teeth, serum IgG2 levels, gender, and smoking status (R2 = 0.253, P &lt
0.001). The effect of IgG2 was greater than that of smoking status. Distribution of IgG2 was not significantly different across the three groups. Conclusion: These data indicate that serum IgG2 levels influences periodontal conditions in an elderly Japanese population independent of smoking status.

DOI： 10.1902/jop.2005.76.4.582

FcγRIIIb genotypes and smoking in periodontal disease progression among community-dwelling older adults in Japan Reviewed

Akihiro Yoshihara, Noriko Sugita, Kouji Yamamoto, Tetsuo Kobayashi, Toshinobu Hirotomi, Hiroshi Ogawa, Hideo Miyazaki, Hiromasa Yoshie

Journal of Periodontology 76 ( 2 ) 250 - 255 2005.2

Language：English Publishing type：Research paper (scientific journal)

Background: FcγRIIIb genotypes and smoking are risk factors for periodontal disease. However, the interaction of FcγRIIIb-NA1-NA2 polymorphism with smoking remains unclear. The purpose of this study was to determine if FcγRIIIb-NA1-NA2 polymorphism and smoking are associated with periodontal disease progression among elderly people. Methods: Among 70-year-old subjects, 164 with neither diabetes mellitus nor blood sugar ≥140 mg/dl, who had more than 20 teeth and who could participate in both the baseline and the follow-up examinations were included in the study. The NA1 group comprised subjects with FcγIIIb-NA1NA1 genotype (N = 53), while the NA2 group included subjects with FcγRIIIb-NA1NA2 or NA2NA2 genotype (N = 111). We examined the progression of periodontitis by measuring attachment loss during 3 years. Results: The frequency of subjects who showed ≥4 mm additional attachment loss at one or more sites was 55.6% for smokers and 37.2% for non-smokers. The odds ratio (OR) was 2.13 (confidence interval [CI]: 0.92 to 4.76). We found a better association between periodontal progression and smoking in the NA2 group. The OR for smokers was 3.03 (CI:1.12 to 8.33, P = 0.028). Additionally, the mean number of sites with ≥4 mm additional attachment loss per person between smokers and non-smokers in the NA2 group or between smokers and non-smokers in the NA1 group was 2.90 ± 3.42 and 0.74 ± 1.53 or 0.57 ± 0.79 and 0.68 ± 1.03, respectively (P &lt
0.001
analysis of variance [ANOVA]). Conclusion: Our results may suggest an association between smoking and periodontal disease progression in elderly people with FcγRIIIb-NA2 polymorphism.

DOI： 10.1902/jop.2005.76.2.250