Papers - YOSHIHARA Akihiro

Association of Hyper-Low-Density Lipoprotein and Hypo-High-Density Lipoprotein Cholesterolemia with Low Saliva Flow Rates in Japanese Community-Dwelling Elders Reviewed

Nana Mizoguchi, Kaname Nohno, Akihiro Yoshihara, Kayoko Ito, Saori Funayama, Hiroshi Ogawa

International Archives of Otorhinolaryngology   2022.7

　More details

Publishing type：Research paper (scientific journal)   Publisher：Georg Thieme Verlag KG  

Abstract

Introduction The associations of low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein (HDL-C) with reduced saliva flow rates have not been previously reported.

Objective The present study aimed to assess the association of cholesterolemia with reduced saliva flow rates in community-dwelling elderly subjects.

Methods The present study analyzed 342 participants (170 males and 172 females aged between 78 and 79 years old). Unstimulated salivary flow rate (USFR) was assessed using a cotton roll method. Low-USFR was defined as 0.10 g/30 seconds. Stimulated salivary flow rate (SSFR) was assessed by having the participants chew tasteless gum for 3 minutes. Low-SSFR was defined as 1.0 mL/minute. Blood samples were collected for the measurement of LDL-C, HDL-C, rheumatoid factor, hemoglobin A1c, and creatinine. To assess depression, the General Health Questionnaire 30 was used. A standardized questionnaire was completed, covering the current and previous medications of the participants and smoking status. We stratified the serum LDL-C levels of the participants as normal, moderate or severe hyper-LDL cholesterolemia and serum HDL-C levels as normal or hypo-HDL cholesterolemia. Multivariate logistic regression models were established and low-USFR or low-SSFR were set as dependent variables in the aforementioned models.

Results After controlling for the effects of the other variables, the odds ratios (ORs) (95% confidence intervals [CIs]) for low-USFR were 2.25 (1.10–4.61) for moderate and 5.69 (1.55–20.8) for severe hyper-LDL cholesterolemia, while that of hypo-HDL cholesterolemia was 3.40 (1.33–8.69). Severe hyper-LDL cholesterolemia was also associated with low-SSFR with an OR of 3.89 (1.39–10.88).

Conclusion Elderly patients with cholesterolemia have a risk of reduced salivary flow rate.

DOI： 10.1055/s-0042-1744167

researchmap

根面う蝕管理のためのフッ化物応用について フッ化ジアンミン銀、フッ化物バニッシュを中心に

宮本 茜, 葭原 明弘

口腔衛生学会雑誌   72 ( 3 )   152 - 157   2022.7

　More details

Language：Japanese   Publisher：(一社)日本口腔衛生学会  

根面う蝕は,加齢による歯槽骨の退縮や歯周疾患,不適切なブラッシング,唾液分泌量の減少などで発症および進行リスクが高まる.また,高齢者の現在歯数増加,歯周疾患罹患率の増加によって,今後も増加が予想される.根面う蝕は,視診,触診により活動性と非活動性に分類でき,活動性う蝕はフッ化物の応用など非侵襲的な処置で非活動性う蝕へのコントロールが可能である.フッ化ジアンミン銀(SDF:Silver Diamine Fluoride)は55,000ppmという高濃度のフッ化物を含有するう蝕予防・進行抑制剤である.塗布は年1～2回で,費用対効果が高い.SDFの欠点であるう蝕病変の黒変軽減のため,ヨウ化カリウム(KI)の併用について研究が進んでいる.また,フッ化物バニッシュは22,600ppmNaFを4～6時間停滞させ,う蝕予防効果を発揮する塗布材料である.う蝕予防や進行抑制に関して十分なエビデンスがあることから,欧米諸国では小児から高齢者に至るまで,積極的に応用されている.国内では,象牙質知覚過敏鈍麻剤として認可されているが,有効性を示す調査が複数存在することから今後根面う蝕予防や根面う蝕進行抑制へと使用用途が広がっていくことを期待する.SDF,フッ化物バニッシュは操作が簡便で,介護が必要な高齢者や,訪問診療での利用にも適している.多くの年代に渡り,セルフケアに加え.プロフェッショナルケアを充実させることで.今後必要性が増加することが予想される根面う蝕管理に対応する必要があると考える.(著者抄録)

researchmap

Other Link： https://search.jamas.or.jp/default/link?pub_year=2022&ichushi_jid=J00440&link_issn=&doc_id=20220815170001&doc_link_id=%2Fdk1dehea%2F2022%2F007203%2F001%2F0152-0157%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdk1dehea%2F2022%2F007203%2F001%2F0152-0157%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Interaction between serum vitamin C levels and smoking on the periodontal condition in older adults. Reviewed International journal

Akihiro Yoshihara, Keisuke Nakashima, Kana Suwama, Ayuko Odajima, Takayuki Yamaga, Hiroshi Ogawa

Journal of periodontal research   2022.4

　More details

Language：English   Publishing type：Research paper (scientific journal)  

BACKGROUND AND OBJECTIVES: Several epidemiological studies have reported that smokers have a higher prevalence and severity of periodontal disease than do nonsmokers, and that smoking negatively affects nutritional status and is associated with a reduced intake of antioxidants, particularly vitamin C. The present investigation aimed to examine the relationship between serum vitamin C levels and smoking and its influence on the periodontal condition in older adults. MATERIALS AND METHODS: A total of 353 respondents met the inclusion criteria and were enrolled in the present study. The periodontal status of the study participants was determined through examinations of one or more residual teeth, which included a measurement of the probing pocket depth (PPD) and clinical attachment level (CAL) at six regions of each tooth. Blood samples were collected during the dental examinations and then sent to a laboratory to evaluate serum vitamin C and cotinine levels. A serum cotinine concentration of 100 ng/ml was considered a relevant threshold for active smoking. After dividing the participants into two groups according to serum cotinine levels, Poisson regression analysis was carried out to compare vitamin C levels with the prevalence rate ratio (PRR) for periodontal condition markers for each group based on serum cotinine levels. RESULTS: We evaluated differences in the PRR of serum vitamin C tertiles between participants with high (≥100 ng/ml) or low (<100 ng/ml) serum cotinine levels after adjusting for sex, the use of interdental brushes or dental floss, and the number of teeth. A negative tendency between the PRR of vitamin C tertiles for the PPD or CAL was seen for both groups. Especially, a bigger difference was observed in the group with high serum cotinine levels. The PRR of the first tertiles in the high serum cotinine group was 5.03, compared with 2.69 in the low serum cotinine group (relative risk: 1.9). CONCLUSION: The results of this study suggest a potential association between vitamin C levels and the periodontal condition, which may be influenced by smoking status.

DOI： 10.1111/jre.12988

PubMed

researchmap

小学生における口唇閉鎖力の年齢による変化と関連要因についての研究 Reviewed

諏訪間 加奈, 野上 有紀子, 葭原 明弘

口腔衛生学会雑誌   72 ( 2 )   92 - 99   2022.4

　More details

Language：Japanese   Publisher：(一社)日本口腔衛生学会  

本研究の目的は小学生における口唇閉鎖力の年齢による変化を示すともに,口唇閉鎖力に影響を与える要因を明らかにすることである.新潟県内Y小学校に通う1年生から6年生の328名(男児167名,女児161名)についてアンケート調査(同意率80.8%)および口唇閉鎖力の測定を実施した.小学生における口唇閉鎖力の年齢による変化を示すために,年齢による口唇閉鎖力の推移を比較した.さらに,9歳未満と9歳以上の2群に分け,各群における口唇閉鎖力4分位群による対象者の特性について比較し,関連する要因についても検討を加えた.その結果,本研究の対象者における口唇閉鎖力は増齢とともに緩やかな増加がみられた.口唇閉鎖力4分位と対象者の特性との関連について,9歳未満では現在歯数,いびきの有無との関連がみられた(オッズ比[95%信頼区間]=1.28[1.01-1.56],0.45[0.24-0.84]).9歳以上の群では,年齢,ローレル指数との関連がみられた(1.45[1.09-1.93],6.02[2.21-16.39]).結論として,小学生における口唇閉鎖力について9歳前後で口唇閉鎖力に影響する要因が異なることが考えられた.口唇閉鎖力の増加に影響する要因として,9歳未満の対象者では現在歯数が,また,9歳以上の対象者では,年齢,肥満との関連がみられた.口唇閉鎖力が低値であることに影響する要因として,9歳未満でいびきと関連していた.(著者抄録)

researchmap

Other Link： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2022&ichushi_jid=J00440&link_issn=&doc_id=20220511210002&doc_link_id=10.5834%2Fjdh.72.2_92&url=https%3A%2F%2Fdoi.org%2F10.5834%2Fjdh.72.2_92&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

地域在住高齢者を対象とした口腔機能訓練が与える頸部可動域の改善効果 Reviewed

小田島 あゆ子, 葭原 明弘, 石上 和男

口腔衛生学会雑誌   72 ( 1 )   11 - 17   2022.1

　More details

Language：Japanese   Publisher：(一社)日本口腔衛生学会  

地域在住高齢者の頸部可動域に対する口腔機能訓練の効果を明らかにすることを目的とした.65歳以上の高齢者を対象に年齢,性別,BMI,ロコモ度テスト,現在歯数,義歯の使用および頸部可動域を調査した.自治会の地域によって運動器機能訓練および口腔機能訓練を実施する複合プログラム群(30名),運動器機能訓練を実施する単一プログラム群(35名)の2群に分けて3ヵ月間訓練を行った後,同一項目の調査を行った.頸部可動域の訓練前後比較はWilcoxonの順位和検定を,変化量の2群間比較はMann-WhitneyのU検定を行った.また,頸部可動域の改善を従属変数として,性別,年齢および口腔機能訓練の介入の有無を独立変数としてロジスティック回帰分析を行った.複合プログラム群ではすべての運動方向において頸部可動域が改善した(p<0.05).前屈を除く運動方向において,単一プログラム群と比べて頸部可動域の変化量が高く(p<0.05),頸部可動域の改善が口腔機能訓練の介入と有意な関連がみられた(オッズ比=7.23～18.52).高齢者における口腔機能訓練は頸部可動域の改善に影響を与えることが明らかとなった.(著者抄録)

researchmap

Other Link： https://search.jamas.or.jp/default/link?pub_year=2022&ichushi_jid=J00440&link_issn=&doc_id=20220210120003&doc_link_id=%2Fdk1dehea%2F2022%2F007201%2F001%2F0011-0017%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdk1dehea%2F2022%2F007201%2F001%2F0011-0017%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Effects of Oral Function Training and Oral Health Status on Physical Performance in Potentially Dependent Older Adults Reviewed

Masataka Sasajima, Akihiro Yoshihara, Ayuko Odajima

International Journal of Environmental Research and Public Health   18 ( 21 )   11348 - 11348   2021.10

　More details

Publishing type：Research paper (scientific journal)   Publisher：MDPI AG  

This study aimed to evaluate the effects of an oral function training program and indicators of oral health status on improvements in physical performance induced by physical function training in dependent older adults. The participants were 131 potentially dependent older adults (age: ≥65 years) who were randomly divided into two groups: an oral intervention and a control group. All participants underwent physical function training, but only the intervention group took part in the oral function training program. In total, 106 participants completed all of the survey components (60 and 46 participants from the intervention and control groups, respectively). The measures of physical fitness examined included the one-leg standing time with eyes open (OLST) and the timed up and go test (TUG). Logistic regression analyses were carried out to determine the effects of the oral function intervention and health status on physical fitness. The results revealed that the oral function intervention significantly improved OLST and TUG times. These findings suggest that evaluations of oral health status and interventions aimed at activating oral functions are associated with improvements in physical fitness among potentially dependent older adults.

DOI： 10.3390/ijerph182111348

researchmap

Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants Reviewed

Bin Zhou, Rodrigo M Carrillo-Larco, Goodarz Danaei, Leanne M Riley, Christopher J Paciorek, Gretchen A Stevens, Edward W Gregg, James E Bennett, Bethlehem Solomon, Rosie K Singleton, Marisa K Sophiea, Maria LC Iurilli, Victor PF Lhoste, Melanie J Cowan, Stefan Savin, Mark Woodward, Yulia Balanova, Renata Cifkova, Albertino Damasceno, Paul Elliott, Farshad Farzadfar, Jiang He, Nayu Ikeda, Andre P Kengne, Young-Ho Khang, Hyeon Chang Kim, Avula Laxmaiah, Hsien-Ho Lin, Paula Margozzini Maira, J Jaime Miranda, Hannelore Neuhauser, Johan Sundström, Cherian Varghese, Indah S Widyahening, Tomasz Zdrojewski, Leandra Abarca-Gómez, Ziad A Abdeen, Hanan F Abdul Rahim, Niveen M Abu-Rmeileh, Benjamin Acosta-Cazares, Robert J Adams, Wichai Aekplakorn, Kaosar Afsana, Shoaib Afzal, Imelda A Agdeppa, Javad Aghazadeh-Attari, Carlos A Aguilar-Salinas, Charles Agyemang, Noor Ani Ahmad, Ali Ahmadi, Naser Ahmadi, Nastaran Ahmadi, Fariba Ahmadizar, Soheir H Ahmed, Wolfgang Ahrens, Kamel Ajlouni, Rajaa Al-Raddadi, Monira Alarouj, Fadia AlBuhairan, Shahla AlDhukair, Mohamed M Ali, Abdullah Alkandari, Ala'a Alkerwi, Kristine Allin, Eman Aly, Deepak N Amarapurkar, Norbert Amougou, Philippe Amouyel, Lars Bo Andersen, Sigmund A Anderssen, Ranjit Mohan Anjana, Alireza Ansari-Moghaddam, Daniel Ansong, Hajer Aounallah-Skhiri, Joana Araújo, Inger Ariansen, Tahir Aris, Raphael E Arku, Nimmathota Arlappa, Krishna K Aryal, Thor Aspelund, Felix K Assah, Maria Cecília F Assunção, Juha Auvinen, Mária Avdićová, Ana Azevedo, Mohsen Azimi-Nezhad, Fereidoun Azizi, Mehrdad Azmin, Bontha V Babu, Suhad Bahijri, Nagalla Balakrishna, Mohamed Bamoshmoosh, Maciej Banach, Maja Banadinović, Piotr Bandosz, José R Banegas, Joanna Baran, Carlo M Barbagallo, Alberto Barceló, Amina Barkat, Marta Barreto, Aluisio JD Barros, Mauro Virgílio Gomes Barros, Anna Bartosiewicz, Abdul Basit, Joao Luiz D Bastos, Iqbal Bata, Anwar M Batieha, Assembekov Batyrbek, Louise A Baur, Robert Beaglehole, Antonisamy Belavendra, Habiba Ben Romdhane, Mikhail Benet, Lowell S Benson, Salim Berkinbayev, Antonio Bernabe-Ortiz, Gailute Bernotiene, Heloísa Bettiol, Jorge Bezerra, Aroor Bhagyalaxmi, Santosh K Bhargava, Daniel Bia, Katia Biasch, Elysée Claude Bika Lele, Mukharram M Bikbov, Bihungum Bista, Peter Bjerregaard, Espen Bjertness, Marius B Bjertness, Cecilia Björkelund, Katia V Bloch, Anneke Blokstra, Simona Bo, Martin Bobak, Heiner Boeing, Jose G Boggia, Carlos P Boissonnet, Stig E Bojesen, Vanina Bongard, Alice Bonilla-Vargas, Matthias Bopp, Herman Borghs, Pascal Bovet, Christopher B Boyer, Lutgart Braeckman, Imperia Brajkovich, Francesco Branca, Juergen Breckenkamp, Hermann Brenner, Lizzy M Brewster, Yajaira Briceño, Miguel Brito, Graziella Bruno, H Bas Bueno-de-Mesquita, Gloria Bueno, Anna Bugge, Con Burns, Michael Bursztyn, Antonio Cabrera de León, Joseph Cacciottolo, Christine Cameron, Günay Can, Ana Paula C Cândido, Mario V Capanzana, Naděžda Čapková, Eduardo Capuano, Vincenzo Capuano, Viviane C Cardoso, Axel C Carlsson, Joana Carvalho, Felipe F Casanueva, Laura Censi, Marvin Cervantes-Loaiza, Charalambos A Chadjigeorgiou, Snehalatha Chamukuttan, Angelique W Chan, Queenie Chan, Himanshu K Chaturvedi, Nish Chaturvedi, Miao Li Chee, Chien-Jen Chen, Fangfang Chen, Huashuai Chen, Shuohua Chen, Zhengming Chen, Ching-Yu Cheng, Bahman Cheraghian, Imane Cherkaoui Dekkaki, Angela Chetrit, Kuo-Liong Chien, Arnaud Chiolero, Shu-Ti Chiou, Adela Chirita-Emandi, María-Dolores Chirlaque, Belong Cho, Kaare Christensen, Diego G Christofaro, Jerzy Chudek, Eliza Cinteza, Frank Claessens, Janine Clarke, Els Clays, Emmanuel Cohen, Hans Concin, Cyrus Cooper, Tara C Coppinger, Simona Costanzo, Dominique Cottel, Chris Cowell, Cora L Craig, Amelia C Crampin, Ana B Crujeiras, Juan J Cruz, Semánová Csilla, Liufu Cui, Felipe V Cureau, Sarah Cuschieri, Graziella D'Arrigo, Eleonora d'Orsi, Jean Dallongeville, Rachel Dankner, Thomas M Dantoft, Luc Dauchet, Kairat Davletov, Guy De Backer, Dirk De Bacquer, Amalia De Curtis, Giovanni de Gaetano, Stefaan De Henauw, Paula Duarte de Oliveira, David De Ridder, Delphine De Smedt, Mohan Deepa, Alexander D Deev, Vincent Jr DeGennaro, Hélène Delisle, Stefaan Demarest, Elaine Dennison, Valérie Deschamps, Meghnath Dhimal, Augusto F Di Castelnuovo, Juvenal Soares Dias-da-Costa, Alejandro Diaz, Ty T Dickerson, Zivka Dika, Shirin Djalalinia, Ha TP Do, Annette J Dobson, Chiara Donfrancesco, Silvana P Donoso, Angela Döring, Maria Dorobantu, Marcus Dörr, Kouamelan Doua, Nico Dragano, Wojciech Drygas, Charmaine A Duante, Priscilla Duboz, Rosemary B Duda, Virginija Dulskiene, Anar Dushpanova, Aleksandar Džakula, Vilnis Dzerve, Elzbieta Dziankowska-Zaborszczyk, Ricky Eddie, Ebrahim Eftekhar, Robert Eggertsen, Sareh Eghtesad, Gabriele Eiben, Ulf Ekelund, Mohammad El-Khateeb, Jalila El Ati, Denise Eldemire-Shearer, Marie Eliasen, Roberto Elosua, Rajiv T Erasmus, Raimund Erbel, Cihangir Erem, Louise Eriksen, Johan G Eriksson, Jorge Escobedo-de la Peña, Saeid Eslami, Ali Esmaeili, Alun Evans, David Faeh, Albina A Fakhretdinova, Caroline H Fall, Elnaz Faramarzi, Mojtaba Farjam, Mohammad Reza Fattahi, Asher Fawwad, Francisco J Felix-Redondo, Stephan B Felix, Trevor S Ferguson, Romulo A Fernandes, Daniel Fernández-Bergés, Daniel Ferrante, Thomas Ferrao, Marika Ferrari, Marco M Ferrario, Catterina Ferreccio, Haroldo S Ferreira, Eldridge Ferrer, Jean Ferrieres, Thamara Hubler Figueiró, Günther Fink, Krista Fischer, Leng Huat Foo, Maria Forsner, Heba M Fouad, Damian K Francis, Maria do Carmo Franco, Ruth Frikke-Schmidt, Guillermo Frontera, Flavio D Fuchs, Sandra C Fuchs, Yuki Fujita, Matsuda Fumihiko, Viktoriya Furdela, Ariel Furer, Takuro Furusawa, Zbigniew Gaciong, Andrzej Galbarczyk, Henrike Galenkamp, Fabio Galvano, Jingli Gao, Pei Gao, Manoli Garcia-de-la-Hera, Pablo Garcia, Dickman Gareta, Sarah P Garnett, Jean-Michel Gaspoz, Magda Gasull, Andrea Gazzinelli, Ulrike Gehring, Johanna M Geleijnse, Ronnie George, Ali Ghanbari, Erfan Ghasemi, Oana-Florentina Gheorghe-Fronea, Anup Ghimire, Alessandro Gialluisi, Simona Giampaoli, Christian Gieger, Tiffany K Gill, Jonathan Giovannelli, Glen Gironella, Aleksander Giwercman, Konstantinos Gkiouras, Marcel Goldberg, Rebecca A Goldsmith, Luis F Gomez, Aleksandra Gomula, Helen Gonçalves, Mauer Gonçalves, Bruna Gonçalves Cordeiro da Silva, David A Gonzalez-Chica, Marcela Gonzalez-Gross, Juan P González-Rivas, Clicerio González-Villalpando, María-Elena González-Villalpando, Angel R Gonzalez, Mariano Bonet Gorbea, Frederic Gottrand, Sidsel Graff-Iversen, Dušan Grafnetter, Aneta Grajda, Maria G Grammatikopoulou, Ronald D Gregor, Tomasz Grodzicki, Giuseppe Grosso, Gabriella Gruden, Dongfeng Gu, Ong Peng Guan, Elias F Gudmundsson, Vilmundur Gudnason, Ramiro Guerrero, Idris Guessous, Andre L Guimaraes, Martin C Gulliford, Johanna Gunnlaugsdottir, Marc J Gunter, Prakash C Gupta, Rajeev Gupta, Oye Gureje, Beata Gurzkowska, Laura Gutierrez, Felix Gutzwiller, Seongjun Ha, Farzad Hadaegh, Rosa Haghshenas, Hamid Hakimi, Jytte Halkjær, Ian R Hambleton, Behrooz Hamzeh, Dominique Hange, Abu AM Hanif, Sari Hantunen, Jie Hao, Carla Menêses Hardman, Rachakulla Hari Kumar, Seyed Mohammad Hashemi-Shahri, Jun Hata, Teresa Haugsgjerd, Alison J Hayes, Yuna He, Margit Heier, Marleen Elisabeth Hendriks, Rafael dos Santos Henrique, Ana Henriques, Leticia Hernandez Cadena, Herqutanto, Sauli Herrala, Ramin Heshmat, Allan G Hill, Sai Yin Ho, Suzanne C Ho, Michael Hobbs, Michelle Holdsworth, Reza Homayounfar, Gonul Horasan Dinc, Andrea RVR Horimoto, Claudia M Hormiga, Bernardo L Horta, Leila Houti, Christina Howitt, Thein Thein Htay, Aung Soe Htet, Maung Maung Than Htike, Yonghua Hu, José María Huerta, Ilpo Tapani Huhtaniemi, Laetitia Huiart, Martijn Huisman, Abdullatif S Husseini, Inge Huybrechts, Nahla Hwalla, Licia Iacoviello, Anna G Iannone, Mohsen M Ibrahim, Norazizah Ibrahim Wong, M Arfan Ikram, Violeta Iotova, Vilma E Irazola, Takafumi Ishida, Godsent C Isiguzo, Muhammad Islam, Sheikh Mohammed Shariful Islam, Masanori Iwasaki, Rod T Jackson, Jeremy M Jacobs, Hashem Y Jaddou, Tazeen Jafar, Kenneth James, Konrad Jamrozik, Imre Janszky, Edward Janus, Marjo-Riitta Jarvelin, Grazyna Jasienska, Ana Jelaković, Bojan Jelaković, Garry Jennings, Anjani Kumar Jha, Chao Qiang Jiang, Ramon O Jimenez, Karl-Heinz Jöckel, Michel Joffres, Mattias Johansson, Jari J Jokelainen, Jost B Jonas, Torben Jørgensen, Pradeep Joshi, Farahnaz Joukar, Jacek Jóżwiak, Anne Juolevi, Gregor Jurak, Vesna Jureša, Rudolf Kaaks, Anthony Kafatos, Eero O Kajantie, Zhanna Kalmatayeva, Natasa Kalpourtzi, Ofra Kalter-Leibovici, Freja B Kampmann, Srinivasan Kannan, Eva Karaglani, Line L Kårhus, Khem B Karki, Marzieh Katibeh, Joanne Katz, Jussi Kauhanen, Prabhdeep Kaur, Maryam Kavousi, Gyulli M Kazakbaeva, Ulrich Keil, Lital Keinan Boker, Sirkka Keinänen-Kiukaanniemi, Roya Kelishadi, Han CG Kemper, Maryam Keramati, Alina Kerimkulova, Mathilde Kersting, Timothy Key, Yousef Saleh Khader, Davood Khalili, Kay-Tee Khaw, Bahareh Kheiri, Motahareh Kheradmand, Alireza Khosravi, Ursula Kiechl-Kohlendorfer, Stefan Kiechl, Japhet Killewo, Dong Wook Kim, Jeongseon Kim, Heidi Klakk, Magdalena Klimek, Jurate Klumbiene, Michael Knoflach, Elin Kolle, Patrick Kolsteren, Jukka P Kontto, Raija Korpelainen, Paul Korrovits, Jelena Kos, Seppo Koskinen, Katsuyasu Kouda, Sudhir Kowlessur, Slawomir Koziel, Jana Kratenova, Vilma Kriaucioniene, Peter Lund Kristensen, Steiner Krokstad, Daan Kromhout, Herculina S Kruger, Ruzena Kubinova, Renata Kuciene, Urho M Kujala, Zbigniew Kulaga, R Krishna Kumar, Pawel Kurjata, Yadlapalli S Kusuma, Vladimir Kutsenko, Kari Kuulasmaa, Catherine Kyobutungi, Tiina Laatikainen, Carl Lachat, Youcef Laid, Tai Hing Lam, Orlando Landrove, Vera Lanska, Georg Lappas, Bagher Larijani, Tint Swe Latt, Gwenaëlle Le Coroller, Khanh Le Nguyen Bao, Tuyen D Le, Jeannette Lee, Jeonghee Lee, Nils Lehmann, Terho Lehtimäki, Daniel Lemogoum, Naomi S Levitt, Yanping Li, Christa L Lilly, Wei-Yen Lim, M Fernanda Lima-Costa, Xu Lin, Yi-Ting Lin, Lars Lind, Vijaya Lingam, Allan Linneberg, Lauren Lissner, Mieczyslaw Litwin, Wei-Cheng Lo, Helle-Mai Loit, Esther Lopez-Garcia, Tania Lopez, Paulo A Lotufo, José Eugenio Lozano, Iva Lukačević Lovrenčić, Janice L Lukrafka, Dalia Luksiene, Annamari Lundqvist, Robert Lundqvist, Nuno Lunet, Michala Lustigová, Edyta Luszczki, Guansheng Ma, Jun Ma, George LL Machado-Coelho, Aristides M Machado-Rodrigues, Enguerran Macia, Luisa M Macieira, Ahmed A Madar, Stefania Maggi, Dianna J Magliano, Emmanuella Magriplis, Gowri Mahasampath, Bernard Maire, Marjeta Majer, Marcia Makdisse, Fatemeh Malekzadeh, Reza Malekzadeh, Rahul Malhotra, Kodavanti Mallikharjuna Rao, Sofia K Malyutina, Lynell V Maniego, Yannis Manios, Jim I Mann, Fariborz Mansour-Ghanaei, Enzo Manzato, Anie Marcil, Staffan B Mårild, Mihalea Marinović Glavić, Pedro Marques-Vidal, Larissa Pruner Marques, Jaume Marrugat, Reynaldo Martorell, Luis P Mascarenhas, Marija Matasin, Ellisiv B Mathiesen, Prashant Mathur, Alicia Matijasevich, Piotr Matlosz, Tandi E Matsha, Christina Mavrogianni, Jean Claude N Mbanya, Anselmo J Mc Donald Posso, Shelly R McFarlane, Stephen T McGarvey, Stela McLachlan, Rachael M McLean, Scott B McLean, Breige A McNulty, Sounnia Mediene Benchekor, Jurate Medzioniene, Parinaz Mehdipour, Kirsten Mehlig, Amir Houshang Mehrparvar, Aline Meirhaeghe, Christa Meisinger, Carlos Mendoza Montano, Ana Maria B Menezes, Geetha R Menon, Alibek Mereke, Indrapal I Meshram, Andres Metspalu, Haakon E Meyer, Jie Mi, Nathalie Michels, Kairit Mikkel, Karolina Milkowska, Jody C Miller, Cláudia S Minderico, GK Mini, Mohammad Reza Mirjalili, Erkin Mirrakhimov, Marjeta Mišigoj-Duraković, Pietro A Modesti, Sahar Saeedi Moghaddam, Bahram Mohajer, Mostafa K Mohamed, Shukri F Mohamed, Kazem Mohammad, Mohammad Reza Mohammadi, Zahra Mohammadi, Noushin Mohammadifard, Reza Mohammadpourhodki, Viswanathan Mohan, Salim Mohanna, Muhammad Fadhli Mohd Yusoff, Iraj Mohebbi, Farnam Mohebi, Marie Moitry, Line T Møllehave, Dénes Molnár, Amirabbas Momenan, Charles K Mondo, Eric Monterrubio-Flores, Kotsedi Daniel K Monyeki, Jin Soo Moon, Mahmood Moosazadeh, Leila B Moreira, Alain Morejon, Luis A Moreno, Karen Morgan, George Moschonis, Malgorzata Mossakowska, Aya Mostafa, Seyed-Ali Mostafavi, Jorge Mota, Mohammad Esmaeel Motlagh, Jorge Motta, Marcos André Moura-dos-Santos, Malay K Mridha, Kelias P Msyamboza, Thet Thet Mu, Alfa J Muhihi, Maria L Muiesan, Martina Müller-Nurasyid, Neil Murphy, Jaakko Mursu, Kamarul Imran Musa, Sanja Musić Milanović, Vera Musil, Norlaila Mustafa, Iraj Nabipour, Shohreh Naderimagham, Gabriele Nagel, Balkish M Naidu, Farid Najafi, Harunobu Nakamura, Jana Námešná, Ei Ei K Nang, Vinay B Nangia, Sameer Narake, Ndeye Coumba Ndiaye, William A Neal, Azim Nejatizadeh, Ilona Nenko, Martin Neovius, Chung T Nguyen, Nguyen D Nguyen, Quang V Nguyen, Quang Ngoc Nguyen, Ramfis E Nieto-Martínez, Teemu J Niiranen, Yury P Nikitin, Toshiharu Ninomiya, Sania Nishtar, Marina A Njelekela, Marianna Noale, Oscar A Noboa, Ahmad Ali Noorbala, Teresa Norat, Maria Nordendahl, Børge G Nordestgaard, Davide Noto, Natalia Nowak-Szczepanska, Mohannad Al Nsour, Baltazar Nunes, Terence W O'Neill, Dermot O'Reilly, Caleb Ochimana, Eiji Oda, Augustine N Odili, Kyungwon Oh, Kumiko Ohara, Ryutaro Ohtsuka, Valérie Olié, Maria Teresa A Olinto, Isabel O Oliveira, Mohd Azahadi Omar, Altan Onat, Sok King Ong, Lariane M Ono, Pedro Ordunez, Rui Ornelas, Pedro J Ortiz, Clive Osmond, Sergej M Ostojic, Afshin Ostovar, Johanna A Otero, Kim Overvad, Ellis Owusu-Dabo, Fred Michel Paccaud, Cristina Padez, Elena Pahomova, Karina Mary de Paiva, Andrzej Pająk, Domenico Palli, Luigi Palmieri, Wen-Harn Pan, Songhomitra Panda-Jonas, Francesco Panza, Mariela Paoli, Dimitrios Papandreou, Soon-Woo Park, Suyeon Park, Winsome R Parnell, Mahboubeh Parsaeian, Patrick Pasquet, Nikhil D Patel, Halyna Pavlyshyn, Ivan Pećin, Mangesh S Pednekar, João M Pedro, Nasheeta Peer, Sergio Viana Peixoto, Markku Peltonen, Alexandre C Pereira, Karen GDA Peres, Marco A Peres, Annette Peters, Janina Petkeviciene, Niloofar Peykari, Son Thai Pham, Rafael N Pichardo, Iris Pigeot, Hynek Pikhart, Aida Pilav, Lorenza Pilotto, Freda Pitakaka, Aleksandra Piwonska, Andreia n Pizarro, Pedro Plans-Rubió, Ozren Polašek, Miquel Porta, Anil Poudyal, Farhad Pourfarzi, Akram Pourshams, Hossein Poustchi, Rajendra Pradeepa, Alison J Price, Jacqueline F Price, Rui Providencia, Soile E Puhakka, Maria Puiu, Margus Punab, Radwan F Qasrawi, Mostafa Qorbani, Daniel Queiroz, Tran Quoc Bao, Ivana Radić, Ricardas Radisauskas, Salar Rahimikazerooni, Mahfuzar Rahman, Olli Raitakari, Manu Raj, Ellina M Rakhimova, Sudha Ramachandra Rao, Ambady Ramachandran, Elisabete Ramos, Lekhraj Rampal, Sanjay Rampal, Daniel A Rangel Reina, Vayia Rarra, Cassiano Ricardo Rech, Josep Redon, Paul Ferdinand M Reganit, Valéria Regecová, Luis Revilla, Abbas Rezaianzadeh, Robespierre Ribeiro, Elio Riboli, Adrian Richter, Fernando Rigo, Tobias F Rinke de Wit, Raphael M Ritti-Dias, Cynthia Robitaille, Fernando Rodríguez-Artalejo, María del Cristo Rodriguez-Perez, Laura A Rodríguez-Villamizar, Ulla Roggenbuck, Rosalba Rojas-Martinez, Dora Romaguera, Elisabetta L Romeo, Annika Rosengren, Joel GR Roy, Adolfo Rubinstein, Jean-Bernard Ruidavets, Blanca Sandra Ruiz-Betancourt, Maria Ruiz-Castell, Iuliia A Rusakova, Paola Russo, Marcin Rutkowski, Charumathi Sabanayagam, Hamideh Sabbaghi, Harshpal S Sachdev, Alireza Sadjadi, Ali Reza Safarpour, Sare Safi, Saeid Safiri, Olfa Saidi, Sibel Sakarya, Nader Saki, Benoit Salanave, Eduardo Salazar Martinez, Diego Salmerón, Veikko Salomaa, Jukka T Salonen, Massimo Salvetti, Jose Sánchez-Abanto, Susana Sans, Diana A Santos, Ina S Santos, Lèlita C Santos, Maria Paula Santos, Rute Santos, Jouko L Saramies, Luis B Sardinha, Giselle Sarganas, Nizal Sarrafzadegan, Thirunavukkarasu Sathish, Kai-Uwe Saum, Savvas Savva, Norie Sawada, Mariana Sbaraini, Marcia Scazufca, Beatriz D Schaan, Herman Schargrodsky, Sabine Schipf, Carsten O Schmidt, Peter Schnohr, Ben Schöttker, Sara Schramm, Constance Schultsz, Aletta E Schutte, Sylvain Sebert, Aye Aye Sein, Abhijit Sen, Idowu O Senbanjo, Sadaf G Sepanlou, Jennifer Servais, Svetlana A Shalnova, Teresa Shamah-Levy, Morteza Shamshirgaran, Coimbatore Subramaniam Shanthirani, Maryam Sharafkhah, Sanjib K Sharma, Jonathan E Shaw, Amaneh Shayanrad, Ali Akbar Shayesteh, Zumin Shi, Kenji Shibuya, Hana Shimizu-Furusawa, Dong Wook Shin, Majid Shirani, Rahman Shiri, Namuna Shrestha, Khairil Si-Ramlee, Alfonso Siani, Rosalynn Siantar, Abla M Sibai, Caroline Ramos de Moura Silva, Diego Augusto Santos Silva, Mary Simon, Judith Simons, Leon A Simons, Michael Sjöström, Jolanta Slowikowska-Hilczer, Przemyslaw Slusarczyk, Liam Smeeth, Hung-Kwan So, Fernanda Cunha Soares, Eugène Sobngwi, Stefan Söderberg, Agustinus Soemantri, Reecha Sofat, Vincenzo Solfrizzi, Mohammad Hossein Somi, Emily Sonestedt, Yi Song, Thorkild IA Sørensen, Elin P Sørgjerd, Maroje Sorić, Charles Sossa Jérome, Aïcha Soumaré, Bente Sparboe-Nilsen, Karen Sparrenberger, Jan A Staessen, Gregor Starc, Bill Stavreski, Jostein Steene-Johannessen, Peter Stehle, Aryeh D Stein, George S Stergiou, Jochanan Stessman, Jutta Stieber, Doris Stöckl, Tanja Stocks, Jakub Stokwiszewski, Karien Stronks, Maria Wany Strufaldi, Machi Suka, Chien-An Sun, Yn-Tz Sung, Paibul Suriyawongpaisal, Rody G Sy, Holly E Syddall, René Charles Sylva, Moyses Szklo, E Shyong Tai, Mari-Liis Tammesoo, Abdonas Tamosiunas, Eng Joo Tan, Xun Tang, Frank Tanser, Yong Tao, Mohammed Rasoul Tarawneh, Carolina B Tarqui-Mamani, Anne Taylor, Julie Taylor, William R Tebar, Grethe S Tell, Tania Tello, Yih Chung Tham, KR Thankappan, Holger Theobald, Xenophon Theodoridis, Lutgarde Thijs, Mikael Thinggaard, Nihal Thomas, Barbara Thorand, Betina H Thuesen, Erik J Timmermans, Dwi H Tjandrarini, Anne Tjonneland, Ulla Toft, Hanna K Tolonen, Janne S Tolstrup, Murat Topbas, Roman Topór-Madry, María José Tormo, Michael J Tornaritis, Maties Torrent, Laura Torres-Collado, Giota Touloumi, Pierre Traissac, Areti Triantafyllou, Dimitrios Trichopoulos, Antonia Trichopoulou, Oanh TH Trinh, Atul Trivedi, Lechaba Tshepo, Shoichiro Tsugane, Azaliia M Tuliakova, Marshall K Tulloch-Reid, Fikru Tullu, Tomi-Pekka Tuomainen, Jaakko Tuomilehto, Maria L Turley, Gilad Twig, Per Tynelius, Christophe Tzourio, Peter Ueda, Eunice Ugel, Hanno Ulmer, Hannu MT Uusitalo, Gonzalo Valdivia, Damaskini Valvi, Rob M van Dam, Bert-Jan van den Born, Johan Van der Heyden, Yvonne T van der Schouw, Koen Van Herck, Hoang Van Minh, Natasja M Van Schoor, Irene GM van Valkengoed, Elisabeth M van Zutphen, Dirk Vanderschueren, Diego Vanuzzo, Anette Varbo, Senthil K Vasan, Tomas Vega, Toomas Veidebaum, Gustavo Velasquez-Melendez, Giovanni Veronesi, WM Monique Verschuren, Roosmarijn Verstraeten, Cesar G Victora, Lucie Viet, Salvador Villalpando, Paolo Vineis, Jesus Vioque, Jyrki K Virtanen, Sophie Visvikis-Siest, Bharathi Viswanathan, Tiina Vlasoff, Peter Vollenweider, Ari Voutilainen, Alisha N Wade, Janette Walton, Elvis OA Wambiya, Wan Mohamad Wan Bebakar, Wan Nazaimoon Wan Mohamud, Rildo de Souza Wanderley Júnior, Ming-Dong Wang, Ningli Wang, Qian Wang, Xiangjun Wang, Ya Xing Wang, Ying-Wei Wang, S Goya Wannamethee, Nicholas Wareham, Wenbin Wei, Aneta Weres, Bo Werner, Peter H Whincup, Kurt Widhalm, Andrzej Wiecek, Rainford J Wilks, Johann Willeit, Peter Willeit, Emmanuel A Williams, Tom Wilsgaard, Bogdan Wojtyniak, Roy A Wong-McClure, Andrew Wong, Tien Yin Wong, Jean Woo, Frederick C Wu, Shouling Wu, Justyna Wyszynska, Haiquan Xu, Liang Xu, Nor Azwany Yaacob, Weili Yan, Ling Yang, Xiaoguang Yang, Yang Yang, Tabara Yasuharu, Xingwang Ye, Panayiotis K Yiallouros, Moein Yoosefi, Akihiro Yoshihara, San-Lin You, Novie O Younger-Coleman, Ahmad Faudzi Yusoff, Ahmad A Zainuddin, Seyed Rasoul Zakavi, Farhad Zamani, Sabina Zambon, Antonis Zampelas, Maria Elisa Zapata, Ko Ko Zaw, Kristyna Zejglicova, Tajana Zeljkovic Vrkic, Yi Zeng, Luxia Zhang, Zhen-Yu Zhang, Dong Zhao, Ming-Hui Zhao, Shiqi Zhen, Yingfeng Zheng, Bekbolat Zholdin, Dan Zhu, Marie Zins, Emanuel Zitt, Yanina Zocalo, Nada Zoghlami, Julio Zuñiga Cisneros, Majid Ezzati

The Lancet   398 ( 10304 )   957 - 980   2021.9

　More details

Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/s0140-6736(21)01330-1

researchmap

地域在住高齢者における歯の喪失と遊離糖類摂取量の関連

佐藤 美寿々, 岩崎 正則, 皆川 久美子, 宮本 茜, 葭原 明弘

日本歯科医師会雑誌   74 ( 4 )   406 - 406   2021.7

　More details

Language：Japanese   Publisher：(公社)日本歯科医師会  

researchmap

新潟県の障害児者施設利用者における口腔保健の実態および歯科専門職配置との関連

宮本 茜, 田村 浩平, 杉本 智子, 葭原 明弘

口腔衛生学会雑誌   71 ( 3 )   126 - 135   2021.7

　More details

Language：Japanese   Publisher：(一社)日本口腔衛生学会  

障害児者の歯科保健は,全身の健康管理において大変重要であるが,その取り組みは施設ごとに大きく異なる.本調査では,新潟県における障害者施設利用者の歯科診療受診状況,および歯科保健取組状況について調査することで,実態および課題を把握し,特に歯科専門職の配置による有効性を評価することを目的とした.新潟県内で開設されている全障害児者施設1,021ヶ所を対象に調査を行ったところ,有効回答があった801施設のうち5.1%に歯科専門職(歯科医師,歯科衛生士)が配置されていた.施設における歯科保健管理,歯科医療,および食事介助や摂食機能維持の状況を評価した.ロジスティック回帰分析の結果,歯科専門職の配置がある施設では,歯科健診を受ける機会(調整オッズ比=7.02,95%信頼区間=2.66-18.55),歯科保健指導を受ける機会(調整オッズ比=4.34,95%信頼区間=1.98-9.51),歯科疾患予防の取り組み(調整オッズ比=3.97,95%信頼区間=1.50-10.44),歯科専門職との日常連携(調整オッズ比=5.02,95%信頼区間=2.29-10.99),歯科専門職への相談(調整オッズ比=6.53,95%信頼区間=2.46-17.35),および歯科保健がニーズを満たしている割合(調整オッズ比=3.37,95%信頼区間=1.58-7.15)が有意に高かった.障害児者施設における歯科専門職の配置が,歯科保健に有意に関連していることが示唆された.(著者抄録)

researchmap

Other Link： https://search.jamas.or.jp/default/link?pub_year=2021&ichushi_jid=J00440&link_issn=&doc_id=20210813270001&doc_link_id=%2Fdk1dehea%2F2021%2F007103%2F001%2F0126-0135%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdk1dehea%2F2021%2F007103%2F001%2F0126-0135%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

地域在宅超高齢者の食事パターンと栄養素摂取量、栄養状態および嚥下状態との関連

秋山 理加, 濱嵜 朋子, 岩崎 正則, 角田 聡子, 片岡 正太, 茂山 博代, 濃野 要, 葭原 明弘, 小川 祐司, 安細 敏弘, 宮崎 秀夫

口腔衛生学会雑誌   71 ( 3 )   136 - 146   2021.7

　More details

Language：Japanese   Publisher：(一社)日本口腔衛生学会  

わが国では,年々超高齢者数が増加している.健康度の高い在宅超高齢者の食生活の実態を把握することは健康寿命延伸の有益な知見になると考えられる.そのため著者らは,在宅超高齢者を対象として,食事パターンを同定し,栄養素摂取量,栄養状態および嚥下状態との関連について明らかにすることを目的として本研究を行った.新潟市の91歳在宅高齢者86名を対象として,簡易型自記式食事歴法質問票(BDHQ),簡易栄養状態評価(MNA-SF),簡易嚥下状態評価票(EAT-10)による調査を行った.食品群別摂取量から主成分分析を行い,食事パターンを同定し,それらと栄養素摂取量の関連を検討した.さらに,各食事パターンと食に関連する因子,MNA-SFおよびEAT-10との関連を比較検討した.主成分分析の結果,4つの食事パターンが同定された.それぞれの主成分得点三分位によって栄養素摂取量を比較したところ,肉,魚,野菜類の摂取量が多く,ご飯,パンが少ない「副菜型」では,高得点群ほどたんぱく質やビタミンDなどの栄養素摂取量が多く,栄養状態も良好な者が多かった.また,MNA-SFで低栄養と判定された群では対照群と比べて嚥下機能低下のリスクのある者の割合が有意に高かった.さらに,「副菜型」の食事パターンでは居住形態や共に食事をする人の有無との関連も示唆された.(著者抄録)

researchmap

Other Link： https://search.jamas.or.jp/default/link?pub_year=2021&ichushi_jid=J00440&link_issn=&doc_id=20210813270002&doc_link_id=%2Fdk1dehea%2F2021%2F007103%2F002%2F0136-0146%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdk1dehea%2F2021%2F007103%2F002%2F0136-0146%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

65歳以上のメタボリックシンドローム有病者における現在歯数と心の健康状態の関連 魚沼コホート調査より

皆川 久美子, 葭原 明弘, 諏訪間 加奈, 小川 祐司

口腔衛生学会雑誌   71 ( 増刊 )   111 - 111   2021.4

　More details

Language：Japanese   Publisher：(一社)日本口腔衛生学会  

researchmap

65歳以上のメタボリックシンドローム有病者における現在歯数と心の健康状態の関連 魚沼コホート調査より

皆川 久美子, 葭原 明弘, 諏訪間 加奈, 小川 祐司

口腔衛生学会雑誌   71 ( 増刊 )   111 - 111   2021.4

　More details

Language：Japanese   Publisher：(一社)日本口腔衛生学会  

researchmap

Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight Reviewed

Maria LC Iurilli, Bin Zhou, James E Bennett, Rodrigo M Carrillo-Larco, Marisa K Sophiea, Andrea Rodriguez-Martinez, Honor Bixby, Bethlehem D Solomon, Cristina Taddei, Goodarz Danaei, Mariachiara Di Cesare, Gretchen A Stevens, Leanne M Riley, Stefan Savin, Melanie J Cowan, Pascal Bovet, Albertino Damasceno, Adela Chirita-Emandi, Alison J Hayes, Nayu Ikeda, Rod T Jackson, Young-Ho Khang, Avula Laxmaiah, Jing Liu, J Jaime Miranda, Olfa Saidi, Sylvain Sebert, Maroje Sorić, Gregor Starc, Edward W Gregg, Leandra Abarca-Gómez, Ziad A Abdeen, Shynar Abdrakhmanova, Suhaila Abdul Ghaffar, Hanan F Abdul Rahim, Niveen M Abu-Rmeileh, Jamila Abubakar Garba, Benjamin Acosta-Cazares, Robert J Adams, Wichai Aekplakorn, Kaosar Afsana, Shoaib Afzal, Imelda A Agdeppa, Javad Aghazadeh-Attari, Carlos A Aguilar-Salinas, Charles Agyemang, Mohamad Hasnan Ahmad, Noor Ani Ahmad, Ali Ahmadi, Naser Ahmadi, Soheir H Ahmed, Wolfgang Ahrens, Gulmira Aitmurzaeva, Kamel Ajlouni, Hazzaa M Al-Hazzaa, Badreya Al-Lahou, Rajaa Al-Raddadi, Monira Alarouj, Fadia AlBuhairan, Shahla AlDhukair, Mohamed M Ali, Abdullah Alkandari, Ala'a Alkerwi, Kristine Allin, Mar Alvarez-Pedrerol, Eman Aly, Deepak N Amarapurkar, Parisa Amiri, Norbert Amougou, Philippe Amouyel, Lars Bo Andersen, Sigmund A Anderssen, Lars Ängquist, Ranjit Mohan Anjana, Alireza Ansari-Moghaddam, Hajer Aounallah-Skhiri, Joana Araújo, Inger Ariansen, Tahir Aris, Raphael E Arku, Nimmathota Arlappa, Krishna K Aryal, Thor Aspelund, Felix K Assah, Maria Cecília F Assunção, May Soe Aung, Juha Auvinen, Mária Avdicová, Shina Avi, Ana Azevedo, Mohsen Azimi-Nezhad, Fereidoun Azizi, Mehrdad Azmin, Bontha V Babu, Maja Bæksgaard Jørgensen, Azli Baharudin, Suhad Bahijri, Jennifer L Baker, Nagalla Balakrishna, Mohamed Bamoshmoosh, Maciej Banach, Piotr Bandosz, José R Banegas, Joanna Baran, Carlo M Barbagallo, Alberto Barceló, Amina Barkat, Aluisio JD Barros, Mauro Virgílio Gomes Barros, Abdul Basit, Joao Luiz D Bastos, Iqbal Bata, Anwar M Batieha, Rosangela L Batista, Zhamilya Battakova, Assembekov Batyrbek, Louise A Baur, Robert Beaglehole, Silvia Bel-Serrat, Antonisamy Belavendra, Habiba Ben Romdhane, Judith Benedics, Mikhail Benet, Ingunn Holden Bergh, Salim Berkinbayev, Antonio Bernabe-Ortiz, Gailute Bernotiene, Heloísa Bettiol, Jorge Bezerra, Aroor Bhagyalaxmi, Sumit Bharadwaj, Santosh K Bhargava, Zulfiqar A Bhutta, Hongsheng Bi, Yufang Bi, Daniel Bia, Elysée Claude Bika Lele, Mukharram M Bikbov, Bihungum Bista, Dusko J Bjelica, Peter Bjerregaard, Espen Bjertness, Marius B Bjertness, Cecilia Björkelund, Katia V Bloch, Anneke Blokstra, Simona Bo, Martin Bobak, Lynne M Boddy, Bernhard O Boehm, Heiner Boeing, Jose G Boggia, Elena Bogova, Carlos P Boissonnet, Stig E Bojesen, Marialaura Bonaccio, Vanina Bongard, Alice Bonilla-Vargas, Matthias Bopp, Herman Borghs, Lien Braeckevelt, Lutgart Braeckman, Marjolijn CE Bragt, Imperia Brajkovich, Francesco Branca, Juergen Breckenkamp, João Breda, Hermann Brenner, Lizzy M Brewster, Garry R Brian, Lacramioara Brinduse, Sinead Brophy, Graziella Bruno, H Bas Bueno-de-Mesquita, Anna Bugge, Marta Buoncristiano, Genc Burazeri, Con Burns, Antonio Cabrera de León, Joseph Cacciottolo, Hui Cai, Tilema Cama, Christine Cameron, José Camolas, Günay Can, Ana Paula C Cândido, Felicia Cañete, Mario V Capanzana, Nadežda Capková, Eduardo Capuano, Vincenzo Capuano, Marloes Cardol, Viviane C Cardoso, Axel C Carlsson, Esteban Carmuega, Joana Carvalho, José A Casajús, Felipe F Casanueva, Ertugrul Celikcan, Laura Censi, Marvin Cervantes-Loaiza, Juraci A Cesar, Snehalatha Chamukuttan, Angelique W Chan, Queenie Chan, Himanshu K Chaturvedi, Nish Chaturvedi, Norsyamlina Che Abdul Rahim, Miao Li Chee, Chien-Jen Chen, Fangfang Chen, Huashuai Chen, Shuohua Chen, Zhengming Chen, Ching-Yu Cheng, Bahman Cheraghian, Angela Chetrit, Ekaterina Chikova-Iscener, Arnaud Chiolero, Shu-Ti Chiou, María-Dolores Chirlaque, Belong Cho, Kaare Christensen, Diego G Christofaro, Jerzy Chudek, Renata Cifkova, Michelle Cilia, Eliza Cinteza, Frank Claessens, Janine Clarke, Els Clays, Emmanuel Cohen, Hans Concin, Susana C Confortin, Cyrus Cooper, Tara C Coppinger, Eva Corpeleijn, Simona Costanzo, Dominique Cottel, Chris Cowell, Cora L Craig, Amelia C Crampin, Ana B Crujeiras, Semánová Csilla, Alexandra M Cucu, Liufu Cui, Felipe V Cureau, Ewelina Czenczek-Lewandowska, Graziella D'Arrigo, Eleonora d'Orsi, Liliana Dacica, María Ángeles Dal Re Saavedra, Jean Dallongeville, Camilla T Damsgaard, Rachel Dankner, Thomas M Dantoft, Parasmani Dasgupta, Saeed Dastgiri, Luc Dauchet, Kairat Davletov, Guy De Backer, Dirk De Bacquer, Giovanni de Gaetano, Stefaan De Henauw, Paula Duarte de Oliveira, David De Ridder, Karin De Ridder, Susanne R de Rooij, Delphine De Smedt, Mohan Deepa, Alexander D Deev, Vincent Jr DeGennaro, Abbas Dehghan, Hélène Delisle, Francis Delpeuch, Stefaan Demarest, Elaine Dennison, Katarzyna Dereń, Valérie Deschamps, Meghnath Dhimal, Augusto F Di Castelnuovo, Juvenal Soares Dias-da-Costa, María Elena Díaz-Sánchez, Alejandro Diaz, Zivka Dika, Shirin Djalalinia, Visnja Djordjic, Ha TP Do, Annette J Dobson, Maria Benedetta Donati, Chiara Donfrancesco, Silvana P Donoso, Angela Döring, Maria Dorobantu, Ahmad Reza Dorosty, Kouamelan Doua, Nico Dragano, Wojciech Drygas, Jia Li Duan, Charmaine A Duante, Priscilla Duboz, Rosemary B Duda, Vesselka Duleva, Virginija Dulskiene, Samuel C Dumith, Anar Dushpanova, Vilnis Dzerve, Elzbieta Dziankowska-Zaborszczyk, Ricky Eddie, Ebrahim Eftekhar, Eruke E Egbagbe, Robert Eggertsen, Sareh Eghtesad, Gabriele Eiben, Ulf Ekelund, Mohammad El-Khateeb, Jalila El Ati, Denise Eldemire-Shearer, Marie Eliasen, Paul Elliott, Reina Engle-Stone, Macia Enguerran, Rajiv T Erasmus, Raimund Erbel, Cihangir Erem, Louise Eriksen, Johan G Eriksson, Jorge Escobedo-de la Peña, Saeid Eslami, Ali Esmaeili, Alun Evans, David Faeh, Albina A Fakhretdinova, Caroline H Fall, Elnaz Faramarzi, Mojtaba Farjam, Victoria Farrugia Sant'Angelo, Farshad Farzadfar, Mohammad Reza Fattahi, Asher Fawwad, Francisco J Felix-Redondo, Trevor S Ferguson, Romulo A Fernandes, Daniel Fernández-Bergés, Daniel Ferrante, Thomas Ferrao, Marika Ferrari, Marco M Ferrario, Catterina Ferreccio, Eldridge Ferrer, Jean Ferrieres, Thamara Hubler Figueiró, Anna Fijalkowska, Günther Fink, Krista Fischer, Leng Huat Foo, Maria Forsner, Heba M Fouad, Damian K Francis, Maria do Carmo Franco, Ruth Frikke-Schmidt, Guillermo Frontera, Flavio D Fuchs, Sandra C Fuchs, Isti I Fujiati, Yuki Fujita, Matsuda Fumihiko, Takuro Furusawa, Zbigniew Gaciong, Mihai Gafencu, Andrzej Galbarczyk, Henrike Galenkamp, Daniela Galeone, Myriam Galfo, Fabio Galvano, Jingli Gao, Manoli Garcia-de-la-Hera, Marta García-Solano, Dickman Gareta, Sarah P Garnett, Jean-Michel Gaspoz, Magda Gasull, Adroaldo Cesar Araujo Gaya, Anelise Reis Gaya, Andrea Gazzinelli, Ulrike Gehring, Harald Geiger, Johanna M Geleijnse, Ali Ghanbari, Erfan Ghasemi, Oana-Florentina Gheorghe-Fronea, Simona Giampaoli, Francesco Gianfagna, Tiffany K Gill, Jonathan Giovannelli, Glen Gironella, Aleksander Giwercman, Konstantinos Gkiouras, Justyna Godos, Sibel Gogen, Marcel Goldberg, Rebecca A Goldsmith, David Goltzman, Santiago F Gómez, Aleksandra Gomula, Bruna Goncalves Cordeiro da Silva, Helen Gonçalves, David A Gonzalez-Chica, Marcela Gonzalez-Gross, Margot González-Leon, Juan P González-Rivas, Clicerio González-Villalpando, María-Elena González-Villalpando, Angel R Gonzalez, Frederic Gottrand, Antonio Pedro Graça, Sidsel Graff-Iversen, Dušan Grafnetter, Aneta Grajda, Maria G Grammatikopoulou, Ronald D Gregor, Tomasz Grodzicki, Else Karin Grøholt, Anders Grøntved, Giuseppe Grosso, Gabriella Gruden, Dongfeng Gu, Emanuela Gualdi-Russo, Pilar Guallar-Castillón, Andrea Gualtieri, Elias F Gudmundsson, Vilmundur Gudnason, Ramiro Guerrero, Idris Guessous, Andre L Guimaraes, Martin C Gulliford, Johanna Gunnlaugsdottir, Marc J Gunter, Xiu-Hua Guo, Yin Guo, Prakash C Gupta, Rajeev Gupta, Oye Gureje, Beata Gurzkowska, Enrique Gutiérrez-González, Laura Gutierrez, Felix Gutzwiller, Seongjun Ha, Farzad Hadaegh, Charalambos A Hadjigeorgiou, Rosa Haghshenas, Hamid Hakimi, Jytte Halkjær, Ian R Hambleton, Behrooz Hamzeh, Dominique Hange, Abu AM Hanif, Sari Hantunen, Jie Hao, Rachakulla Hari Kumar, Seyed Mohammad Hashemi-Shahri, Maria Hassapidou, Jun Hata, Teresa Haugsgjerd, Jiang He, Yuan He, Yuna He, Regina Heidinger-Felso, Mirjam Heinen, Tatjana Hejgaard, Marleen Elisabeth Hendriks, Rafael dos Santos Henrique, Ana Henriques, Leticia Hernandez Cadena, Sauli Herrala, Victor M Herrera, Isabelle Herter-Aeberli, Ramin Heshmat, Allan G Hill, Sai Yin Ho, Suzanne C Ho, Michael Hobbs, Michelle Holdsworth, Reza Homayounfar, Clara Homs, Wilma M Hopman, Andrea RVR Horimoto, Claudia M Hormiga, Bernardo L Horta, Leila Houti, Christina Howitt, Thein Thein Htay, Aung Soe Htet, Maung Maung Than Htike, Yonghua Hu, José María Huerta, Ilpo Tapani Huhtaniemi, Laetitia Huiart, Constanta Huidumac Petrescu, Martijn Huisman, Abdullatif Husseini, Chinh Nguyen Huu, Inge Huybrechts, Nahla Hwalla, Jolanda Hyska, Licia Iacoviello, Jesús M Ibarluzea, Mohsen M Ibrahim, Norazizah Ibrahim Wong, M Arfan Ikram, Violeta Iotova, Vilma E Irazola, Takafumi Ishida, Muhammad Islam, Sheikh Mohammed Shariful Islam, Masanori Iwasaki, Jeremy M Jacobs, Hashem Y Jaddou, Tazeen Jafar, Kenneth James, Kazi M Jamil, Konrad Jamrozik, Imre Janszky, Edward Janus, Juel Jarani, Marjo-Riitta Jarvelin, Grazyna Jasienska, Ana Jelakovic, Bojan Jelakovic, Garry Jennings, Anjani Kumar Jha, Chao Qiang Jiang, Ramon O Jimenez, Karl-Heinz Jöckel, Michel Joffres, Mattias Johansson, Jari J Jokelainen, Jost B Jonas, Jitendra Jonnagaddala, Torben Jørgensen, Pradeep Joshi, Farahnaz Joukar, Dragana P Jovic, Jacek J Jóźwiak, Anne Juolevi, Gregor Jurak, Iulia Jurca Simina, Vesna Juresa, Rudolf Kaaks, Felix O Kaducu, Anthony Kafatos, Eero O Kajantie, Zhanna Kalmatayeva, Ofra Kalter-Leibovici, Yves Kameli, Freja B Kampmann, Kodanda R Kanala, Srinivasan Kannan, Efthymios Kapantais, Argyro Karakosta, Line L Kårhus, Khem B Karki, Marzieh Katibeh, Joanne Katz, Peter T Katzmarzyk, Jussi Kauhanen, Prabhdeep Kaur, Maryam Kavousi, Gyulli M Kazakbaeva, Ulrich Keil, Lital Keinan Boker, Sirkka Keinänen-Kiukaanniemi, Roya Kelishadi, Cecily Kelleher, Han CG Kemper, Andre P Kengne, Maryam Keramati, Alina Kerimkulova, Mathilde Kersting, Timothy Key, Yousef Saleh Khader, Davood Khalili, Kay-Tee Khaw, Bahareh Kheiri, Motahareh Kheradmand, Alireza Khosravi, Ilse MSL Khouw, Ursula Kiechl-Kohlendorfer, Stefan Kiechl, Japhet Killewo, Dong Wook Kim, Hyeon Chang Kim, Jeongseon Kim, Jenny M Kindblom, Heidi Klakk, Magdalena Klimek, Jeannette Klimont, Jurate Klumbiene, Michael Knoflach, Bhawesh Koirala, Elin Kolle, Patrick Kolsteren, Jürgen König, Raija Korpelainen, Paul Korrovits, Magdalena Korzycka, Jelena Kos, Seppo Koskinen, Katsuyasu Kouda, Viktoria A Kovacs, Sudhir Kowlessur, Slawomir Koziel, Jana Kratenova, Wolfgang Kratzer, Susi Kriemler, Peter Lund Kristensen, Steiner Krokstad, Daan Kromhout, Herculina S Kruger, Ruzena Kubinova, Renata Kuciene, Urho M Kujala, Enisa Kujundzic, Zbigniew Kulaga, R Krishna Kumar, Marie Kunešová, Pawel Kurjata, Yadlapalli S Kusuma, Kari Kuulasmaa, Catherine Kyobutungi, Quang Ngoc La, Fatima Zahra Laamiri, Tiina Laatikainen, Carl Lachat, Youcef Laid, Tai Hing Lam, Christina-Paulina Lambrinou, Edwige Landais, Vera Lanska, Georg Lappas, Bagher Larijani, Tint Swe Latt, Laura Lauria, Maria Lazo-Porras, Gwenaëlle Le Coroller, Khanh Le Nguyen Bao, Agnès Le Port, Tuyen D Le, Jeannette Lee, Jeonghee Lee, Paul H Lee, Nils Lehmann, Terho Lehtimäki, Daniel Lemogoum, Naomi S Levitt, Yanping Li, Merike Liivak, Christa L Lilly, Wei-Yen Lim, M Fernanda Lima-Costa, Hsien-Ho Lin, Xu Lin, Yi-Ting Lin, Lars Lind, Allan Linneberg, Lauren Lissner, Mieczyslaw Litwin, Lijuan Liu, Wei-Cheng Lo, Helle-Mai Loit, Khuong Quynh Long, Luis Lopes, Oscar Lopes, Esther Lopez-Garcia, Tania Lopez, Paulo A Lotufo, José Eugenio Lozano, Janice L Lukrafka, Dalia Luksiene, Annamari Lundqvist, Robert Lundqvist, Nuno Lunet, Charles Lunogelo, Michala Lustigová, Edyta Łuszczki, Guansheng Ma, Jun Ma, Xu Ma, George LL Machado-Coelho, Aristides M Machado-Rodrigues, Luisa M Macieira, Ahmed A Madar, Stefania Maggi, Dianna J Magliano, Sara Magnacca, Emmanuella Magriplis, Gowri Mahasampath, Bernard Maire, Marjeta Majer, Marcia Makdisse, Päivi Mäki, Fatemeh Malekzadeh, Reza Malekzadeh, Rahul Malhotra, Kodavanti Mallikharjuna Rao, Sofia K Malyutina, Lynell V Maniego, Yannis Manios, Jim I Mann, Fariborz Mansour-Ghanaei, Enzo Manzato, Paula Margozzini, Anastasia Markaki, Oonagh Markey, Eliza Markidou Ioannidou, Pedro Marques-Vidal, Larissa Pruner Marques, Jaume Marrugat, Yves Martin-Prevel, Rosemarie Martin, Reynaldo Martorell, Eva Martos, Katharina Maruszczak, Stefano Marventano, Luis P Mascarenhas, Shariq R Masoodi, Ellisiv B Mathiesen, Prashant Mathur, Alicia Matijasevich, Tandi E Matsha, Christina Mavrogianni, Artur Mazur, Jean Claude N Mbanya, Shelly R McFarlane, Stephen T McGarvey, Martin McKee, Stela McLachlan, Rachael M McLean, Scott B McLean, Breige A McNulty, Sounnia Mediene Benchekor, Jurate Medzioniene, Parinaz Mehdipour, Kirsten Mehlig, Amir Houshang Mehrparvar, Aline Meirhaeghe, Jørgen Meisfjord, Christa Meisinger, Ana Maria B Menezes, Geetha R Menon, Gert BM Mensink, Maria Teresa Menzano, Alibek Mereke, Indrapal I Meshram, Andres Metspalu, Haakon E Meyer, Jie Mi, Kim F Michaelsen, Nathalie Michels, Kairit Mikkel, Karolina Milkowska, Jody C Miller, Cláudia S Minderico, GK Mini, Juan Francisco Miquel, Mohammad Reza Mirjalili, Daphne Mirkopoulou, Erkin Mirrakhimov, Marjeta Mišigoj-Durakovic, Antonio Mistretta, Veronica Mocanu, Pietro A Modesti, Sahar Saeedi Moghaddam, Bahram Mohajer, Mostafa K Mohamed, Shukri F Mohamed, Kazem Mohammad, Zahra Mohammadi, Noushin Mohammadifard, Reza Mohammadpourhodki, Viswanathan Mohan, Salim Mohanna, Muhammad Fadhli Mohd Yusoff, Iraj Mohebbi, Farnam Mohebi, Marie Moitry, Drude Molbo, Line T Møllehave, Niels C Møller, Dénes Molnár, Amirabbas Momenan, Charles K Mondo, Michele Monroy-Valle, Eric Monterrubio-Flores, Kotsedi Daniel K Monyeki, Jin Soo Moon, Mahmood Moosazadeh, Leila B Moreira, Alain Morejon, Luis A Moreno, Karen Morgan, Suzanne N Morin, Erik Lykke Mortensen, George Moschonis, Malgorzata Mossakowska, Aya Mostafa, Anabela Mota-Pinto, Jorge Mota, Mohammad Esmaeel Motlagh, Jorge Motta, Marcos André Moura-dos-Santos, Malay K Mridha, Kelias P Msyamboza, Thet Thet Mu, Magdalena Muc, Boban Mugoša, Maria L Muiesan, Parvina Mukhtorova, Martina Müller-Nurasyid, Neil Murphy, Jaakko Mursu, Elaine M Murtagh, Kamarul Imran Musa, Sanja Music Milanovic, Vera Musil, Norlaila Mustafa, Iraj Nabipour, Shohreh Naderimagham, Gabriele Nagel, Balkish M Naidu, Farid Najafi, Harunobu Nakamura, Jana Námešná, Ei Ei K Nang, Vinay B Nangia, Martin Nankap, Sameer Narake, Paola Nardone, Matthias Nauck, William A Neal, Azim Nejatizadeh, Chandini Nekkantti, Keiu Nelis, Liis Nelis, Ilona Nenko, Martin Neovius, Flavio Nervi, Chung T Nguyen, Nguyen D Nguyen, Quang Ngoc Nguyen, Ramfis E Nieto-Martínez, Yury P Nikitin, Guang Ning, Toshiharu Ninomiya, Sania Nishtar, Marianna Noale, Oscar A Noboa, Helena Nogueira, Teresa Norat, Maria Nordendahl, Børge G Nordestgaard, Davide Noto, Natalia Nowak-Szczepanska, Mohannad Al Nsour, Irfan Nuhoglu, Eha Nurk, Terence W O'Neill, Dermot O'Reilly, Galina Obreja, Caleb Ochimana, Angélica M Ochoa-Avilés, Eiji Oda, Kyungwon Oh, Kumiko Ohara, Claes Ohlsson, Ryutaro Ohtsuka, Örn Olafsson, Maria Teresa A Olinto, Isabel O Oliveira, Mohd Azahadi Omar, Altan Onat, Sok King Ong, Lariane M Ono, Pedro Ordunez, Rui Ornelas, Ana P Ortiz, Pedro J Ortiz, Merete Osler, Clive Osmond, Sergej M Ostojic, Afshin Ostovar, Johanna A Otero, Kim Overvad, Ellis Owusu-Dabo, Fred Michel Paccaud, Cristina Padez, Ioannis Pagkalos, Elena Pahomova, Karina Mary de Paiva, Andrzej Pajak, Domenico Palli, Alberto Palloni, Luigi Palmieri, Wen-Harn Pan, Songhomitra Panda-Jonas, Arvind Pandey, Francesco Panza, Dimitrios Papandreou, Soon-Woo Park, Suyeon Park, Winsome R Parnell, Mahboubeh Parsaeian, Ionela M Pascanu, Patrick Pasquet, Nikhil D Patel, Ivan Pecin, Mangesh S Pednekar, Nasheeta Peer, Gao Pei, Sergio Viana Peixoto, Markku Peltonen, Alexandre C Pereira, Marco A Peres, Napoleón Pérez-Farinós, Cynthia M Pérez, Valentina Peterkova, Annette Peters, Astrid Petersmann, Janina Petkeviciene, Ausra Petrauskiene, Emanuela Pettenuzzo, Niloofar Peykari, Son Thai Pham, Rafael N Pichardo, Daniela Pierannunzio, Iris Pigeot, Hynek Pikhart, Aida Pilav, Lorenza Pilotto, Francesco Pistelli, Freda Pitakaka, Aleksandra Piwonska, Andreia N Pizarro, Pedro Plans-Rubió, Bee Koon Poh, Hermann Pohlabeln, Raluca M Pop, Stevo R Popovic, Miquel Porta, Georg Posch, Anil Poudyal, Dimitrios Poulimeneas, Hamed Pouraram, Farhad Pourfarzi, Akram Pourshams, Hossein Poustchi, Rajendra Pradeepa, Alison J Price, Jacqueline F Price, Rui Providencia, Jardena J Puder, Iveta Pudule, Soile E Puhakka, Maria Puiu, Margus Punab, Radwan F Qasrawi, Mostafa Qorbani, Tran Quoc Bao, Ivana Radic, Ricardas Radisauskas, Salar Rahimikazerooni, Mahfuzar Rahman, Mahmudur Rahman, Olli Raitakari, Manu Raj, Ellina Rakhimova, Sherali Rakhmatulloev, Ivo Rakovac, Sudha Ramachandra Rao, Ambady Ramachandran, Jacqueline Ramke, Elisabete Ramos, Rafel Ramos, Lekhraj Rampal, Sanjay Rampal, Vayia Rarra, Ramon A Rascon-Pacheco, Mette Rasmussen, Cassiano Ricardo Rech, Josep Redon, Paul Ferdinand M Reganit, Valéria Regecová, Luis Revilla, Abbas Rezaianzadeh, Lourdes Ribas-Barba, Robespierre Ribeiro, Elio Riboli, Adrian Richter, Fernando Rigo, Natascia Rinaldo, Tobias F Rinke de Wit, Ana Rito, Raphael M Ritti-Dias, Juan A Rivera, Cynthia Robitaille, Romana Roccaldo, Daniela Rodrigues, Fernando Rodríguez-Artalejo, María del Cristo Rodriguez-Perez, Laura A Rodríguez-Villamizar, Ulla Roggenbuck, Rosalba Rojas-Martinez, Nipa Rojroongwasinkul, Dora Romaguera, Elisabetta L Romeo, Rafaela V Rosario, Annika Rosengren, Ian Rouse, Joel GR Roy, Adolfo Rubinstein, Frank J Rühli, Jean-Bernard Ruidavets, Blanca Sandra Ruiz-Betancourt, Maria Ruiz-Castell, Emma Ruiz Moreno, Iuliia A Rusakova, Kenisha Russell Jonsson, Paola Russo, Petra Rust, Marcin Rutkowski, Charumathi Sabanayagam, Elena Sacchini, Harshpal S Sachdev, Alireza Sadjadi, Ali Reza Safarpour, Saeid Safiri, Nader Saki, Benoit Salanave, Eduardo Salazar Martinez, Diego Salmerón, Veikko Salomaa, Jukka T Salonen, Massimo Salvetti, Margarita Samoutian, Jose Sánchez-Abanto, Sandjaja, Susana Sans, Loreto Santa Marina, Diana A Santos, Ina S Santos, Lèlita C Santos, Maria Paula Santos, Osvaldo Santos, Rute Santos, Sara Santos Sanz, Jouko L Saramies, Luis B Sardinha, Nizal Sarrafzadegan, Thirunavukkarasu Sathish, Kai-Uwe Saum, Savvas Savva, Mathilde Savy, Norie Sawada, Mariana Sbaraini, Marcia Scazufca, Beatriz D Schaan, Angelika Schaffrath Rosario, Herman Schargrodsky, Anja Schienkiewitz, Sabine Schipf, Carsten O Schmidt, Ida Maria Schmidt, Peter Schnohr, Ben Schöttker, Sara Schramm, Stine Schramm, Helmut Schröder, Constance Schultsz, Aletta E Schutte, Aye Aye Sein, Rusidah Selamat, Vedrana Sember, Abhijit Sen, Idowu O Senbanjo, Sadaf G Sepanlou, Victor Sequera, Luis Serra-Majem, Jennifer Servais, Ludmila Ševcíková, Svetlana A Shalnova, Teresa Shamah-Levy, Morteza Shamshirgaran, Coimbatore Subramaniam Shanthirani, Maryam Sharafkhah, Sanjib K Sharma, Jonathan E Shaw, Amaneh Shayanrad, Ali Akbar Shayesteh, Lela Shengelia, Zumin Shi, Kenji Shibuya, Hana Shimizu-Furusawa, Dong Wook Shin, Majid Shirani, Rahman Shiri, Namuna Shrestha, Khairil Si-Ramlee, Alfonso Siani, Rosalynn Siantar, Abla M Sibai, Antonio M Silva, Diego Augusto Santos Silva, Mary Simon, Judith Simons, Leon A Simons, Agneta Sjöberg, Michael Sjöström, Gry Skodje, Jolanta Slowikowska-Hilczer, Przemyslaw Slusarczyk, Liam Smeeth, Hung-Kwan So, Fernanda Cunha Soares, Grzegorz Sobek, Eugène Sobngwi, Morten Sodemann, Stefan Söderberg, Moesijanti YE Soekatri, Agustinus Soemantri, Reecha Sofat, Vincenzo Solfrizzi, Mohammad Hossein Somi, Emily Sonestedt, Yi Song, Thorkild IA Sørensen, Elin P Sørgjerd, Charles Sossa Jérome, Victoria E Soto-Rojas, Aïcha Soumaré, Slavica Sovic, Bente Sparboe-Nilsen, Karen Sparrenberger, Angela Spinelli, Igor Spiroski, Jan A Staessen, Hanspeter Stamm, Maria G Stathopoulou, Kaspar Staub, Bill Stavreski, Jostein Steene-Johannessen, Peter Stehle, Aryeh D Stein, George S Stergiou, Jochanan Stessman, Ranko Stevanovic, Jutta Stieber, Doris Stöckl, Tanja Stocks, Jakub Stokwiszewski, Ekaterina Stoyanova, Gareth Stratton, Karien Stronks, Maria Wany Strufaldi, Lela Sturua, Ramón Suárez-Medina, Machi Suka, Chien-An Sun, Johan Sundström, Yn-Tz Sung, Jordi Sunyer, Paibul Suriyawongpaisal, Boyd A Swinburn, Rody G Sy, Holly E Syddall, René Charles Sylva, Moyses Szklo, Lucjan Szponar, E Shyong Tai, Mari-Liis Tammesoo, Abdonas Tamosiunas, Eng Joo Tan, Xun Tang, Maya Tanrygulyyeva, Frank Tanser, Yong Tao, Mohammed Rasoul Tarawneh, Jakob Tarp, Carolina B Tarqui-Mamani, Radka Taxová Braunerová, Anne Taylor, Julie Taylor, Félicité Tchibindat, William R Tebar, Grethe S Tell, Tania Tello, Yih Chung Tham, KR Thankappan, Holger Theobald, Xenophon Theodoridis, Lutgarde Thijs, Nihal Thomas, Betina H Thuesen, Lubica Tichá, Erik J Timmermans, Anne Tjonneland, Hanna K Tolonen, Janne S Tolstrup, Murat Topbas, Roman Topór-Madry, Liv Elin Torheim, María José Tormo, Michael J Tornaritis, Maties Torrent, Laura Torres-Collado, Stefania Toselli, Giota Touloumi, Pierre Traissac, Thi Tuyet-Hanh Tran, Dimitrios Trichopoulos, Antonia Trichopoulou, Oanh TH Trinh, Atul Trivedi, Lechaba Tshepo, Maria Tsigga, Shoichiro Tsugane, Azaliia M Tuliakova, Marshall K Tulloch-Reid, Fikru Tullu, Tomi-Pekka Tuomainen, Jaakko Tuomilehto, Maria L Turley, Gilad Twig, Per Tynelius, Themistoklis Tzotzas, Christophe Tzourio, Peter Ueda, Eunice Ugel, Flora AM Ukoli, Hanno Ulmer, Belgin Unal, Zhamyila Usupova, Hannu MT Uusitalo, Nalan Uysal, Justina Vaitkeviciute, Gonzalo Valdivia, Susana Vale, Damaskini Valvi, Rob M van Dam, Johan Van der Heyden, Yvonne T van der Schouw, Koen Van Herck, Hoang Van Minh, Natasja M Van Schoor, Irene GM van Valkengoed, Dirk Vanderschueren, Diego Vanuzzo, Anette Varbo, Gregorio Varela-Moreiras, Patricia Varona-Pérez, Senthil K Vasan, Tomas Vega, Toomas Veidebaum, Gustavo Velasquez-Melendez, Biruta Velika, Giovanni Veronesi, WM Monique Verschuren, Cesar G Victora, Giovanni Viegi, Lucie Viet, Salvador Villalpando, Paolo Vineis, Jesus Vioque, Jyrki K Virtanen, Marjolein Visser, Sophie Visvikis-Siest, Bharathi Viswanathan, Mihaela Vladulescu, Tiina Vlasoff, Dorja Vocanec, Peter Vollenweider, Henry Völzke, Ari Voutilainen, Sari Voutilainen, Martine Vrijheid, Tanja GM Vrijkotte, Alisha N Wade, Aline Wagner, Thomas Waldhör, Janette Walton, Elvis OA Wambiya, Wan Mohamad Wan Bebakar, Wan Nazaimoon Wan Mohamud, Rildo de Souza Wanderley Júnior, Ming-Dong Wang, Ningli Wang, Qian Wang, Xiangjun Wang, Ya Xing Wang, Ying-Wei Wang, S Goya Wannamethee, Nicholas Wareham, Adelheid Weber, Niels Wedderkopp, Deepa Weerasekera, Daniel Weghuber, Wenbin Wei, Aneta Weres, Bo Werner, Peter H Whincup, Kurt Widhalm, Indah S Widyahening, Andrzej Wiecek, Rainford J Wilks, Johann Willeit, Peter Willeit, Julianne Williams, Tom Wilsgaard, Bogdan Wojtyniak, Roy A Wong-McClure, Andrew Wong, Jyh Eiin Wong, Tien Yin Wong, Jean Woo, Mark Woodward, Frederick C Wu, Jianfeng Wu, Li Juan Wu, Shouling Wu, Haiquan Xu, Liang Xu, Nor Azwany Yaacob, Uruwan Yamborisut, Weili Yan, Ling Yang, Xiaoguang Yang, Yang Yang, Nazan Yardim, Mehdi Yaseri, Tabara Yasuharu, Xingwang Ye, Panayiotis K Yiallouros, Moein Yoosefi, Akihiro Yoshihara, Qi Sheng You, San-Lin You, Novie O Younger-Coleman, Safiah Md Yusof, Ahmad Faudzi Yusoff, Luciana Zaccagni, Vassilis Zafiropulos, Ahmad A Zainuddin, Seyed Rasoul Zakavi, Farhad Zamani, Sabina Zambon, Antonis Zampelas, Hana Zamrazilová, Maria Elisa Zapata, Abdul Hamid Zargar, Ko Ko Zaw, Tomasz Zdrojewski, Kristyna Zejglicova, Tajana Zeljkovic Vrkic, Yi Zeng, Luxia Zhang, Zhen-Yu Zhang, Dong Zhao, Ming-Hui Zhao, Wenhua Zhao, Shiqi Zhen, Wei Zheng, Yingfeng Zheng, Bekbolat Zholdin, Maigeng Zhou, Dan Zhu, Marie Zins, Emanuel Zitt, Yanina Zocalo, Julio Zuñiga Cisneros, Monika Zuziak, Majid Ezzati, Sarah Filippi

eLife   10   2021.3

　More details

Publishing type：Research paper (scientific journal)   Publisher：eLife Sciences Publications, Ltd  

From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia and sub-Saharan Africa, the underweight tail of the BMI distribution was left behind as the distribution shifted. There is a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions.

DOI： 10.7554/elife.60060

researchmap

Other Link： https://cdn.elifesciences.org/articles/60060/elife-60060-v1.xml

A 5-year longitudinal association between dietary fermented soya bean (natto) intake and tooth loss through bone mineral density in postmenopausal women: The Yokogoshi cohort study. International journal

Masanori Iwasaki, Misuzu Sato, Akihiro Yoshihara, Toshiko Saito, Kaori Kitamura, Toshihiro Ansai, Kazutoshi Nakamura

Gerodontology   38 ( 3 )   267 - 275   2021.1

　More details

Language：English   Publishing type：Research paper (scientific journal)  

OBJECTIVE: In this 5-year cohort study, we aimed to determine whether the intake of natto, a fermented soya bean food product, has an indirect effect on tooth loss incidence through BMD changes among postmenopausal women. BACKGROUND: Evidence indicates (1) that natto has a beneficial effect on bone health and (2) that a decrease in bone mineral density (BMD) is associated with tooth loss. METHODS: The study recruited 435 postmenopausal women (average age = 64.2 years). Natto intake (exposure) was assessed at baseline using a food frequency questionnaire. Lumbar spine BMD and number of teeth were measured at baseline and 5-year follow-up. BMD change (mediator) and the number of teeth lost (outcome) over time were calculated. The mediation model consisted of these 3 variables. Mediation analysis was performed to test the indirect effect of the natto intake measured through BMD change on tooth loss. RESULTS: During the study, the mean number of teeth lost was 1.2 (standard deviation = 1.8), and the mean BMD decline was 2.5% (standard deviation = 7.1). After adjusting for potential confounders, increasing habitual natto intake was significantly indirectly associated with a lower incidence of tooth loss mediated by BMD change (incidence rate ratio of tooth loss among women with "≥1 pack/day" natto intake was 0.90 [95% confidence interval = 0.82-0.99] compared to those with natto consumption of "rarely"). CONCLUSIONS: Dietary natto intake is significantly indirectly associated with a lower incidence of tooth loss among postmenopausal women, and systemic bone density could be a mediator of this association.

DOI： 10.1111/ger.12523

PubMed

researchmap

Interaction between and impact of IL-6 genotype and alpha-tocopherol levels on periodontal condition in aging individuals. International journal

Akihiro Yoshihara, Noboru Kaneko, Akane Miyamoto, Kaname Nohno

Journal of periodontal research   56 ( 1 )   139 - 146   2021.1

　More details

Language：English   Publishing type：Research paper (scientific journal)  

BACKGROUND AND OBJECTIVES: Few studies have assessed the possible interaction between and impact of IL-6 variants and serum α-tocopherol levels on periodontal condition in older individuals. Here, we assessed the relationship between IL-6 variants and serum α-tocopherol levels on periodontal condition by considering effect modification. MATERIAL AND METHODS: Among the study participants, 359 who were 71 years of age underwent a dental examination, biochemical analysis, and interview. After dividing the participants into tertiles based on serum α-tocopherol levels, we conducted Poisson regression analysis to compare the prevalence rate ratio (PRR) for periodontal disease markers with the IL-6 genotype (rs1800796) based on each tertile adjusted by the number of teeth present (offset). RESULTS: The PRRs of the IL-6 genotype for periodontal condition (probing pocket depth [PPD], clinical attachment level [CAL], and bleeding on probing [BOP]) which were adjusted by the number of teeth present (offset) were 1.17 (P < .001), 1.37 (P < .001), and 1.08 (P = .048), respectively. In addition, a significant association was found between the reciprocal number of PRRs of the IL-6 genotype and three serum α-tocopherol levels. The adjusted PRRs (± standard error) of the IL-6 genotypes for PPD were 0.48 (0.12) for the first group (P < .001), 1.54 (0.04) for the second group (P < .001), and 2.11 (0.03) for the third group (P < .001); similar tendencies were seen for CAL and BOP. CONCLUSION: The results of this study suggest a potential association between the IL-6 genotype and periodontal condition in relation to serum antioxidant concentrations.

DOI： 10.1111/jre.12802

PubMed

researchmap

Dentition status and 10-year higher-level functional capacity trajectories in older adults.

Masanori Iwasaki, Akihiro Yoshihara

Geriatrics & gerontology international   21 ( 1 )   48 - 53   2021.1

　More details

Language：English   Publishing type：Research paper (scientific journal)  

AIM: The effect of dentition status on higher-level functional capacity patterns over time remains unclear. We aimed to identify distinct higher-level functional capacity trajectories in individuals aged 70-80 years, and examine whether dentition status at 70 years predicted the trajectory. METHODS: The study included 551 community-dwelling adults aged 70 years at baseline. Higher-level functional capacity was measured using the Tokyo Metropolitan Institute of Gerontology Index of Competence (TMIG-IC) up to the age of 80 years. A higher TMIG-IC score indicated a higher level of competence. Group-based trajectory modeling was used to identify distinct TMIG-IC trajectories. The number of teeth, use of dentures, sex and education were added as baseline group membership predictors. Dental visits, health behaviors, body mass index and comorbidities during observation were added as time-varying covariates. RESULTS: Three TMIG-IC trajectories were identified: "high/stable" (65.3%), "middle/decline" (24.5%) and "low/decline" (10.2%). A lower number of teeth and non-denture use were associated with increased odds of a low/decline trajectory relative to a high/stable trajectory (odds ratio 1.09, 95% confidence interval 1.04-1.14 [per one decrease] and odds ratio 3.96, 95% confidence interval 1.54-10.16, respectively). CONCLUSIONS: Older adults with fewer teeth and those without dentures at the age of 70 years were more likely to follow a trajectory toward functional decline with low baseline TMIG-IC scores, which further declines by the age of 80 years. These findings suggest that preserving natural teeth later in life, as well as using dentures, could contribute toward maintaining a higher-level functional competence. Geriatr Gerontol Int 2021; 21: 48-53.

DOI： 10.1111/ggi.14099

PubMed

researchmap

腎機能と歯の本数との関連(魚沼コホート胴査より)

皆川 久美子, 葭原 明弘, 諏訪間 加奈, 小川 祐司

口腔衛生学会雑誌   71 ( 1 )   52 - 52   2021.1

　More details

Language：Japanese   Publisher：(一社)日本口腔衛生学会  

researchmap

抗Porphyromonas gingivalis IgG血清抗体価と肝機能マーカー値および肥満との関連性 佐渡コホートにおける横断研究

高見澤 圭, 杉田 典子, 葭原 明弘, 小林 哲夫, 吉江 弘正, 多部田 康一

新潟歯学会雑誌   50 ( 2 )   108 - 109   2020.12

　More details

Language：Japanese   Publisher：新潟歯学会  

researchmap

Diet and root surface caries in a cohort of older Japanese. International journal

Akihiro Yoshihara, Kana Suwama, Akane Miyamoto, Reiko Watanabe, Hiroshi Ogawa

Community dentistry and oral epidemiology   49 ( 3 )   301 - 308   2020.11

　More details

Language：English   Publishing type：Research paper (scientific journal)  

OBJECTIVES: Root surface caries experience tends to increase with age. The purpose of this longitudinal study was to evaluate the relationship between aspects of dietary intake, including milk and sucrose in coffee or tea (SCT), and root surface caries in older Japanese individuals. METHODS: 303 community-dwelling older individuals (age 75 years) were enrolled for analysis. All participants underwent a dental examination at baseline and then annually from 2003 to 2008 (ie six times over a 5-year period). A disease event was considered to have occurred when root surface caries was detected on a previously sound or nonexposed root surface. Over the observation period, disease events in each year were counted. Dietary habits during the preceding month were evaluated using a brief self-administered diet history questionnaire (BDHQ) in 2003 and 2008. Poisson regression analysis performed crude and adjusted increment-rate ratios (IRRs) for root surface caries and the intake of milk and SCT. RESULTS: The adjusted increment-rate ratio (IRR) of the increment of root surface caries for participants in the highest SCT tertile was 1.72 (95%CI: 1.40-2.14) compared with the referent group. In addition, for the amount of milk intake, the adjusted IRR in the highest tertile was 0.63 (95% CI: 0.51-0.78) compared with the referent group. CONCLUSIONS: Much SCT and low milk intake were associated with the increment of root surface caries in community-dwelling older people in Japan. These findings suggest that to help prevent root surface caries, community-dwelling older people in Japan should consume adequate amounts of milk daily and limit their intake of SCT.

DOI： 10.1111/cdoe.12602

PubMed

researchmap

Association between serum IgG antibody titers against Porphyromonas gingivalis and liver enzyme levels: A cross-sectional study in Sado Island. International journal

Kei Takamisawa, Noriko Sugita, Shigeki Komatsu, Minako Wakasugi, Akio Yokoseki, Akihiro Yoshihara, Tetsuo Kobayashi, Kazutoshi Nakamura, Osamu Onodera, Takeshi Momotsu, Naoto Endo, Kenji Sato, Ichiei Narita, Hiromasa Yoshie, Koichi Tabeta

Heliyon   6 ( 11 )   e05531   2020.11

　More details

Language：English   Publishing type：Research paper (scientific journal)  

Background: Previous studies have reported associations between nonalcoholic fatty liver disease, periodontitis, and obesity. Serum immunoglobulin G (IgG) antibody titer against Porphyromonas gingivalis, a major pathogen of periodontitis, is an established indicator of periodontal infection. However, the relationship between the antibody titer and liver enzyme levels has not been clarified yet. A study in the elderly was needed to evaluate the effect of long-term persistent bacterial infection on liver function. The objective of this study was to investigate the association between liver function and infection by P. gingivalis, and the effect of obesity on the association. Methods: A cross-sectional study was conducted in adult outpatients visiting Sado General Hospital, in Niigata Prefecture, Japan, from 2008 to 2010. The final participants included 192 men and 196 women (mean age 68.1 years). Multivariable logistic regression analyses were performed to assess the association between the serum IgG antibody titer and the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamine transferase (GGT) levels. Results: In women, serum IgG antibody titers against P. gingivalis was associated with elevated ALT, but not with AST or GGT, independent of covariates (p = 0.015). No significant association was found between the antibody titer and the elevated liver enzymes in men. The effect of obesity on the relationship between antibody titer and liver enzyme levels was not statistically significant. Conclusions: A cross-sectional analysis of adult outpatients suggested an association between P. gingivalis infection and ALT levels in women. The effect of obesity on this association was not statistically significant.

DOI： 10.1016/j.heliyon.2020.e05531

PubMed

researchmap